#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q60631 uniprotkb:Q52KG5 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 intact:EBI-2480646|ensembl:ENSMUSP00000119482|uniprotkb:C9EF47|uniprotkb:Q6PCY3|uniprotkb:Q6ZPV4|uniprotkb:Q99PT4 psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:ki26a_mouse(display_long)|uniprotkb:Kif26a(gene name)|psi-mi:Kif26a(display_short)|uniprotkb:Kiaa1236(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480664|imex:IM-12108-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 ensembl:ENSMUSG00000021294(gene)|ensembl:ENSMUST00000128402(transcript)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0048484"(enteric nervous system development)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_001091090.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)") - 2009/11/18 2014/10/16 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rogid:NIFE0tJtdf5GGjT6l0Iwaq/Z5UM10090 intact-crc:BFC3EA0A9C5E51A6|rigid:+E0evOUZSzUyG2DR4TmuJtYxYvk false - flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62993 uniprotkb:Q9ULI4 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 intact:EBI-1642152|uniprotkb:Q8TAZ7|uniprotkb:Q9UFL3|uniprotkb:Q96GK3|ensembl:ENSP00000388241 psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:ki26a_human(display_long)|uniprotkb:KIF26A(gene name)|psi-mi:KIF26A(display_short)|uniprotkb:KIAA1236(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480677|imex:IM-12108-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N refseq:NP_056471.1|ensembl:ENSP00000388241|ensembl:ENSG00000066735(gene)|ensembl:ENST00000423312(transcript)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0048484"(enteric nervous system development)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-983189 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-tgw)|taxid:9606(Human TGW neuroblastoma cells) - 2009/11/18 2014/10/16 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 rogid:rGOWX3QnXCCRJ0EUsGxRUTsQoe09606 intact-crc:8346AAB015D0EB55|rigid:Vl9vqNQJX/gSjvXX7MSVFRk/pAg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P07949 uniprotkb:Q13480 intact:EBI-2480756|intact:EBI-28967738|ensembl:ENSP00000347942|uniprotkb:A8K6Z2|uniprotkb:Q9BTB0|uniprotkb:Q15250|uniprotkb:Q9H4A2 intact:EBI-517684|uniprotkb:Q4W5G2|uniprotkb:Q6P1W2|uniprotkb:A8K152|ensembl:ENSP00000262994 psi-mi:ret_human(display_long)|uniprotkb:RET(gene name)|psi-mi:RET(display_short)|uniprotkb:CDHF12(gene name synonym)|uniprotkb:Cadherin family member 12(gene name synonym)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)|uniprotkb:CDHR16(gene name synonym)|uniprotkb:PTC(gene name synonym)|uniprotkb:RET51(gene name synonym) psi-mi:gab1_human(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:GAB1(gene name)|psi-mi:GAB1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480789|imex:IM-12108-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165731(gene)|ensembl:ENST00000355710(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007497"(posterior midgut development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|go:"GO:0098797"(plasma membrane protein complex)|mint:P07949|rcsb pdb:1XPD|rcsb pdb:2IVS|rcsb pdb:2IVT|rcsb pdb:2IVU|rcsb pdb:2IVV|rcsb pdb:2X2K|rcsb pdb:2X2L|rcsb pdb:2X2M|rcsb pdb:2X2U|rcsb pdb:4CKI|go:"GO:0035799"(ureter maturation)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0097021"(lymphocyte migration into lymphoid organs)|go:"GO:0033674"(positive regulation of kinase activity)|rcsb pdb:4UX8|rcsb pdb:5AMN|rcsb pdb:5FM2|rcsb pdb:5FM3|rcsb pdb:6FEK|rcsb pdb:6GL7|rcsb pdb:6I82|rcsb pdb:6I83|rcsb pdb:6NE7|rcsb pdb:6NEC|rcsb pdb:6NJA|rcsb pdb:6Q2J|rcsb pdb:6Q2N|rcsb pdb:6Q2O|rcsb pdb:6Q2R|rcsb pdb:4CKJ|rcsb pdb:6Q2S|rcsb pdb:6VHG|rcsb pdb:7JU5|rcsb pdb:7JU6|reactome:R-HSA-5673001|reactome:R-HSA-8853659|ensembl:ENST00000340058|ensembl:ENSP00000344798|ensembl:ENSP00000347942|refseq:NP_065681.1|refseq:NP_066124.1|dip:DIP-41449N ensembl:ENSP00000262994|ensembl:ENST00000262995|ensembl:ENSP00000262995|refseq:NP_002030.2|refseq:NP_997006.1|ensembl:ENSG00000109458(gene)|ensembl:ENST00000262994(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q13480|rcsb pdb:4QSY|reactome:R-HSA-109704|reactome:R-HSA-1236382|reactome:R-HSA-1257604|reactome:R-HSA-180292|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8865999|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-9664565|reactome:R-HSA-9665348 psi-mi:"MI:0469"(intact) - - agonist:"Glial cell-derived neurotrophic factor (GDNF)"|comment:"When full-length or tail domain (731-1881) of KIF26A was overexpressed in TGW cells, GDNF-induced formation of the SHC-Grb2 complex was significantly inhibited"|figure legend:Fig. 5G|antagonist:KIF26A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-tgw)|taxid:9606(Human TGW neuroblastoma cells) - 2009/11/18 2014/10/16 rogid:vNKdBK5ZYchweyidTdbDFkd02VM9606 rogid:AIK39gZJknpy3vQK/GraIpBbgzU9606 intact-crc:BB5645C298484CC5|rigid:NbNfQGYNMnRosZkHD6gzNtopvL0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P07949 uniprotkb:Q07889 intact:EBI-2480756|intact:EBI-28967738|ensembl:ENSP00000347942|uniprotkb:A8K6Z2|uniprotkb:Q9BTB0|uniprotkb:Q15250|uniprotkb:Q9H4A2 intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2 psi-mi:ret_human(display_long)|uniprotkb:RET(gene name)|psi-mi:RET(display_short)|uniprotkb:CDHF12(gene name synonym)|uniprotkb:Cadherin family member 12(gene name synonym)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)|uniprotkb:CDHR16(gene name synonym)|uniprotkb:PTC(gene name synonym)|uniprotkb:RET51(gene name synonym) psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480789|imex:IM-12108-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165731(gene)|ensembl:ENST00000355710(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007497"(posterior midgut development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|go:"GO:0098797"(plasma membrane protein complex)|mint:P07949|rcsb pdb:1XPD|rcsb pdb:2IVS|rcsb pdb:2IVT|rcsb pdb:2IVU|rcsb pdb:2IVV|rcsb pdb:2X2K|rcsb pdb:2X2L|rcsb pdb:2X2M|rcsb pdb:2X2U|rcsb pdb:4CKI|go:"GO:0035799"(ureter maturation)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0097021"(lymphocyte migration into lymphoid organs)|go:"GO:0033674"(positive regulation of kinase activity)|rcsb pdb:4UX8|rcsb pdb:5AMN|rcsb pdb:5FM2|rcsb pdb:5FM3|rcsb pdb:6FEK|rcsb pdb:6GL7|rcsb pdb:6I82|rcsb pdb:6I83|rcsb pdb:6NE7|rcsb pdb:6NEC|rcsb pdb:6NJA|rcsb pdb:6Q2J|rcsb pdb:6Q2N|rcsb pdb:6Q2O|rcsb pdb:6Q2R|rcsb pdb:4CKJ|rcsb pdb:6Q2S|rcsb pdb:6VHG|rcsb pdb:7JU5|rcsb pdb:7JU6|reactome:R-HSA-5673001|reactome:R-HSA-8853659|ensembl:ENST00000340058|ensembl:ENSP00000344798|ensembl:ENSP00000347942|refseq:NP_065681.1|refseq:NP_066124.1|dip:DIP-41449N refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N psi-mi:"MI:0469"(intact) - - agonist:"Glial cell-derived neurotrophic factor (GDNF)"|comment:"When full-length or tail domain (731-1881) of KIF26A was overexpressed in TGW cells, GDNF-induced formation of the SHC-Grb2 complex was significantly inhibited"|figure legend:Fig. 5G|antagonist:KIF26A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-tgw)|taxid:9606(Human TGW neuroblastoma cells) - 2009/11/18 2014/10/16 rogid:vNKdBK5ZYchweyidTdbDFkd02VM9606 rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606 intact-crc:BB5645C298484CC5|rigid:NbNfQGYNMnRosZkHD6gzNtopvL0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62993 uniprotkb:Q52KG5 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 intact:EBI-2480646|ensembl:ENSMUSP00000119482|uniprotkb:C9EF47|uniprotkb:Q6PCY3|uniprotkb:Q6ZPV4|uniprotkb:Q99PT4 psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:ki26a_mouse(display_long)|uniprotkb:Kif26a(gene name)|psi-mi:Kif26a(display_short)|uniprotkb:Kiaa1236(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480693|imex:IM-12108-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N ensembl:ENSMUSG00000021294(gene)|ensembl:ENSMUST00000128402(transcript)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0048484"(enteric nervous system development)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_001091090.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-tgw)|taxid:9606(Human TGW neuroblastoma cells) - 2009/11/18 2014/10/16 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 rogid:NIFE0tJtdf5GGjT6l0Iwaq/Z5UM10090 intact-crc:233AFE342B1D8F8A|rigid:Tx1EHqqIOEXHSdnuX/wxKrV4gBo false green fluorescent protein tag:?-?|necessary binding region:60-158(IPR000980) flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35546 uniprotkb:Q9QYY0 intact:EBI-2480800|ensembl:ENSMUSP00000032201|uniprotkb:Q8BQ34|uniprotkb:Q9QXH9 intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150 psi-mi:ret_mouse(display_long)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym) psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480844|imex:IM-12108-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035799"(ureter maturation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000032201(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-8853659|reactome:R-MMU-5673001|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|rcsb pdb:1UEF|refseq:NP_001074249.1|refseq:NP_033076.2 refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 6B, 6E|agonist:"Glial cell-derived neurotrophic factor (GDNF)"|comment:Interaction appeared to increase in Kif26a-/- mice.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-colon)|taxid:10090(Mouse colon) - 2009/11/18 2014/10/16 rogid:BDIyZk6l26Iuth4Pce2alRhCG1Q10090 rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090 intact-crc:0E104E4D627D0AB0|rigid:hytgpTcdA0iUb57LSrJAdVlUAE4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35546 uniprotkb:Q62245 intact:EBI-2480800|ensembl:ENSMUSP00000032201|uniprotkb:Q8BQ34|uniprotkb:Q9QXH9 intact:EBI-1693|uniprotkb:Q62244|ensembl:ENSMUSP00000067786 psi-mi:ret_mouse(display_long)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym) psi-mi:sos1_mouse(display_long)|uniprotkb:Sos1(gene name)|psi-mi:Sos1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480844|imex:IM-12108-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035799"(ureter maturation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000032201(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-8853659|reactome:R-MMU-5673001|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|rcsb pdb:1UEF|refseq:NP_001074249.1|refseq:NP_033076.2 refseq:NP_033257.2|dip:DIP-29230N|ensembl:ENSMUSG00000024241(gene)|ensembl:ENSMUST00000068714(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q62245|rcsb pdb:1B07|rcsb pdb:1GBQ|rcsb pdb:1PMS|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-193648|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-416482|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8853659|reactome:R-MMU-8983432|reactome:R-MMU-9013149|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-9607240|reactome:R-MMU-983695 psi-mi:"MI:0469"(intact) - crc64:3286088A5BA0A4A6 figure legend:Fig. 6B, 6E|agonist:"Glial cell-derived neurotrophic factor (GDNF)"|comment:Interaction appeared to increase in Kif26a-/- mice.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-colon)|taxid:10090(Mouse colon) - 2009/11/18 2014/10/16 rogid:BDIyZk6l26Iuth4Pce2alRhCG1Q10090 rogid:n5Gaz6esU+5ryBPr8s91dizgMnE10090 intact-crc:0E104E4D627D0AB0|rigid:hytgpTcdA0iUb57LSrJAdVlUAE4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60631 uniprotkb:Q52KG5 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 intact:EBI-2480646|ensembl:ENSMUSP00000119482|uniprotkb:C9EF47|uniprotkb:Q6PCY3|uniprotkb:Q6ZPV4|uniprotkb:Q99PT4 psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:ki26a_mouse(display_long)|uniprotkb:Kif26a(gene name)|psi-mi:Kif26a(display_short)|uniprotkb:Kiaa1236(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zhou et al. (2009) imex:IM-12108|pubmed:19914172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2480859|imex:IM-12108-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 ensembl:ENSMUSG00000021294(gene)|ensembl:ENSMUST00000128402(transcript)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0048484"(enteric nervous system development)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|refseq:NP_001091090.1 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Figs. 5A, 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2009/11/18 2014/10/16 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rogid:NIFE0tJtdf5GGjT6l0Iwaq/Z5UM10090 intact-crc:ED647A6C4D03FE66|rigid:+E0evOUZSzUyG2DR4TmuJtYxYvk false sufficient binding region:60-158(IPR000980) sufficient binding region:1420-1600 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)