#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14543	uniprotkb:P20936	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cacalano et al. (2001)	pubmed:11331873|mint:MINT-6731288	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7836641|mint:MINT-8036497	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-8036501(identity)|uniprotkb:O14543(original identifier)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N|mint:MINT-8036498(identity)|uniprotkb:P20936(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/29	2014/10/16	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:C93A7F640B409AE9|rigid:Mw6df+zjtwVCqcKcA62T/NCIJgs	false	binding-associated region:214-225(MINT-8036504)|phosphorylated residue:221-221(MINT-8036506)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20936	uniprotkb:O14543	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Cacalano et al. (2001)	pubmed:11331873|mint:MINT-6731288	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7836671|mint:MINT-8036512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N|mint:MINT-8036513(identity)|uniprotkb:P20936(original identifier)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-8036516(identity)|uniprotkb:O14543(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/29	2014/10/16	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	intact-crc:E8052F66D374CAED|rigid:Mw6df+zjtwVCqcKcA62T/NCIJgs	false	-	phosphorylated residue:221-221(MINT-8036521)|binding-associated region:214-225(MINT-8036519)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)