#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q10953 uniprotkb:Q9U9Y8 intact:EBI-2530558|uniprotkb:O16145|ensemblmetazoa:B0336.1a.1|ensemblmetazoa:B0336.1a.2 intact:EBI-318513|uniprotkb:O62395|uniprotkb:Q69YW9|uniprotkb:Q8WQB7|uniprotkb:Q9U343|uniprotkb:Q9UA07|uniprotkb:Q9Y198|ensemblmetazoa:W06F12.1a.1 psi-mi:wrm1_caeel(display_long)|uniprotkb:wrm-1(gene name)|psi-mi:wrm-1(display_short)|uniprotkb:Worm armadillo protein 1(gene name synonym)|uniprotkb:B0336.1(orf name) psi-mi:nlk_caeel(display_long)|uniprotkb:nlk(gene name synonym)|uniprotkb:W06F12.1(orf name)|uniprotkb:lit-1(gene name)|psi-mi:lit-1(display_short)|uniprotkb:Nemo-like kinase(gene name synonym)|uniprotkb:Loss of intestine protein 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2530511|imex:IM-19569-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:B0336.1a.1(transcript)|ensemblmetazoa:B0336.1a.2(transcript)|ensemblmetazoa:WBGene00006943(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044332"(Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1903224"(regulation of endodermal cell differentiation)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|reactome:R-CEL-5218920|reactome:R-CEL-6798695|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|go:"GO:1904787"(positive regulation of asymmetric protein localization involved in cell fate determination)|refseq:NP_498236.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:Q10953|interpro:IPR013284(Beta-catenin)|wormbase:B0336.1a refseq:NP_001022805.1|refseq:NP_001022806.1|refseq:NP_001022807.1|refseq:NP_001022808.1|refseq:NP_001022809.1|wormbase:W06F12.1a|wormbase:W06F12.1b|wormbase:W06F12.1c|wormbase:W06F12.1d|wormbase:W06F12.1e|reactome:R-CEL-4086398|ensemblmetazoa:W06F12.1a.1(transcript)|ensemblmetazoa:WBGene00003048(gene)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110039"(positive regulation of nematode male tail tip morphogenesis)|go:"GO:1902554"(serine/threonine protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-25624N go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig 3A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/13 2014/10/16 rogid:cvujZ6Ubdj3XgPVHjjPH3aOV2lI6239 rogid:A/PDBtOSh+boZbWJL/ky/9hv+jg6239 intact-crc:4299E0D354C0F071|rigid:e2Lns2XCUbS15T/h1b+zpawn4sg false ha tag:?-? mutation disrupting interaction rate:269-269|flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q10666 uniprotkb:Q9U9Y8 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 intact:EBI-318513|uniprotkb:O62395|uniprotkb:Q69YW9|uniprotkb:Q8WQB7|uniprotkb:Q9U343|uniprotkb:Q9UA07|uniprotkb:Q9Y198|ensemblmetazoa:W06F12.1a.1 psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:nlk_caeel(display_long)|uniprotkb:nlk(gene name synonym)|uniprotkb:W06F12.1(orf name)|uniprotkb:lit-1(gene name)|psi-mi:lit-1(display_short)|uniprotkb:Nemo-like kinase(gene name synonym)|uniprotkb:Loss of intestine protein 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2530586|imex:IM-19569-2 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 refseq:NP_001022805.1|refseq:NP_001022806.1|refseq:NP_001022807.1|refseq:NP_001022808.1|refseq:NP_001022809.1|wormbase:W06F12.1a|wormbase:W06F12.1b|wormbase:W06F12.1c|wormbase:W06F12.1d|wormbase:W06F12.1e|reactome:R-CEL-4086398|ensemblmetazoa:W06F12.1a.1(transcript)|ensemblmetazoa:WBGene00003048(gene)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110039"(positive regulation of nematode male tail tip morphogenesis)|go:"GO:1902554"(serine/threonine protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-25624N go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig 3B.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/13 2014/10/16 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 rogid:A/PDBtOSh+boZbWJL/ky/9hv+jg6239 intact-crc:4BA304DCF85D23D1|rigid:m8lWToQAMD9DRT0ul479PsQ8n4g false glutathione s tranferase tag:?-? flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q10953 uniprotkb:Q9U9Y8 intact:EBI-2530558|uniprotkb:O16145|ensemblmetazoa:B0336.1a.1|ensemblmetazoa:B0336.1a.2 intact:EBI-318513|uniprotkb:O62395|uniprotkb:Q69YW9|uniprotkb:Q8WQB7|uniprotkb:Q9U343|uniprotkb:Q9UA07|uniprotkb:Q9Y198|ensemblmetazoa:W06F12.1a.1 psi-mi:wrm1_caeel(display_long)|uniprotkb:wrm-1(gene name)|psi-mi:wrm-1(display_short)|uniprotkb:Worm armadillo protein 1(gene name synonym)|uniprotkb:B0336.1(orf name) psi-mi:nlk_caeel(display_long)|uniprotkb:nlk(gene name synonym)|uniprotkb:W06F12.1(orf name)|uniprotkb:lit-1(gene name)|psi-mi:lit-1(display_short)|uniprotkb:Nemo-like kinase(gene name synonym)|uniprotkb:Loss of intestine protein 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2531499|imex:IM-19569-3 - - psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:B0336.1a.1(transcript)|ensemblmetazoa:B0336.1a.2(transcript)|ensemblmetazoa:WBGene00006943(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044332"(Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1903224"(regulation of endodermal cell differentiation)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|reactome:R-CEL-5218920|reactome:R-CEL-6798695|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|go:"GO:1904787"(positive regulation of asymmetric protein localization involved in cell fate determination)|refseq:NP_498236.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:Q10953|interpro:IPR013284(Beta-catenin)|wormbase:B0336.1a refseq:NP_001022805.1|refseq:NP_001022806.1|refseq:NP_001022807.1|refseq:NP_001022808.1|refseq:NP_001022809.1|wormbase:W06F12.1a|wormbase:W06F12.1b|wormbase:W06F12.1c|wormbase:W06F12.1d|wormbase:W06F12.1e|reactome:R-CEL-4086398|ensemblmetazoa:W06F12.1a.1(transcript)|ensemblmetazoa:WBGene00003048(gene)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110039"(positive regulation of nematode male tail tip morphogenesis)|go:"GO:1902554"(serine/threonine protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-25624N go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation) - - figure legend:Fig 3A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/13 2014/10/16 rogid:cvujZ6Ubdj3XgPVHjjPH3aOV2lI6239 rogid:A/PDBtOSh+boZbWJL/ky/9hv+jg6239 intact-crc:79B2782B5AF2C9AF|rigid:e2Lns2XCUbS15T/h1b+zpawn4sg false ha tag:?-? mutation:269-269 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q10953 uniprotkb:Q9U9Y8 intact:EBI-2530558|uniprotkb:O16145|ensemblmetazoa:B0336.1a.1|ensemblmetazoa:B0336.1a.2 intact:EBI-318513|uniprotkb:O62395|uniprotkb:Q69YW9|uniprotkb:Q8WQB7|uniprotkb:Q9U343|uniprotkb:Q9UA07|uniprotkb:Q9Y198|ensemblmetazoa:W06F12.1a.1 psi-mi:wrm1_caeel(display_long)|uniprotkb:wrm-1(gene name)|psi-mi:wrm-1(display_short)|uniprotkb:Worm armadillo protein 1(gene name synonym)|uniprotkb:B0336.1(orf name) psi-mi:nlk_caeel(display_long)|uniprotkb:nlk(gene name synonym)|uniprotkb:W06F12.1(orf name)|uniprotkb:lit-1(gene name)|psi-mi:lit-1(display_short)|uniprotkb:Nemo-like kinase(gene name synonym)|uniprotkb:Loss of intestine protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2530619|imex:IM-19569-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:B0336.1a.1(transcript)|ensemblmetazoa:B0336.1a.2(transcript)|ensemblmetazoa:WBGene00006943(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044332"(Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1903224"(regulation of endodermal cell differentiation)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|reactome:R-CEL-5218920|reactome:R-CEL-6798695|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|go:"GO:1904787"(positive regulation of asymmetric protein localization involved in cell fate determination)|refseq:NP_498236.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:Q10953|interpro:IPR013284(Beta-catenin)|wormbase:B0336.1a refseq:NP_001022805.1|refseq:NP_001022806.1|refseq:NP_001022807.1|refseq:NP_001022808.1|refseq:NP_001022809.1|wormbase:W06F12.1a|wormbase:W06F12.1b|wormbase:W06F12.1c|wormbase:W06F12.1d|wormbase:W06F12.1e|reactome:R-CEL-4086398|ensemblmetazoa:W06F12.1a.1(transcript)|ensemblmetazoa:WBGene00003048(gene)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110039"(positive regulation of nematode male tail tip morphogenesis)|go:"GO:1902554"(serine/threonine protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-25624N - - - figure legend:Fig 4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/13 2014/10/16 rogid:cvujZ6Ubdj3XgPVHjjPH3aOV2lI6239 rogid:A/PDBtOSh+boZbWJL/ky/9hv+jg6239 intact-crc:A354DA5ADE6886D5|rigid:e2Lns2XCUbS15T/h1b+zpawn4sg false sufficient binding region:103-148 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q10953 uniprotkb:Q10666 intact:EBI-2530558|uniprotkb:O16145|ensemblmetazoa:B0336.1a.1|ensemblmetazoa:B0336.1a.2 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 psi-mi:wrm1_caeel(display_long)|uniprotkb:wrm-1(gene name)|psi-mi:wrm-1(display_short)|uniprotkb:Worm armadillo protein 1(gene name synonym)|uniprotkb:B0336.1(orf name) psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2530635|imex:IM-19569-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:B0336.1a.1(transcript)|ensemblmetazoa:B0336.1a.2(transcript)|ensemblmetazoa:WBGene00006943(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044332"(Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1903224"(regulation of endodermal cell differentiation)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|reactome:R-CEL-5218920|reactome:R-CEL-6798695|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|go:"GO:1904787"(positive regulation of asymmetric protein localization involved in cell fate determination)|refseq:NP_498236.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:Q10953|interpro:IPR013284(Beta-catenin)|wormbase:B0336.1a reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 - - - figure legend:Fig 4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/13 2014/10/16 rogid:cvujZ6Ubdj3XgPVHjjPH3aOV2lI6239 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 intact-crc:782DD7426028B300|rigid:TIJMG0pBDOkvpxgvHkxKcppSCaQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q10953 uniprotkb:Q9U9Y8 intact:EBI-2530558|uniprotkb:O16145|ensemblmetazoa:B0336.1a.1|ensemblmetazoa:B0336.1a.2 intact:EBI-318513|uniprotkb:O62395|uniprotkb:Q69YW9|uniprotkb:Q8WQB7|uniprotkb:Q9U343|uniprotkb:Q9UA07|uniprotkb:Q9Y198|ensemblmetazoa:W06F12.1a.1 psi-mi:wrm1_caeel(display_long)|uniprotkb:wrm-1(gene name)|psi-mi:wrm-1(display_short)|uniprotkb:Worm armadillo protein 1(gene name synonym)|uniprotkb:B0336.1(orf name) psi-mi:nlk_caeel(display_long)|uniprotkb:nlk(gene name synonym)|uniprotkb:W06F12.1(orf name)|uniprotkb:lit-1(gene name)|psi-mi:lit-1(display_short)|uniprotkb:Nemo-like kinase(gene name synonym)|uniprotkb:Loss of intestine protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2530676|imex:IM-19569-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:B0336.1a.1(transcript)|ensemblmetazoa:B0336.1a.2(transcript)|ensemblmetazoa:WBGene00006943(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044332"(Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1903224"(regulation of endodermal cell differentiation)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|reactome:R-CEL-5218920|reactome:R-CEL-6798695|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|go:"GO:1904787"(positive regulation of asymmetric protein localization involved in cell fate determination)|refseq:NP_498236.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:Q10953|interpro:IPR013284(Beta-catenin)|wormbase:B0336.1a refseq:NP_001022805.1|refseq:NP_001022806.1|refseq:NP_001022807.1|refseq:NP_001022808.1|refseq:NP_001022809.1|wormbase:W06F12.1a|wormbase:W06F12.1b|wormbase:W06F12.1c|wormbase:W06F12.1d|wormbase:W06F12.1e|reactome:R-CEL-4086398|ensemblmetazoa:W06F12.1a.1(transcript)|ensemblmetazoa:WBGene00003048(gene)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110039"(positive regulation of nematode male tail tip morphogenesis)|go:"GO:1902554"(serine/threonine protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-25624N - - - figure legend:Fig 5 top image.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/01/13 2014/10/16 rogid:cvujZ6Ubdj3XgPVHjjPH3aOV2lI6239 rogid:A/PDBtOSh+boZbWJL/ky/9hv+jg6239 intact-crc:C82B8893DC336C4E|rigid:e2Lns2XCUbS15T/h1b+zpawn4sg false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q10953 uniprotkb:Q9U9Y8 intact:EBI-2530558|uniprotkb:O16145|ensemblmetazoa:B0336.1a.1|ensemblmetazoa:B0336.1a.2 intact:EBI-318513|uniprotkb:O62395|uniprotkb:Q69YW9|uniprotkb:Q8WQB7|uniprotkb:Q9U343|uniprotkb:Q9UA07|uniprotkb:Q9Y198|ensemblmetazoa:W06F12.1a.1 psi-mi:wrm1_caeel(display_long)|uniprotkb:wrm-1(gene name)|psi-mi:wrm-1(display_short)|uniprotkb:Worm armadillo protein 1(gene name synonym)|uniprotkb:B0336.1(orf name) psi-mi:nlk_caeel(display_long)|uniprotkb:nlk(gene name synonym)|uniprotkb:W06F12.1(orf name)|uniprotkb:lit-1(gene name)|psi-mi:lit-1(display_short)|uniprotkb:Nemo-like kinase(gene name synonym)|uniprotkb:Loss of intestine protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2530687|imex:IM-19569-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:B0336.1a.1(transcript)|ensemblmetazoa:B0336.1a.2(transcript)|ensemblmetazoa:WBGene00006943(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044332"(Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1903224"(regulation of endodermal cell differentiation)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|reactome:R-CEL-5218920|reactome:R-CEL-6798695|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|go:"GO:1904787"(positive regulation of asymmetric protein localization involved in cell fate determination)|refseq:NP_498236.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:Q10953|interpro:IPR013284(Beta-catenin)|wormbase:B0336.1a refseq:NP_001022805.1|refseq:NP_001022806.1|refseq:NP_001022807.1|refseq:NP_001022808.1|refseq:NP_001022809.1|wormbase:W06F12.1a|wormbase:W06F12.1b|wormbase:W06F12.1c|wormbase:W06F12.1d|wormbase:W06F12.1e|reactome:R-CEL-4086398|ensemblmetazoa:W06F12.1a.1(transcript)|ensemblmetazoa:WBGene00003048(gene)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110039"(positive regulation of nematode male tail tip morphogenesis)|go:"GO:1902554"(serine/threonine protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-25624N - - - figure legend:Fig 5 bottom image.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/01/13 2014/10/16 rogid:cvujZ6Ubdj3XgPVHjjPH3aOV2lI6239 rogid:A/PDBtOSh+boZbWJL/ky/9hv+jg6239 intact-crc:C36BB5606D283315|rigid:e2Lns2XCUbS15T/h1b+zpawn4sg false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9U9Y8 uniprotkb:Q10953 intact:EBI-318513|uniprotkb:O62395|uniprotkb:Q69YW9|uniprotkb:Q8WQB7|uniprotkb:Q9U343|uniprotkb:Q9UA07|uniprotkb:Q9Y198|ensemblmetazoa:W06F12.1a.1 intact:EBI-2530558|uniprotkb:O16145|ensemblmetazoa:B0336.1a.1|ensemblmetazoa:B0336.1a.2 psi-mi:nlk_caeel(display_long)|uniprotkb:nlk(gene name synonym)|uniprotkb:W06F12.1(orf name)|uniprotkb:lit-1(gene name)|psi-mi:lit-1(display_short)|uniprotkb:Nemo-like kinase(gene name synonym)|uniprotkb:Loss of intestine protein 1(gene name synonym) psi-mi:wrm1_caeel(display_long)|uniprotkb:wrm-1(gene name)|psi-mi:wrm-1(display_short)|uniprotkb:Worm armadillo protein 1(gene name synonym)|uniprotkb:B0336.1(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rocheleau et al. (1999) pubmed:10380924|imex:IM-19569 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2530704|imex:IM-19569-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001022805.1|refseq:NP_001022806.1|refseq:NP_001022807.1|refseq:NP_001022808.1|refseq:NP_001022809.1|wormbase:W06F12.1a|wormbase:W06F12.1b|wormbase:W06F12.1c|wormbase:W06F12.1d|wormbase:W06F12.1e|reactome:R-CEL-4086398|ensemblmetazoa:W06F12.1a.1(transcript)|ensemblmetazoa:WBGene00003048(gene)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110039"(positive regulation of nematode male tail tip morphogenesis)|go:"GO:1902554"(serine/threonine protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-25624N ensemblmetazoa:B0336.1a.1(transcript)|ensemblmetazoa:B0336.1a.2(transcript)|ensemblmetazoa:WBGene00006943(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044332"(Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1903224"(regulation of endodermal cell differentiation)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|reactome:R-CEL-5218920|reactome:R-CEL-6798695|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|go:"GO:1904787"(positive regulation of asymmetric protein localization involved in cell fate determination)|refseq:NP_498236.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|mint:Q10953|interpro:IPR013284(Beta-catenin)|wormbase:B0336.1a - - - figure legend:Fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2010/01/13 2014/10/16 rogid:A/PDBtOSh+boZbWJL/ky/9hv+jg6239 rogid:cvujZ6Ubdj3XgPVHjjPH3aOV2lI6239 intact-crc:AE5EC281882D3A5A|rigid:e2Lns2XCUbS15T/h1b+zpawn4sg false green fluorescent protein tag:?-? - - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot)