#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31424-1	uniprotkb:P29274	intact:EBI-2902778	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:p31424-1(display_long)|uniprotkb:5b(isoform synonym)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Ferre et al. (2002)	pubmed:12189203|imex:IM-20497	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2902730|imex:IM-20497-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2902734(isoform-parent)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	-	-	-	figure legend:Fig. 1A, 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/05	2014/10/16	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	intact-crc:E253DD5BBE75A742|rigid:iJvfxVnJ2MQRYccz+SHQBfr+A2c	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31424-1	uniprotkb:P29274	intact:EBI-2902778	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:p31424-1(display_long)|uniprotkb:5b(isoform synonym)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ferre et al. (2002)	pubmed:12189203|imex:IM-20497	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2902799|imex:IM-20497-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2902734(isoform-parent)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	-	-	-	figure legend:Fig. 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/05	2014/10/16	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	intact-crc:2BB595E74F04D061|rigid:iJvfxVnJ2MQRYccz+SHQBfr+A2c	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29274	uniprotkb:P31424-1	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2902778	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:p31424-1(display_long)|uniprotkb:5b(isoform synonym)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ferre et al. (2002)	pubmed:12189203|imex:IM-20497	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2902807|imex:IM-20497-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	intact:EBI-2902734(isoform-parent)	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/05	2014/10/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:C281E713E7EF5216|rigid:iJvfxVnJ2MQRYccz+SHQBfr+A2c	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30543	uniprotkb:P31424	intact:EBI-2902822|ensembl:ENSRNOP00000001759	intact:EBI-2902734	psi-mi:aa2ar_rat(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ferre et al. (2002)	pubmed:12189203|imex:IM-20497	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2902881|imex:IM-20497-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000001302(gene)|ensembl:ENSRNOT00000001759(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-5683826|go:"GO:0043116"(negative regulation of vascular permeability)|rgd:2049|refseq:NP_445746.3|refseq:XP_017457041.1|refseq:XP_017457042.1|refseq:XP_017457043.1|refseq:XP_017457044.1	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-striatum)|taxid:10116(Rattus norvegicus brian stiatum)	-	2010/08/05	2014/10/16	rogid:sXgn+A8OWk43DSsggsiGWPmC8gk10116	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:129F6D022FC1BD15|rigid:MPBEO4PjFy2TBMNpOsqQAa3X0Hc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)