#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26675	uniprotkb:Q08012	intact:EBI-82070|uniprotkb:Q6AWF4|uniprotkb:Q8I067|uniprotkb:Q8I0F7|uniprotkb:Q8ITK2|uniprotkb:Q95TI8|uniprotkb:Q969D6|uniprotkb:Q9VJV9|ensemblmetazoa:FBpp0080118	intact:EBI-161391|uniprotkb:Q0E989|uniprotkb:Q9V6Q5|uniprotkb:A4UZF9|ensemblmetazoa:FBpp0086813|ensemblmetazoa:FBpp0086814|ensemblmetazoa:FBpp0086815|ensemblmetazoa:FBpp0086816|ensemblmetazoa:FBpp0086817	psi-mi:sos_drome(display_long)|uniprotkb:Sos(gene name)|psi-mi:Sos(display_short)|uniprotkb:CG7793(orf name)	psi-mi:grap_drome(display_long)|uniprotkb:drk(gene name)|psi-mi:drk(display_short)|uniprotkb:"E(sev)2B"(gene name synonym)|uniprotkb:Downstream of receptor kinase(gene name synonym)|uniprotkb:Grb2(gene name synonym)|uniprotkb:Protein enhancer of sevenless 2B(gene name synonym)|uniprotkb:CG6033(orf name)	psi-mi:"MI:0096"(pull down)	Hime et al. (1997)	pubmed:9178769|imex:IM-20279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2294344|imex:IM-20279-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476597.2|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|rcsb pdb:1AZE|reactome:R-DME-112412|reactome:R-DME-1250347|reactome:R-DME-1433557|reactome:R-DME-1433559|reactome:R-DME-167044|reactome:R-DME-179812|reactome:R-DME-180336|reactome:R-DME-186763|reactome:R-DME-193648|reactome:R-DME-1963640|reactome:R-DME-210993|reactome:R-DME-2179392|reactome:R-DME-2424491|reactome:R-DME-2428933|reactome:R-DME-2730905|reactome:R-DME-2871796|reactome:R-DME-2871809|reactome:R-DME-375165|reactome:R-DME-416482|reactome:R-DME-5654688|reactome:R-DME-5654693|reactome:R-DME-5654699|reactome:R-DME-5654700|reactome:R-DME-5654704|reactome:R-DME-5654706|reactome:R-DME-5654712|reactome:R-DME-5654719|reactome:R-DME-5673001|reactome:R-DME-74749|reactome:R-DME-74751|reactome:R-DME-9013149|reactome:R-DME-9607240|ensemblmetazoa:FBgn0001965(gene)|ensemblmetazoa:FBtr0080541(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035997"(rhabdomere microvillus membrane)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0045500"(sevenless signaling pathway)|flybase:FBgn0001965|dip:DIP-22308N	refseq:NP_476858.1|refseq:NP_725302.1|refseq:NP_725303.1|refseq:NP_725304.1|refseq:NP_725306.1|flybase:FBgn0004638|ensemblmetazoa:FBgn0004638(gene)|ensemblmetazoa:FBtr0087694(transcript)|ensemblmetazoa:FBtr0087695(transcript)|ensemblmetazoa:FBtr0087696(transcript)|ensemblmetazoa:FBtr0087697(transcript)|ensemblmetazoa:FBtr0087698(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005118"(sevenless binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007614"(short-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR030219|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2A36|go:"GO:0008306"(associative learning)|rcsb pdb:2A37|rcsb pdb:2AZS|rcsb pdb:2AZV|reactome:R-DME-109704|reactome:R-DME-112412|reactome:R-DME-1250347|reactome:R-DME-1257604|reactome:R-DME-1295596|reactome:R-DME-1433557|reactome:R-DME-1433559|reactome:R-DME-167044|reactome:R-DME-179812|reactome:R-DME-180292|reactome:R-DME-180336|reactome:R-DME-182971|reactome:R-DME-186763|reactome:R-DME-1963640|reactome:R-DME-1963642|reactome:R-DME-210993|reactome:R-DME-2179392|reactome:R-DME-2424491|reactome:R-DME-2428933|reactome:R-DME-2730905|reactome:R-DME-2871796|reactome:R-DME-2871809|reactome:R-DME-375165|reactome:R-DME-5654688|go:"GO:0008355"(olfactory learning)|reactome:R-DME-5654689|reactome:R-DME-5654693|reactome:R-DME-5654695|reactome:R-DME-5654699|reactome:R-DME-5654700|reactome:R-DME-5654704|reactome:R-DME-5654706|reactome:R-DME-5654710|reactome:R-DME-5654712|reactome:R-DME-5654719|reactome:R-DME-5654720|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-74751|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-9027284|reactome:R-DME-912631|reactome:R-DME-9607240|reactome:R-DME-983695|reactome:R-DME-5654733|dip:DIP-21223N	-	-	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/24	2014/10/16	rogid:TxXgLxqhzkv9TdP1KrgoN7wEyFo7227	rogid:GNPfKX2LH0HRXEW4ASFDTrXN3VY7227	intact-crc:91D5F49D1FFC49F0|rigid:S9Yt7EKFy90bw6gCt8/k4yhutMk	false	35s radiolabel:?-?|sufficient binding region:c-c	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P22681	uniprotkb:Q08012	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-161391|uniprotkb:Q0E989|uniprotkb:Q9V6Q5|uniprotkb:A4UZF9|ensemblmetazoa:FBpp0086813|ensemblmetazoa:FBpp0086814|ensemblmetazoa:FBpp0086815|ensemblmetazoa:FBpp0086816|ensemblmetazoa:FBpp0086817	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:grap_drome(display_long)|uniprotkb:drk(gene name)|psi-mi:drk(display_short)|uniprotkb:"E(sev)2B"(gene name synonym)|uniprotkb:Downstream of receptor kinase(gene name synonym)|uniprotkb:Grb2(gene name synonym)|uniprotkb:Protein enhancer of sevenless 2B(gene name synonym)|uniprotkb:CG6033(orf name)	psi-mi:"MI:0096"(pull down)	Hime et al. (1997)	pubmed:9178769|imex:IM-20279	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2294355|imex:IM-20279-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	refseq:NP_476858.1|refseq:NP_725302.1|refseq:NP_725303.1|refseq:NP_725304.1|refseq:NP_725306.1|flybase:FBgn0004638|ensemblmetazoa:FBgn0004638(gene)|ensemblmetazoa:FBtr0087694(transcript)|ensemblmetazoa:FBtr0087695(transcript)|ensemblmetazoa:FBtr0087696(transcript)|ensemblmetazoa:FBtr0087697(transcript)|ensemblmetazoa:FBtr0087698(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005118"(sevenless binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007614"(short-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR030219|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2A36|go:"GO:0008306"(associative learning)|rcsb pdb:2A37|rcsb pdb:2AZS|rcsb pdb:2AZV|reactome:R-DME-109704|reactome:R-DME-112412|reactome:R-DME-1250347|reactome:R-DME-1257604|reactome:R-DME-1295596|reactome:R-DME-1433557|reactome:R-DME-1433559|reactome:R-DME-167044|reactome:R-DME-179812|reactome:R-DME-180292|reactome:R-DME-180336|reactome:R-DME-182971|reactome:R-DME-186763|reactome:R-DME-1963640|reactome:R-DME-1963642|reactome:R-DME-210993|reactome:R-DME-2179392|reactome:R-DME-2424491|reactome:R-DME-2428933|reactome:R-DME-2730905|reactome:R-DME-2871796|reactome:R-DME-2871809|reactome:R-DME-375165|reactome:R-DME-5654688|go:"GO:0008355"(olfactory learning)|reactome:R-DME-5654689|reactome:R-DME-5654693|reactome:R-DME-5654695|reactome:R-DME-5654699|reactome:R-DME-5654700|reactome:R-DME-5654704|reactome:R-DME-5654706|reactome:R-DME-5654710|reactome:R-DME-5654712|reactome:R-DME-5654719|reactome:R-DME-5654720|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-74751|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-9027284|reactome:R-DME-912631|reactome:R-DME-9607240|reactome:R-DME-983695|reactome:R-DME-5654733|dip:DIP-21223N	-	-	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/24	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:GNPfKX2LH0HRXEW4ASFDTrXN3VY7227	intact-crc:D4BD6B6E59C09B10|rigid:nulQ8tHIBnfpuFUrJVfRBkfCJGw	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P04412	uniprotkb:Q9VSK2	intact:EBI-197863|uniprotkb:O18370|uniprotkb:O61601|uniprotkb:P81868|uniprotkb:Q9W2G0|ensemblmetazoa:FBpp0071571	intact:EBI-2464942|uniprotkb:Q9GV78|ensemblmetazoa:FBpp0076342	psi-mi:egfr_drome(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:top(gene name synonym)|uniprotkb:DER(gene name synonym)|uniprotkb:c-erbB(gene name synonym)|uniprotkb:CG10079(orf name)|uniprotkb:Gurken receptor(gene name synonym)|uniprotkb:Protein torpedo(gene name synonym)|uniprotkb:Drosophila relative of ERBB(gene name synonym)	psi-mi:q9vsk2_drome(display_long)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:cbl(gene name synonym)|uniprotkb:CG7043(gene name synonym)|uniprotkb:CG7037(orf name)|uniprotkb:CBL(gene name synonym)|uniprotkb:D-Cbl(gene name synonym)|uniprotkb:D-Cbl L(gene name synonym)|uniprotkb:D-CblL(gene name synonym)|uniprotkb:D-cbl(gene name synonym)|uniprotkb:D-cblL(gene name synonym)|uniprotkb:D-cblS(gene name synonym)|uniprotkb:DCbl(gene name synonym)|uniprotkb:Dcbl(gene name synonym)|uniprotkb:Dmel\CG7037(gene name synonym)|uniprotkb:Dv-Cbl(gene name synonym)|uniprotkb:Dv-cbl(gene name synonym)|uniprotkb:F165(gene name synonym)|uniprotkb:anon-WO0118547.68(gene name synonym)|uniprotkb:d-cbl(gene name synonym)|uniprotkb:dCbl(gene name synonym)|uniprotkb:v-Cbl(gene name synonym)|uniprotkb:Dmel_CG7037(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hime et al. (1997)	pubmed:9178769|imex:IM-20279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2465047|imex:IM-20279-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476759.1|flybase:FBgn0003731|dip:DIP-17316N|ensemblmetazoa:FBgn0003731(gene)|ensemblmetazoa:FBtr0071654(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001742"(oenocyte differentiation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003015"(heart process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007309"(oocyte axis specification)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007431"(salivary gland development)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007477"(notum development)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007482"(haltere development)|go:"GO:0008071"(maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0008406"(gonad development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016330"(second mitotic wave involved in compound eye morphogenesis)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0022008"(neurogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035310"(notum cell fate specification)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048749"(compound eye development)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P04412|rcsb pdb:3I2T|rcsb pdb:3LTF|rcsb pdb:3LTG|reactome:R-DME-1227986|reactome:R-DME-1250196|reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1358803|reactome:R-DME-177929|reactome:R-DME-179812|reactome:R-DME-180292|reactome:R-DME-180336|reactome:R-DME-182971|reactome:R-DME-1963642|reactome:R-DME-212718|reactome:R-DME-2179392|reactome:R-DME-416572|reactome:R-DME-5673001|reactome:R-DME-6785631|reactome:R-DME-6811558|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-8863795|reactome:R-DME-9018519|reactome:R-DME-9652282	refseq:NP_648224.1|flybase:FBgn0020224|ensemblmetazoa:FBgn0020224(gene)|ensemblmetazoa:FBtr0076615(transcript)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0047690"(aspartyltransferase activity)|go:"GO:0048134"(germ-line cyst formation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|reactome:R-DME-1295596|reactome:R-DME-1433559|reactome:R-DME-182971|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-8849469|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-912631|reactome:R-DME-983168|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)	-	-	-	figure legend:6b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2009/03/24	2014/10/16	rogid:Ae9kedh1v+TZ5zG4QorNPm9/FgA7227	rogid:FpJKT1NVWEfSuI5IFinUg5IIjmU7227	intact-crc:70CC30F954FB7221|rigid:b3cqEzF5wIADr1tMDEG7YDYN3S0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)