#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02699	uniprotkb:P08168	intact:EBI-8592832|ensembl:ENSBTAP00000001730|intact:MINT-1507462	intact:EBI-8066804|intact:UNK-6022713|ensembl:ENSBTAP00000028633	psi-mi:opsd_bovin(display_long)|uniprotkb:RHO(gene name)|psi-mi:RHO(display_short)	psi-mi:arrs_bovin(display_long)|uniprotkb:SAG(gene name)|psi-mi:SAG(display_short)|uniprotkb:Retinal S-antigen(gene name synonym)|uniprotkb:48 kDa protein(gene name synonym)|uniprotkb:Rod photoreceptor arrestin(gene name synonym)	psi-mi:"MI:0091"(chromatography technology)	Gurevich et al. (1993)	mint:MINT-6825303|pubmed:8505295	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8662703|mint:MINT-6825308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000001310(gene)|ensembl:ENSBTAT00000001730(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002046"(opsin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005502"(11-cis retinal binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0008020"(G protein-coupled photoreceptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016038"(absorption of visible light)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019867"(outer membrane)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043052"(thermotaxis)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050960"(detection of temperature stimulus involved in thermoception)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097381"(photoreceptor disc membrane)|go:"GO:0097648"(G protein-coupled receptor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990913"(sperm head plasma membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000732(Rhodopsin)|interpro:IPR001760(Opsin)|rcsb pdb:1NZS|rcsb pdb:1OV0|rcsb pdb:1OV1|rcsb pdb:1U19|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1VQX|rcsb pdb:2G87|rcsb pdb:2HPY|interpro:IPR019477|rcsb pdb:2I35|interpro:IPR027430|mint:P02699|rcsb pdb:1BOJ|rcsb pdb:1BOK|rcsb pdb:1EDS|rcsb pdb:1EDV|rcsb pdb:1EDW|rcsb pdb:2I36|rcsb pdb:2I37|rcsb pdb:2IQK|rcsb pdb:2J4Y|rcsb pdb:1EDX|rcsb pdb:2PED|rcsb pdb:2X72|rcsb pdb:3C9L|rcsb pdb:3C9M|rcsb pdb:3CAP|rcsb pdb:3DQB|rcsb pdb:3OAX|rcsb pdb:3PQR|rcsb pdb:3PXO|rcsb pdb:4A4M|rcsb pdb:4BEY|rcsb pdb:1F88|rcsb pdb:4BEZ|rcsb pdb:1FDF|rcsb pdb:1GZM|rcsb pdb:4J4Q|rcsb pdb:4PXF|rcsb pdb:4X1H|rcsb pdb:5DYS|rcsb pdb:5EN0|rcsb pdb:5TE3|rcsb pdb:5TE5|rcsb pdb:5WKT|rcsb pdb:6FK6|rcsb pdb:6FK7|rcsb pdb:6FK8|rcsb pdb:6FK9|rcsb pdb:6FKA|rcsb pdb:6FKB|rcsb pdb:6FKC|rcsb pdb:6FKD|rcsb pdb:6FUF|rcsb pdb:6NWE|rcsb pdb:6OFJ|rcsb pdb:6OY9|rcsb pdb:6OYA|rcsb pdb:6PEL|rcsb pdb:6PGS|rcsb pdb:6PH7|rcsb pdb:6QNO|reactome:R-BTA-2453902|reactome:R-BTA-2485179|reactome:R-BTA-2514859|reactome:R-BTA-418594|reactome:R-BTA-419771|reactome:R-BTA-5620916|rcsb pdb:1HZX|rcsb pdb:1JFP|rcsb pdb:1L9H|rcsb pdb:1LN6|rcsb pdb:1N3M|refseq:NP_001014890.1|dip:DIP-29225N|mint:MINT-6825314(identity)|uniprotkb:P02699(P02699)	refseq:XP_010802144.1|refseq:NP_851343.1|dip:DIP-47525N|ensembl:ENSBTAG00000021480(gene)|ensembl:ENSBTAT00000028633(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002046"(opsin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009416"(response to light stimulus)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P08168|rcsb pdb:1AYR|rcsb pdb:1CF1|rcsb pdb:1Y6Y|rcsb pdb:3UGU|rcsb pdb:3UGX|rcsb pdb:4J2Q|rcsb pdb:4PXF|rcsb pdb:4ZRG|go:"GO:0001664"(G protein-coupled receptor binding)|mint:MINT-6825309(identity)|uniprotkb:P08168(P08168)	-	comment:mint|function:Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal	comment:mint|function:S-antigen induces autoimmune uveitis|function:"Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade"	figure legend:F2B|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/01/23	2014/10/16	rogid:ntvPNbJU0fcn+gajwUZzvfd/YCI9913	rogid:wvFCf1d/GCpXcuaaexugxh5qGiY9913	intact-crc:5050857922DEAFD5|rigid:il2QGJHFOnQtvspryDUPQF5fxkM	false	-	binding-associated region:1-404(MINT-6825312)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)