#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49840	uniprotkb:Q9P0R6	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-1052580|uniprotkb:Q9BST1|uniprotkb:Q9NWK0|uniprotkb:B3KSZ0|ensembl:ENSP00000412315|ensembl:ENSP00000450420|ensembl:ENSP00000451188|ensembl:ENSP00000451384	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:gskip_human(display_long)|uniprotkb:GSK3beta interaction protein(gene name synonym)|uniprotkb:HSPC210(orf name)|uniprotkb:GSKIP(gene name)|psi-mi:GSKIP(display_short)|uniprotkb:C14orf129(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361729|imex:IM-11703-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_057556.2|refseq:NP_001258833.1|refseq:NP_001258834.1|refseq:NP_001258835.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR007967(Protein of unknown function DUF727)|interpro:IPR023231|interpro:IPR037395|rcsb pdb:1SGO|ensembl:ENSG00000100744(gene)|ensembl:ENST00000438650(transcript)|ensembl:ENST00000554182(transcript)|ensembl:ENST00000555181(transcript)|ensembl:ENST00000556095(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0019207"(kinase regulator activity)|refseq:XP_016876854.1	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:Uyu0JSbjadDfFdUUxycavaEj1ys9606	intact-crc:99C96749E21B1E35|rigid:oOYFVu7/eGLOuIjcI+gClImmLsw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q9NZD8	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-742688|uniprotkb:B4DW44|uniprotkb:Q6ZMB6|ensembl:ENSP00000204566|ensembl:ENSP00000404111	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:spg21_human(display_long)|uniprotkb:Spastic paraplegia 21 autosomal recessive Mast syndrome protein(gene name synonym)|uniprotkb:Acid cluster protein 33(gene name synonym)|uniprotkb:SPG21(gene name)|psi-mi:SPG21(display_short)|uniprotkb:ACP33(gene name synonym)|uniprotkb:BM-019(orf name)|uniprotkb:GL010(orf name)|uniprotkb:Spastic paraplegia 21 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361733|imex:IM-11703-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_001121361.1|refseq:NP_001121362.1|refseq:NP_057714.1|ensembl:ENSG00000090487(gene)|ensembl:ENST00000204566(transcript)|ensembl:ENST00000433215(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR026151|interpro:IPR029058|mint:Q9NZD8|refseq:XP_005254494.1|refseq:XP_016877786.1|refseq:XP_016877787.1	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:MoKySBpEYFNm7Lox/HM5nnkmhkA9606	intact-crc:1A36D4F76529AE55|rigid:HBBcWXpt1MYDxiUuRNFB/hDI2Jw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15357	uniprotkb:Q8IV36	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	intact:EBI-743438|uniprotkb:Q8N5L6|uniprotkb:Q8TE83|uniprotkb:Q9NT34|ensembl:ENSP00000413520	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:hid1_human(display_long)|uniprotkb:HID1(gene name)|psi-mi:HID1(display_short)|uniprotkb:C17orf28(gene name synonym)|uniprotkb:DMC1(gene name synonym)|uniprotkb:Down-regulated in multiple cancers 1(gene name synonym)|uniprotkb:HID1 domain-containing protein(gene name synonym)|uniprotkb:Protein hid-1 homolog(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361743|imex:IM-11703-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	refseq:NP_085133.1|refseq:XP_005257283.1|ensembl:ENSG00000167861(gene)|ensembl:ENST00000425042(transcript)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090498"(extrinsic component of Golgi membrane)|interpro:IPR026705	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rogid:JbuUtArSvjy+ToF/IuqCDBvZb/Q9606	intact-crc:BCA0D2FEBC9B9E2B|rigid:OqJTvXOGPR03MeaiLUdsfVvSzxo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15654	uniprotkb:Q3TUQ7	intact:EBI-742327|uniprotkb:O15170|uniprotkb:O15275|uniprotkb:Q9BTB2|uniprotkb:Q9BUE5|uniprotkb:Q9BXP3|uniprotkb:Q9UNT4|uniprotkb:A4D2E7|ensembl:ENSP00000200457|uniprotkb:F2ZC07|uniprotkb:F2ZC08	intact:EBI-2361746|ensembl:ENSMUSP00000154562	psi-mi:trip6_human(display_long)|uniprotkb:TRIP6(gene name)|psi-mi:TRIP6(display_short)|uniprotkb:OIP1(gene name synonym)|uniprotkb:Opa-interacting protein 1(gene name synonym)|uniprotkb:Zyxin-related protein 1(gene name synonym)	psi-mi:q3tuq7_mouse(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361765|imex:IM-11703-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003293.2|ensembl:ENSP00000200457|ensembl:ENST00000417475|ensembl:ENSP00000413817|ensembl:ENST00000437505|ensembl:ENSP00000410736|ensembl:ENST00000619988|ensembl:ENSP00000479865|ensembl:ENSG00000087077(gene)|ensembl:ENST00000200457(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q15654|rcsb pdb:1X61|rcsb pdb:2DLO|dip:DIP-34466N	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000228218(transcript)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:9Okf3b6sMMwX5awAx991GN9iSsQ9606	rogid:aM8EZbROJK4Rohff7Rye4lsFD7010090	intact-crc:D3EE5CA3BCB5F484|rigid:+4kiaUq9bCzz3VlH0Z+SA7PMI/k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P83876	uniprotkb:Q8TAI7	intact:EBI-746539|uniprotkb:O14834|uniprotkb:B2RC18|ensembl:ENSP00000269601	intact:EBI-746555|uniprotkb:Q56VH8|ensembl:ENSP00000301068	psi-mi:txn4a_human(display_long)|uniprotkb:Thioredoxin-like U5 snRNP protein U5-15kD(gene name synonym)|uniprotkb:Spliceosomal U5 snRNP-specific 15 kDa protein(gene name synonym)|uniprotkb:DIM1 protein homolog(gene name synonym)|uniprotkb:TXNL4A(gene name)|psi-mi:TXNL4A(display_short)|uniprotkb:DIM1(gene name synonym)|uniprotkb:TXNL4(gene name synonym)	psi-mi:rebl1_human(display_long)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)|uniprotkb:Rheb2(gene name synonym)|uniprotkb:Ras homolog enriched in brain like-1 c(gene name synonym)|uniprotkb:RHEBL1(gene name)|psi-mi:RHEBL1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361768|imex:IM-11703-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006692.1|refseq:NP_001290400.1|refseq:NP_001292486.1|refseq:NP_001292492.1|refseq:NP_001292493.1|ensembl:ENSG00000141759(gene)|ensembl:ENST00000269601(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR004123(mRNA splicing factor, thioredoxin-like U5 snRNP)|interpro:IPR036249|rcsb pdb:1PQN|rcsb pdb:1QGV|rcsb pdb:1SYX|rcsb pdb:3JCR|rcsb pdb:4BWQ|rcsb pdb:4BWS|rcsb pdb:4CDO|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0005682"(U5 snRNP)	refseq:NP_653194.1|refseq:NP_001290055.1|ensembl:ENSG00000167550(gene)|ensembl:ENST00000301068(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:3OES	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:gGYj9Meks26JpYxw6wB5S2vIrkE9606	rogid:mHmXUvULxk42M1kPOjh4jsn4Q3w9606	intact-crc:37B99388B6A5A756|rigid:Jehji/i3YJRFSKwSpZ38cXdlLOw	false	-	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P43355	uniprotkb:O00141	intact:EBI-740978|ensembl:ENSP00000349085|uniprotkb:O00346|uniprotkb:B2RC81	intact:EBI-1042854|uniprotkb:Q5TCN3|uniprotkb:Q9UN56|uniprotkb:B7UUP7|uniprotkb:B7UUP8|uniprotkb:B7UUP9|uniprotkb:B7Z5B2|uniprotkb:Q5TCN2|uniprotkb:Q5TCN4|uniprotkb:Q5VY65|uniprotkb:E1P583|ensembl:ENSP00000237305	psi-mi:maga1_human(display_long)|uniprotkb:MAGE-1 antigen(gene name synonym)|uniprotkb:Antigen MZ2-E(gene name synonym)|uniprotkb:Cancer/testis antigen 1.1(gene name synonym)|uniprotkb:MAGEA1(gene name)|psi-mi:MAGEA1(display_short)|uniprotkb:MAGE1(gene name synonym)|uniprotkb:MAGE1A(gene name synonym)	psi-mi:sgk1_human(display_long)|uniprotkb:SGK1(gene name)|psi-mi:SGK1(display_short)|uniprotkb:SGK(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361771|imex:IM-11703-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004979.3|ensembl:ENSG00000198681(gene)|ensembl:ENST00000356661(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030093|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:1W72|rcsb pdb:3BO8|dip:DIP-54794N	refseq:NP_001137148.1|refseq:NP_001137149.1|refseq:NP_001137150.1|refseq:NP_005618.2|refseq:XP_011534373.1|refseq:NP_001278924.1|dip:DIP-42464N|ensembl:ENSG00000118515(gene)|ensembl:ENST00000237305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007616"(long-term memory)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:O00141|rcsb pdb:2R5T|rcsb pdb:3HDM|rcsb pdb:3HDN|reactome:R-HSA-2672351|reactome:R-HSA-6804757|reactome:R-HSA-8986944|reactome:R-HSA-9031628	psi-mi:"MI:0469"(intact)	crc64:544EEB1F9F4E9D33	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:6XW3mnTNM3yvOtXmiFbU8Uz3hjA9606	rogid:JtUnW4acvjrgKwRCWC6bu1P1aYs9606	intact-crc:6CF14FECE7D203D4|rigid:dFiozcQZQyjRuXm+3SELNIbGIOI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q16539	uniprotkb:Q92574	intact:EBI-73946|uniprotkb:A8K6P4|uniprotkb:B0LPH0|uniprotkb:A6ZJ92|uniprotkb:O60776|uniprotkb:Q13083|uniprotkb:Q14084|uniprotkb:Q8TDX0|uniprotkb:B5TY32|ensembl:ENSP00000229794	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:mk14_human(display_long)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:Cytokine suppressive anti-inflammatory drug-binding protein(gene name synonym)|uniprotkb:MAX-interacting protein 2(gene name synonym)|uniprotkb:MAP kinase MXI2(gene name synonym)|uniprotkb:SAPK2A(gene name synonym)|uniprotkb:MAPK14(gene name)|psi-mi:MAPK14(display_short)|uniprotkb:CSBP(gene name synonym)|uniprotkb:CSBP1(gene name synonym)|uniprotkb:CSBP2(gene name synonym)|uniprotkb:CSPB1(gene name synonym)|uniprotkb:MXI2(gene name synonym)|uniprotkb:Stress-activated protein kinase 2a(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361792|imex:IM-11703-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306.1|refseq:NP_620581.1|refseq:NP_620582.1|refseq:NP_620583.1|dip:DIP-30987N|ensembl:ENSG00000112062(gene)|ensembl:ENST00000229794(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:Q16539|rcsb pdb:1A9U|rcsb pdb:1BL6|rcsb pdb:1BL7|rcsb pdb:1BMK|rcsb pdb:1DI9|rcsb pdb:1IAN|rcsb pdb:1KV1|rcsb pdb:1KV2|rcsb pdb:1M7Q|rcsb pdb:1OUK|rcsb pdb:1OUY|rcsb pdb:1OVE|rcsb pdb:1OZ1|rcsb pdb:1R39|rcsb pdb:1R3C|rcsb pdb:1W7H|rcsb pdb:1W82|rcsb pdb:1W83|rcsb pdb:1W84|rcsb pdb:1WBN|rcsb pdb:1WBO|rcsb pdb:1WBS|rcsb pdb:1WBT|rcsb pdb:1WBV|rcsb pdb:1WBW|rcsb pdb:1WFC|rcsb pdb:1YQJ|rcsb pdb:1ZYJ|rcsb pdb:1ZZ2|rcsb pdb:1ZZL|rcsb pdb:2BAJ|rcsb pdb:2BAK|rcsb pdb:2BAL|rcsb pdb:2BAQ|rcsb pdb:2FSL|rcsb pdb:2FSM|rcsb pdb:2FSO|rcsb pdb:2FST|rcsb pdb:2GFS|rcsb pdb:2I0H|rcsb pdb:2LGC|rcsb pdb:2NPQ|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2QD9|rcsb pdb:2RG5|rcsb pdb:2RG6|rcsb pdb:2Y8O|rcsb pdb:2YIS|rcsb pdb:2YIW|rcsb pdb:2YIX|rcsb pdb:2ZAZ|rcsb pdb:2ZB0|rcsb pdb:2ZB1|rcsb pdb:3BV2|rcsb pdb:3BV3|rcsb pdb:3BX5|rcsb pdb:3C5U|rcsb pdb:3CTQ|rcsb pdb:3D7Z|rcsb pdb:3D83|rcsb pdb:3DS6|rcsb pdb:3DT1|rcsb pdb:3E92|rcsb pdb:3E93|rcsb pdb:3FC1|rcsb pdb:3FI4|rcsb pdb:3FKL|rcsb pdb:3FKN|rcsb pdb:3FKO|rcsb pdb:3FL4|rcsb pdb:3FLN|rcsb pdb:3FLQ|rcsb pdb:3FLS|rcsb pdb:3FLW|rcsb pdb:3FLY|rcsb pdb:3FLZ|rcsb pdb:3FMH|rcsb pdb:3FMJ|rcsb pdb:3FMK|rcsb pdb:3FML|rcsb pdb:3FMM|rcsb pdb:3FMN|rcsb pdb:3FSF|rcsb pdb:3FSK|rcsb pdb:3GC7|rcsb pdb:3GCP|rcsb pdb:3GCQ|rcsb pdb:3GCS|rcsb pdb:3GCU|rcsb pdb:3GCV|rcsb pdb:3GFE|rcsb pdb:3GI3|rcsb pdb:3HA8|rcsb pdb:3HEC|rcsb pdb:3HEG|rcsb pdb:3HL7|rcsb pdb:3HLL|rcsb pdb:3HP2|rcsb pdb:3HP5|rcsb pdb:3HRB|rcsb pdb:3HUB|rcsb pdb:3HUC|rcsb pdb:3HV3|rcsb pdb:3HV4|rcsb pdb:3HV5|rcsb pdb:3HV6|rcsb pdb:3HV7|rcsb pdb:3HVC|rcsb pdb:3IPH|rcsb pdb:3ITZ|rcsb pdb:3IW5|rcsb pdb:3IW6|rcsb pdb:3IW7|rcsb pdb:3IW8|rcsb pdb:3K3I|rcsb pdb:3K3J|rcsb pdb:3KF7|rcsb pdb:3KQ7|rcsb pdb:3L8S|rcsb pdb:3L8X|rcsb pdb:3LFA|rcsb pdb:3LFB|rcsb pdb:3LFC|rcsb pdb:3LFD|rcsb pdb:3LFE|rcsb pdb:3LFF|rcsb pdb:3LHJ|rcsb pdb:3MGY|rcsb pdb:3MH0|rcsb pdb:3MH1|rcsb pdb:3MH2|rcsb pdb:3MH3|rcsb pdb:3MPA|rcsb pdb:3MPT|rcsb pdb:3MVL|rcsb pdb:3MVM|rcsb pdb:3MW1|rcsb pdb:3NEW|rcsb pdb:3NNU|rcsb pdb:3NNV|rcsb pdb:3NNW|rcsb pdb:3NNX|rcsb pdb:3NWW|rcsb pdb:3O8P|rcsb pdb:3O8T|rcsb pdb:3O8U|rcsb pdb:3OBG|rcsb pdb:3OBJ|rcsb pdb:3OC1|rcsb pdb:3OCG|rcsb pdb:3OD6|rcsb pdb:3ODY|rcsb pdb:3ODZ|rcsb pdb:3OEF|rcsb pdb:3PG3|rcsb pdb:3QUD|rcsb pdb:3QUE|rcsb pdb:3RIN|rcsb pdb:3ROC|rcsb pdb:3S3I|rcsb pdb:3S4Q|rcsb pdb:3U8W|rcsb pdb:3UVP|rcsb pdb:3UVQ|rcsb pdb:3UVR|rcsb pdb:3ZS5|rcsb pdb:3ZSG|rcsb pdb:3ZSH|rcsb pdb:3ZSI|rcsb pdb:3ZYA|rcsb pdb:4A9Y|rcsb pdb:4AA0|rcsb pdb:4AA4|rcsb pdb:4AA5|rcsb pdb:4AAC|rcsb pdb:4DLI|rcsb pdb:4DLJ|rcsb pdb:4E5A|rcsb pdb:4E5B|rcsb pdb:4E6A|rcsb pdb:4E6C|rcsb pdb:4E8A|rcsb pdb:4EH2|rcsb pdb:4EH3|rcsb pdb:4EH4|rcsb pdb:4EH5|rcsb pdb:4EH6|rcsb pdb:4EH7|rcsb pdb:4EH8|rcsb pdb:4EH9|rcsb pdb:4EHV|rcsb pdb:4EWQ|rcsb pdb:4F9W|rcsb pdb:4F9Y|rcsb pdb:4FA2|rcsb pdb:4GEO|rcsb pdb:4KIN|rcsb pdb:4KIP|rcsb pdb:4KIQ|rcsb pdb:4L8M|rcsb pdb:4R3C|rcsb pdb:4ZTH|rcsb pdb:5ETA|rcsb pdb:5ETC|rcsb pdb:5ETF|rcsb pdb:5ETI|rcsb pdb:5ML5|rcsb pdb:5MTX|rcsb pdb:5MTY|rcsb pdb:5MZ3|rcsb pdb:5N63|rcsb pdb:5N64|rcsb pdb:5N65|rcsb pdb:5N66|rcsb pdb:5N67|rcsb pdb:5N68|rcsb pdb:5O8U|rcsb pdb:5O8V|rcsb pdb:5OMG|rcsb pdb:5OMH|rcsb pdb:5TBE|rcsb pdb:5TCO|rcsb pdb:5WJJ|rcsb pdb:5XYX|rcsb pdb:5XYY|rcsb pdb:6ANL|rcsb pdb:6HWT|rcsb pdb:6HWU|rcsb pdb:6HWV|rcsb pdb:6M95|rcsb pdb:6M9L|rcsb pdb:6OHD|rcsb pdb:6QDZ|rcsb pdb:6QE1|rcsb pdb:6QYX|rcsb pdb:6RFO|rcsb pdb:6SFI|rcsb pdb:6SFJ|rcsb pdb:6SFK|rcsb pdb:6SFO|rcsb pdb:6TCA|rcsb pdb:6ZQS|rcsb pdb:6ZWP|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-198753|reactome:R-HSA-2151209|reactome:R-HSA-2559580|reactome:R-HSA-376172|reactome:R-HSA-418592|reactome:R-HSA-432142|reactome:R-HSA-4420097|reactome:R-HSA-450302|reactome:R-HSA-450341|reactome:R-HSA-450604|reactome:R-HSA-525793|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-9662834	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:oI6EOrCDVMQ6FDVBHSiYYoKZHns9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:61187E2C05743A77|rigid:x/f//AU+YEh5tasPCppYdB8eVB4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75398	uniprotkb:P49840	intact:EBI-718185|uniprotkb:O15152|uniprotkb:O75399|uniprotkb:O75510|uniprotkb:O75511|uniprotkb:O75512|uniprotkb:O75513|uniprotkb:Q9UET1|uniprotkb:A8K5R8|uniprotkb:A8K1F8|uniprotkb:C7T5V5|intact:EBI-28974412|ensembl:ENSP00000371846	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:deaf1_human(display_long)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)|uniprotkb:Suppressin(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 5(gene name synonym)|uniprotkb:DEAF1(gene name)|psi-mi:DEAF1(display_short)|uniprotkb:SPN(gene name synonym)|uniprotkb:ZMYND5(gene name synonym)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361799|imex:IM-11703-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066288.2|ensembl:ENSP00000371846|refseq:NP_001280563.1|ensembl:ENSG00000177030(gene)|ensembl:ENST00000382409(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001843"(neural tube closure)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|mint:O75398|rcsb pdb:2JW6|rcsb pdb:4A24|rcsb pdb:5UWW	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/07	2014/10/16	rogid:2wVDKJ2CcROUYc5whZI3JWATnI89606	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:8F5F5FAE30ACF435|rigid:9cVsLRmE2VHtNO9TBh6HzJdQW18	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49841	uniprotkb:O75398	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-718185|uniprotkb:O15152|uniprotkb:O75399|uniprotkb:O75510|uniprotkb:O75511|uniprotkb:O75512|uniprotkb:O75513|uniprotkb:Q9UET1|uniprotkb:A8K5R8|uniprotkb:A8K1F8|uniprotkb:C7T5V5|intact:EBI-28974412|ensembl:ENSP00000371846	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:deaf1_human(display_long)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)|uniprotkb:Suppressin(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 5(gene name synonym)|uniprotkb:DEAF1(gene name)|psi-mi:DEAF1(display_short)|uniprotkb:SPN(gene name synonym)|uniprotkb:ZMYND5(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361811|imex:IM-11703-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_066288.2|ensembl:ENSP00000371846|refseq:NP_001280563.1|ensembl:ENSG00000177030(gene)|ensembl:ENST00000382409(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001843"(neural tube closure)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|mint:O75398|rcsb pdb:2JW6|rcsb pdb:4A24|rcsb pdb:5UWW	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:2wVDKJ2CcROUYc5whZI3JWATnI89606	intact-crc:C7F4B6C623806FD7|rigid:ye7+FyJ+LiSwZuSJPUKt3R8CnHQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NUC0	uniprotkb:P31749	intact:EBI-1773811|uniprotkb:B2RD32|ensembl:ENSP00000355979|ensembl:ENSP00000486369	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:srtd4_human(display_long)|uniprotkb:SERTAD4(gene name)|psi-mi:SERTAD4(display_short)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361821|imex:IM-11703-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062551.1|ensembl:ENSG00000082497(gene)|ensembl:ENSG00000281230(gene)|ensembl:ENST00000367012(transcript)|ensembl:ENST00000630425(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR009263(SERTA)|interpro:IPR029708	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:us8AIu8sIAtj+ZOqwAH2vzWE0ik9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:1E6F73FEF40E9E69|rigid:4vxrVcfkFyq6KLe3JgxHXU3F+9M	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99490	uniprotkb:Q5ZEZ6	intact:EBI-2361824|uniprotkb:O00578|uniprotkb:Q548E0|uniprotkb:Q8IWU3|uniprotkb:A8K9F7	intact:EBI-2361841	psi-mi:agap2_human(display_long)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:q5zez6_human(display_long)|uniprotkb:M-RIP(gene name)|psi-mi:M-RIP(display_short)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361847|imex:IM-11703-96	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116244.1|refseq:NP_055585.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:2BMJ|rcsb pdb:2IWR|rcsb pdb:2RLO|interpro:IPR037278|interpro:IPR038508|interpro:IPR027417|interpro:IPR001806(Ras GTPase)|reactome:R-HSA-373752|interpro:IPR036770|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)	-	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:8/lz/H3aXs+maU1J2TTJbV7DpKc9606	rogid:MKwriTLDZqbnFTE8u8rpNEInqn49606	intact-crc:D9AB58261EEC7EE2|rigid:q2EW0St1G8+IpkdB6HPb9xsL6cY	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2361892	uniprotkb:P49840	-	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:a6nfk4_human(display_short)|psi-mi:EBI-2361892(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361910|imex:IM-11703-104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A6NFK4(uniprot-removed-ac)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:B67i/BgwFHh7tBd2cyRFRu+aWAU9606	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:0565B4579E06DFE7|rigid:8vHHjmsGqKNeC3hSKxRvA3c82ZU	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49840	uniprotkb:Q8N0Z3	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2361917|uniprotkb:Q8WUX6|uniprotkb:D3DN72|intact:EBI-28978711|ensembl:ENSP00000295872	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:spice_human(display_long)|uniprotkb:CCDC52(gene name synonym)|uniprotkb:SPICE(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 52(gene name synonym)|uniprotkb:Spindle and centriole-associated protein(gene name synonym)|uniprotkb:SPICE1(gene name)|psi-mi:SPICE1(display_short)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361925|imex:IM-11703-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_653319.1|ensembl:ENSP00000295872|refseq:NP_001318007.1|refseq:XP_016861267.1|refseq:NP_001318008.1|ensembl:ENSG00000163611(gene)|ensembl:ENST00000295872(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR031387|mint:Q8N0Z3	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:Ogv5G3kQP2liovo9dVap83bif2M9606	intact-crc:A0DAE6156458266E|rigid:TujpY0rTzdh+fENu/q5qJz9tNWs	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75398	uniprotkb:P49840	intact:EBI-718185|uniprotkb:O15152|uniprotkb:O75399|uniprotkb:O75510|uniprotkb:O75511|uniprotkb:O75512|uniprotkb:O75513|uniprotkb:Q9UET1|uniprotkb:A8K5R8|uniprotkb:A8K1F8|uniprotkb:C7T5V5|intact:EBI-28974412|ensembl:ENSP00000371846	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:deaf1_human(display_long)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)|uniprotkb:Suppressin(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 5(gene name synonym)|uniprotkb:DEAF1(gene name)|psi-mi:DEAF1(display_short)|uniprotkb:SPN(gene name synonym)|uniprotkb:ZMYND5(gene name synonym)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361932|imex:IM-11703-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066288.2|ensembl:ENSP00000371846|refseq:NP_001280563.1|ensembl:ENSG00000177030(gene)|ensembl:ENST00000382409(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001843"(neural tube closure)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|mint:O75398|rcsb pdb:2JW6|rcsb pdb:4A24|rcsb pdb:5UWW	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:2wVDKJ2CcROUYc5whZI3JWATnI89606	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:19F47C2C4AF238C6|rigid:9cVsLRmE2VHtNO9TBh6HzJdQW18	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q16584	uniprotkb:P49840	intact:EBI-49961|uniprotkb:Q53H00|uniprotkb:Q59F06|uniprotkb:Q6P2G4|uniprotkb:B4DS76|ensembl:ENSP00000309597	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:m3k11_human(display_long)|uniprotkb:MAP3K11(gene name)|psi-mi:MAP3K11(display_short)|uniprotkb:Mixed lineage kinase 3(gene name synonym)|uniprotkb:Src-homology 3 domain-containing proline-rich kinase(gene name synonym)|uniprotkb:SPRK(gene name synonym)|uniprotkb:PTK1(gene name synonym)|uniprotkb:MLK3(gene name synonym)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361939|imex:IM-11703-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002410.1|ensembl:ENSG00000173327(gene)|ensembl:ENST00000309100(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016231(Mitogen-activated protein kinase kinase kinase, 9/10/11)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035779|interpro:IPR036028|mint:Q16584|rcsb pdb:5K26|rcsb pdb:5K28|rcsb pdb:6AQB|rcsb pdb:6CQ7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9013148|reactome:R-HSA-9013408|reactome:R-HSA-9649948	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:njuMQIbuVFlWXNggegg3zYAKmS49606	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:E8A725B05CF16C20|rigid:EWnc6VvOc0oS7WyL01meRl9c1wc	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49840	uniprotkb:Q14596	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-742698|uniprotkb:Q13173|uniprotkb:Q15026|uniprotkb:Q96GB6|uniprotkb:Q9NRF7|uniprotkb:Q5J7Q8|intact:EBI-2859623|ensembl:ENSP00000343479|ensembl:ENSP00000466667	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:nbr1_human(display_long)|uniprotkb:Neighbor of BRCA1 gene 1 protein(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 2(gene name synonym)|uniprotkb:Protein 1A1-3B(gene name synonym)|uniprotkb:NBR1(gene name)|psi-mi:NBR1(display_short)|uniprotkb:1A13B(gene name synonym)|uniprotkb:KIAA0049(gene name synonym)|uniprotkb:M17S2(gene name synonym)|uniprotkb:Cell migration-inducing gene 19 protein(gene name synonym)|uniprotkb:MIG19(orf name)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361946|imex:IM-11703-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_005890.2|refseq:NP_114068.1|ensembl:ENST00000341165(transcript)|ensembl:ENST00000590996(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016604"(nuclear body)|ensembl:ENSG00000188554(gene)|refseq:XP_011523115.1|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031430"(M band)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR032350|interpro:IPR033513|interpro:IPR034852|interpro:IPR043145|mint:Q14596|rcsb pdb:1WJ6|rcsb pdb:2BKF|rcsb pdb:2CP8|rcsb pdb:2G4S|rcsb pdb:2L8J|rcsb pdb:2MGW|rcsb pdb:2MJ5|rcsb pdb:4OLE|reactome:R-HSA-9664873|refseq:NP_001278500.1|refseq:NP_001278501.1|refseq:XP_016880131.1	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:rRlRq4sK4fkVQCliQ68/MIEOX6g9606	intact-crc:A6E8DAA01512E396|rigid:xQusP4ABBF9GqCFILXkVuHMABGE	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NP79	uniprotkb:P49840	intact:EBI-740160|uniprotkb:Q5TGM1|uniprotkb:Q6IAE8|uniprotkb:Q9H0R2|uniprotkb:Q9H3K9|uniprotkb:Q9P0Q0|uniprotkb:E1P594|ensembl:ENSP00000356602|uniprotkb:B4DW55|uniprotkb:E7ETQ7	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:vta1_human(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:HSPC228(orf name)|uniprotkb:My012(orf name)|uniprotkb:SKD1-binding protein 1(gene name synonym)|uniprotkb:C6orf55(gene name synonym)|uniprotkb:Dopamine-responsive gene 1 protein(gene name synonym)|uniprotkb:LYST-interacting protein 5(gene name synonym)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361955|imex:IM-11703-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273300.1|refseq:NP_001273301.1|refseq:NP_057569.2|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:4U7E|reactome:R-HSA-162588|reactome:R-HSA-917729|ensembl:ENSG00000009844(gene)|ensembl:ENST00000367630(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LXL|rcsb pdb:2LXM|rcsb pdb:4TXP	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:QIeYrvtJGJ2jWli8PWK9TeO6gus9606	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:D9C8DEF11FB28CC6|rigid:mlyvLT8yc4jStTVnToG4e0khNp8	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:A5PL33	uniprotkb:P49840	intact:EBI-2361962|uniprotkb:Q8N4X0|uniprotkb:Q96JG5|uniprotkb:A7E2F5|uniprotkb:E7ENE9|ensembl:ENSP00000317165	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:krba1_human(display_long)|uniprotkb:KRBA1(gene name)|psi-mi:KRBA1(display_short)|uniprotkb:KIAA1862(gene name synonym)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2361986|imex:IM-11703-98	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115923.2|refseq:NP_001277116.1|ensembl:ENSG00000133619(gene)|ensembl:ENST00000319551(transcript)|interpro:IPR029317|interpro:IPR040095|reactome:R-HSA-212436	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:82+SQo83RDOZkUPKU8hNiPCL5SI9606	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:E8348AC86875A6DD|rigid:DgqTxBtNUsvz2O2gba5eg1nkMJQ	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96F24	uniprotkb:Q3TUQ7	intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746	intact:EBI-2361746|ensembl:ENSMUSP00000154562	psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym)	psi-mi:q3tuq7_mouse(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362010|imex:IM-11703-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000228218(transcript)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606	rogid:aM8EZbROJK4Rohff7Rye4lsFD7010090	intact-crc:AC445F08E379C831|rigid:p/2IbrjsySUbDmIog7truKCgNPQ	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q12933	uniprotkb:Q15382	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362042|imex:IM-11703-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	intact-crc:C9C02ECF6BDBB281|rigid:Tdxpp+ELkvSL5gqcYG0kTca+0xU	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TAI7	uniprotkb:Q12933	intact:EBI-746555|uniprotkb:Q56VH8|ensembl:ENSP00000301068	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:rebl1_human(display_long)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)|uniprotkb:Rheb2(gene name synonym)|uniprotkb:Ras homolog enriched in brain like-1 c(gene name synonym)|uniprotkb:RHEBL1(gene name)|psi-mi:RHEBL1(display_short)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362049|imex:IM-11703-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_653194.1|refseq:NP_001290055.1|ensembl:ENSG00000167550(gene)|ensembl:ENST00000301068(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:3OES	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:mHmXUvULxk42M1kPOjh4jsn4Q3w9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	intact-crc:68761A5BD04D11CF|rigid:Zh25e1gf7RXapiTu2juemVTwkMs	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96CW1	uniprotkb:Q15831	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362056|imex:IM-11703-80	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:5E5064B807A5F6FB|rigid:1UOs+DdJsWJx9ggSnPd60uzUBs0	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15831	uniprotkb:Q14232	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-491065|uniprotkb:A6NLY9|uniprotkb:Q3SXP4|uniprotkb:B4DGX0|ensembl:ENSP00000416250	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:ei2ba_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)|uniprotkb:EIF2B1(gene name)|psi-mi:EIF2B1(display_short)|uniprotkb:EIF2BA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362063|imex:IM-11703-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001405.1|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:3ECS|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000111361(gene)|ensembl:ENST00000424014(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:HAThUj88pwaLd6kmAlO5s1xtntM9606	intact-crc:4F310D6F2DAA91B2|rigid:ejHk+hd5dXqVE1wdvgwcmAiXLrA	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q16539	uniprotkb:Q92574	intact:EBI-73946|uniprotkb:A8K6P4|uniprotkb:B0LPH0|uniprotkb:A6ZJ92|uniprotkb:O60776|uniprotkb:Q13083|uniprotkb:Q14084|uniprotkb:Q8TDX0|uniprotkb:B5TY32|ensembl:ENSP00000229794	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:mk14_human(display_long)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:Cytokine suppressive anti-inflammatory drug-binding protein(gene name synonym)|uniprotkb:MAX-interacting protein 2(gene name synonym)|uniprotkb:MAP kinase MXI2(gene name synonym)|uniprotkb:SAPK2A(gene name synonym)|uniprotkb:MAPK14(gene name)|psi-mi:MAPK14(display_short)|uniprotkb:CSBP(gene name synonym)|uniprotkb:CSBP1(gene name synonym)|uniprotkb:CSBP2(gene name synonym)|uniprotkb:CSPB1(gene name synonym)|uniprotkb:MXI2(gene name synonym)|uniprotkb:Stress-activated protein kinase 2a(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362071|imex:IM-11703-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306.1|refseq:NP_620581.1|refseq:NP_620582.1|refseq:NP_620583.1|dip:DIP-30987N|ensembl:ENSG00000112062(gene)|ensembl:ENST00000229794(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:Q16539|rcsb pdb:1A9U|rcsb pdb:1BL6|rcsb pdb:1BL7|rcsb pdb:1BMK|rcsb pdb:1DI9|rcsb pdb:1IAN|rcsb pdb:1KV1|rcsb pdb:1KV2|rcsb pdb:1M7Q|rcsb pdb:1OUK|rcsb pdb:1OUY|rcsb pdb:1OVE|rcsb pdb:1OZ1|rcsb pdb:1R39|rcsb pdb:1R3C|rcsb pdb:1W7H|rcsb pdb:1W82|rcsb pdb:1W83|rcsb pdb:1W84|rcsb pdb:1WBN|rcsb pdb:1WBO|rcsb pdb:1WBS|rcsb pdb:1WBT|rcsb pdb:1WBV|rcsb pdb:1WBW|rcsb pdb:1WFC|rcsb pdb:1YQJ|rcsb pdb:1ZYJ|rcsb pdb:1ZZ2|rcsb pdb:1ZZL|rcsb pdb:2BAJ|rcsb pdb:2BAK|rcsb pdb:2BAL|rcsb pdb:2BAQ|rcsb pdb:2FSL|rcsb pdb:2FSM|rcsb pdb:2FSO|rcsb pdb:2FST|rcsb pdb:2GFS|rcsb pdb:2I0H|rcsb pdb:2LGC|rcsb pdb:2NPQ|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2QD9|rcsb pdb:2RG5|rcsb pdb:2RG6|rcsb pdb:2Y8O|rcsb pdb:2YIS|rcsb pdb:2YIW|rcsb pdb:2YIX|rcsb pdb:2ZAZ|rcsb pdb:2ZB0|rcsb pdb:2ZB1|rcsb pdb:3BV2|rcsb pdb:3BV3|rcsb pdb:3BX5|rcsb pdb:3C5U|rcsb pdb:3CTQ|rcsb pdb:3D7Z|rcsb pdb:3D83|rcsb pdb:3DS6|rcsb pdb:3DT1|rcsb pdb:3E92|rcsb pdb:3E93|rcsb pdb:3FC1|rcsb pdb:3FI4|rcsb pdb:3FKL|rcsb pdb:3FKN|rcsb pdb:3FKO|rcsb pdb:3FL4|rcsb pdb:3FLN|rcsb pdb:3FLQ|rcsb pdb:3FLS|rcsb pdb:3FLW|rcsb pdb:3FLY|rcsb pdb:3FLZ|rcsb pdb:3FMH|rcsb pdb:3FMJ|rcsb pdb:3FMK|rcsb pdb:3FML|rcsb pdb:3FMM|rcsb pdb:3FMN|rcsb pdb:3FSF|rcsb pdb:3FSK|rcsb pdb:3GC7|rcsb pdb:3GCP|rcsb pdb:3GCQ|rcsb pdb:3GCS|rcsb pdb:3GCU|rcsb pdb:3GCV|rcsb pdb:3GFE|rcsb pdb:3GI3|rcsb pdb:3HA8|rcsb pdb:3HEC|rcsb pdb:3HEG|rcsb pdb:3HL7|rcsb pdb:3HLL|rcsb pdb:3HP2|rcsb pdb:3HP5|rcsb pdb:3HRB|rcsb pdb:3HUB|rcsb pdb:3HUC|rcsb pdb:3HV3|rcsb pdb:3HV4|rcsb pdb:3HV5|rcsb pdb:3HV6|rcsb pdb:3HV7|rcsb pdb:3HVC|rcsb pdb:3IPH|rcsb pdb:3ITZ|rcsb pdb:3IW5|rcsb pdb:3IW6|rcsb pdb:3IW7|rcsb pdb:3IW8|rcsb pdb:3K3I|rcsb pdb:3K3J|rcsb pdb:3KF7|rcsb pdb:3KQ7|rcsb pdb:3L8S|rcsb pdb:3L8X|rcsb pdb:3LFA|rcsb pdb:3LFB|rcsb pdb:3LFC|rcsb pdb:3LFD|rcsb pdb:3LFE|rcsb pdb:3LFF|rcsb pdb:3LHJ|rcsb pdb:3MGY|rcsb pdb:3MH0|rcsb pdb:3MH1|rcsb pdb:3MH2|rcsb pdb:3MH3|rcsb pdb:3MPA|rcsb pdb:3MPT|rcsb pdb:3MVL|rcsb pdb:3MVM|rcsb pdb:3MW1|rcsb pdb:3NEW|rcsb pdb:3NNU|rcsb pdb:3NNV|rcsb pdb:3NNW|rcsb pdb:3NNX|rcsb pdb:3NWW|rcsb pdb:3O8P|rcsb pdb:3O8T|rcsb pdb:3O8U|rcsb pdb:3OBG|rcsb pdb:3OBJ|rcsb pdb:3OC1|rcsb pdb:3OCG|rcsb pdb:3OD6|rcsb pdb:3ODY|rcsb pdb:3ODZ|rcsb pdb:3OEF|rcsb pdb:3PG3|rcsb pdb:3QUD|rcsb pdb:3QUE|rcsb pdb:3RIN|rcsb pdb:3ROC|rcsb pdb:3S3I|rcsb pdb:3S4Q|rcsb pdb:3U8W|rcsb pdb:3UVP|rcsb pdb:3UVQ|rcsb pdb:3UVR|rcsb pdb:3ZS5|rcsb pdb:3ZSG|rcsb pdb:3ZSH|rcsb pdb:3ZSI|rcsb pdb:3ZYA|rcsb pdb:4A9Y|rcsb pdb:4AA0|rcsb pdb:4AA4|rcsb pdb:4AA5|rcsb pdb:4AAC|rcsb pdb:4DLI|rcsb pdb:4DLJ|rcsb pdb:4E5A|rcsb pdb:4E5B|rcsb pdb:4E6A|rcsb pdb:4E6C|rcsb pdb:4E8A|rcsb pdb:4EH2|rcsb pdb:4EH3|rcsb pdb:4EH4|rcsb pdb:4EH5|rcsb pdb:4EH6|rcsb pdb:4EH7|rcsb pdb:4EH8|rcsb pdb:4EH9|rcsb pdb:4EHV|rcsb pdb:4EWQ|rcsb pdb:4F9W|rcsb pdb:4F9Y|rcsb pdb:4FA2|rcsb pdb:4GEO|rcsb pdb:4KIN|rcsb pdb:4KIP|rcsb pdb:4KIQ|rcsb pdb:4L8M|rcsb pdb:4R3C|rcsb pdb:4ZTH|rcsb pdb:5ETA|rcsb pdb:5ETC|rcsb pdb:5ETF|rcsb pdb:5ETI|rcsb pdb:5ML5|rcsb pdb:5MTX|rcsb pdb:5MTY|rcsb pdb:5MZ3|rcsb pdb:5N63|rcsb pdb:5N64|rcsb pdb:5N65|rcsb pdb:5N66|rcsb pdb:5N67|rcsb pdb:5N68|rcsb pdb:5O8U|rcsb pdb:5O8V|rcsb pdb:5OMG|rcsb pdb:5OMH|rcsb pdb:5TBE|rcsb pdb:5TCO|rcsb pdb:5WJJ|rcsb pdb:5XYX|rcsb pdb:5XYY|rcsb pdb:6ANL|rcsb pdb:6HWT|rcsb pdb:6HWU|rcsb pdb:6HWV|rcsb pdb:6M95|rcsb pdb:6M9L|rcsb pdb:6OHD|rcsb pdb:6QDZ|rcsb pdb:6QE1|rcsb pdb:6QYX|rcsb pdb:6RFO|rcsb pdb:6SFI|rcsb pdb:6SFJ|rcsb pdb:6SFK|rcsb pdb:6SFO|rcsb pdb:6TCA|rcsb pdb:6ZQS|rcsb pdb:6ZWP|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-198753|reactome:R-HSA-2151209|reactome:R-HSA-2559580|reactome:R-HSA-376172|reactome:R-HSA-418592|reactome:R-HSA-432142|reactome:R-HSA-4420097|reactome:R-HSA-450302|reactome:R-HSA-450341|reactome:R-HSA-450604|reactome:R-HSA-525793|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-9662834	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:oI6EOrCDVMQ6FDVBHSiYYoKZHns9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:4C741ED39E391C2B|rigid:x/f//AU+YEh5tasPCppYdB8eVB4	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2361892	uniprotkb:P49841	-	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:a6nfk4_human(display_short)|psi-mi:EBI-2361892(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362078|imex:IM-11703-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A6NFK4(uniprot-removed-ac)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:B67i/BgwFHh7tBd2cyRFRu+aWAU9606	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:B7431E95CEAA19A7|rigid:hBsaCMo71pfh+g82SPCvsMDgVqI	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N0Z3	uniprotkb:P49841	intact:EBI-2361917|uniprotkb:Q8WUX6|uniprotkb:D3DN72|intact:EBI-28978711|ensembl:ENSP00000295872	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:spice_human(display_long)|uniprotkb:CCDC52(gene name synonym)|uniprotkb:SPICE(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 52(gene name synonym)|uniprotkb:Spindle and centriole-associated protein(gene name synonym)|uniprotkb:SPICE1(gene name)|psi-mi:SPICE1(display_short)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362107|imex:IM-11703-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_653319.1|ensembl:ENSP00000295872|refseq:NP_001318007.1|refseq:XP_016861267.1|refseq:NP_001318008.1|ensembl:ENSG00000163611(gene)|ensembl:ENST00000295872(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR031387|mint:Q8N0Z3	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:Ogv5G3kQP2liovo9dVap83bif2M9606	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:420F312B02A1EC26|rigid:lICsiCU0bFFtx1MmF3dDBFa7mPM	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75398	uniprotkb:P49841	intact:EBI-718185|uniprotkb:O15152|uniprotkb:O75399|uniprotkb:O75510|uniprotkb:O75511|uniprotkb:O75512|uniprotkb:O75513|uniprotkb:Q9UET1|uniprotkb:A8K5R8|uniprotkb:A8K1F8|uniprotkb:C7T5V5|intact:EBI-28974412|ensembl:ENSP00000371846	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:deaf1_human(display_long)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)|uniprotkb:Suppressin(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 5(gene name synonym)|uniprotkb:DEAF1(gene name)|psi-mi:DEAF1(display_short)|uniprotkb:SPN(gene name synonym)|uniprotkb:ZMYND5(gene name synonym)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362114|imex:IM-11703-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066288.2|ensembl:ENSP00000371846|refseq:NP_001280563.1|ensembl:ENSG00000177030(gene)|ensembl:ENST00000382409(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001843"(neural tube closure)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|mint:O75398|rcsb pdb:2JW6|rcsb pdb:4A24|rcsb pdb:5UWW	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:2wVDKJ2CcROUYc5whZI3JWATnI89606	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:3EE80DEB919F8E1D|rigid:ye7+FyJ+LiSwZuSJPUKt3R8CnHQ	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49841	uniprotkb:A5PL33	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2361962|uniprotkb:Q8N4X0|uniprotkb:Q96JG5|uniprotkb:A7E2F5|uniprotkb:E7ENE9|ensembl:ENSP00000317165	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:krba1_human(display_long)|uniprotkb:KRBA1(gene name)|psi-mi:KRBA1(display_short)|uniprotkb:KIAA1862(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362144|imex:IM-11703-102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_115923.2|refseq:NP_001277116.1|ensembl:ENSG00000133619(gene)|ensembl:ENST00000319551(transcript)|interpro:IPR029317|interpro:IPR040095|reactome:R-HSA-212436	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:82+SQo83RDOZkUPKU8hNiPCL5SI9606	intact-crc:CF28FB0FB3181006|rigid:q5n88KRU6A9gNjUJtLb7QieJTmI	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49841	uniprotkb:A6QQU8	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2362151	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:a6qqu8_bovin(display_long)|uniprotkb:MAP3K11(gene name)|psi-mi:MAP3K11(display_short)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362178|imex:IM-11703-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_001095461.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001452(Src homology-3)|interpro:IPR016231(Mitogen-activated protein kinase kinase kinase, 9/10/11)|interpro:IPR035779|interpro:IPR036028|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:C3z5+Nomguv+Yo4UZRUMvHLQFNw9913	intact-crc:2FEDDD33A5856508|rigid:MZcjRVQebJxRrKI1arFXmzDdd+Y	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49841	uniprotkb:Q9NP79	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-740160|uniprotkb:Q5TGM1|uniprotkb:Q6IAE8|uniprotkb:Q9H0R2|uniprotkb:Q9H3K9|uniprotkb:Q9P0Q0|uniprotkb:E1P594|ensembl:ENSP00000356602|uniprotkb:B4DW55|uniprotkb:E7ETQ7	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:vta1_human(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:HSPC228(orf name)|uniprotkb:My012(orf name)|uniprotkb:SKD1-binding protein 1(gene name synonym)|uniprotkb:C6orf55(gene name synonym)|uniprotkb:Dopamine-responsive gene 1 protein(gene name synonym)|uniprotkb:LYST-interacting protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362185|imex:IM-11703-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_001273300.1|refseq:NP_001273301.1|refseq:NP_057569.2|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:4U7E|reactome:R-HSA-162588|reactome:R-HSA-917729|ensembl:ENSG00000009844(gene)|ensembl:ENST00000367630(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LXL|rcsb pdb:2LXM|rcsb pdb:4TXP	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:QIeYrvtJGJ2jWli8PWK9TeO6gus9606	intact-crc:94B98EB40BB31B58|rigid:bOCncHT85vXHShH0WNe2NFF39dU	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08069	uniprotkb:Q6PIS1	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	intact:EBI-2362199|uniprotkb:Q2PYN6|uniprotkb:Q96NA6|uniprotkb:B7Z512|ensembl:ENSP00000386473	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:s23a3_human(display_long)|uniprotkb:SLC23A3(gene name)|psi-mi:SLC23A3(display_short)|uniprotkb:E2BP3(gene name synonym)|uniprotkb:SVCT3(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 3(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 3"(gene name synonym)|uniprotkb:HPC E2-binding protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362225|imex:IM-11703-103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	refseq:NP_001138361.1|refseq:NP_653313.3|refseq:NP_001138362.1|ensembl:ENSG00000213901(gene)|ensembl:ENST00000409878(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029957	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	rogid:EpNx2rGeYUG8h5d3mfgzyCmiyJQ9606	intact-crc:B5BCD9FF2675D338|rigid:8tX4qNnYDXrbAoueivH2+Yok8Zc	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IV36	uniprotkb:O15357	intact:EBI-743438|uniprotkb:Q8N5L6|uniprotkb:Q8TE83|uniprotkb:Q9NT34|ensembl:ENSP00000413520	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:hid1_human(display_long)|uniprotkb:HID1(gene name)|psi-mi:HID1(display_short)|uniprotkb:C17orf28(gene name synonym)|uniprotkb:DMC1(gene name synonym)|uniprotkb:Down-regulated in multiple cancers 1(gene name synonym)|uniprotkb:HID1 domain-containing protein(gene name synonym)|uniprotkb:Protein hid-1 homolog(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362232|imex:IM-11703-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085133.1|refseq:XP_005257283.1|ensembl:ENSG00000167861(gene)|ensembl:ENST00000425042(transcript)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090498"(extrinsic component of Golgi membrane)|interpro:IPR026705	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:JbuUtArSvjy+ToF/IuqCDBvZb/Q9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	intact-crc:A1F0121C99D3D112|rigid:OqJTvXOGPR03MeaiLUdsfVvSzxo	false	myc tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13131	uniprotkb:Q8IZP0	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362242|imex:IM-11703-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:163D3BCD876A4FFF|rigid:NtIr4pBYvyjwCOFLKIv2p5AvddU	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13131	uniprotkb:P16870	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-711320|intact:EBI-3450168|uniprotkb:D3DP33|uniprotkb:Q9UIU9|uniprotkb:A8K4N1|uniprotkb:B3KR42|uniprotkb:B4DFN4|ensembl:ENSP00000386104	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:cbpe_human(display_long)|uniprotkb:CPE(gene name)|psi-mi:CPE(display_short)|uniprotkb:Carboxypeptidase H(gene name synonym)|uniprotkb:Enkephalin convertase(gene name synonym)|uniprotkb:Prohormone-processing carboxypeptidase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362251|imex:IM-11703-100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_001864.1|ensembl:ENSG00000109472(gene)|ensembl:ENST00000402744(transcript)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016485"(protein processing)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR000834(Peptidase M14, carboxypeptidase A)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR034232|reactome:R-HSA-264876	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:jabFRA/oHUuGAu59g+uty3RWVt09606	intact-crc:608A60ACBC4B5B7C|rigid:Wrqwj8YXrskcFXRR+chcFvLWBQY	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31749	uniprotkb:A7DTG3	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-2255582|uniprotkb:Q6PAK2|ensembl:ENSMUSP00000016406|ensembl:ENSMUSP00000116176	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:srtd4_mouse(display_long)|uniprotkb:Sertad4(gene name)|psi-mi:Sertad4(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362445|imex:IM-11703-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	refseq:NP_001171265.1|refseq:NP_937890.2|refseq:XP_006497311.1|ensembl:ENSMUSG00000016262(gene)|ensembl:ENSMUST00000016406(transcript)|ensembl:ENSMUST00000155579(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR009263(SERTA)|interpro:IPR029708	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:40FodUmm1gcyuxqEZDFX12sNho410090	intact-crc:0006EF5023D9DDD7|rigid:0g2ed3qhOCsh6aZemHsuAPwgVc4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P31749	uniprotkb:P62830	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-2365752|uniprotkb:P23131|uniprotkb:P24048|uniprotkb:Q29246|uniprotkb:Q3THU4|uniprotkb:Q9CZE6|uniprotkb:Q9DCQ4|ensembl:ENSMUSP00000099435	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:rl23_mouse(display_long)|uniprotkb:Rpl23(gene name)|psi-mi:Rpl23(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362451|imex:IM-11703-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	refseq:NP_075029.1|refseq:XP_003688806.1|refseq:XP_003689266.1|ensembl:ENSMUSG00000071415(gene)|ensembl:ENSMUST00000103146(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62830|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA10090	intact-crc:3F10FD6DBEC835BC|rigid:5/EHsU6qt6mkI0uhuSVFboQFnI4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99490	uniprotkb:P97434	intact:EBI-2361824|uniprotkb:O00578|uniprotkb:Q548E0|uniprotkb:Q8IWU3|uniprotkb:A8K9F7	intact:EBI-2365654|uniprotkb:Q3TBR5|uniprotkb:Q3TC85|uniprotkb:Q3TRS0|uniprotkb:Q3U1Y8|uniprotkb:Q3U3E4|uniprotkb:Q5SWZ3|uniprotkb:Q5SWZ4|uniprotkb:Q5SWZ7|uniprotkb:Q6P559|uniprotkb:Q80YC8|ensembl:ENSMUSP00000112072	psi-mi:agap2_human(display_long)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:mprip_mouse(display_long)|uniprotkb:Mprip(gene name)|psi-mi:Mprip(display_short)|uniprotkb:Kiaa0864(gene name synonym)|uniprotkb:Mrip(gene name synonym)|uniprotkb:Rhoip3(gene name synonym)|uniprotkb:Rho-interacting protein 3(gene name synonym)|uniprotkb:p116Rip(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362473|imex:IM-11703-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116244.1|refseq:NP_055585.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:2BMJ|rcsb pdb:2IWR|rcsb pdb:2RLO|interpro:IPR037278|interpro:IPR038508|interpro:IPR027417|interpro:IPR001806(Ras GTPase)|reactome:R-HSA-373752|interpro:IPR036770|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)	refseq:NP_036157.2|refseq:NP_957697.1|refseq:XP_006533503.1|ensembl:ENSMUSG00000005417(gene)|ensembl:ENSMUST00000116371(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0051015"(actin filament binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:P97434	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:8/lz/H3aXs+maU1J2TTJbV7DpKc9606	rogid:jwOKcVLEosfXdMVQ5LfEjkan/U410090	intact-crc:49D29D14E16895E2|rigid:NZBpZGQ/4m20mTQk4X+568qiPwg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99490	uniprotkb:Q545Q1	intact:EBI-2361824|uniprotkb:O00578|uniprotkb:Q548E0|uniprotkb:Q8IWU3|uniprotkb:A8K9F7	intact:EBI-2365603	psi-mi:agap2_human(display_long)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:q545q1_mouse(display_long)|uniprotkb:Nr4a1(gene name)|psi-mi:Nr4a1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362477|imex:IM-11703-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116244.1|refseq:NP_055585.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:2BMJ|rcsb pdb:2IWR|rcsb pdb:2RLO|interpro:IPR037278|interpro:IPR038508|interpro:IPR027417|interpro:IPR001806(Ras GTPase)|reactome:R-HSA-373752|interpro:IPR036770|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)	refseq:NP_034574.1|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|refseq:XP_006520519.1|refseq:XP_006520521.1|refseq:XP_006520522.1|refseq:XP_017171925.1|interpro:IPR035500|refseq:XP_006520518.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:8/lz/H3aXs+maU1J2TTJbV7DpKc9606	rogid:IE0dfkpGJtQ4kF0BIctzU9aprtU10090	intact-crc:E5EBB874C2D2A598|rigid:8GFlkqXhXZm72tU94OF87zEStqE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99490	uniprotkb:P61092	intact:EBI-2361824|uniprotkb:O00578|uniprotkb:Q548E0|uniprotkb:Q8IWU3|uniprotkb:A8K9F7	intact:EBI-446761|uniprotkb:Q06984|ensembl:ENSMUSP00000044123	psi-mi:agap2_human(display_long)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:sia1a_mouse(display_long)|uniprotkb:Seven in absentia homolog 1a(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1A(gene name synonym)|uniprotkb:Siah1a(gene name)|psi-mi:Siah1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362480|imex:IM-11703-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116244.1|refseq:NP_055585.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:2BMJ|rcsb pdb:2IWR|rcsb pdb:2RLO|interpro:IPR037278|interpro:IPR038508|interpro:IPR027417|interpro:IPR001806(Ras GTPase)|reactome:R-HSA-373752|interpro:IPR036770|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)	refseq:NP_033198.1|refseq:XP_006530847.2|dip:DIP-29100N|ensembl:ENSMUSG00000036840(gene)|ensembl:ENSMUST00000045296(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005886"(plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|rcsb pdb:1K2F|rcsb pdb:2AN6|reactome:R-MMU-373752|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:8/lz/H3aXs+maU1J2TTJbV7DpKc9606	rogid:C7i3ubOqLVDW4MzmA6OLDZq2TM810090	intact-crc:1815802AC487984F|rigid:obRu/ukKsZEx29gwZlkky+iI5jk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUD1	uniprotkb:Q53GL0	intact:EBI-773027|uniprotkb:Q9DCJ0|ensembl:ENSMUSP00000040431	intact:EBI-949945|ensembl:ENSP00000358120|uniprotkb:Q336K5|uniprotkb:Q8IZ51|uniprotkb:Q9UL48|uniprotkb:Q9NRV3	psi-mi:chip_mouse(display_long)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:Stub1(gene name)|psi-mi:Stub1(display_short)|uniprotkb:Chip(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)	psi-mi:pkho1_human(display_long)|uniprotkb:HQ0024c(orf name)|uniprotkb:PLEKHO1(gene name)|psi-mi:PLEKHO1(display_short)|uniprotkb:CKIP1(gene name synonym)|uniprotkb:Casein kinase 2-interacting protein 1(gene name synonym)|uniprotkb:Osteoclast maturation-associated gene 120 protein(gene name synonym)|uniprotkb:C-Jun-binding protein(gene name synonym)|uniprotkb:OC120(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362485|imex:IM-11703-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062693.1|dip:DIP-29751N|ensembl:ENSMUSG00000039615(gene)|ensembl:ENSMUST00000044911(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006457"(protein folding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9WUD1|rcsb pdb:2C2L|rcsb pdb:2C2V|rcsb pdb:3Q47|rcsb pdb:3Q49|rcsb pdb:3Q4A|reactome:R-MMU-2173788|reactome:R-MMU-5675482|reactome:R-MMU-8863795|reactome:R-MMU-8939902|reactome:R-MMU-8948751|reactome:R-MMU-983168	refseq:NP_057358.2|go:"GO:0008360"(regulation of cell shape)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0051451"(myoblast migration)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028452|interpro:IPR043448|mint:Q53GL0|rcsb pdb:3AA1|ensembl:ENSG00000023902(gene)|ensembl:ENST00000369124(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007520"(myoblast fusion)|refseq:NP_001291651.1|refseq:NP_001291652.1|refseq:NP_001291653.1|ensembl:ENSP00000358120|refseq:XP_016856909.1|dip:DIP-46903N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:C5WR6X2IRpYeSijSpib3cquUaBQ10090	rogid:f+fuKzDy9VwrKcC9fJMo3JqRenM9606	intact-crc:0CF353F0DFB1FFB6|rigid:N5lSU8EX2nzYOjdZcHJjOKu1q0Q	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q53GL0	uniprotkb:P97351	intact:EBI-949945|ensembl:ENSP00000358120|uniprotkb:Q336K5|uniprotkb:Q8IZ51|uniprotkb:Q9UL48|uniprotkb:Q9NRV3	intact:EBI-773982|ensembl:ENSMUSP00000029722	psi-mi:pkho1_human(display_long)|uniprotkb:HQ0024c(orf name)|uniprotkb:PLEKHO1(gene name)|psi-mi:PLEKHO1(display_short)|uniprotkb:CKIP1(gene name synonym)|uniprotkb:Casein kinase 2-interacting protein 1(gene name synonym)|uniprotkb:Osteoclast maturation-associated gene 120 protein(gene name synonym)|uniprotkb:C-Jun-binding protein(gene name synonym)|uniprotkb:OC120(gene name synonym)	psi-mi:rs3a_mouse(display_long)|uniprotkb:Rps3a(gene name)|psi-mi:Rps3a(display_short)|uniprotkb:Protein TU-11(gene name synonym)|uniprotkb:Rps3a1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362488|imex:IM-11703-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057358.2|go:"GO:0008360"(regulation of cell shape)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0051451"(myoblast migration)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028452|interpro:IPR043448|mint:Q53GL0|rcsb pdb:3AA1|ensembl:ENSG00000023902(gene)|ensembl:ENST00000369124(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007520"(myoblast fusion)|refseq:NP_001291651.1|refseq:NP_001291652.1|refseq:NP_001291653.1|ensembl:ENSP00000358120|refseq:XP_016856909.1|dip:DIP-46903N	refseq:NP_058655.3|ensembl:ENSMUSG00000028081(gene)|ensembl:ENSMUST00000029722(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:f+fuKzDy9VwrKcC9fJMo3JqRenM9606	rogid:pi623FvaPjjNAiN44zPHjtep4gs10090	intact-crc:F8206E004943B3C3|rigid:1pJWIfcrQRMI48ed4CtmifOEuQk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q53GL0	uniprotkb:Q9R0Q6	intact:EBI-949945|ensembl:ENSP00000358120|uniprotkb:Q336K5|uniprotkb:Q8IZ51|uniprotkb:Q9UL48|uniprotkb:Q9NRV3	intact:EBI-774003|uniprotkb:Q3UL75|ensembl:ENSMUSP00000031625	psi-mi:pkho1_human(display_long)|uniprotkb:HQ0024c(orf name)|uniprotkb:PLEKHO1(gene name)|psi-mi:PLEKHO1(display_short)|uniprotkb:CKIP1(gene name synonym)|uniprotkb:Casein kinase 2-interacting protein 1(gene name synonym)|uniprotkb:Osteoclast maturation-associated gene 120 protein(gene name synonym)|uniprotkb:C-Jun-binding protein(gene name synonym)|uniprotkb:OC120(gene name synonym)	psi-mi:arc1a_mouse(display_long)|uniprotkb:SOP2-like protein(gene name synonym)|uniprotkb:Sid 329(gene name synonym)|uniprotkb:Arpc1a(gene name)|psi-mi:Arpc1a(display_short)|uniprotkb:Sid329(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362501|imex:IM-11703-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057358.2|go:"GO:0008360"(regulation of cell shape)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0051451"(myoblast migration)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028452|interpro:IPR043448|mint:Q53GL0|rcsb pdb:3AA1|ensembl:ENSG00000023902(gene)|ensembl:ENST00000369124(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007520"(myoblast fusion)|refseq:NP_001291651.1|refseq:NP_001291652.1|refseq:NP_001291653.1|ensembl:ENSP00000358120|refseq:XP_016856909.1|dip:DIP-46903N	refseq:NP_062741.1|ensembl:ENSMUSG00000029621(gene)|ensembl:ENSMUST00000031625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR030140|interpro:IPR036322|mint:Q9R0Q6|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:f+fuKzDy9VwrKcC9fJMo3JqRenM9606	rogid:FZAq1/Vf3u+xzNZtYqvrpAKloZs10090	intact-crc:0B94BDF08808233A|rigid:eSSVQmtAD+Z/5UZcGOIY87BwHW4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5U5J2	uniprotkb:P67871	intact:EBI-2362512|uniprotkb:E7EN85	intact:EBI-348179|ensembl:ENSMUSP00000025246|ensembl:ENSMUSP00000134218|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q3TTJ7	psi-mi:q5u5j2_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)	psi-mi:csk2b_mouse(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Csnk2b(gene name)|psi-mi:Csnk2b(display_short)|uniprotkb:Ck2n(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362527|imex:IM-11703-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)	ensembl:ENSMUSG00000024387(gene)|ensembl:ENSMUST00000025246(transcript)|ensembl:ENSMUST00000173114(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67871|reactome:R-MMU-1483191|reactome:R-MMU-201688|reactome:R-MMU-2514853|reactome:R-MMU-445144|reactome:R-MMU-6798695|reactome:R-MMU-6804756|reactome:R-MMU-6814122|reactome:R-MMU-8934903|reactome:R-MMU-8939243|reactome:R-MMU-8948751|refseq:NP_034105.1|refseq:NP_001290374.1|dip:DIP-35573N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:TozNRNfA8iMywoqMmMCwlSHfE489606	rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg10090	intact-crc:EAE6AC51159BF0AC|rigid:UG7INfwI7l731VdSxT/cMkqsqRk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K1M6	uniprotkb:Q5U5J2	intact:EBI-2365792|uniprotkb:Q8BNQ5|uniprotkb:Q8BQ64|uniprotkb:Q8CGD0|uniprotkb:Q8K1A1	intact:EBI-2362512|uniprotkb:E7EN85	psi-mi:dnm1l_mouse(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)	psi-mi:q5u5j2_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362531|imex:IM-11703-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021118.1|refseq:XP_006522694.1|refseq:NP_001263269.1|refseq:NP_001263270.1|refseq:NP_690029.2|dip:DIP-54818N|mint:Q8K1M6|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0016559"(peroxisome fission)|go:"GO:0030276"(clathrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036466"(synaptic vesicle recycling via endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048511"(rhythmic process)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051433"(BH2 domain binding)|go:"GO:0060047"(heart contraction)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070266"(necroptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090149"(mitochondrial membrane fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099503"(secretory vesicle)|go:"GO:1900063"(regulation of peroxisome organization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904579"(cellular response to thapsigargin)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:1905395"(response to flavonoid)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR030556|reactome:R-MMU-75153|go:"GO:0005903"(brush border)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:5yGX3+QNfz3+dKRHA2ffkIVq3yU10090	rogid:TozNRNfA8iMywoqMmMCwlSHfE489606	intact-crc:D770F89986D0FE6A|rigid:u1ZVTPjzpJdZAcfN+OHFbdLU2pM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5U5J2	uniprotkb:Q64279	intact:EBI-2362512|uniprotkb:E7EN85	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	psi-mi:q5u5j2_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362548|imex:IM-11703-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:TozNRNfA8iMywoqMmMCwlSHfE489606	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	intact-crc:19481934BDCCE170|rigid:y+uKIbTa+06uvBvFjjxfKFerayY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIY5	uniprotkb:Q5U5J2	intact:EBI-2365838|uniprotkb:Q9R108|ensembl:ENSMUSP00000087073	intact:EBI-2362512|uniprotkb:E7EN85	psi-mi:htra2_mouse(display_long)|uniprotkb:Htra2(gene name)|psi-mi:Htra2(display_short)|uniprotkb:Omi(gene name synonym)|uniprotkb:Prss25(gene name synonym)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)	psi-mi:q5u5j2_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362552|imex:IM-11703-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062726.3|dip:DIP-41272N|ensembl:ENSMUSG00000068329(gene)|ensembl:ENSMUST00000089645(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0048666"(neuron development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:Q9JIY5	interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:hFFaMR4foetALMvFA0cg4KuxjuE10090	rogid:TozNRNfA8iMywoqMmMCwlSHfE489606	intact-crc:E06C89FF3430A982|rigid:SnU6lgwIG7IpZ6P7NmeFlslQijA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99ML9	uniprotkb:Q5U5J2	intact:EBI-646015|uniprotkb:Q8C881|uniprotkb:Q8CBC0|uniprotkb:Q3UVL7|uniprotkb:Q6NSW2|uniprotkb:Q7TMR3|ensembl:ENSMUSP00000034739|ensembl:ENSMUSP00000109225	intact:EBI-2362512|uniprotkb:E7EN85	psi-mi:rn111_mouse(display_long)|uniprotkb:RING finger protein 111(gene name synonym)|uniprotkb:Rnf111(gene name)|psi-mi:Rnf111(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Arkadia(gene name synonym)	psi-mi:q5u5j2_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362555|imex:IM-11703-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_291082.1|refseq:XP_006511649.1|ensembl:ENSMUSG00000032217(gene)|ensembl:ENSMUST00000034739(transcript)|ensembl:ENSMUST00000113595(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR029306|reactome:R-MMU-2173796|reactome:R-MMU-5696395|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:1jqb63Pi0keEW6WZyK0W4+A1PIo10090	rogid:TozNRNfA8iMywoqMmMCwlSHfE489606	intact-crc:F06C8B60915BD745|rigid:QP23vyDGD74T0q47AmIiTf8SZLk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BY46	uniprotkb:Q5U5J2	intact:EBI-2365891|uniprotkb:Q3TDE5|uniprotkb:Q3UNU1|uniprotkb:Q8BKB5|ensembl:ENSMUSP00000057817|ensembl:ENSMUSP00000136547	intact:EBI-2362512|uniprotkb:E7EN85	psi-mi:zn574_mouse(display_long)|uniprotkb:Znf574(gene name)|psi-mi:Znf574(display_short)|uniprotkb:Zfp574(gene name synonym)	psi-mi:q5u5j2_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362585|imex:IM-11703-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161978.1|refseq:NP_780686.1|refseq:XP_006539914.1|refseq:XP_006539915.1|refseq:XP_017177647.1|ensembl:ENSMUSG00000045252(gene)|ensembl:ENSMUST00000053410(transcript)|ensembl:ENSMUST00000179556(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BY46	interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:Qg0UffX7x2NdjTnjK8KeIkRvsfk10090	rogid:TozNRNfA8iMywoqMmMCwlSHfE489606	intact-crc:B3E2B1A0DF816786|rigid:E17rWr0/jt2zYsJSuPrZuo9/zuE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q68FM7	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2365869|ensembl:ENSMUSP00000039900	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362588|imex:IM-11703-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090	intact-crc:D03B3EB629CBFFC9|rigid:JUehZhKZvpfKveRcNFY6OsYmpK4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:O35625	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2365912	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362592|imex:IM-11703-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	intact-crc:32860C63B030E1D8|rigid:9qPDPEse5HdD2VpNRn0wc0S9dCg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	intact:EBI-2364964	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	-	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:flj10404_mus_protein(display_short)|psi-mi:EBI-2364964(display_long)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362595|imex:IM-11703-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	genbank_nucl_gi:212483(see-also)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	-	intact-crc:23D7B4D6B89634AF	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q8C804	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2364887|uniprotkb:Q8K3I7|ensembl:ENSMUSP00000058832	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:spice_mouse(display_long)|uniprotkb:Ccdc52(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 52(gene name synonym)|uniprotkb:Spice1(gene name)|psi-mi:Spice1(display_short)|uniprotkb:D16Ertd480e(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362598|imex:IM-11703-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_653133.3|refseq:XP_017172412.1|ensembl:ENSMUSG00000043065(gene)|ensembl:ENSMUST00000050897(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR031387	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:ooOc9RIErFGvKSf3y0b6dcYddWw10090	intact-crc:D03B3E0C7615FD5F|rigid:49y3wVTMTPdrgPYJPfoLlBr6Sog	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q9Z1T5	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2364863|uniprotkb:C7SHZ9|uniprotkb:Q3UJA4|ensembl:ENSMUSP00000079395	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:deaf1_mouse(display_long)|uniprotkb:Deaf1(gene name)|psi-mi:Deaf1(display_short)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362601|imex:IM-11703-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_058570.1|ensembl:ENSMUSG00000058886(gene)|ensembl:ENSMUST00000080553(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008542"(visual learning)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|rcsb pdb:2MBV	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:q9ATRueieoNxwZuVe5enenGvERE10090	intact-crc:CC4AF96B07AC81FA|rigid:sL6J2+1zfTOJTyFwuYMao3nH6xA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q91YU6	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-646581|uniprotkb:E9QKK6|uniprotkb:Q569X6|ensembl:ENSMUSP00000045478|ensembl:ENSMUSP00000136405|ensembl:ENSMUSP00000137571	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:lzts2_mouse(display_long)|uniprotkb:Lzts2(gene name)|psi-mi:Lzts2(display_short)|uniprotkb:Kiaa1813(gene name synonym)|uniprotkb:Lapser1(gene name synonym)|uniprotkb:Protein LAPSER1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362604|imex:IM-11703-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_001123997.1|refseq:NP_001123998.1|refseq:NP_663478.2|refseq:XP_006527067.1|ensembl:ENSMUSG00000035342(gene)|ensembl:ENSMUST00000039016(transcript)|ensembl:ENSMUST00000178087(transcript)|ensembl:ENSMUST00000179108(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001822"(kidney development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:8vF1Urk1kDHDPcvi4VqWQyRbxig10090	intact-crc:D03B3ED1147A77AA|rigid:7JCN0uKF/n6auw89LbVL+5d0kxI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80XI6	uniprotkb:P49840	intact:EBI-2364817|uniprotkb:Q8K0M8|uniprotkb:Q9JJ15|ensembl:ENSMUSP00000004156	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:m3k11_mouse(display_long)|uniprotkb:Map3k11(gene name)|psi-mi:Map3k11(display_short)|uniprotkb:Mlk3(gene name synonym)|uniprotkb:Mixed lineage kinase 3(gene name synonym)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362607|imex:IM-11703-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071295.2|refseq:XP_006531815.1|ensembl:ENSMUSG00000004054(gene)|ensembl:ENSMUST00000004156(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016231(Mitogen-activated protein kinase kinase kinase, 9/10/11)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035779|interpro:IPR036028|reactome:R-MMU-5673000|reactome:R-MMU-9013148|reactome:R-MMU-9013408	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:zuCPy4LP4hnWLYw19vo+QdAegGI10090	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:5FC4C12A531EACDA|rigid:NUTXC7jRAIw0PF0EW2ZTe5mZiJs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:P97432	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-642554|uniprotkb:Q9JIH9|ensembl:ENSMUSP00000099387|ensembl:ENSMUSP00000099388|ensembl:ENSMUSP00000102836	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:nbr1_mouse(display_long)|uniprotkb:Neighbor of BRCA1 gene 1 protein(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 2 homolog(gene name synonym)|uniprotkb:Nbr1(gene name)|psi-mi:Nbr1(display_short)|uniprotkb:M17s2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362610|imex:IM-11703-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_032702.1|refseq:NP_001239149.1|ensembl:ENSMUSG00000017119(gene)|ensembl:ENSMUST00000103098(transcript)|ensembl:ENSMUST00000103099(transcript)|ensembl:ENSMUST00000107218(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031430"(M band)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR032350|interpro:IPR033513|interpro:IPR034852|interpro:IPR043145|mint:P97432|reactome:R-MMU-9664873	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:B+P3/9nq+dNGv/Pcy28HI4deZic10090	intact-crc:DB1E6A15B0FF0F4E|rigid:ZwMdxH97mC++kyrhUke4Y1aQOss	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99K48	uniprotkb:P49840	intact:EBI-607499|ensembl:ENSMUSP00000033673|uniprotkb:Q63887|uniprotkb:Q9CYQ4|uniprotkb:Q9DBP2	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:nono_mouse(display_long)|uniprotkb:Nono(gene name)|psi-mi:Nono(display_short)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362613|imex:IM-11703-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031311(gene)|ensembl:ENSMUST00000033673(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q99K48|rcsb pdb:2CPJ|rcsb pdb:2RS8|refseq:NP_075633.2|refseq:NP_001239447.1|dip:DIP-34308N	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:78ly3/4yzdfLjl9d/cV6Ob/SFG810090	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:1B568A4EE3D9A64D|rigid:fvJ1mfE1Ey41Xey+9HNdOCY3khQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q8BIW1	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2364846|uniprotkb:Q80VU0|ensembl:ENSMUSP00000015855	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:prun1_mouse(display_long)|uniprotkb:Prune1(gene name)|psi-mi:Prune1(display_short)|uniprotkb:PRUNEM1(gene name synonym)|uniprotkb:Prune(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362616|imex:IM-11703-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_775482.1|ensembl:ENSMUSG00000015711(gene)|ensembl:ENSMUST00000015855(transcript)|go:"GO:0004309"(exopolyphosphatase activity)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006798"(polyphosphate catabolic process)|go:"GO:0015631"(tubulin binding)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR001667(Phosphoesterase, RecJ-like)|interpro:IPR004097(DHHA2)|interpro:IPR038222|interpro:IPR038763	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:KVIyL+CFvotqNUZAkR7b1eojPM010090	intact-crc:9FC4C00017FA1FFE|rigid:9rLk827KTUGeVtwBDj0UrBeqjPc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q9CR26	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2364748|ensembl:ENSMUSP00000119829	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:vta1_mouse(display_long)|uniprotkb:Vta1(gene name)|psi-mi:Vta1(display_short)|uniprotkb:SKD1-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362619|imex:IM-11703-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_079694.2|dip:DIP-54810N|ensembl:ENSMUSG00000019868(gene)|ensembl:ENSMUST00000154132(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0071985"(multivesicular body sorting pathway)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|reactome:R-MMU-917729	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:+3gL069RROf6km3nNQofh5K8dlE10090	intact-crc:66E0537E60DD819A|rigid:LnjLG4VKKrpXayIHoV3ZhR3g4yE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q8BII1	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2364927|ensembl:ENSMUSP00000105878|ensembl:ENSMUSP00000135881	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:prox2_mouse(display_long)|uniprotkb:Prox2(gene name)|psi-mi:Prox2(display_short)|uniprotkb:Homeobox prospero-like protein PROX2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362643|imex:IM-11703-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:XP_011242489.1|refseq:NP_780407.1|refseq:XP_006516341.1|refseq:XP_006516342.1|refseq:XP_006516344.1|refseq:XP_017170702.1|ensembl:ENSMUSG00000042320(gene)|ensembl:ENSMUST00000110249(transcript)|ensembl:ENSMUST00000177289(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:PerBO5Zrj8Pq+JSpELm5DwMr+hY10090	intact-crc:B2721B69DDCADCF2|rigid:ER4rDIz4kgvldGDDMonxuMkyY6E	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q6NXZ1	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2364905|uniprotkb:E9QNG7|uniprotkb:Q69Z85|uniprotkb:Q9JJG3|ensembl:ENSMUSP00000076345|ensembl:ENSMUSP00000110218	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:krba1_mouse(display_long)|uniprotkb:Krba1(gene name)|psi-mi:Krba1(display_short)|uniprotkb:Kiaa1862(gene name synonym)|uniprotkb:MNCb-1826(orf name)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362646|imex:IM-11703-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_598683.3|refseq:XP_006506827.1|ensembl:ENSMUSG00000042810(gene)|ensembl:ENSMUST00000077093(transcript)|ensembl:ENSMUST00000114571(transcript)|interpro:IPR029317|interpro:IPR040095|reactome:R-MMU-212436	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:1MrcZJDREGAcSWXT5zKSwbxE+Xo10090	intact-crc:94A976D9866BF6AB|rigid:OfYDVCC/ipQlI7RfdLEtNKK9JMY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49840	uniprotkb:Q9D0L1	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	intact:EBI-2364761|ensembl:ENSMUSP00000044774|ensembl:ENSMUSP00000152153	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:zbed3_mouse(display_long)|uniprotkb:Zbed3(gene name)|psi-mi:Zbed3(display_short)|uniprotkb:Axin-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362657|imex:IM-11703-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	refseq:NP_082382.1|refseq:NP_001289467.1|refseq:NP_001289468.1|ensembl:ENSMUSG00000041995(gene)|ensembl:ENSMUST00000045909(transcript)|ensembl:ENSMUST00000221807(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR033546|interpro:IPR036236|interpro:IPR043471	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	rogid:XbG4QIbX+rgox7eqpTRo/LiLxCE10090	intact-crc:CE03DC745BF0B7C5|rigid:d/Zvv2RO0WOr7LQXTP6scO9HoAU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49841	uniprotkb:O35625	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2365912	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362660|imex:IM-11703-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	intact-crc:634110707E5C0716|rigid:wGTZNJYnsCoA3fELUIKZ5Ju4Vjg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49841	uniprotkb:P97432	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-642554|uniprotkb:Q9JIH9|ensembl:ENSMUSP00000099387|ensembl:ENSMUSP00000099388|ensembl:ENSMUSP00000102836	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:nbr1_mouse(display_long)|uniprotkb:Neighbor of BRCA1 gene 1 protein(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 2 homolog(gene name synonym)|uniprotkb:Nbr1(gene name)|psi-mi:Nbr1(display_short)|uniprotkb:M17s2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362663|imex:IM-11703-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_032702.1|refseq:NP_001239149.1|ensembl:ENSMUSG00000017119(gene)|ensembl:ENSMUST00000103098(transcript)|ensembl:ENSMUST00000103099(transcript)|ensembl:ENSMUST00000107218(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031430"(M band)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR032350|interpro:IPR033513|interpro:IPR034852|interpro:IPR043145|mint:P97432|reactome:R-MMU-9664873	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:B+P3/9nq+dNGv/Pcy28HI4deZic10090	intact-crc:DB1E6A15B0B104FE|rigid:CsrvWAuq8GWaQBxuvGk3iufQuLQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08069	uniprotkb:Q60850	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	intact:EBI-2366079|uniprotkb:Q149H3|uniprotkb:Q4VBX5|uniprotkb:Q60851|uniprotkb:Q60852|uniprotkb:Q60853|uniprotkb:Q78E82|uniprotkb:Q78E83|uniprotkb:Q78E84	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:s23a3_mouse(display_long)|uniprotkb:Slc23a3(gene name)|psi-mi:Slc23a3(display_short)|uniprotkb:Svct3(gene name synonym)|uniprotkb:Yspl1(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 3(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 3"(gene name synonym)|uniprotkb:Yolk sac permease-like molecule 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362690|imex:IM-11703-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	refseq:NP_919314.2|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029957|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	rogid:wYEpDCuK4iauvBv3VG4AGejT5i410090	intact-crc:3D53DBEE44242295|rigid:suwkpmq5MZ6gs2z3k/nzuWN5NkM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42336	uniprotkb:Q9WVM3	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	intact:EBI-642653|uniprotkb:Q3UBM7|uniprotkb:Q8BSR2|uniprotkb:Q91W13|ensembl:ENSMUSP00000031422|ensembl:ENSMUSP00000113928	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:apc7_mouse(display_long)|uniprotkb:Cyclosome subunit 7(gene name synonym)|uniprotkb:Prediabetic NOD sera-reactive autoantigen(gene name synonym)|uniprotkb:Apc7(gene name synonym)|uniprotkb:Anapc7(gene name)|psi-mi:Anapc7(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362706|imex:IM-11703-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_062779.3|ensembl:ENSMUSG00000029466(gene)|ensembl:ENSMUST00000031422(transcript)|ensembl:ENSMUST00000122010(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-141430|reactome:R-MMU-174048|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-176407|reactome:R-MMU-176408|reactome:R-MMU-176409|reactome:R-MMU-176412|reactome:R-MMU-179409|reactome:R-MMU-2467813|reactome:R-MMU-2559582|reactome:R-MMU-69017|reactome:R-MMU-983168|go:"GO:0005819"(spindle)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	rogid:kGGF+W/eposBQfb3C/PiDJEdC+k10090	intact-crc:815B5294A13CF16A|rigid:MA5djr2st9gGCo0YqBy9xVEaV+k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q8K1J5	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2366121|uniprotkb:Q8BJX1|ensembl:ENSMUSP00000037890	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:sde2_mouse(display_long)|uniprotkb:Sde2(gene name)|psi-mi:Sde2(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362730|imex:IM-11703-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_666055.1|ensembl:ENSMUSG00000038806(gene)|ensembl:ENSMUST00000038091(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0016485"(protein processing)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0034644"(cellular response to UV)|go:"GO:0051301"(cell division)|interpro:IPR024974	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:9PErxloTZuUe1m613jgUwwZsGoQ10090	intact-crc:5160A96DAFC99273|rigid:WHnqfBYSMlGYxhbdh4NAKcw26W0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q8VED8	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2366069|uniprotkb:E9PX02|ensembl:ENSMUSP00000129315	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:mtfr2_mouse(display_long)|uniprotkb:Mtfr2(gene name)|psi-mi:Mtfr2(display_short)|uniprotkb:DUF729 domain-containing protein 1(gene name synonym)|uniprotkb:Dufd1(gene name synonym)|uniprotkb:Fam54a(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362755|imex:IM-11703-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_082206.2|ensembl:ENSMUSG00000019992(gene)|ensembl:ENSMUST00000169712(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0009060"(aerobic respiration)|interpro:IPR007972(Protein of unknown function DUF729)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:YKqX2LSWN+ZCvfvTrxO/e+ru0gs10090	intact-crc:2D116C89FA6A6EB1|rigid:SLAFOnWtFUoPzhk8eszzteueilk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DBR1	uniprotkb:Q13131	intact:EBI-2365150|uniprotkb:Q3TI26|uniprotkb:Q3TKF2|uniprotkb:Q3UZT9|uniprotkb:Q61489|uniprotkb:Q99KS7|ensembl:ENSMUSP00000028921	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:xrn2_mouse(display_long)|uniprotkb:Xrn2(gene name)|psi-mi:Xrn2(display_short)|uniprotkb:Dhm1(gene name synonym)|uniprotkb:Protein Dhm1(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362758|imex:IM-11703-76	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036047.2|ensembl:ENSMUSG00000027433(gene)|ensembl:ENSMUST00000028921(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000738"(DNA catabolic process, exonucleolytic)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006397"(mRNA processing)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR017151(5'-3' exoribonuclease 2)|interpro:IPR027073|interpro:IPR041412|mint:Q9DBR1|reactome:R-MMU-6791226	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:Bq3eDLXS2Tfo1TRmJ8pp1ePNzEc10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:1A0D1E3BC9677659|rigid:CYSDWP2VFkzZ/PDPff7SANrnCsU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q8CBW3	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362761|imex:IM-11703-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:9D116F392DDA03C0|rigid:mOLzT73OW+oOW4+XJViiAmh/OTs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:P08030	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-1634025|intact:EBI-2366132|uniprotkb:Q564P4|uniprotkb:Q61319|uniprotkb:Q6PK77|uniprotkb:Q9DCY3|ensembl:ENSMUSP00000006764	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:apt_mouse(display_long)|uniprotkb:Aprt(gene name)|psi-mi:Aprt(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362765|imex:IM-11703-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_033828.2|ensembl:ENSMUSG00000006589(gene)|ensembl:ENSMUST00000006764(transcript)|go:"GO:0002055"(adenine binding)|go:"GO:0003999"(adenine phosphoribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0007595"(lactation)|go:"GO:0007625"(grooming behavior)|go:"GO:0016208"(AMP binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044209"(AMP salvage)|go:"GO:0046083"(adenine metabolic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005764(Adenine phosphoribosyl transferase)|interpro:IPR029057|mint:P08030|reactome:R-MMU-6798695|reactome:R-MMU-74217	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:GvueBfTd2tp0OKA6mbbjZJjcBdE10090	intact-crc:311DFDBAE7BEC4DE|rigid:ctwQb7QARzRVzFFV1AnIXhOCP5s	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q2VPC9	uniprotkb:Q13131	intact:EBI-2365188	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:q2vpc9_mouse(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362768|imex:IM-11703-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|go:"GO:0032559"(adenyl ribonucleotide binding)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:lEWMmBdG+AZMdI4GFNa1jlI736A10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:B84439BF8FBB4767|rigid:na2mpq1DQ54gkeOeo58UPvAZqWQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q91WG5	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2366148|uniprotkb:E9QK80|uniprotkb:Q6V7V5|ensembl:ENSMUSP00000030784	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:aakg2_mouse(display_long)|uniprotkb:Prkag2(gene name)|psi-mi:Prkag2(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362821|imex:IM-11703-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_001164027.1|refseq:NP_663376.2|ensembl:ENSMUSG00000028944(gene)|ensembl:ENSMUST00000030784(transcript)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0008607"(phosphorylase kinase regulator activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016208"(AMP binding)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039170|reactome:R-MMU-1632852|reactome:R-MMU-163680|reactome:R-MMU-200425|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:rkRGWEL9D9YP9yDpO35+HjaxX1M10090	intact-crc:D67CD8A8500C7EEA|rigid:OKPwoti49Ht360HvAMS5/sBXPjw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:O35185	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2366168|uniprotkb:P97289|ensembl:ENSMUSP00000032194	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:bhe40_mouse(display_long)|uniprotkb:Bhlhe40(gene name)|psi-mi:Bhlhe40(display_short)|uniprotkb:Bhlhb2(gene name synonym)|uniprotkb:Clast5(gene name synonym)|uniprotkb:Stra13(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 2(gene name synonym)|uniprotkb:E47 interaction protein 1(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 13 protein(gene name synonym)|uniprotkb:Dec1(gene name synonym)|uniprotkb:Differentially expressed in chondrocytes protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362825|imex:IM-11703-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_035628.1|ensembl:ENSMUSG00000030103(gene)|ensembl:ENSMUST00000032194(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:z0iuWyN/XjbRBr2tbPN1ZGXy/A810090	intact-crc:4CFCCB1CE5CA43A2|rigid:s+R0QE1tdpzlqqUQzNylMC93MU0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q8CGZ0	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2366446|uniprotkb:Q8K291|uniprotkb:Q8VCD2	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:cherp_mouse(display_long)|uniprotkb:Cherp(gene name)|psi-mi:Cherp(display_short)|uniprotkb:Scaf6(gene name synonym)|uniprotkb:SR-related CTD-associated factor 6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362860|imex:IM-11703-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_613051.3|interpro:IPR008942(ENTH/VHS)|interpro:IPR000467(D111/G-patch)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR000061(SWAP/Surp)|interpro:IPR035967|interpro:IPR039037|mint:Q8CGZ0|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|reactome:R-MMU-72163	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:mPEKMUbwYs/8ryr9RBLWjNF0nnk10090	intact-crc:FA0D1E5AD1B76706|rigid:VqkM6zOio3rA9iIQstv1392YKFo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q00493	uniprotkb:Q13131	intact:EBI-2012957|uniprotkb:Q64439|ensembl:ENSMUSP00000048555	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:cbpe_mouse(display_long)|uniprotkb:Cpe(gene name)|psi-mi:Cpe(display_short)|uniprotkb:Carboxypeptidase H(gene name synonym)|uniprotkb:Enkephalin convertase(gene name synonym)|uniprotkb:Prohormone-processing carboxypeptidase(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362863|imex:IM-11703-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038522.2|ensembl:ENSMUSG00000037852(gene)|ensembl:ENSMUST00000048967(transcript)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016485"(protein processing)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030070"(insulin processing)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0033366"(protein localization to secretory granule)|go:"GO:0034230"(enkephalin processing)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097060"(synaptic membrane)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR000834(Peptidase M14, carboxypeptidase A)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR034232|mint:Q00493	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:n62UX3yaIskZ11WAn7fWOhqtmYE10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:CCF4B195426E357E|rigid:F7vg1+d9h5QpNQg5aOZWcE5WMgI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99K41	uniprotkb:Q13131	intact:EBI-906561|ensembl:ENSMUSP00000031055	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:emil1_mouse(display_long)|uniprotkb:Emilin1(gene name)|psi-mi:Emilin1(display_short)|uniprotkb:Elastin microfibril interface-located protein 1(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362868|imex:IM-11703-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598679.1|ensembl:ENSMUSG00000029163(gene)|ensembl:ENSMUST00000031055(transcript)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098640"(integrin binding involved in cell-matrix adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1904027"(negative regulation of collagen fibril organization)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:1990971"(EMILIN complex)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|mint:Q99K41|reactome:R-MMU-2129379	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:aebUu/5vuCmUIETy6uQJpa/QE8410090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:F5F2E1DDFB9D954E|rigid:FXXhj1ytpVqkUlIdmTF83FHD3Pk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:P28798	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2365205|ensembl:ENSMUSP00000159379	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:grn_mouse(display_long)|uniprotkb:Grn(gene name)|psi-mi:Grn(display_short)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin/granulin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362873|imex:IM-11703-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_032201.2|ensembl:ENSMUSG00000034708(gene)|ensembl:ENSMUST00000239431(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060179"(male mating behavior)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905671"(regulation of lysosome organization)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28798|reactome:R-MMU-6798695	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:2nKMRNqLyZN/IXAvz1zMzDCpDmg10090	intact-crc:9DAEA2F0E5CC74FE|rigid:o1FUdPZh3j+266Ih9JKQpwg+wOU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q8BL80	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2366372|uniprotkb:Q6QHH6|uniprotkb:Q8BVH4|uniprotkb:Q8CHY5|ensembl:ENSMUSP00000107587	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:rhg22_mouse(display_long)|uniprotkb:Arhgap22(gene name)|psi-mi:Arhgap22(display_short)|uniprotkb:Rho-type GTPase-activating protein 22(gene name synonym)|uniprotkb:p68RacGAP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362887|imex:IM-11703-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:XP_011243355.1|refseq:NP_722495.3|go:"GO:0007165"(signal transduction)|go:"GO:0030154"(cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|interpro:IPR000198(RhoGAP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|ensembl:ENSMUSG00000063506(gene)|ensembl:ENSMUST00000111956(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:YIgO5hWUzfO/fB/WKnj6eXb09hw10090	intact-crc:BE9F57660606B564|rigid:V8sZbmlClMyvzNTAjLThd4Ih07k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:P14602	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-299023|ensembl:ENSMUSP00000005077	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:hspb1_mouse(display_long)|uniprotkb:Hspb1(gene name)|psi-mi:Hspb1(display_short)|uniprotkb:Hsp25(gene name synonym)|uniprotkb:Hsp27(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Heat shock 25 kDa protein(gene name synonym)|uniprotkb:Growth-related 25 kDa protein(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362891|imex:IM-11703-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	ensembl:ENSMUSG00000004951(gene)|ensembl:ENSMUST00000005077(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045202"(synapse)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097512"(cardiac myofibril)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P14602|reactome:R-MMU-4420097|reactome:R-MMU-450408|reactome:R-MMU-5687128|reactome:R-MMU-9009391|refseq:NP_038588.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:c79cDHl0WGQlEO7vGeDaZfr2oAE10090	intact-crc:DE646E1FE7220005|rigid:RfdX7eyMG5j79BjcUX0IQbqTx/s	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35071	uniprotkb:Q13131	intact:EBI-2366194|uniprotkb:Q5SX62|ensembl:ENSMUSP00000092075|ensembl:ENSMUSP00000099614|ensembl:ENSMUSP00000123242	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:kif1c_mouse(display_long)|uniprotkb:Kif1c(gene name)|psi-mi:Kif1c(display_short)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362895|imex:IM-11703-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694743.2|refseq:XP_006532383.1|refseq:XP_006532384.1|refseq:XP_006532385.1|ensembl:ENSMUSG00000020821(gene)|ensembl:ENSMUST00000094499(transcript)|ensembl:ENSMUST00000102554(transcript)|ensembl:ENSMUST00000137119(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR032405|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:gjYSVmZB1hUpTVh1kzMiov8Uwsg10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:8059CB1CE4F1F743|rigid:L2+XR6Iiv5VTrBDF5BUpnY6P67M	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91YU6	uniprotkb:Q13131	intact:EBI-646581|uniprotkb:E9QKK6|uniprotkb:Q569X6|ensembl:ENSMUSP00000045478|ensembl:ENSMUSP00000136405|ensembl:ENSMUSP00000137571	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:lzts2_mouse(display_long)|uniprotkb:Lzts2(gene name)|psi-mi:Lzts2(display_short)|uniprotkb:Kiaa1813(gene name synonym)|uniprotkb:Lapser1(gene name synonym)|uniprotkb:Protein LAPSER1(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362898|imex:IM-11703-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123997.1|refseq:NP_001123998.1|refseq:NP_663478.2|refseq:XP_006527067.1|ensembl:ENSMUSG00000035342(gene)|ensembl:ENSMUST00000039016(transcript)|ensembl:ENSMUST00000178087(transcript)|ensembl:ENSMUST00000179108(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001822"(kidney development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:8vF1Urk1kDHDPcvi4VqWQyRbxig10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:3160A9CFB1359414|rigid:I/bdO5k1y0WLEORKoU+XWNebzt4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q9QYH6	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-1801274|uniprotkb:Q543L6|uniprotkb:Q99PB5|uniprotkb:Q9CYX1|ensembl:ENSMUSP00000026142	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:magd1_mouse(display_long)|uniprotkb:Maged1(gene name)|psi-mi:Maged1(display_short)|uniprotkb:Nrage(gene name synonym)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:Dlxin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362901|imex:IM-11703-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_062765.1|interpro:IPR041898|interpro:IPR041899|mint:Q9QYH6|ensembl:ENSMUSG00000025151(gene)|ensembl:ENSMUST00000026142(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:yQjDWQnoyOmw1R+BGkK3EO5blik10090	intact-crc:498327F3885311A8|rigid:l4Z5SSZ2Qx6iNvoC0tR1hXBnSiM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P33215	uniprotkb:Q13131	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362923|imex:IM-11703-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:99F64A55E6C87D27|rigid:zP/kl+xL2C1CCFoPXHxcHrwjM3Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q61127	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2366420|uniprotkb:Q80VR9|ensembl:ENSMUSP00000026469	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:nab2_mouse(display_long)|uniprotkb:Nab2(gene name)|psi-mi:Nab2(display_short)|uniprotkb:EGR-1-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362958|imex:IM-11703-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_001116367.1|refseq:NP_032694.2|ensembl:ENSMUSG00000025402(gene)|ensembl:ENSMUST00000026469(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016480"(negative regulation of transcription by RNA polymerase III)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|interpro:IPR006988(Nab, N-terminal)|interpro:IPR006989(Nab, central region)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038398|interpro:IPR039040|mint:Q61127|reactome:R-MMU-9031628	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:rf3ukqRbH6FRLzgfVxvpwEl9Kvc10090	intact-crc:30A7B5C5C8A91162|rigid:bDRpTceGXntpIqk7qe2rwEl6xIU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q8VCQ3	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362982|imex:IM-11703-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090	intact-crc:E983261CF3C1C7EB|rigid:H45NCKnsLwoTtQBniKxP9PKR2Ro	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R078	uniprotkb:Q13131	intact:EBI-2366248|uniprotkb:Q91YN6|ensembl:ENSMUSP00000031486|ensembl:ENSMUSP00000107630	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:aakb1_mouse(display_long)|uniprotkb:Prkab1(gene name)|psi-mi:Prkab1(display_short)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362985|imex:IM-11703-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114075.1|refseq:XP_006530264.1|ensembl:ENSMUSG00000029513(gene)|ensembl:ENSMUST00000031486(transcript)|ensembl:ENSMUST00000111999(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9R078|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:FutyYXgmMYBa1yaSlduxfVqV7z410090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:B435FEDEC561F547|rigid:8btDS14fp9TrEy+jtb8GQhw7aIU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q4VGL6	uniprotkb:Q13131	intact:EBI-2366263|uniprotkb:Q69Z31|uniprotkb:B2RS13|ensembl:ENSMUSP00000124871	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:rc3h1_mouse(display_long)|uniprotkb:Rc3h1(gene name)|psi-mi:Rc3h1(display_short)|uniprotkb:Gm551(gene name synonym)|uniprotkb:Kiaa2025(gene name synonym)|uniprotkb:RING finger and C3H zinc finger protein 1(gene name synonym)|uniprotkb:Protein Sanroque(gene name synonym)|uniprotkb:RING finger and CCCH-type zinc finger domain-containing protein 1(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363022|imex:IM-11703-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020123.1|ensembl:ENSMUSG00000040423(gene)|ensembl:ENSMUST00000161609(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002635"(negative regulation of germinal center formation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0033962"(P-body assembly)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045623"(negative regulation of T-helper cell differentiation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1900151"(regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1905762"(CCR4-NOT complex binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032671|interpro:IPR036855|interpro:IPR041523|rcsb pdb:4QI0|rcsb pdb:4QI2|rcsb pdb:4TXA|rcsb pdb:5F5F|rcsb pdb:5F5H|rcsb pdb:6TQA|rcsb pdb:6TQB	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:MRRQ1OTzvG6aSUot+T7O69K1jxo10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:B8443B83C3176559|rigid:/ZL6jiIkG3yTcdy8/rvW9nQ1H04	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62417	uniprotkb:Q13131	intact:EBI-2365368|uniprotkb:Q80TF8|uniprotkb:Q8BZI3|uniprotkb:Q8K3Y2|uniprotkb:Q921F8|uniprotkb:Q9Z0Z8|uniprotkb:Q9Z0Z9	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:srbs1_mouse(display_long)|uniprotkb:Sorbs1(gene name)|psi-mi:Sorbs1(display_short)|uniprotkb:Kiaa1296(gene name synonym)|uniprotkb:Sh3d5(gene name synonym)|uniprotkb:Ponsin(gene name synonym)|uniprotkb:c-Cbl-associated protein(gene name synonym)|uniprotkb:SH3 domain protein 5(gene name synonym)|uniprotkb:SH3P12(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363026|imex:IM-11703-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001030134.1|refseq:NP_001030135.1|refseq:NP_001030136.1|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR035606|interpro:IPR035610|interpro:IPR035611|interpro:IPR036028|mint:Q62417|go:"GO:0001725"(stress fiber)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|reactome:R-MMU-445355	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:3+0ZfSkNB+9ujOF3uyXmP2ovl8A10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:FD116EA8D98367C4|rigid:GA0nMmmfwYkulNBn9NOnxXljFsg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3U1J1	uniprotkb:Q13131	intact:EBI-2365444|uniprotkb:Q9EP77|ensembl:ENSMUSP00000104281	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:tfpt_mouse(display_long)|uniprotkb:Tfpt(gene name)|psi-mi:Tfpt(display_short)|uniprotkb:Amida(gene name synonym)|uniprotkb:Protein FB1(gene name synonym)|uniprotkb:Protein amida(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363029|imex:IM-11703-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076013.1|refseq:NP_001277310.1|ensembl:ENSMUSG00000006335(gene)|ensembl:ENSMUST00000108641(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR033555|reactome:R-MMU-5689603|reactome:R-MMU-5696394	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:sHGvXn3bBNjbm6hh9KWpyeye27M10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:27BBC553516207D0|rigid:ab/KiTxxEW04MvbtuLbPujH01vk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VCZ3	uniprotkb:Q13131	intact:EBI-2366286|ensembl:ENSMUSP00000097701|ensembl:ENSMUSP00000156168	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:thap7_mouse(display_long)|uniprotkb:Thap7(gene name)|psi-mi:Thap7(display_short)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363033|imex:IM-11703-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081185.1|refseq:XP_006522574.1|ensembl:ENSMUSG00000022760(gene)|ensembl:ENSMUST00000100125(transcript)|ensembl:ENSMUST00000231548(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0106153"(phosphorylated histone binding)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR006612(Zinc finger, C2CH-type)|interpro:IPR026519	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:kmhoZr6XbQ1rbtg5ezGn/nH6WMM10090	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:DE9F57D859E015F6|rigid:5RF+Va8rtatQhUFXBfULwhD+aLc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q9Z1Y4	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-643879|uniprotkb:Q3TX74|ensembl:ENSMUSP00000024119	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:trip6_mouse(display_long)|uniprotkb:Zyxin-related protein 1(gene name synonym)|uniprotkb:Trip6(gene name)|psi-mi:Trip6(display_short)|uniprotkb:Zrp1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363036|imex:IM-11703-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	refseq:NP_035769.1|ensembl:ENSMUSG00000023348(gene)|ensembl:ENSMUST00000024119(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q9Z1Y4	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:7eIRYOt0EYhXcPOpabbr1GUYO0g10090	intact-crc:A2EE91EAAE0B3CC1|rigid:4a6kM4irNU3y0VmE50sfsFbdkaA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13131	uniprotkb:Q3U3T8	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-2365469|uniprotkb:Q6PGG0|uniprotkb:Q7TQE9	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:wdr62_mouse(display_long)|uniprotkb:Wdr62(gene name)|psi-mi:Wdr62(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363040|imex:IM-11703-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR024977|mint:Q3U3T8|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007099"(centriole replication)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0097150"(neuronal stem cell population maintenance)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:l1ykYPJWylrUCk6FY/w9DHoAZz810090	intact-crc:BBCA01391E7E88B8|rigid:8UmRC3n5Q62O+qIJlh1qCBP2OyQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05513	uniprotkb:O35658	intact:EBI-295351|uniprotkb:Q15207|uniprotkb:Q5SYT5|uniprotkb:Q969S4|uniprotkb:A8K4N0|uniprotkb:A8MU64|uniprotkb:B7Z2J7|uniprotkb:E9PCW2|ensembl:ENSP00000367830	intact:EBI-642072	psi-mi:kpcz_human(display_long)|uniprotkb:PRKCZ(gene name)|psi-mi:PRKCZ(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:c1qbp_mouse(display_long)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:GC1q-R protein(gene name synonym)|uniprotkb:C1qbp(gene name)|psi-mi:C1qbp(display_short)|uniprotkb:Gc1qbp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363043|imex:IM-11703-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028753.1|refseq:NP_001028754.1|refseq:NP_001229803.1|refseq:NP_002735.3|refseq:XP_016857288.1|ensembl:ENSG00000067606(gene)|ensembl:ENST00000378567(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034662|interpro:IPR034877|mint:Q05513|reactome:R-HSA-114604|reactome:R-HSA-2173791|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-9634635	reactome:R-MMU-140837|reactome:R-MMU-8980692|reactome:R-MMU-9013106|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|dip:DIP-32249N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:ZSNTfuQXROHgAT6oDLjP1Ij7KxY9606	rogid:tPoLimqgF2SXeVXk7Z5rCQa+wTc10090	intact-crc:B4783427CE4A6594|rigid:OTdXfLMQL5STVyOgwImDjTqEysU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K3H0	uniprotkb:Q8TAI7	intact:EBI-400377|uniprotkb:Q3UJP7|uniprotkb:Q69ZJ9|uniprotkb:Q8BWZ8|uniprotkb:Q8VCJ8|uniprotkb:Q9CUW4|ensembl:ENSMUSP00000042875	intact:EBI-746555|uniprotkb:Q56VH8|ensembl:ENSP00000301068	psi-mi:dp13a_mouse(display_long)|uniprotkb:Appl1(gene name)|psi-mi:Appl1(display_short)|uniprotkb:Dip13a(gene name synonym)|uniprotkb:Kiaa1428(gene name synonym)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)	psi-mi:rebl1_human(display_long)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)|uniprotkb:Rheb2(gene name synonym)|uniprotkb:Ras homolog enriched in brain like-1 c(gene name synonym)|uniprotkb:RHEBL1(gene name)|psi-mi:RHEBL1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363046|imex:IM-11703-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660256.1|ensembl:ENSMUSG00000040760(gene)|ensembl:ENSMUST00000036570(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR037929|mint:Q8K3H0|reactome:R-MMU-418889	refseq:NP_653194.1|refseq:NP_001290055.1|ensembl:ENSG00000167550(gene)|ensembl:ENST00000301068(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:3OES	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:1ZML/W0Qi+jMAeZQ7PXfiHA6YBE10090	rogid:mHmXUvULxk42M1kPOjh4jsn4Q3w9606	intact-crc:382D36BCCD1970BC|rigid:jH1i95J4CXxNEJWeOczZBddMQHs	false	-	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R2X8	uniprotkb:Q8TAI7	intact:EBI-2364712|uniprotkb:Q3TJC4|uniprotkb:Q8C0U6|uniprotkb:Q9DAV7|ensembl:ENSMUSP00000083196|ensembl:ENSMUSP00000113479	intact:EBI-746555|uniprotkb:Q56VH8|ensembl:ENSP00000301068	psi-mi:go45_mouse(display_long)|uniprotkb:Blzf1(gene name)|psi-mi:Blzf1(display_short)|uniprotkb:Basic leucine zipper nuclear factor 1(gene name synonym)	psi-mi:rebl1_human(display_long)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)|uniprotkb:Rheb2(gene name synonym)|uniprotkb:Ras homolog enriched in brain like-1 c(gene name synonym)|uniprotkb:RHEBL1(gene name)|psi-mi:RHEBL1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363076|imex:IM-11703-78	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153680.1|refseq:NP_001153681.1|refseq:NP_079781.2|ensembl:ENSMUSG00000026577(gene)|ensembl:ENSMUST00000086032(transcript)|ensembl:ENSMUST00000120447(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007030"(Golgi organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|interpro:IPR013183(Protein of unknown function DUF1721, fungi)|interpro:IPR027095|mint:Q8R2X8|rcsb pdb:5H3J|reactome:R-MMU-162658	refseq:NP_653194.1|refseq:NP_001290055.1|ensembl:ENSG00000167550(gene)|ensembl:ENST00000301068(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:3OES	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:uKlwREE2gcEIp+l1JRlfHGzZY0c10090	rogid:mHmXUvULxk42M1kPOjh4jsn4Q3w9606	intact-crc:3BCC7D22158FE055|rigid:+IJeqZgE5sJ2aXjAumhg32o9XXs	false	-	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39429	uniprotkb:Q8TAI7	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-746555|uniprotkb:Q56VH8|ensembl:ENSP00000301068	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:rebl1_human(display_long)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)|uniprotkb:Rheb2(gene name synonym)|uniprotkb:Ras homolog enriched in brain like-1 c(gene name synonym)|uniprotkb:RHEBL1(gene name)|psi-mi:RHEBL1(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363079|imex:IM-11703-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_653194.1|refseq:NP_001290055.1|ensembl:ENSG00000167550(gene)|ensembl:ENST00000301068(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:3OES	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:mHmXUvULxk42M1kPOjh4jsn4Q3w9606	intact-crc:8A4C37F9DFC99D52|rigid:P/4V3wHfrkbKQL3AT/KjIbVlI3A	false	-	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z0S9	uniprotkb:O00141	intact:EBI-476965|ensembl:ENSMUSP00000076227|uniprotkb:Q3TDB4	intact:EBI-1042854|uniprotkb:Q5TCN3|uniprotkb:Q9UN56|uniprotkb:B7UUP7|uniprotkb:B7UUP8|uniprotkb:B7UUP9|uniprotkb:B7Z5B2|uniprotkb:Q5TCN2|uniprotkb:Q5TCN4|uniprotkb:Q5VY65|uniprotkb:E1P583|ensembl:ENSP00000237305	psi-mi:praf1_mouse(display_long)|uniprotkb:PRA1 family protein 1(gene name synonym)|uniprotkb:Prenylin(gene name synonym)|uniprotkb:Rabac1(gene name)|psi-mi:Rabac1(display_short)|uniprotkb:Pra(gene name synonym)|uniprotkb:Pra1(gene name synonym)|uniprotkb:Praf1(gene name synonym)	psi-mi:sgk1_human(display_long)|uniprotkb:SGK1(gene name)|psi-mi:SGK1(display_short)|uniprotkb:SGK(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363084|imex:IM-11703-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000003380(gene)|ensembl:ENSMUST00000076961(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR004895(Prenylated rab acceptor PRA1)|refseq:NP_034391.1	refseq:NP_001137148.1|refseq:NP_001137149.1|refseq:NP_001137150.1|refseq:NP_005618.2|refseq:XP_011534373.1|refseq:NP_001278924.1|dip:DIP-42464N|ensembl:ENSG00000118515(gene)|ensembl:ENST00000237305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007616"(long-term memory)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:O00141|rcsb pdb:2R5T|rcsb pdb:3HDM|rcsb pdb:3HDN|reactome:R-HSA-2672351|reactome:R-HSA-6804757|reactome:R-HSA-8986944|reactome:R-HSA-9031628	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:cBDA6mrObxTPZRfwXIJSP3YkNIc10090	rogid:JtUnW4acvjrgKwRCWC6bu1P1aYs9606	intact-crc:E16C21F4294EEDE0|rigid:UTbvK6JL2e323rfnkPlTfBJQJsQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UBX0	uniprotkb:O00141	intact:EBI-2366300|uniprotkb:Q8R006|ensembl:ENSMUSP00000039529	intact:EBI-1042854|uniprotkb:Q5TCN3|uniprotkb:Q9UN56|uniprotkb:B7UUP7|uniprotkb:B7UUP8|uniprotkb:B7UUP9|uniprotkb:B7Z5B2|uniprotkb:Q5TCN2|uniprotkb:Q5TCN4|uniprotkb:Q5VY65|uniprotkb:E1P583|ensembl:ENSP00000237305	psi-mi:tm109_mouse(display_long)|uniprotkb:Tmem109(gene name)|psi-mi:Tmem109(display_short)|uniprotkb:Mitsugumin-23(gene name synonym)	psi-mi:sgk1_human(display_long)|uniprotkb:SGK1(gene name)|psi-mi:SGK1(display_short)|uniprotkb:SGK(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363087|imex:IM-11703-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598903.1|refseq:XP_006527380.1|ensembl:ENSMUSG00000034659(gene)|ensembl:ENSMUST00000038128(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071480"(cellular response to gamma radiation)|interpro:IPR039492|mint:Q3UBX0	refseq:NP_001137148.1|refseq:NP_001137149.1|refseq:NP_001137150.1|refseq:NP_005618.2|refseq:XP_011534373.1|refseq:NP_001278924.1|dip:DIP-42464N|ensembl:ENSG00000118515(gene)|ensembl:ENST00000237305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007616"(long-term memory)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:O00141|rcsb pdb:2R5T|rcsb pdb:3HDM|rcsb pdb:3HDN|reactome:R-HSA-2672351|reactome:R-HSA-6804757|reactome:R-HSA-8986944|reactome:R-HSA-9031628	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:A1j0QAd+iFKHsQUAGSp63nR++ik10090	rogid:JtUnW4acvjrgKwRCWC6bu1P1aYs9606	intact-crc:116C2285C38E33CF|rigid:Wl/yVzRYQ+ZmsqaoHaGOxrsA2xs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P84091	uniprotkb:Q15831	intact:EBI-297703|uniprotkb:P53679|uniprotkb:P20172|ensembl:ENSMUSP00000007216	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:ap2m1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:Ap2m1(gene name)|psi-mi:Ap2m1(display_short)|uniprotkb:Clapm1(gene name synonym)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363090|imex:IM-11703-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033809.1|ensembl:ENSMUSG00000022841(gene)|ensembl:ENSMUST00000007216(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:P84091|rcsb pdb:6OWO|rcsb pdb:6OWT|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA10090	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:2A928A498937F689|rigid:8k9tFi49z90TCBTOek6LooA0zL0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99LC8	uniprotkb:Q15831	intact:EBI-2365545|ensembl:ENSMUSP00000031334	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:ei2ba_mouse(display_long)|uniprotkb:Eif2b1(gene name)|psi-mi:Eif2b1(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363093|imex:IM-11703-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_663346.1|ensembl:ENSMUSG00000029388(gene)|ensembl:ENSMUST00000031334(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|reactome:R-MMU-72731	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:RSHs6+1trJ0shp48hJma1C2jBHY10090	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:8B0C7594A6FBDDA5|rigid:W9xQ3YmALeeRK8u1qhDjEyBCN9g	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A0A1B0GR91	uniprotkb:P49840	intact:EBI-2363428|ensembl:ENSMUSP00000147427	intact:EBI-1044067|uniprotkb:O14959|ensembl:ENSP00000222330|ensembl:ENSP00000412663	psi-mi:a0a1b0gr91_mouse(display_long)|uniprotkb:Gm4779(gene name)|psi-mi:Gm4779(display_short)	psi-mi:gsk3a_human(display_long)|uniprotkb:GSK3A(gene name)|psi-mi:GSK3A(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363431|imex:IM-11703-74	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006528432.1|ensembl:ENSMUSG00000045010(gene)|ensembl:ENSMUST00000147742(transcript)|interpro:IPR027822	ensembl:ENSG00000105723(gene)|ensembl:ENST00000222330(transcript)|ensembl:ENST00000453535(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010905"(negative regulation of UDP-glucose catabolic process)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071879"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904227"(negative regulation of glycogen synthase activity, transferring glucose-1-phosphate)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|mint:P49840|rcsb pdb:2DFM|reactome:R-HSA-198323|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|reactome:R-HSA-381038|reactome:R-HSA-5674400|reactome:R-HSA-9635465|reactome:R-HSA-9682706|reactome:R-HSA-9694686|refseq:NP_063937.2	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2016/11/30	rogid:MROa21LUngLnwzaWSeVKURPkv3M10090	rogid:CTNNFDhWycUTAOEW/KD2UXu0U7Y9606	intact-crc:AA38B4D6B8953205|rigid:ppKQw45eweIwPKBxHiuIacVvVrg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15382	uniprotkb:Q8K3H0	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	intact:EBI-400377|uniprotkb:Q3UJP7|uniprotkb:Q69ZJ9|uniprotkb:Q8BWZ8|uniprotkb:Q8VCJ8|uniprotkb:Q9CUW4|ensembl:ENSMUSP00000042875	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:dp13a_mouse(display_long)|uniprotkb:Appl1(gene name)|psi-mi:Appl1(display_short)|uniprotkb:Dip13a(gene name synonym)|uniprotkb:Kiaa1428(gene name synonym)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362283|imex:IM-11703-107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	refseq:NP_660256.1|ensembl:ENSMUSG00000040760(gene)|ensembl:ENSMUST00000036570(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR037929|mint:Q8K3H0|reactome:R-MMU-418889	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	rogid:1ZML/W0Qi+jMAeZQ7PXfiHA6YBE10090	intact-crc:09CE6D11A68F7F0D|rigid:O4/y9UTPHLUcOmidfYZx9EkG/7c	false	sufficient binding region:1-180	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R2X8	uniprotkb:Q15382	intact:EBI-2364712|uniprotkb:Q3TJC4|uniprotkb:Q8C0U6|uniprotkb:Q9DAV7|ensembl:ENSMUSP00000083196|ensembl:ENSMUSP00000113479	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	psi-mi:go45_mouse(display_long)|uniprotkb:Blzf1(gene name)|psi-mi:Blzf1(display_short)|uniprotkb:Basic leucine zipper nuclear factor 1(gene name synonym)	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362316|imex:IM-11703-116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153680.1|refseq:NP_001153681.1|refseq:NP_079781.2|ensembl:ENSMUSG00000026577(gene)|ensembl:ENSMUST00000086032(transcript)|ensembl:ENSMUST00000120447(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007030"(Golgi organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|interpro:IPR013183(Protein of unknown function DUF1721, fungi)|interpro:IPR027095|mint:Q8R2X8|rcsb pdb:5H3J|reactome:R-MMU-162658	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:uKlwREE2gcEIp+l1JRlfHGzZY0c10090	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	intact-crc:93263928617EB6CA|rigid:T/5xPFFDYIJ1P3V+W+wk8QoJQ/E	false	-	sufficient binding region:1-180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39429	uniprotkb:Q15382	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362319|imex:IM-11703-110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	intact-crc:50BAC7EB3CCE6F30|rigid:/0IhnmmL3KNxnbuKB497yXYwMYk	false	-	sufficient binding region:1-180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	uniprotkb:Q7TQK9	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2364772	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:q7tqk9_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362324|imex:IM-11703-106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	interpro:IPR032919|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:ArnUGNFk2AGJ+ejqwzT/3MKy06Y10090	intact-crc:CAAA52AF4C93B196|rigid:yhDgIQnNp4VF7Mfa0Pf3LsIU3xw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23150	uniprotkb:P49841	intact:EBI-2364960	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:ha2j_mouse(display_long)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362328|imex:IM-11703-121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR036179|go:"GO:0002250"(adaptive immune response)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0048002"(antigen processing and presentation of peptide antigen)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:zQyWhXVYEnYubzmkRpdy3s/56GY10090	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:58C70EB35DD85B22|rigid:+AHSfDS/9cm33yy1+MAAXm9upT8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8C804	uniprotkb:P49841	intact:EBI-2364887|uniprotkb:Q8K3I7|ensembl:ENSMUSP00000058832	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:spice_mouse(display_long)|uniprotkb:Ccdc52(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 52(gene name synonym)|uniprotkb:Spice1(gene name)|psi-mi:Spice1(display_short)|uniprotkb:D16Ertd480e(gene name synonym)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362333|imex:IM-11703-114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_653133.3|refseq:XP_017172412.1|ensembl:ENSMUSG00000043065(gene)|ensembl:ENSMUST00000050897(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR031387	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:ooOc9RIErFGvKSf3y0b6dcYddWw10090	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:D1C06B05DCD46B83|rigid:7yzgfwkhhw7gaeHihURyQlYKlwg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z1T5	uniprotkb:P49841	intact:EBI-2364863|uniprotkb:C7SHZ9|uniprotkb:Q3UJA4|ensembl:ENSMUSP00000079395	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:deaf1_mouse(display_long)|uniprotkb:Deaf1(gene name)|psi-mi:Deaf1(display_short)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362336|imex:IM-11703-113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058570.1|ensembl:ENSMUSG00000058886(gene)|ensembl:ENSMUST00000080553(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008542"(visual learning)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|rcsb pdb:2MBV	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:q9ATRueieoNxwZuVe5enenGvERE10090	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:E0499D39F15B0474|rigid:o3OQCwH+dvumol2tSTGJZ40TPuI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	intact:EBI-2364964	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	-	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:flj10404_mus_protein(display_short)|psi-mi:EBI-2364964(display_long)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362339|imex:IM-11703-111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	genbank_nucl_gi:212483(see-also)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	-	intact-crc:29B5461C3E68E8EA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6NXZ1	uniprotkb:P49841	intact:EBI-2364905|uniprotkb:E9QNG7|uniprotkb:Q69Z85|uniprotkb:Q9JJG3|ensembl:ENSMUSP00000076345|ensembl:ENSMUSP00000110218	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:krba1_mouse(display_long)|uniprotkb:Krba1(gene name)|psi-mi:Krba1(display_short)|uniprotkb:Kiaa1862(gene name synonym)|uniprotkb:MNCb-1826(orf name)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362342|imex:IM-11703-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598683.3|refseq:XP_006506827.1|ensembl:ENSMUSG00000042810(gene)|ensembl:ENSMUST00000077093(transcript)|ensembl:ENSMUST00000114571(transcript)|interpro:IPR029317|interpro:IPR040095|reactome:R-MMU-212436	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:1MrcZJDREGAcSWXT5zKSwbxE+Xo10090	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:7B845F0B6CFCD66C|rigid:3IBrTZfxuVTd+NXbYmF/xe32hOY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	uniprotkb:Q91YU6	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-646581|uniprotkb:E9QKK6|uniprotkb:Q569X6|ensembl:ENSMUSP00000045478|ensembl:ENSMUSP00000136405|ensembl:ENSMUSP00000137571	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:lzts2_mouse(display_long)|uniprotkb:Lzts2(gene name)|psi-mi:Lzts2(display_short)|uniprotkb:Kiaa1813(gene name synonym)|uniprotkb:Lapser1(gene name synonym)|uniprotkb:Protein LAPSER1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362350|imex:IM-11703-105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_001123997.1|refseq:NP_001123998.1|refseq:NP_663478.2|refseq:XP_006527067.1|ensembl:ENSMUSG00000035342(gene)|ensembl:ENSMUST00000039016(transcript)|ensembl:ENSMUST00000178087(transcript)|ensembl:ENSMUST00000179108(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001822"(kidney development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:8vF1Urk1kDHDPcvi4VqWQyRbxig10090	intact-crc:96B040FBEDA07CC2|rigid:kKA037hAaelYY1bm3zXr0gfIy+k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	uniprotkb:Q80XI6	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2364817|uniprotkb:Q8K0M8|uniprotkb:Q9JJ15|ensembl:ENSMUSP00000004156	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:m3k11_mouse(display_long)|uniprotkb:Map3k11(gene name)|psi-mi:Map3k11(display_short)|uniprotkb:Mlk3(gene name synonym)|uniprotkb:Mixed lineage kinase 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362378|imex:IM-11703-109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_071295.2|refseq:XP_006531815.1|ensembl:ENSMUSG00000004054(gene)|ensembl:ENSMUST00000004156(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016231(Mitogen-activated protein kinase kinase kinase, 9/10/11)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035779|interpro:IPR036028|reactome:R-MMU-5673000|reactome:R-MMU-9013148|reactome:R-MMU-9013408	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:zuCPy4LP4hnWLYw19vo+QdAegGI10090	intact-crc:8696D3CB2143CA81|rigid:ugMn2xlPZTTyfIfK1WFmKuAwu5U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99K48	uniprotkb:P49841	intact:EBI-607499|ensembl:ENSMUSP00000033673|uniprotkb:Q63887|uniprotkb:Q9CYQ4|uniprotkb:Q9DBP2	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:nono_mouse(display_long)|uniprotkb:Nono(gene name)|psi-mi:Nono(display_short)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362382|imex:IM-11703-118	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031311(gene)|ensembl:ENSMUST00000033673(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q99K48|rcsb pdb:2CPJ|rcsb pdb:2RS8|refseq:NP_075633.2|refseq:NP_001239447.1|dip:DIP-34308N	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:78ly3/4yzdfLjl9d/cV6Ob/SFG810090	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:1BD70238CF493FE0|rigid:1kTO0SB2p0ygHJteJVWCkpWyL60	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BII1	uniprotkb:P49841	intact:EBI-2364927|ensembl:ENSMUSP00000105878|ensembl:ENSMUSP00000135881	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:prox2_mouse(display_long)|uniprotkb:Prox2(gene name)|psi-mi:Prox2(display_short)|uniprotkb:Homeobox prospero-like protein PROX2(gene name synonym)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362407|imex:IM-11703-120	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011242489.1|refseq:NP_780407.1|refseq:XP_006516341.1|refseq:XP_006516342.1|refseq:XP_006516344.1|refseq:XP_017170702.1|ensembl:ENSMUSG00000042320(gene)|ensembl:ENSMUST00000110249(transcript)|ensembl:ENSMUST00000177289(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:PerBO5Zrj8Pq+JSpELm5DwMr+hY10090	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:53EFF3AFC8CA4E68|rigid:zL8h2OTum8IDPbbWCtS80VwOjhU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BIW1	uniprotkb:P49841	intact:EBI-2364846|uniprotkb:Q80VU0|ensembl:ENSMUSP00000015855	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:prun1_mouse(display_long)|uniprotkb:Prune1(gene name)|psi-mi:Prune1(display_short)|uniprotkb:PRUNEM1(gene name synonym)|uniprotkb:Prune(gene name synonym)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362411|imex:IM-11703-112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775482.1|ensembl:ENSMUSG00000015711(gene)|ensembl:ENSMUST00000015855(transcript)|go:"GO:0004309"(exopolyphosphatase activity)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006798"(polyphosphate catabolic process)|go:"GO:0015631"(tubulin binding)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR001667(Phosphoesterase, RecJ-like)|interpro:IPR004097(DHHA2)|interpro:IPR038222|interpro:IPR038763	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:KVIyL+CFvotqNUZAkR7b1eojPM010090	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:CD07065A803FBB20|rigid:eqBVZh+eCg3NZt+Fe2X8pd4RHoQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	uniprotkb:Q9CR26	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2364748|ensembl:ENSMUSP00000119829	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:vta1_mouse(display_long)|uniprotkb:Vta1(gene name)|psi-mi:Vta1(display_short)|uniprotkb:SKD1-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362414|imex:IM-11703-108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_079694.2|dip:DIP-54810N|ensembl:ENSMUSG00000019868(gene)|ensembl:ENSMUST00000154132(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0071985"(multivesicular body sorting pathway)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|reactome:R-MMU-917729	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:+3gL069RROf6km3nNQofh5K8dlE10090	intact-crc:8F299A7D7AB31A55|rigid:PQm1QwLmcJo0ObUVFWfyYVYi2AA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	uniprotkb:Q9D0L1	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2364761|ensembl:ENSMUSP00000044774|ensembl:ENSMUSP00000152153	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:zbed3_mouse(display_long)|uniprotkb:Zbed3(gene name)|psi-mi:Zbed3(display_short)|uniprotkb:Axin-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2362427|imex:IM-11703-117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_082382.1|refseq:NP_001289467.1|refseq:NP_001289468.1|ensembl:ENSMUSG00000041995(gene)|ensembl:ENSMUST00000045909(transcript)|ensembl:ENSMUST00000221807(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR033546|interpro:IPR036236|interpro:IPR043471	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:XbG4QIbX+rgox7eqpTRo/LiLxCE10090	intact-crc:B7276FAD0DCDCF77|rigid:HQFBcSdsatJzgOhHWFvgCjT4M1k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	uniprotkb:A0A1B0GR91	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2363428|ensembl:ENSMUSP00000147427	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:a0a1b0gr91_mouse(display_long)|uniprotkb:Gm4779(gene name)|psi-mi:Gm4779(display_short)	psi-mi:"MI:0018"(two hybrid)	Pilot-Storck et al.	imex:IM-11703|pubmed:20368287	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363434|imex:IM-11703-115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:XP_006528432.1|ensembl:ENSMUSG00000045010(gene)|ensembl:ENSMUST00000147742(transcript)|interpro:IPR027822	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/07/07	2016/11/30	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:MROa21LUngLnwzaWSeVKURPkv3M10090	intact-crc:1DF9C7C56C1EF51A|rigid:Cp0/N6yxoCLu7G8ko0CW8DOhYIg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)