#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8K4S7	uniprotkb:Q62844	intact:EBI-8536678|uniprotkb:Q9QZ69|intact:MINT-2880613	intact:EBI-8666986|ensembl:ENSRNOP00000000733|intact:UNK-5463756	psi-mi:cblb_rat(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:fyn_rat(display_long)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:p59-Fyn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667038|mint:MINT-7214754	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598285.1|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR024162|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR024159|rgd:620535|interpro:IPR039520|mint:Q8K4S7|interpro:IPR036537|interpro:IPR036860|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0009629"(response to gravity)|go:"GO:0009725"(response to hormone)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|reactome:R-RNO-983168|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|mint:MINT-7214757(identity)	ensembl:ENSRNOG00000000596(gene)|ensembl:ENSRNOT00000000733(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:Q62844|reactome:R-RNO-114604|reactome:R-RNO-1227986|reactome:R-RNO-1257604|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-2029481|reactome:R-RNO-210990|reactome:R-RNO-2424491|reactome:R-RNO-373753|reactome:R-RNO-375165|reactome:R-RNO-389356|reactome:R-RNO-389357|reactome:R-RNO-389359|reactome:R-RNO-389513|reactome:R-RNO-3928662|reactome:R-RNO-3928663|reactome:R-RNO-3928664|reactome:R-RNO-3928665|reactome:R-RNO-399954|reactome:R-RNO-399955|reactome:R-RNO-399956|reactome:R-RNO-418885|reactome:R-RNO-4420097|reactome:R-RNO-5621480|reactome:R-RNO-5621575|reactome:R-RNO-5673001|reactome:R-RNO-202733|reactome:R-RNO-6811558|reactome:R-RNO-75892|go:"GO:0016020"(membrane)|reactome:R-RNO-8866376|reactome:R-RNO-9032759|reactome:R-RNO-912631|rgd:2641|refseq:NP_036887.1|mint:MINT-7214756(identity)	-	comment:mint|function:"E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization"|function:"Lack of Cblb expression is the cause of the Komeda diabetes-prone (KDP) phenotype, characterized by autoimmune destruction of pancreatic beta cells and rapid onset of overt diabetes with no sex difference and no significant T-cell lymphopenia. The KPD rat is a spontaneous animal model for human type 1 diabetes mellitus"	comment:mint|function:Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC	figure legend:f1|comment:homomint|comment:mint|curation depth:mimix curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2009/07/03	2014/10/16	rogid:wCVjU/iMMcnWu5qJ4lkpQPCwVQI10116	rogid:ItClNqSSj3upTgW1jvgv66rrrHk10116	intact-crc:29660DD552DF6F34|rigid:wNKNO1tiPLh+/D+QR+8s0bBHJF8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39688	uniprotkb:P22682	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667061|mint:MINT-7214763	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N|mint:MINT-7214767(identity)	interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N|mint:MINT-7214765(identity)	-	-	-	figure legend:f1|comment:homomint|comment:mint|curation depth:mimix curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2009/07/03	2014/10/16	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	rogid:8MpthfXwJFMSMC6mDaTdb063dj010090	intact-crc:6FA99731C59F6CD7|rigid:hXYGd/zX86ZM5a8H+M41ETCZdhM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K4S7	uniprotkb:P06241	intact:EBI-8536678|uniprotkb:Q9QZ69|intact:MINT-2880613	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:cblb_rat(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667084|mint:MINT-7214774	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598285.1|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR024162|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR024159|rgd:620535|interpro:IPR039520|mint:Q8K4S7|interpro:IPR036537|interpro:IPR036860|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0009629"(response to gravity)|go:"GO:0009725"(response to hormone)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|reactome:R-RNO-983168|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|mint:MINT-7214776(identity)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439|mint:MINT-7214777(identity)	-	comment:mint|function:"E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization"|function:"Lack of Cblb expression is the cause of the Komeda diabetes-prone (KDP) phenotype, characterized by autoimmune destruction of pancreatic beta cells and rapid onset of overt diabetes with no sex difference and no significant T-cell lymphopenia. The KPD rat is a spontaneous animal model for human type 1 diabetes mellitus"	-	comment:homomint|comment:domino|comment:mint|figure legend:f2 f3a f3b|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/03	2014/10/16	rogid:wCVjU/iMMcnWu5qJ4lkpQPCwVQI10116	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	intact-crc:2B1227FE5BC1A4D3|rigid:9VANwpa1GlPF/L2WaJ/fEAVht2Q	false	-	binding-associated region:82-246(IPR000980)|glutathione s tranferase tag:?-?(MINT-7214779)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K4S7	uniprotkb:P08631	intact:EBI-8536678|uniprotkb:Q9QZ69|intact:MINT-2880613	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	psi-mi:cblb_rat(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667126|mint:MINT-7214803	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598285.1|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR024162|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR024159|rgd:620535|interpro:IPR039520|mint:Q8K4S7|interpro:IPR036537|interpro:IPR036860|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0009629"(response to gravity)|go:"GO:0009725"(response to hormone)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|reactome:R-RNO-983168|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|mint:MINT-7214813(identity)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|mint:MINT-7214805(identity)	-	comment:mint|function:"E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization"|function:"Lack of Cblb expression is the cause of the Komeda diabetes-prone (KDP) phenotype, characterized by autoimmune destruction of pancreatic beta cells and rapid onset of overt diabetes with no sex difference and no significant T-cell lymphopenia. The KPD rat is a spontaneous animal model for human type 1 diabetes mellitus"	-	figure legend:f2|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/03	2014/10/16	rogid:wCVjU/iMMcnWu5qJ4lkpQPCwVQI10116	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	intact-crc:2AF9A398027F8AD5|rigid:T6YdJ6Q4TK/NAugPQYpuZM3zDr0	false	-	glutathione s tranferase tag:?-?(MINT-7214806)|binding-associated region:78-241(IPR000980)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K4S7	uniprotkb:P07948	intact:EBI-8536678|uniprotkb:Q9QZ69|intact:MINT-2880613	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:cblb_rat(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0096"(pull down)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667105|mint:MINT-7214789	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598285.1|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR024162|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR024159|rgd:620535|interpro:IPR039520|mint:Q8K4S7|interpro:IPR036537|interpro:IPR036860|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0009629"(response to gravity)|go:"GO:0009725"(response to hormone)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|reactome:R-RNO-983168|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|mint:MINT-7214799(identity)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N|mint:MINT-7214791(identity)	-	comment:mint|function:"E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization"|function:"Lack of Cblb expression is the cause of the Komeda diabetes-prone (KDP) phenotype, characterized by autoimmune destruction of pancreatic beta cells and rapid onset of overt diabetes with no sex difference and no significant T-cell lymphopenia. The KPD rat is a spontaneous animal model for human type 1 diabetes mellitus"	-	figure legend:f2|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/03	2014/10/16	rogid:wCVjU/iMMcnWu5qJ4lkpQPCwVQI10116	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	intact-crc:ED0F2290C31FAD8F|rigid:kWtuzjuX9cfZr2eXo05tLntpoDM	false	-	glutathione s tranferase tag:?-?(MINT-7214796)|binding-associated region:63-226(MINT-7214792)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986	uniprotkb:P22681	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667167|mint:MINT-7214865	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7214874(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7214867(identity)	-	-	-	figure legend:f7a|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/03	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:E5D1626DCC3A9EF0|rigid:rxRfg3ZafGPhM7h/oaaF+qZ3Gdk	false	-	binding-associated region:726-906(MINT-7214870)|glutathione s tranferase tag:?-?(MINT-7214868)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P39688	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667147|mint:MINT-7214822	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7214832(identity)	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N|mint:MINT-7214824(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/03	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:E6291340D5B11143|rigid:S2Xae5Na5Q5VJqZ9TQA35hD2/i4	false	glutathione s tranferase tag:?-?(MINT-7214837)|binding-associated region:474-694(MINT-7214839)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P39688	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667198|mint:MINT-7214843	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7214847(identity)	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N|mint:MINT-7214845(identity)	-	-	-	figure legend:f5a|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/03	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:810AD945B6663A9A|rigid:S2Xae5Na5Q5VJqZ9TQA35hD2/i4	false	binding-associated region:474-694(MINT-7214848)|glutathione s tranferase tag:?-?(MINT-7214851)	biotin tag:?-?(MINT-7214862)|binding-associated region:82-143(MINT-7214858)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P39688	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hunter et al. (1999)	mint:MINT-6731011|pubmed:9890970	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8667236|mint:MINT-8036160	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-8036164(identity)|uniprotkb:P22681(original identifier)	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N|mint:MINT-8036161(identity)|uniprotkb:P39688(original identifier)	-	-	-	comment:homomint|comment:mint|curation depth:mimix curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2009/07/03	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:CE2237849B7AD5C2|rigid:S2Xae5Na5Q5VJqZ9TQA35hD2/i4	false	phosphorylated residue:731-731(MINT-8036169)|binding-associated region:724-737(MINT-8036167)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)