#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P26618 uniprotkb:Q15464 intact:EBI-7290093|uniprotkb:Q7TSJ3|uniprotkb:Q62046|uniprotkb:Q3TQ37|intact:UNK-5406796|uniprotkb:Q8C4N3|intact:MINT-4107325|ensembl:ENSMUSP00000000476|ensembl:ENSMUSP00000127173 intact:EBI-4402156|uniprotkb:B9EGM0|uniprotkb:D3DRQ5|uniprotkb:Q504U5|uniprotkb:Q5VUM8|ensembl:ENSP00000366936 psi-mi:pgfra_mouse(display_long)|uniprotkb:Pdgfra(gene name)|psi-mi:Pdgfra(display_short)|uniprotkb:CD140 antigen-like family member A(gene name synonym)|uniprotkb:Alpha platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Alpha-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha receptor(gene name synonym) psi-mi:shb_human(display_long)|uniprotkb:SHB(gene name)|psi-mi:SHB(display_short) psi-mi:"MI:0096"(pull down) Hooshmand-Rad et al. (2000) pubmed:10837138|mint:MINT-6731216 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7290089|mint:MINT-8026827 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001334647.1|refseq:NP_001334648.1|refseq:XP_006504324.1|refseq:XP_006504325.1|refseq:XP_006504326.1|refseq:NP_035188.2|refseq:NP_001076785.1|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030054"(cell junction)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030539"(male genitalia development)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035790"(platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:2000739"(regulation of mesenchymal stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027290|interpro:IPR036179|mint:P26618|reactome:R-MMU-1257604|reactome:R-MMU-186763|reactome:R-MMU-186797|reactome:R-MMU-5673001|reactome:R-MMU-6811558|ensembl:ENSMUSG00000029231(gene)|ensembl:ENSMUST00000000476(transcript)|ensembl:ENSMUST00000168162(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005018"(platelet-derived growth factor alpha-receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008210"(estrogen metabolic process)|mint:MINT-8026831(identity)|uniprotkb:P26618(original identifier) refseq:NP_003019.2|ensembl:ENSG00000107338(gene)|ensembl:ENST00000377707(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR000980(SH2 motif)|interpro:IPR035040|interpro:IPR035045|interpro:IPR036860|mint:Q15464|reactome:R-HSA-4420097|mint:MINT-8026828(identity)|uniprotkb:Q15464(original identifier) - comment:mint|function:Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity - comment:homomint|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:6dCcRjuYL8o4r3GvUzls/1uGM2810090 rogid:DD+KZlDzdHYok9if0pI0b4yKcf49606 intact-crc:B900FFEE05F1C4B0|rigid:e/JW7mUp7TvpTI38S28FZbUu39E false phosphorylated residue:720-720(MINT-8026836)|binding-associated region:713-726(MINT-8026834) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PD21 uniprotkb:P26618 intact:EBI-7290204|uniprotkb:A2AKW3|uniprotkb:Q3ULM3|intact:MINT-8013521|ensembl:ENSMUSP00000060433 intact:EBI-7290093|uniprotkb:Q7TSJ3|uniprotkb:Q62046|uniprotkb:Q3TQ37|intact:UNK-5406796|uniprotkb:Q8C4N3|intact:MINT-4107325|ensembl:ENSMUSP00000000476|ensembl:ENSMUSP00000127173 psi-mi:shb_mouse(display_long)|uniprotkb:Shb(gene name)|psi-mi:Shb(display_short) psi-mi:pgfra_mouse(display_long)|uniprotkb:Pdgfra(gene name)|psi-mi:Pdgfra(display_short)|uniprotkb:CD140 antigen-like family member A(gene name synonym)|uniprotkb:Alpha platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Alpha-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha receptor(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Hooshmand-Rad et al. (2000) pubmed:10837138|mint:MINT-6731216 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7290200|mint:MINT-8026842 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028478.1|ensembl:ENSMUSG00000044813(gene)|ensembl:ENSMUST00000061986(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042100"(B cell proliferation)|go:"GO:0045624"(positive regulation of T-helper cell differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1900194"(negative regulation of oocyte maturation)|interpro:IPR000980(SH2 motif)|interpro:IPR035040|interpro:IPR035045|interpro:IPR036860|reactome:R-MMU-4420097|mint:MINT-8026843(identity)|uniprotkb:Q6PD21(original identifier) refseq:NP_001334647.1|refseq:NP_001334648.1|refseq:XP_006504324.1|refseq:XP_006504325.1|refseq:XP_006504326.1|refseq:NP_035188.2|refseq:NP_001076785.1|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030054"(cell junction)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030539"(male genitalia development)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035790"(platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:2000739"(regulation of mesenchymal stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027290|interpro:IPR036179|mint:P26618|reactome:R-MMU-1257604|reactome:R-MMU-186763|reactome:R-MMU-186797|reactome:R-MMU-5673001|reactome:R-MMU-6811558|ensembl:ENSMUSG00000029231(gene)|ensembl:ENSMUST00000000476(transcript)|ensembl:ENSMUST00000168162(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005018"(platelet-derived growth factor alpha-receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008210"(estrogen metabolic process)|mint:MINT-8026846(identity)|uniprotkb:P26618(original identifier) - comment:mint comment:mint|function:Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity comment:homomint|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:rq4QRfyfU3SDdH2qAGzj2voJkRg10090 rogid:6dCcRjuYL8o4r3GvUzls/1uGM2810090 intact-crc:A1399F50439D1185|rigid:vPn41HDZPa9Apn454WpmMIP0QBM false - binding-associated region:713-726(MINT-8026849)|phosphorylated residue:720-720(MINT-8026851) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)