#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-2528817 uniprotkb:Q10666 - intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 psi-mi:gatcaaag(display_short)|psi-mi:EBI-2528817(display_long) psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Korswagen et al. (2000) pubmed:10952315|imex:IM-20418 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2528814|imex:IM-20418-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 - - - figure legend:Fig 1a.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/11 2014/10/16 crc64:737DDDDDDEA1ADD8 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 intact-crc:63A1C05D0EAB44A7 false - sufficient binding region:180-280(IPR000910)|his tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q18825 uniprotkb:Q10666 intact:EBI-2528850|ensemblmetazoa:C54D1.6.1 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 psi-mi:bar1_caeel(display_long)|uniprotkb:bar-1(gene name)|psi-mi:bar-1(display_short)|uniprotkb:pvl-1(gene name synonym)|uniprotkb:spy-1(gene name synonym)|uniprotkb:Protruding vulva protein 1(gene name synonym)|uniprotkb:Suppressor of polyray 1(gene name synonym)|uniprotkb:C54D1.6(orf name) psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Korswagen et al. (2000) pubmed:10952315|imex:IM-20418 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2528880|imex:IM-20418-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_509206.1|wormbase:C54D1.6|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR013284(Beta-catenin)|ensemblmetazoa:C54D1.6.1(transcript)|ensemblmetazoa:WBGene00000238(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007617"(mating behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0016020"(membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018991"(oviposition)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040024"(dauer larval development)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0043058"(regulation of backward locomotion)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070986"(left/right axis specification)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903356"(positive regulation of distal tip cell migration)|go:"GO:0040035"(hermaphrodite genitalia development)|reactome:R-CEL-6798695|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407 reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 - - - figure legend:Fig 2a.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/11 2014/10/16 rogid:2cYTDh2x+j/Ln7GTP5KQQ3eZO3A6239 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 intact-crc:47F375290C4452F5|rigid:qxiXEV1sPq1GOBf7B5KtNT3PMZI false sufficient binding region:85-811 sufficient binding region:1-181 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q967F4 uniprotkb:O44326 intact:EBI-2528888|uniprotkb:O44327|ensemblmetazoa:W02B9.1b.1|ensemblmetazoa:W02B9.1b.2|uniprotkb:B2MZC5|uniprotkb:H2FLJ9|uniprotkb:H2FLK0 intact:EBI-317320|ensemblmetazoa:K05C4.6a.1|ensemblmetazoa:K05C4.6a.2 psi-mi:hmr1_caeel(display_long)|uniprotkb:hmr-1(gene name)|psi-mi:hmr-1(display_short)|uniprotkb:Protein Hammerhead(gene name synonym)|uniprotkb:W02B9.1(orf name) psi-mi:hmp2_caeel(display_long)|uniprotkb:hmp-2(gene name)|psi-mi:hmp-2(display_short)|uniprotkb:Protein humpback-2(gene name synonym)|uniprotkb:K05C4.6(orf name) psi-mi:"MI:0018"(two hybrid) Korswagen et al. (2000) pubmed:10952315|imex:IM-20418 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2528936|imex:IM-20418-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:W02B9.1b.1(transcript)|ensemblmetazoa:W02B9.1b.2(transcript)|ensemblmetazoa:WBGene00001980(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0003384"(apical constriction involved in gastrulation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR001791(Laminin G)|interpro:IPR002126(Cadherin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR018247|interpro:IPR020894|rcsb pdb:4R10|rcsb pdb:4R11|interpro:IPR000742(EGF-like, type 3)|refseq:NP_001021650.1|wormbase:W02B9.1a|wormbase:W02B9.1b|wormbase:W02B9.1d|wormbase:W02B9.1c|wormbase:W02B9.1e|refseq:NP_001021649.2|refseq:NP_001129794.1|refseq:NP_001251561.1|refseq:NP_001251562.1|dip:DIP-56285N wormbase:K05C4.6a|reactome:R-CEL-8853884|refseq:NP_001252426.1|rcsb pdb:4R0Z|rcsb pdb:4R10|rcsb pdb:4R11|rcsb pdb:5XA5|interpro:IPR016024(Armadillo-type fold)|ensemblmetazoa:K05C4.6a.1(transcript)|ensemblmetazoa:K05C4.6a.2(transcript)|ensemblmetazoa:WBGene00001979(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070986"(left/right axis specification)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|reactome:R-CEL-6798695|reactome:R-CEL-351906|reactome:R-CEL-525793|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|dip:DIP-27261N|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-201681|reactome:R-CEL-201722|reactome:R-CEL-3134973|reactome:R-CEL-3769402|reactome:R-CEL-4086398|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8951430 - - - figure legend:Fig 2a.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/11 2014/10/16 rogid:ogbuiUw6rS5+SMw515Bday0fg246239 rogid:8DLyhATsxCZq1Vthd5haUE54Kmw6239 intact-crc:69F5BE3947BBB6E0|rigid:ev3Gecv0RWZ87bpfqg6J4pGOq6w false sufficient binding region:1124-1223 sufficient binding region:1-678 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q10666 uniprotkb:Q18825 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 intact:EBI-2528850|ensemblmetazoa:C54D1.6.1 psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:bar1_caeel(display_long)|uniprotkb:bar-1(gene name)|psi-mi:bar-1(display_short)|uniprotkb:pvl-1(gene name synonym)|uniprotkb:spy-1(gene name synonym)|uniprotkb:Protruding vulva protein 1(gene name synonym)|uniprotkb:Suppressor of polyray 1(gene name synonym)|uniprotkb:C54D1.6(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Korswagen et al. (2000) pubmed:10952315|imex:IM-20418 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2528993|imex:IM-20418-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 refseq:NP_509206.1|wormbase:C54D1.6|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR013284(Beta-catenin)|ensemblmetazoa:C54D1.6.1(transcript)|ensemblmetazoa:WBGene00000238(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007617"(mating behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0016020"(membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018991"(oviposition)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040024"(dauer larval development)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0043058"(regulation of backward locomotion)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070986"(left/right axis specification)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903356"(positive regulation of distal tip cell migration)|go:"GO:0040035"(hermaphrodite genitalia development)|reactome:R-CEL-6798695|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407 - - - figure legend:Fig 2b.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/01/11 2014/10/16 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 rogid:2cYTDh2x+j/Ln7GTP5KQQ3eZO3A6239 intact-crc:93536507686F81B8|rigid:qxiXEV1sPq1GOBf7B5KtNT3PMZI false flag tag:?-? vsv tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q10666 uniprotkb:Q18825 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 intact:EBI-2528850|ensemblmetazoa:C54D1.6.1 psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:bar1_caeel(display_long)|uniprotkb:bar-1(gene name)|psi-mi:bar-1(display_short)|uniprotkb:pvl-1(gene name synonym)|uniprotkb:spy-1(gene name synonym)|uniprotkb:Protruding vulva protein 1(gene name synonym)|uniprotkb:Suppressor of polyray 1(gene name synonym)|uniprotkb:C54D1.6(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Korswagen et al. (2000) pubmed:10952315|imex:IM-20418 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2529036|imex:IM-20418-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 refseq:NP_509206.1|wormbase:C54D1.6|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR013284(Beta-catenin)|ensemblmetazoa:C54D1.6.1(transcript)|ensemblmetazoa:WBGene00000238(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007617"(mating behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0016020"(membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018991"(oviposition)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040024"(dauer larval development)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0043058"(regulation of backward locomotion)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070986"(left/right axis specification)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903356"(positive regulation of distal tip cell migration)|go:"GO:0040035"(hermaphrodite genitalia development)|reactome:R-CEL-6798695|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407 - - - figure legend:Fig 2b, middle image.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/01/11 2014/10/16 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 rogid:2cYTDh2x+j/Ln7GTP5KQQ3eZO3A6239 intact-crc:F0F2E1C6146C94A9|rigid:qxiXEV1sPq1GOBf7B5KtNT3PMZI false necessary binding region:1-44|myc tag:?-? vsv tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O44326 uniprotkb:Q967F4 intact:EBI-317320|ensemblmetazoa:K05C4.6a.1|ensemblmetazoa:K05C4.6a.2 intact:EBI-2528888|uniprotkb:O44327|ensemblmetazoa:W02B9.1b.1|ensemblmetazoa:W02B9.1b.2|uniprotkb:B2MZC5|uniprotkb:H2FLJ9|uniprotkb:H2FLK0 psi-mi:hmp2_caeel(display_long)|uniprotkb:hmp-2(gene name)|psi-mi:hmp-2(display_short)|uniprotkb:Protein humpback-2(gene name synonym)|uniprotkb:K05C4.6(orf name) psi-mi:hmr1_caeel(display_long)|uniprotkb:hmr-1(gene name)|psi-mi:hmr-1(display_short)|uniprotkb:Protein Hammerhead(gene name synonym)|uniprotkb:W02B9.1(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Korswagen et al. (2000) pubmed:10952315|imex:IM-20418 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2529048|imex:IM-20418-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:K05C4.6a|reactome:R-CEL-8853884|refseq:NP_001252426.1|rcsb pdb:4R0Z|rcsb pdb:4R10|rcsb pdb:4R11|rcsb pdb:5XA5|interpro:IPR016024(Armadillo-type fold)|ensemblmetazoa:K05C4.6a.1(transcript)|ensemblmetazoa:K05C4.6a.2(transcript)|ensemblmetazoa:WBGene00001979(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070986"(left/right axis specification)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|reactome:R-CEL-6798695|reactome:R-CEL-351906|reactome:R-CEL-525793|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|dip:DIP-27261N|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-201681|reactome:R-CEL-201722|reactome:R-CEL-3134973|reactome:R-CEL-3769402|reactome:R-CEL-4086398|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8951430 ensemblmetazoa:W02B9.1b.1(transcript)|ensemblmetazoa:W02B9.1b.2(transcript)|ensemblmetazoa:WBGene00001980(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0003384"(apical constriction involved in gastrulation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR001791(Laminin G)|interpro:IPR002126(Cadherin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR018247|interpro:IPR020894|rcsb pdb:4R10|rcsb pdb:4R11|interpro:IPR000742(EGF-like, type 3)|refseq:NP_001021650.1|wormbase:W02B9.1a|wormbase:W02B9.1b|wormbase:W02B9.1d|wormbase:W02B9.1c|wormbase:W02B9.1e|refseq:NP_001021649.2|refseq:NP_001129794.1|refseq:NP_001251561.1|refseq:NP_001251562.1|dip:DIP-56285N - - - figure legend:Fig 2b, rhs image.|caution:The sequence numbers for the transmembrane and intracellular domains of HMR-1 were taken from UniProtKB/Swiss-Prot.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/01/11 2014/10/16 rogid:8DLyhATsxCZq1Vthd5haUE54Kmw6239 rogid:ogbuiUw6rS5+SMw515Bday0fg246239 intact-crc:F74411B08447513F|rigid:ev3Gecv0RWZ87bpfqg6J4pGOq6w false vsv tag:?-? myc tag:c-c|sufficient binding region:2780..2780-2920..2920|fusion protein:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)