#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JID9	uniprotkb:Q61851	intact:EBI-8100899|uniprotkb:Q6PG00|uniprotkb:O88936|intact:UNK-5548831|ensembl:ENSMUSP00000005188|ensembl:ENSMUSP00000142398	intact:EBI-6287052|uniprotkb:Q61564|uniprotkb:Q63834	psi-mi:sh2b2_mouse(display_long)|uniprotkb:Sh2b2(gene name)|psi-mi:Sh2b2(display_short)|uniprotkb:Aps(gene name synonym)|uniprotkb:SH2 and PH domain-containing adapter protein APS(gene name synonym)|uniprotkb:Adapter protein with pleckstrin homology and Src homology 2 domains(gene name synonym)	psi-mi:fgfr3_mouse(display_long)|uniprotkb:Fgfr3(gene name)|psi-mi:Fgfr3(display_short)|uniprotkb:Mfr3(gene name synonym)|uniprotkb:Sam3(gene name synonym)|uniprotkb:Heparin-binding growth factor receptor(gene name synonym)	psi-mi:"MI:0369"(lex-a dimerization assay)	Kong et al. (2002)	pubmed:11827956|mint:MINT-6731405	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8100940|mint:MINT-8034258	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006504483.2|refseq:NP_061295.2|refseq:NP_001289867.1|refseq:NP_001289868.1|refseq:XP_006504485.1|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0050776"(regulation of immune response)|ensembl:ENSMUST00000196397(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|ensembl:ENSMUSG00000005057(gene)|ensembl:ENSMUST00000005188(transcript)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050873"(brown fat cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015012(Phenylalanine zipper)|interpro:IPR030520|interpro:IPR030523|interpro:IPR035058|interpro:IPR036290|interpro:IPR036860|rcsb pdb:1V5M|reactome:R-MMU-1433559|reactome:R-MMU-983231|mint:MINT-8034259(identity)|uniprotkb:Q9JID9(original identifier)	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0010712"(regulation of collagen metabolic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030282"(bone mineralization)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0005524"(ATP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0048678"(response to axon injury)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060348"(bone development)|go:"GO:0005634"(nucleus)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0061430"(bone trabecula morphogenesis)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0005737"(cytoplasm)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005764"(lysosome)|go:"GO:0070977"(bone maturation)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0072148"(epithelial cell fate commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR013098(Immunoglobulin I-set)|go:"GO:0090102"(cochlea development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|dip:DIP-6031N|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190371|reactome:R-MMU-190372|reactome:R-MMU-5654227|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654732|reactome:R-MMU-5673001|reactome:R-MMU-6811558|mint:MINT-8034262(identity)|uniprotkb:Q61851(original identifier)	-	comment:mint|function:Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3	-	comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:WwK5OEI2vnDxYTTK8koXgBpP1dk10090	rogid:3jdly+HWh0GwI6obkw98fhYrj0k10090	intact-crc:9453BAC35010911D|rigid:NZvM8orYHwfav4fy83r4bTRRjVk	false	-	binding-associated region:712-725(MINT-8034265)|phosphorylated residue:719-719(MINT-8034267)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JID9	uniprotkb:Q61851	intact:EBI-8100899|uniprotkb:Q6PG00|uniprotkb:O88936|intact:UNK-5548831|ensembl:ENSMUSP00000005188|ensembl:ENSMUSP00000142398	intact:EBI-6287052|uniprotkb:Q61564|uniprotkb:Q63834	psi-mi:sh2b2_mouse(display_long)|uniprotkb:Sh2b2(gene name)|psi-mi:Sh2b2(display_short)|uniprotkb:Aps(gene name synonym)|uniprotkb:SH2 and PH domain-containing adapter protein APS(gene name synonym)|uniprotkb:Adapter protein with pleckstrin homology and Src homology 2 domains(gene name synonym)	psi-mi:fgfr3_mouse(display_long)|uniprotkb:Fgfr3(gene name)|psi-mi:Fgfr3(display_short)|uniprotkb:Mfr3(gene name synonym)|uniprotkb:Sam3(gene name synonym)|uniprotkb:Heparin-binding growth factor receptor(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Kong et al. (2002)	pubmed:11827956|mint:MINT-6731405	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8101009|mint:MINT-8034273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006504483.2|refseq:NP_061295.2|refseq:NP_001289867.1|refseq:NP_001289868.1|refseq:XP_006504485.1|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0050776"(regulation of immune response)|ensembl:ENSMUST00000196397(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|ensembl:ENSMUSG00000005057(gene)|ensembl:ENSMUST00000005188(transcript)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050873"(brown fat cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015012(Phenylalanine zipper)|interpro:IPR030520|interpro:IPR030523|interpro:IPR035058|interpro:IPR036290|interpro:IPR036860|rcsb pdb:1V5M|reactome:R-MMU-1433559|reactome:R-MMU-983231|mint:MINT-8034274(identity)|uniprotkb:Q9JID9(original identifier)	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0010712"(regulation of collagen metabolic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030282"(bone mineralization)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0005524"(ATP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0048678"(response to axon injury)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060348"(bone development)|go:"GO:0005634"(nucleus)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0061430"(bone trabecula morphogenesis)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0005737"(cytoplasm)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005764"(lysosome)|go:"GO:0070977"(bone maturation)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0072148"(epithelial cell fate commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR013098(Immunoglobulin I-set)|go:"GO:0090102"(cochlea development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|dip:DIP-6031N|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190371|reactome:R-MMU-190372|reactome:R-MMU-5654227|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654732|reactome:R-MMU-5673001|reactome:R-MMU-6811558|mint:MINT-8034277(identity)|uniprotkb:Q61851(original identifier)	-	comment:mint|function:Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3	-	comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:WwK5OEI2vnDxYTTK8koXgBpP1dk10090	rogid:3jdly+HWh0GwI6obkw98fhYrj0k10090	intact-crc:132514964ED4E3F9|rigid:NZvM8orYHwfav4fy83r4bTRRjVk	false	-	binding-associated region:712-725(MINT-8034280)|phosphorylated residue:719-719(MINT-8034282)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JID9	uniprotkb:Q61851	intact:EBI-8100899|uniprotkb:Q6PG00|uniprotkb:O88936|intact:UNK-5548831|ensembl:ENSMUSP00000005188|ensembl:ENSMUSP00000142398	intact:EBI-6287052|uniprotkb:Q61564|uniprotkb:Q63834	psi-mi:sh2b2_mouse(display_long)|uniprotkb:Sh2b2(gene name)|psi-mi:Sh2b2(display_short)|uniprotkb:Aps(gene name synonym)|uniprotkb:SH2 and PH domain-containing adapter protein APS(gene name synonym)|uniprotkb:Adapter protein with pleckstrin homology and Src homology 2 domains(gene name synonym)	psi-mi:fgfr3_mouse(display_long)|uniprotkb:Fgfr3(gene name)|psi-mi:Fgfr3(display_short)|uniprotkb:Mfr3(gene name synonym)|uniprotkb:Sam3(gene name synonym)|uniprotkb:Heparin-binding growth factor receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kong et al. (2002)	pubmed:11827956|mint:MINT-6731405	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8101038|mint:MINT-8034288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006504483.2|refseq:NP_061295.2|refseq:NP_001289867.1|refseq:NP_001289868.1|refseq:XP_006504485.1|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0050776"(regulation of immune response)|ensembl:ENSMUST00000196397(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|ensembl:ENSMUSG00000005057(gene)|ensembl:ENSMUST00000005188(transcript)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050873"(brown fat cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015012(Phenylalanine zipper)|interpro:IPR030520|interpro:IPR030523|interpro:IPR035058|interpro:IPR036290|interpro:IPR036860|rcsb pdb:1V5M|reactome:R-MMU-1433559|reactome:R-MMU-983231|mint:MINT-8034289(identity)|uniprotkb:Q9JID9(original identifier)	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0010712"(regulation of collagen metabolic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030282"(bone mineralization)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0005524"(ATP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0048678"(response to axon injury)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060348"(bone development)|go:"GO:0005634"(nucleus)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0061430"(bone trabecula morphogenesis)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0005737"(cytoplasm)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005764"(lysosome)|go:"GO:0070977"(bone maturation)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0072148"(epithelial cell fate commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR013098(Immunoglobulin I-set)|go:"GO:0090102"(cochlea development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|dip:DIP-6031N|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190371|reactome:R-MMU-190372|reactome:R-MMU-5654227|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654732|reactome:R-MMU-5673001|reactome:R-MMU-6811558|mint:MINT-8034292(identity)|uniprotkb:Q61851(original identifier)	-	comment:mint|function:Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3	-	comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:WwK5OEI2vnDxYTTK8koXgBpP1dk10090	rogid:3jdly+HWh0GwI6obkw98fhYrj0k10090	intact-crc:BEE8E1760BB38E78|rigid:NZvM8orYHwfav4fy83r4bTRRjVk	false	-	phosphorylated residue:719-719(MINT-8034297)|binding-associated region:712-725(MINT-8034295)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)