#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99665 uniprotkb:Q14765 intact:EBI-7045630|ensembl:ENSP00000262345|ensembl:ENSP00000497959|ensembl:ENSP00000501329|uniprotkb:B1AN98|uniprotkb:Q2M3V3|intact:MINT-6780861|uniprotkb:B7ZKL9|uniprotkb:F5H7L6 intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134 psi-mi:i12r2_human(display_long)|uniprotkb:IL12RB2(gene name)|psi-mi:IL12RB2(display_short) psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short) psi-mi:"MI:0096"(pull down) Yao et al. (1999) pubmed:10415122|mint:MINT-6731089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061070|mint:MINT-8033462 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006710680.1|refseq:XP_011539685.1|ensembl:ENSG00000081985(gene)|ensembl:ENST00000262345(transcript)|ensembl:ENST00000648487(transcript)|ensembl:ENST00000674203(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|reactome:R-HSA-8984722|reactome:R-HSA-9020591|refseq:NP_001306162.1|refseq:XP_016856692.1|refseq:NP_001550.1|refseq:NP_001245144.1|refseq:NP_001245143.1|refseq:NP_001245145.1|refseq:XP_005270882.1|refseq:XP_005270884.1|refseq:XP_005270885.1|dip:DIP-6011N|mint:MINT-8033466(identity)|uniprotkb:Q99665(original identifier) refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N|mint:MINT-8033463(identity)|uniprotkb:Q14765(original identifier) - function:Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production|comment:mint - comment:homomint|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:sEIp9PldsBfySqU9O+sPvz1V5eM9606 rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606 intact-crc:FA952F3A72447486|rigid:jh/URqoZ07JvS2OBvQC3EvOGU1c false phosphorylated residue:800-800(MINT-8033471)|binding-associated region:793-806(MINT-8033469) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)