#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00241	uniprotkb:O43914	intact:EBI-2615458|uniprotkb:Q9H1U5|uniprotkb:Q5TFR0|uniprotkb:Q8TB12|uniprotkb:Q5TFQ9|uniprotkb:Q9Y4V0|uniprotkb:B2R8V0|uniprotkb:A6NLM2|ensembl:ENSP00000371018	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	psi-mi:sirb1_human(display_long)|uniprotkb:CD172 antigen-like family member B(gene name synonym)|uniprotkb:SIRPB1(gene name)|psi-mi:SIRPB1(display_short)	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Elena et al. (2000)	pubmed:10940905|imex:IM-19467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615473|imex:IM-19467-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077379.1|refseq:NP_006056.2|refseq:NP_001317568.1|refseq:XP_016883066.1|ensembl:ENSG00000101307(gene)|ensembl:ENST00000381605(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2D9C|rcsb pdb:2JJU|reactome:R-HSA-2172127|reactome:R-HSA-391160|reactome:R-HSA-6798695	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/15	2014/10/16	rogid:WChxqhoW8UPxaVrdQDYEL2zsN589606	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	intact-crc:9720F871DDD3F27E|rigid:6FNE9ULzMV5xCcKnUd6xfIZYnrs	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43914	uniprotkb:O00241	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	intact:EBI-2615458|uniprotkb:Q9H1U5|uniprotkb:Q5TFR0|uniprotkb:Q8TB12|uniprotkb:Q5TFQ9|uniprotkb:Q9Y4V0|uniprotkb:B2R8V0|uniprotkb:A6NLM2|ensembl:ENSP00000371018	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:sirb1_human(display_long)|uniprotkb:CD172 antigen-like family member B(gene name synonym)|uniprotkb:SIRPB1(gene name)|psi-mi:SIRPB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Elena et al. (2000)	pubmed:10940905|imex:IM-19467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615485|imex:IM-19467-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	refseq:NP_001077379.1|refseq:NP_006056.2|refseq:NP_001317568.1|refseq:XP_016883066.1|ensembl:ENSG00000101307(gene)|ensembl:ENST00000381605(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2D9C|rcsb pdb:2JJU|reactome:R-HSA-2172127|reactome:R-HSA-391160|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/15	2014/10/16	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	rogid:WChxqhoW8UPxaVrdQDYEL2zsN589606	intact-crc:62C11A01A33E7A2E|rigid:6FNE9ULzMV5xCcKnUd6xfIZYnrs	false	flag tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00241	uniprotkb:O43914	intact:EBI-2615458|uniprotkb:Q9H1U5|uniprotkb:Q5TFR0|uniprotkb:Q8TB12|uniprotkb:Q5TFQ9|uniprotkb:Q9Y4V0|uniprotkb:B2R8V0|uniprotkb:A6NLM2|ensembl:ENSP00000371018	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	psi-mi:sirb1_human(display_long)|uniprotkb:CD172 antigen-like family member B(gene name synonym)|uniprotkb:SIRPB1(gene name)|psi-mi:SIRPB1(display_short)	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Elena et al. (2000)	pubmed:10940905|imex:IM-19467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615500|imex:IM-19467-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077379.1|refseq:NP_006056.2|refseq:NP_001317568.1|refseq:XP_016883066.1|ensembl:ENSG00000101307(gene)|ensembl:ENST00000381605(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2D9C|rcsb pdb:2JJU|reactome:R-HSA-2172127|reactome:R-HSA-391160|reactome:R-HSA-6798695	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2010/03/15	2014/10/16	rogid:WChxqhoW8UPxaVrdQDYEL2zsN589606	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	intact-crc:C00F5F66D1844BBA|rigid:6FNE9ULzMV5xCcKnUd6xfIZYnrs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q64725	uniprotkb:O00241	intact:EBI-2615512	intact:EBI-2615458|uniprotkb:Q9H1U5|uniprotkb:Q5TFR0|uniprotkb:Q8TB12|uniprotkb:Q5TFQ9|uniprotkb:Q9Y4V0|uniprotkb:B2R8V0|uniprotkb:A6NLM2|ensembl:ENSP00000371018	psi-mi:ksyk_rat(display_long)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:Syk(gene name)|psi-mi:Syk(display_short)|uniprotkb:p72Syk(gene name synonym)	psi-mi:sirb1_human(display_long)|uniprotkb:CD172 antigen-like family member B(gene name synonym)|uniprotkb:SIRPB1(gene name)|psi-mi:SIRPB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Elena et al. (2000)	pubmed:10940905|imex:IM-19467	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615510|imex:IM-19467-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9674555|reactome:R-RNO-9705462|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR000980(SH2 motif)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|rgd:3796|refseq:NP_036890.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR023420|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0043366"(beta selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001820"(serotonin secretion)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016170"(interleukin-15 receptor binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|interpro:IPR035838|interpro:IPR036860|reactome:R-RNO-114604|reactome:R-RNO-2029481|reactome:R-RNO-2029482|reactome:R-RNO-2029485|reactome:R-RNO-2424491|reactome:R-RNO-2454202|reactome:R-RNO-2871809|reactome:R-RNO-354192|reactome:R-RNO-5621480|reactome:R-RNO-9020558|reactome:R-RNO-912631|reactome:R-RNO-983695|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-9706374	refseq:NP_001077379.1|refseq:NP_006056.2|refseq:NP_001317568.1|refseq:XP_016883066.1|ensembl:ENSG00000101307(gene)|ensembl:ENST00000381605(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2D9C|rcsb pdb:2JJU|reactome:R-HSA-2172127|reactome:R-HSA-391160|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 4C|agonist:Anti-SIRPB1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rbl_2h3)|taxid:10116(Rat basophilic leukemia cell line)	-	2010/03/15	2014/10/16	rogid:iszczU05LfqmZOLi7hkNTl1+WGY10116	rogid:WChxqhoW8UPxaVrdQDYEL2zsN589606	intact-crc:A97D26A1C66D50D4|rigid:oMvj8rpeU73/aipdGsPCk0D2X/U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P43405	uniprotkb:O43914	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Elena et al. (2000)	pubmed:10940905|imex:IM-19467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615528|imex:IM-19467-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 2B|agonist:Pervanadate - phosphatase inhibitor|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/15	2014/10/16	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	intact-crc:B083178575CD470D|rigid:wSm9sLmRn8gJ/kNx9xL/zqdPURE	false	-	glutathione s tranferase tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00241	uniprotkb:P43405	intact:EBI-2615458|uniprotkb:Q9H1U5|uniprotkb:Q5TFR0|uniprotkb:Q8TB12|uniprotkb:Q5TFQ9|uniprotkb:Q9Y4V0|uniprotkb:B2R8V0|uniprotkb:A6NLM2|ensembl:ENSP00000371018	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:sirb1_human(display_long)|uniprotkb:CD172 antigen-like family member B(gene name synonym)|uniprotkb:SIRPB1(gene name)|psi-mi:SIRPB1(display_short)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Elena et al. (2000)	pubmed:10940905|imex:IM-19467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615553|imex:IM-19467-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077379.1|refseq:NP_006056.2|refseq:NP_001317568.1|refseq:XP_016883066.1|ensembl:ENSG00000101307(gene)|ensembl:ENST00000381605(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2D9C|rcsb pdb:2JJU|reactome:R-HSA-2172127|reactome:R-HSA-391160|reactome:R-HSA-6798695	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:Fig 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2010/03/15	2014/10/16	rogid:WChxqhoW8UPxaVrdQDYEL2zsN589606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:8E83C5DF6B8892B8|rigid:8hOWYglqBpKTvuYiJajauHgjuj4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00241	uniprotkb:O43914	intact:EBI-2615458|uniprotkb:Q9H1U5|uniprotkb:Q5TFR0|uniprotkb:Q8TB12|uniprotkb:Q5TFQ9|uniprotkb:Q9Y4V0|uniprotkb:B2R8V0|uniprotkb:A6NLM2|ensembl:ENSP00000371018	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	psi-mi:sirb1_human(display_long)|uniprotkb:CD172 antigen-like family member B(gene name synonym)|uniprotkb:SIRPB1(gene name)|psi-mi:SIRPB1(display_short)	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Elena et al. (2000)	pubmed:10940905|imex:IM-19467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615553|imex:IM-19467-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077379.1|refseq:NP_006056.2|refseq:NP_001317568.1|refseq:XP_016883066.1|ensembl:ENSG00000101307(gene)|ensembl:ENST00000381605(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2D9C|rcsb pdb:2JJU|reactome:R-HSA-2172127|reactome:R-HSA-391160|reactome:R-HSA-6798695	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2010/03/15	2014/10/16	rogid:WChxqhoW8UPxaVrdQDYEL2zsN589606	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	intact-crc:8E83C5DF6B8892B8|rigid:8hOWYglqBpKTvuYiJajauHgjuj4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)