#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07101	uniprotkb:P68509	intact:EBI-7146714|uniprotkb:B7ZL73|uniprotkb:Q2M3B4|ensembl:ENSP00000370571|uniprotkb:Q15589|uniprotkb:Q15585|uniprotkb:Q15588|intact:MINT-198913|uniprotkb:B7ZL70|uniprotkb:Q0PWM2|uniprotkb:Q0PWM3	intact:EBI-7146697|ensembl:ENSBTAP00000041575|intact:UNK-6047323|uniprotkb:P11576|uniprotkb:P70198|uniprotkb:Q3ZC14	psi-mi:ty3h_human(display_long)|uniprotkb:TH(gene name)|psi-mi:TH(display_short)|uniprotkb:TYH(gene name synonym)|uniprotkb:Tyrosine 3-hydroxylase(gene name synonym)	psi-mi:1433f_bovin(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Itagaki et al. (1999)	pubmed:10569954|mint:MINT-8005408|doi:10.1021/bi9914255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7146814|mint:MINT-8005417	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011518637.1|ensembl:ENSG00000180176(gene)|ensembl:ENST00000381178(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004511"(tyrosine 3-monooxygenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006585"(dopamine biosynthetic process from tyrosine)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009635"(response to herbicide)|go:"GO:0009651"(response to salt stress)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0014823"(response to activity)|go:"GO:0015842"(aminergic neurotransmitter loading into synaptic vesicle)|go:"GO:0016137"(glycoside metabolic process)|go:"GO:0016597"(amino acid binding)|go:"GO:0018963"(phthalate metabolic process)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033076"(isoquinoline alkaloid metabolic process)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0035690"|go:"GO:0035900"(response to isolation stress)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042214"(terpene metabolic process)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042418"(epinephrine biosynthetic process)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043473"(pigmentation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045472"(response to ether)|go:"GO:0046684"(response to pyrethroid)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0052314"(phytoalexin metabolic process)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR019773|interpro:IPR019774|interpro:IPR021164|interpro:IPR036329|interpro:IPR036951|interpro:IPR041903|rcsb pdb:2XSN|rcsb pdb:4J6S|reactome:R-HSA-209905|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR001273(Aromatic amino acid hydroxylase)|interpro:IPR005962(Tyrosine 3-monooxygenase)|interpro:IPR018301|refseq:NP_954987.2|refseq:NP_954986.2|refseq:NP_000351.2|mint:MINT-8005421(identity)|uniprotkb:P07101(original identifier)	ensembl:ENSBTAG00000031134(gene)|ensembl:ENSBTAT00000044059(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|refseq:NP_776917.2|mint:MINT-8005418(identity)|uniprotkb:P68509(original identifier)	-	function:Plays an important role in the physiology of adrenergic neurons|comment:mint|function:"Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism"	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint	comment:domino|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/21	2014/10/16	rogid:RnA77EcI8qqtkVevV6XnVbQjvGY9606	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc9913	intact-crc:400BED7C961327BD|rigid:r3run6GI3olJqamh7AngEcXIr5E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)