#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29353-2	uniprotkb:P08069	intact:EBI-1000553|ensembl:ENSP00000357435	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	psi-mi:p29353-2(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:"MI:0018"(two hybrid)	Craparo et al. (1995)	pubmed:7541045|imex:IM-19397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2437595|imex:IM-19397-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160691(gene)|ensembl:ENST00000368450(transcript)|intact:EBI-78835(shc1_human)|uniprotkb:P29353-2(isoform-parent)	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	-	isoform-comment:Contains a N-acetylmethionine at position 1.	-	figure legend:1, 3, 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/29	2014/10/16	rogid:NE+rid3JiZ01DxVHe5f+FKvSRI49606	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	intact-crc:21ABC0AE21E91839|rigid:wrSb6Dki4Ok1tQk+nXraL149JBw	false	sufficient binding region:1-238(IPR011993)	sufficient binding region:960..960-1367..1367|mutation disrupting interaction:1033-1033|mutation disrupting interaction:980-980	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08069	uniprotkb:O00459	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Craparo et al. (1995)	pubmed:7541045|imex:IM-19397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2437598|imex:IM-19397-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:1, 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/29	2014/10/16	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:26B2E4FA59D60905|rigid:ufaJxtFbIAj+Uh5ziXNUabpimlQ	false	sufficient binding region:960..960-1367..1367|mutation disrupting interaction:1033-1033	sufficient binding region:319-714(IPR000980)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08069	uniprotkb:P35568	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0018"(two hybrid)	Craparo et al. (1995)	pubmed:7541045|imex:IM-19397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2437601|imex:IM-19397-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772	-	-	-	figure legend:1, 4B, 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/29	2014/10/16	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:4D590FAC20D61E22|rigid:13JpMaAj4e8d/e82v7adNNIx9Ys	false	mutation disrupting interaction:980-980|sufficient binding region:960..960-1367..1367|mutation disrupting interaction:1033-1033	sufficient binding region:160-400	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29353-2	uniprotkb:P08069	intact:EBI-1000553|ensembl:ENSP00000357435	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	psi-mi:p29353-2(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:"MI:0047"(far western blotting)	Craparo et al. (1995)	pubmed:7541045|imex:IM-19397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2437761|imex:IM-19397-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160691(gene)|ensembl:ENST00000368450(transcript)|intact:EBI-78835(shc1_human)|uniprotkb:P29353-2(isoform-parent)	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	-	isoform-comment:Contains a N-acetylmethionine at position 1.	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/29	2014/10/16	rogid:NE+rid3JiZ01DxVHe5f+FKvSRI49606	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	intact-crc:7C41A31B9584C980|rigid:wrSb6Dki4Ok1tQk+nXraL149JBw	false	sufficient binding region:1-238(IPR011993)|maltose binding protein tag:?-?	sufficient binding region:960..960-1367..1367|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)