#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:17283"	uniprotkb:P35991	intact:EBI-1257113	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296276|imex:IM-11692-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:06CA41BB44EA2B9A	false	-	sufficient binding region:278-380(IPR000980)|glutathione s tranferase tag:?-?|mutation decreasing interaction:348-349	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:16500"	uniprotkb:P35991	intact:EBI-1257117	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:pi5p(display_short)|psi-mi:"CHEBI:16500"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296311|imex:IM-11692-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:54D51804D87C9E3E	false	-	sufficient binding region:278-380(IPR000980)|glutathione s tranferase tag:?-?|mutation decreasing interaction:348-349	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:16500"	uniprotkb:P35991	intact:EBI-1257117	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:pi5p(display_short)|psi-mi:"CHEBI:16500"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296317|imex:IM-11692-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:E3201D7916D360B5	false	-	sufficient binding region:278-380(IPR000980)|mutation decreasing interaction:348-349|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:16851"	uniprotkb:P35991	intact:EBI-1257121	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate(display_short)|psi-mi:"CHEBI:16851"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296323|imex:IM-11692-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:49CA26054FF3EA1A	false	-	glutathione s tranferase tag:?-?|mutation decreasing interaction:348-349|sufficient binding region:278-380(IPR000980)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:16618"	uniprotkb:P35991	intact:EBI-1257125	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate(display_short)|psi-mi:"CHEBI:16618"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296329|imex:IM-11692-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:2F52D2FB8A6186F4	false	-	mutation decreasing interaction:348-349|glutathione s tranferase tag:?-?|sufficient binding region:278-380(IPR000980)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:18348"	uniprotkb:P35991	intact:EBI-1257123	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate(display_short)|psi-mi:"CHEBI:18348"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296541|imex:IM-11692-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:C65058D855AF214A	false	-	glutathione s tranferase tag:?-?|sufficient binding region:163-338(IPR001452)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:16749"	uniprotkb:P35991	intact:EBI-1373365	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:1-phosphatidyl-1d-myo-inositol(display_short)|psi-mi:"CHEBI:16749"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296554|imex:IM-11692-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2014/10/16	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:DC550986AA94AE9A	false	-	glutathione s tranferase tag:?-?|sufficient binding region:163-338(IPR001452)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:16337"	uniprotkb:P35991	intact:EBI-1263288	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:phosphatidic acids(display_short)|psi-mi:"CHEBI:16337"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296564|imex:IM-11692-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ws)|taxid:9606("Homo sapiens Werner Syndrom (WS) cell line transformed with SV40 (AG11395 cell line)")	-	2009/03/27	2014/10/16	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:BABC2A54CCB6401C	false	-	sufficient binding region:163-338(IPR001452)|glutathione s tranferase tag:?-?|mutation decreasing interaction:348-349	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
chebi:"CHEBI:18348"	uniprotkb:P35991	intact:EBI-1257123	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate(display_short)|psi-mi:"CHEBI:18348"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296377|imex:IM-11692-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3b, 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2014/10/16	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:DF6B719EC9CD496E	false	-	his tag:?-?|mutation decreasing interaction:365-365|mutation decreasing interaction:372-372|mutation increasing interaction:288-288|sufficient binding region:163-338(IPR000980)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16749"	uniprotkb:P35991	intact:EBI-1373365	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:1-phosphatidyl-1d-myo-inositol(display_short)|psi-mi:"CHEBI:16749"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296393|imex:IM-11692-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:3B3DD710986BB03E	false	-	his tag:?-?|sufficient binding region:163-338(IPR000980)|mutation increasing interaction:288-288|mutation decreasing interaction:365-365	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:18035"	uniprotkb:P42682	intact:EBI-2296405	intact:EBI-2296413|ensembl:ENSMUSP00000109234	psi-mi:diglycerides(display_short)|psi-mi:"CHEBI:18035"(display_long)	psi-mi:txk_mouse(display_long)|uniprotkb:Txk(gene name)|psi-mi:Txk(display_short)|uniprotkb:Rlk(gene name synonym)|uniprotkb:PTK-RL-18(gene name synonym)|uniprotkb:Resting lymphocyte kinase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296407|imex:IM-11692-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011239024.1|refseq:NP_001116226.1|refseq:NP_001276424.1|ensembl:ENSMUSG00000054892(gene)|ensembl:ENSMUST00000113604(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060335"(positive regulation of interferon-gamma-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035579|interpro:IPR035870|interpro:IPR036028|interpro:IPR036860|mint:P42682|reactome:R-MMU-2871809	-	-	-	figure legend:3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2019/01/30	-	rogid:lOZZKm2ifSecg4CcK+KyLR2ndVs10090	intact-crc:1359A3B676A40D71	false	-	O4'-phospho-L-tyrosine:55..55-207..207(IPR001452)|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:18035"	uniprotkb:Q03526	intact:EBI-2296405	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:diglycerides(display_short)|psi-mi:"CHEBI:18035"(display_long)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296474|imex:IM-11692-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	-	-	-	figure legend:3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2019/01/30	-	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:134CD729E0D329B4	false	-	sufficient binding region:147..147-303..303(IPR001452)|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16337"	uniprotkb:P42682	intact:EBI-1263288	intact:EBI-2296413|ensembl:ENSMUSP00000109234	psi-mi:phosphatidic acids(display_short)|psi-mi:"CHEBI:16337"(display_long)	psi-mi:txk_mouse(display_long)|uniprotkb:Txk(gene name)|psi-mi:Txk(display_short)|uniprotkb:Rlk(gene name synonym)|uniprotkb:PTK-RL-18(gene name synonym)|uniprotkb:Resting lymphocyte kinase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296478|imex:IM-11692-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011239024.1|refseq:NP_001116226.1|refseq:NP_001276424.1|ensembl:ENSMUSG00000054892(gene)|ensembl:ENSMUST00000113604(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060335"(positive regulation of interferon-gamma-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035579|interpro:IPR035870|interpro:IPR036028|interpro:IPR036860|mint:P42682|reactome:R-MMU-2871809	-	-	-	figure legend:3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2019/01/30	-	rogid:lOZZKm2ifSecg4CcK+KyLR2ndVs10090	intact-crc:E6C8B204A3160AE7	false	-	his tag:?-?|sufficient binding region:55..55-207..207(IPR000980)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16337"	uniprotkb:Q03526	intact:EBI-1263288	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:phosphatidic acids(display_short)|psi-mi:"CHEBI:16337"(display_long)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296489|imex:IM-11692-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	-	-	-	figure legend:3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2019/01/30	-	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:D79A80C1A0840522	false	-	his tag:?-?|sufficient binding region:147..147-303..303(IPR000980)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16337"	uniprotkb:P35991	intact:EBI-1263288	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:phosphatidic acids(display_short)|psi-mi:"CHEBI:16337"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296535|imex:IM-11692-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3b, 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:D091A99F24825F2F	false	-	his tag:?-?|mutation decreasing interaction:288-288|mutation decreasing interaction:362-362|mutation decreasing interaction:365-365|mutation decreasing interaction:372-372	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:18035"	uniprotkb:P35991	intact:EBI-2296405	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:diglycerides(display_short)|psi-mi:"CHEBI:18035"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296593|imex:IM-11692-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2019/01/30	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:57B21D03925EC4D7	false	-	his tag:?-?|mutation decreasing interaction:288-288|mutation decreasing interaction:362-362|mutation decreasing interaction:365-365|mutation decreasing interaction:372-372	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16618"	uniprotkb:P35991	intact:EBI-1257125	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate(display_short)|psi-mi:"CHEBI:16618"(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Hong et al. (2009)	imex:IM-11692|pubmed:19946567	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296607|imex:IM-11692-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	-	-	-	figure legend:3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/27	2014/10/16	-	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:D7E4CD8342C2FFF3	false	-	his tag:?-?|mutation increasing interaction:288-288|mutation decreasing interaction:365-365	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)