#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N122	uniprotkb:P42345	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639282|imex:IM-19492-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:Fig. 1. B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:95425201812C3609|rigid:dQs0nVDm5FWkds9pTVXtLjfPklc	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8N122	uniprotkb:Q9JLN9	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639286|imex:IM-19492-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	-	-	-	figure legend:Fig. 2. A and Fig. 3. A|delivery method:Q8N122;Q9JLN9 transfection|comment:the interaction is abolished if the immunoprecipitates are washed with a wash buffer containing 1% NP-40.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	intact-crc:08B01A627FBB1559|rigid:3mPyMx6NIPIwy8a+8BO3ncW2n5A	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JLN9	uniprotkb:Q8N122	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639298|imex:IM-19492-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2. A|delivery method:Q8N122;Q9JLN9 transfection|comment:the interaction is abolished if the immunoprecipitates are washed with a wash buffer containing 1% NP-40.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:243690CC07171A99|rigid:3mPyMx6NIPIwy8a+8BO3ncW2n5A	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N122	uniprotkb:Q13541	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639661|imex:IM-19492-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	-	-	-	figure legend:Fig. 4. B|delivery method:Q8N122;Q9JLN9;B2R502 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	intact-crc:61F369E535075CB3|rigid:qCLtVlT89fnvnE//fWUMGAmy94M	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N122	uniprotkb:Q9JLN9	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639661|imex:IM-19492-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	-	-	-	figure legend:Fig. 4. B|delivery method:Q8N122;Q9JLN9;B2R502 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	intact-crc:61F369E535075CB3|rigid:qCLtVlT89fnvnE//fWUMGAmy94M	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N122	uniprotkb:Q9JLN9	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639677|imex:IM-19492-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	-	-	-	figure legend:Fig. 4. B|delivery method:Q8N122;Q9JLN9;P67999 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	intact-crc:A73C576AD1338575|rigid:UcFwP/qGCk5+FQSJxjKp2AEBr+0	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N122	uniprotkb:P67999	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	intact:EBI-2639458|uniprotkb:P21425|ensembl:ENSRNOP00000005226	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:ks6b1_rat(display_long)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639677|imex:IM-19492-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	rgd:620683|refseq:NP_114191.1|ensembl:ENSRNOG00000003919(gene)|ensembl:ENSRNOT00000005226(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043201"(response to leucine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0106311"|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P67999|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|reactome:R-RNO-166208|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)	-	-	-	figure legend:Fig. 4. B|delivery method:Q8N122;Q9JLN9;P67999 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	rogid:hBuNefgCfqyO/LhEhClgcQrTjlM10116	intact-crc:A73C576AD1338575|rigid:UcFwP/qGCk5+FQSJxjKp2AEBr+0	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13541	uniprotkb:Q8N122	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639992|imex:IM-19492-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 5. C|delivery method:Q8N122;B2R502 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:90059D8478EE214D|rigid:fziK/RmjTi4Z+bs3lGweE2U6b/I	false	mutation decreasing interaction:83-83,65-65,70-70,37-37,46-46|flag tag:?-?|mutation increasing interaction:70-70,83-83,65-65,46-46,37-37	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42345	uniprotkb:Q8N122	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639317|imex:IM-19492-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2. B and fig. 6. A|antibodies:specific monoclonal antibody against FRAP1 for the co-immunoprecipitation and specific polyclonal antibodies against RPTOR for the immuno blot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:A87AAF276E98B02D|rigid:dQs0nVDm5FWkds9pTVXtLjfPklc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42345	uniprotkb:Q8N122	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639322|imex:IM-19492-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2. B|antibodies:specific polyclonal antibodies antibody against RPTOR for the co-immunoprecipitation and specific monoclonal antibody against FRAP1 for the immuno blot|comment:The immunoprecipitate was subjected to the kinase assay using GST-4EBP1 as a substrate.The anti-N-raptor Ab precipitates a kinase activity toward GST-4EBP1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:B803A4EE2A387575|rigid:dQs0nVDm5FWkds9pTVXtLjfPklc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JLN9	uniprotkb:Q13541	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639380|imex:IM-19492-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 3. A and B|delivery method:Q9JLN9;B2R502 transfection|inhibition:Rapamycin decreases the phosphorylation of EIF4EBP1 by FRAP1|comment:"RPTOR (Q8N122) increases the kinase activity of FRAP1"|resulting-ptm:EIF4EBP1 is phosphorylated by Frap1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/04/12	2014/10/16	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	intact-crc:586446EDEC96C457|rigid:f+Oph3tkM4Z3dpwhiXTNvKszwiA	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P67999	uniprotkb:Q9JLN9	intact:EBI-2639458|uniprotkb:P21425|ensembl:ENSRNOP00000005226	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	psi-mi:ks6b1_rat(display_long)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639539|imex:IM-19492-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620683|refseq:NP_114191.1|ensembl:ENSRNOG00000003919(gene)|ensembl:ENSRNOT00000005226(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043201"(response to leucine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0106311"|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P67999|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|reactome:R-RNO-166208|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 3. C|delivery method:P42345;P67999 transfection|comment:"RPTOR (Q8N122) increases the kinase activity of FRAP1"|antibodies:specific monoclonal antibody against FRAP1 has been used to immunoprecipitate FRAP1|resulting-ptm:Rps6kb1 is phosphorylated by Frap1. The required amino acid for the kinase activity of Frap1 is asn 2343.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/04/12	2014/10/16	rogid:hBuNefgCfqyO/LhEhClgcQrTjlM10116	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	intact-crc:3754887414FC0651|rigid:Bz6GCKNkwOVv7XXo+U1nIdZUjUg	false	glutathione s tranferase tag:?-?	ha tag:?-?|mutation:2343-2343	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P42345	uniprotkb:Q13541	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2640036|imex:IM-19492-14	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 2. B|delivery method:B2R502 transfection|comment:"RPTOR (Q8N122) increases the kinase activity of FRAP1"|antibodies:specific monoclonal antibody against FRAP1 has been used to immunoprecipitate FRAP1|resulting-ptm:EIF4EBP1 is phosphorylated by FRAP1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/04/12	2014/10/16	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	intact-crc:80D483DF057C30B6|rigid:Fy8MqLZvLiO1Sr7T8QzWmZ2I6hA	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13541	uniprotkb:P42345	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2640102|imex:IM-19492-15	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 6. A|delivery method:B2R502 transfection|comment:"RPTOR (Q8N122) increases the kinase activity of FRAP1"|antibodies:specific monoclonal antibody against FRAP1 has been used to immunoprecipitate FRAP1|inhibition:"The mTOR kinase activity toward GST-4EBP1 were severely reduced in cells transfected with siRNA 47-67 duplex (bp 47 to 67 of Raptor) but moderately reduced with siRNA 127-147 (bp 127 to 147 of raptor)"|resulting-ptm:Phosphorylation of EIF4EP1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/04/12	2014/10/16	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:97AA52A96AE18CE0|rigid:Fy8MqLZvLiO1Sr7T8QzWmZ2I6hA	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13541	uniprotkb:Q8N122	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639612|imex:IM-19492-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 4. A|delivery method:Q8N122;B2R502 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:AA5B5F27C712B601|rigid:fziK/RmjTi4Z+bs3lGweE2U6b/I	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N122	uniprotkb:P67999	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	intact:EBI-2639458|uniprotkb:P21425|ensembl:ENSRNOP00000005226	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:ks6b1_rat(display_long)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639638|imex:IM-19492-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	rgd:620683|refseq:NP_114191.1|ensembl:ENSRNOG00000003919(gene)|ensembl:ENSRNOT00000005226(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043201"(response to leucine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0106311"|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P67999|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|reactome:R-RNO-166208|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)	-	-	-	figure legend:Fig. 4. A and C|delivery method:Q8N122;P67999 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	rogid:hBuNefgCfqyO/LhEhClgcQrTjlM10116	intact-crc:10B1FB03A9EBCE5B|rigid:CNbTM1NFAFgy2wA77tClFHNIFkE	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13541	uniprotkb:Q9JLN9	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	intact:EBI-1571628|uniprotkb:Q811J5|uniprotkb:Q9CST1|ensembl:ENSMUSP00000099510|uniprotkb:Q2KHT0	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:mtor_mouse(display_long)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:Mtor(gene name)|psi-mi:Mtor(display_short)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:Frap1(gene name synonym)|uniprotkb:Frap(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639698|imex:IM-19492-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	ensembl:ENSMUSG00000028991(gene)|ensembl:ENSMUST00000103221(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0007569"(cell aging)|go:"GO:0016301"(kinase activity)|go:"GO:0007584"(response to nutrient)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0007616"(long-term memory)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008361"(regulation of cell size)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0008542"(visual learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0031929"(TOR signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055006"(cardiac cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:1904058"(positive regulation of sensory perception of pain)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR036738|interpro:IPR036940|mint:Q9JLN9|reactome:R-MMU-1257604|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-389357|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-8943724|reactome:R-MMU-9639288|refseq:NP_064393.2|dip:DIP-40570N	-	-	-	figure legend:Fig. 4. C|delivery method:Q8N122;Q9JLN9;B2R502 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	rogid:Vc4KAHPBcOKi9OKdCv0vbzLaj2Y10090	intact-crc:9822FE974F919B75|rigid:qCLtVlT89fnvnE//fWUMGAmy94M	false	glutathione s tranferase tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13541	uniprotkb:Q8N122	intact:EBI-74090|uniprotkb:B2R502|uniprotkb:Q6IBN3|uniprotkb:D3DSW8|ensembl:ENSP00000340691	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:4ebp1_human(display_long)|uniprotkb:Phosphorylated heat- and acid-stable protein regulated by insulin 1(gene name synonym)|uniprotkb:EIF4EBP1(gene name)|psi-mi:EIF4EBP1(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hara et al. (2002)	pubmed:12150926|imex:IM-19492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639698|imex:IM-19492-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004086.1|ensembl:ENSP00000340691|ensembl:ENSG00000187840(gene)|ensembl:ENST00000338825(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-30944N|go:"GO:0005829"(cytosol)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0030324"(lung development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|interpro:IPR037582|mint:Q13541|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1WKW|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:2V8W|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:3HXG|rcsb pdb:3HXI|rcsb pdb:3M93|rcsb pdb:3M94|rcsb pdb:3U7X|rcsb pdb:4UED|rcsb pdb:5BXV|rcsb pdb:5EKV|rcsb pdb:5NVN|rcsb pdb:5WBJ|rcsb pdb:6BCU|rcsb pdb:6BCX|reactome:R-HSA-166208|reactome:R-HSA-72662	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 4. C|delivery method:Q8N122;Q9JLN9;B2R502 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/04/12	2014/10/16	rogid:abkjWitYZ9erPSlC88IWI2FtKto9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:9822FE974F919B75|rigid:qCLtVlT89fnvnE//fWUMGAmy94M	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)