#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q91ZM2 uniprotkb:P05622 intact:EBI-7178606|ensembl:ENSMUSP00000145754|uniprotkb:Q91ZV5|intact:MINT-124210|uniprotkb:Q05DJ7|uniprotkb:Q9WVM5|uniprotkb:Q792R7|intact:MINT-8025517|uniprotkb:O54867|uniprotkb:Q91ZM3 intact:EBI-1554855|uniprotkb:E9QPE2 psi-mi:sh2b1_mouse(display_long)|uniprotkb:Sh2bpsm1(gene name synonym)|uniprotkb:Sh2b1(gene name)|psi-mi:Sh2b1(display_short)|uniprotkb:SH2-B PH domain-containing signaling mediator 1(gene name synonym)|uniprotkb:Pro-rich, PH and SH2 domain-containing signaling mediator(gene name synonym)|uniprotkb:SH2 domain-containing protein 1B(gene name synonym) psi-mi:pgfrb_mouse(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:Pdgfrb(gene name)|psi-mi:Pdgfrb(display_short)|uniprotkb:Pdgfr(gene name synonym)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Pdgfr1(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Riedel et al. (2000) pubmed:10644978|mint:MINT-6731149 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7178648|mint:MINT-8029918 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006507541.1|refseq:XP_006507543.1|refseq:XP_006507544.1|refseq:XP_006507545.1|refseq:XP_006507548.1|refseq:XP_006507550.1|ensembl:ENSMUSG00000030733(gene)|ensembl:ENSMUST00000205733(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:2000278"(regulation of DNA biosynthetic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015012(Phenylalanine zipper)|interpro:IPR030521|interpro:IPR030523|interpro:IPR035057|interpro:IPR036290|interpro:IPR036860|mint:Q91ZM2|rcsb pdb:2HDV|rcsb pdb:2HDX|reactome:R-MMU-1170546|reactome:R-MMU-982772|reactome:R-MMU-983231|refseq:NP_001074928.1|refseq:NP_035493.2|refseq:NP_001276467.1|refseq:NP_001276468.1|refseq:NP_001276469.1|refseq:NP_001276470.1|refseq:NP_001276471.1|mint:MINT-8029919(identity)|uniprotkb:Q91ZM2(original identifier) refseq:NP_001139740.1|refseq:NP_032835.2|mint:P05622|dip:DIP-39669N|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001822"(kidney development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072223"(metanephric glomerular mesangium development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0097178"(ruffle assembly)|go:"GO:0106096"(response to ceramide)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|rcsb pdb:1AYA|rcsb pdb:1AYC|reactome:R-MMU-1257604|reactome:R-MMU-186763|reactome:R-MMU-186797|reactome:R-MMU-5673001|reactome:R-MMU-6811558|mint:MINT-8029922(identity)|uniprotkb:P05622(original identifier) - - - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2019/07/08 rogid:8ChBcbAUHGqx3nqdEXIAbeMhfMs10090 rogid:Z5QKa7DWFevufdsXMCQhd2ui/U810090 intact-crc:3C25277BD1D38CF3|rigid:qwCuTVyLENgRyJ4H66mUIKKDNLQ false - binding-associated region:732-745(MINT-8029925)|phosphorylated residue:739-739(MINT-8029927) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)