#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
ensembl:ENSMUSG00000042745	uniprotkb:Q15797	intact:EBI-2479621	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:id1_mouse_gene(display_short)|psi-mi:ENSMUSG00000042745(display_long)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479630|imex:IM-12107-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	go:"GO:0043565"(sequence-specific DNA binding)	-	-	figure legend:Fig. 2D|comment:The BMP-responsive regions of the Id1 gene were sufficient to bind in this interaction.|agonist:"Bone morphogenetic protein (BMP)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/11/18	2014/10/16	-	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:B70017A51573690A	false	-	O-phospho-L-serine:206-206	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSMUSG00000025880	uniprotkb:Q15797	intact:EBI-2479619	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:smad7_mouse_gene(display_short)|psi-mi:ENSMUSG00000025880(display_long)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479639|imex:IM-12107-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	go:"GO:0043565"(sequence-specific DNA binding)	-	-	figure legend:Fig. 2D|comment:The BMP-responsive regions of the Smad7 gene were sufficient to bind in this interaction.|agonist:"Bone morphogenetic protein (BMP)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/11/18	2014/10/16	-	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:EEF5376FC256D440	false	-	O-phospho-L-serine:206-206	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSMUSG00000025880	uniprotkb:Q8BUN5	intact:EBI-2479619	intact:EBI-2337983|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q8BX84|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|ensembl:ENSMUSP00000034973	psi-mi:smad7_mouse_gene(display_short)|psi-mi:ENSMUSG00000025880(display_long)	psi-mi:smad3_mouse(display_long)|uniprotkb:Smad3(gene name)|psi-mi:Smad3(display_short)|uniprotkb:Madh3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479650|imex:IM-12107-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_058049.3|dip:DIP-29717N|ensembl:ENSMUSG00000032402(gene)|ensembl:ENSMUST00000034973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007369"(gastrulation)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941855|reactome:R-MMU-9617828	go:"GO:0043565"(sequence-specific DNA binding)	-	-	figure legend:Fig. 2D|comment:The TGF-B-responsive regions of the Smad7 gene were sufficient to bind in this interaction.|agonist:"Transforming growth factor-beta (TGF-B)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/11/18	2014/10/16	-	rogid:47/62Iz3MOJAyDNCYtisL+unRDg10090	intact-crc:E3418B1C551652D8	false	-	phosphorylated residue:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:O60563	uniprotkb:P50750	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479667|imex:IM-12107-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	comment:Phosphorylation of Smad1, preferentially on Ser-206 and Ser-214 but also on Ser-186 and Ser-195|figure legend:Figs. 4C, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/18	2014/10/16	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:5C6233C73642C373|rigid:3JLCMrN/RqyS1CMFzorbDRVG8E8	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60563	uniprotkb:Q15797	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479667|imex:IM-12107-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0469"(intact)	-	-	comment:Phosphorylation of Smad1, preferentially on Ser-206 and Ser-214 but also on Ser-186 and Ser-195|figure legend:Figs. 4C, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/18	2014/10/16	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:5C6233C73642C373|rigid:3JLCMrN/RqyS1CMFzorbDRVG8E8	false	his tag:?-?	mutation:187-187,195-195,206-206,214-214	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24863	uniprotkb:P49336	intact:EBI-395261|uniprotkb:Q9H543|ensembl:ENSP00000428982|uniprotkb:B4DPZ1	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:ccnc_human(display_long)|uniprotkb:CCNC(gene name)|psi-mi:CCNC(display_short)|uniprotkb:SRB11 homolog(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479719|imex:IM-12107-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112237(gene)|ensembl:ENST00000520429(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028367|interpro:IPR036915|interpro:IPR043198|mint:P24863|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5FGK|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|refseq:NP_005181.2|refseq:NP_001013417.1|dip:DIP-32920N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0469"(intact)	-	-	comment:Phosphorylation of Smad1, preferentially on Ser-206 and Ser-214 but also on Ser-186 and Ser-195|figure legend:Figs. 4C, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/18	2014/10/16	rogid:Gu327q98H8ggQoYCb4UnR2Mcsyg9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:6AEC72F059E673FA|rigid:iPCZHmP/+uJapMjnykb5KlZWQ18	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24863	uniprotkb:Q15797	intact:EBI-395261|uniprotkb:Q9H543|ensembl:ENSP00000428982|uniprotkb:B4DPZ1	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:ccnc_human(display_long)|uniprotkb:CCNC(gene name)|psi-mi:CCNC(display_short)|uniprotkb:SRB11 homolog(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479719|imex:IM-12107-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112237(gene)|ensembl:ENST00000520429(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028367|interpro:IPR036915|interpro:IPR043198|mint:P24863|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5FGK|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|refseq:NP_005181.2|refseq:NP_001013417.1|dip:DIP-32920N	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0469"(intact)	-	-	comment:Phosphorylation of Smad1, preferentially on Ser-206 and Ser-214 but also on Ser-186 and Ser-195|figure legend:Figs. 4C, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/18	2014/10/16	rogid:Gu327q98H8ggQoYCb4UnR2Mcsyg9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:6AEC72F059E673FA|rigid:iPCZHmP/+uJapMjnykb5KlZWQ18	false	his tag:?-?	mutation:187-187,195-195,206-206,214-214	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60563	uniprotkb:P50750	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479735|imex:IM-12107-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	comment:Phosphorylation of Smad3, on Thr-179, Ser-208, and Ser-213 in|figure legend:Figs. 4C, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/18	2014/10/16	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:7E77517049CE3575|rigid:uMZqrfhBEzE9YmFASWLD8B3IdO8	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60563	uniprotkb:P84022	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479735|imex:IM-12107-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	psi-mi:"MI:0469"(intact)	-	-	comment:Phosphorylation of Smad3, on Thr-179, Ser-208, and Ser-213 in|figure legend:Figs. 4C, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/18	2014/10/16	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	intact-crc:7E77517049CE3575|rigid:uMZqrfhBEzE9YmFASWLD8B3IdO8	false	his tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:P49336	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2480569|imex:IM-12107-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2009/11/18	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:8C935E6B0B8623F9|rigid:VjpoB3bVy7bz6wr4srnbeQm/qx8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15797	uniprotkb:P46937	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-1044059|uniprotkb:Q7Z574|uniprotkb:Q8IUY9|ensembl:ENSP00000282441|intact:EBI-28992622|uniprotkb:B7ZA01|uniprotkb:E3WEB5|uniprotkb:E3WEB6|uniprotkb:E9PRV2|uniprotkb:F5H202|uniprotkb:K0KQ18|uniprotkb:K0KYZ8|uniprotkb:K0L195|uniprotkb:K0L1G3|uniprotkb:B4DTY1	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:yap1_human(display_long)|uniprotkb:YAP1(gene name)|psi-mi:YAP1(display_short)|uniprotkb:YAP65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479805|imex:IM-12107-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_001269026.1|ensembl:ENST00000282441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003015"(heart process)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|ensembl:ENSG00000137693(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035329"(hippo signaling)|go:"GO:0042060"(wound healing)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050847"(progesterone receptor signaling pathway)|refseq:NP_001123617.1|refseq:NP_001181973.1|refseq:NP_001181974.1|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140552"(TEAD-YAP complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|mint:P46937|rcsb pdb:1JMQ|rcsb pdb:1K5R|rcsb pdb:1K9Q|rcsb pdb:1K9R|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LTV|rcsb pdb:2LTW|rcsb pdb:3KYS|rcsb pdb:3MHR|rcsb pdb:4RE1|rcsb pdb:4REX|rcsb pdb:5OAQ|rcsb pdb:5YDX|rcsb pdb:5YDY|rcsb pdb:6G6X|rcsb pdb:6G8I|rcsb pdb:6G8J|rcsb pdb:6G8K|rcsb pdb:6G8L|rcsb pdb:6G8P|rcsb pdb:6G8Q|rcsb pdb:6GE3|rcsb pdb:6GE4|rcsb pdb:6GE5|rcsb pdb:6GE6|rcsb pdb:6GEC|rcsb pdb:6GEE|rcsb pdb:6GEG|go:"GO:0070064"(proline-rich region binding)|rcsb pdb:6GEI|rcsb pdb:6GEK|rcsb pdb:6HIK|rcsb pdb:6HIL|rcsb pdb:6Q2X|reactome:R-HSA-1251985|reactome:R-HSA-2028269|reactome:R-HSA-2032785|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-8951671|reactome:R-HSA-9619665|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060242"(contact inhibition)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0065003"(protein-containing complex assembly)|ensembl:ENSP00000282441|ensembl:ENST00000345877|ensembl:ENSP00000331023|ensembl:ENST00000524575|ensembl:ENSP00000435602|ensembl:ENST00000526343|refseq:NP_001269027.1|refseq:NP_001269028.1|refseq:NP_001269029.1|refseq:NP_001269030.1|ensembl:ENSP00000434134|ensembl:ENST00000531439|ensembl:ENSP00000431574|ensembl:ENSP00000487519|ensembl:ENST00000537274|ensembl:ENSP00000445635|ensembl:ENST00000615667|ensembl:ENSP00000478927|ensembl:ENST00000629586|dip:DIP-40839N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6E|comment:Reducing the SMAD1 peptide to 220-232 decreased the KD to 1.7E-5M. Phosphorylation of Ser-206 and Ser-214 increased the Kd to 7.7E-6M.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/18	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:bDNDhtCh5Qjdk1+PNM8Qb/340A09606	intact-crc:5C8118CA0AAB4F92|rigid:AJdBbDSAlUzDMb2ax/g2/4ZqUWY	false	sufficient binding region:200-232	sufficient binding region:165-217(IPR001202)|15n label:?-?|13c label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46937	uniprotkb:Q15797	intact:EBI-1044059|uniprotkb:Q7Z574|uniprotkb:Q8IUY9|ensembl:ENSP00000282441|intact:EBI-28992622|uniprotkb:B7ZA01|uniprotkb:E3WEB5|uniprotkb:E3WEB6|uniprotkb:E9PRV2|uniprotkb:F5H202|uniprotkb:K0KQ18|uniprotkb:K0KYZ8|uniprotkb:K0L195|uniprotkb:K0L1G3|uniprotkb:B4DTY1	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:yap1_human(display_long)|uniprotkb:YAP1(gene name)|psi-mi:YAP1(display_short)|uniprotkb:YAP65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479763|imex:IM-12107-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269026.1|ensembl:ENST00000282441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003015"(heart process)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|ensembl:ENSG00000137693(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035329"(hippo signaling)|go:"GO:0042060"(wound healing)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050847"(progesterone receptor signaling pathway)|refseq:NP_001123617.1|refseq:NP_001181973.1|refseq:NP_001181974.1|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140552"(TEAD-YAP complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|mint:P46937|rcsb pdb:1JMQ|rcsb pdb:1K5R|rcsb pdb:1K9Q|rcsb pdb:1K9R|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LTV|rcsb pdb:2LTW|rcsb pdb:3KYS|rcsb pdb:3MHR|rcsb pdb:4RE1|rcsb pdb:4REX|rcsb pdb:5OAQ|rcsb pdb:5YDX|rcsb pdb:5YDY|rcsb pdb:6G6X|rcsb pdb:6G8I|rcsb pdb:6G8J|rcsb pdb:6G8K|rcsb pdb:6G8L|rcsb pdb:6G8P|rcsb pdb:6G8Q|rcsb pdb:6GE3|rcsb pdb:6GE4|rcsb pdb:6GE5|rcsb pdb:6GE6|rcsb pdb:6GEC|rcsb pdb:6GEE|rcsb pdb:6GEG|go:"GO:0070064"(proline-rich region binding)|rcsb pdb:6GEI|rcsb pdb:6GEK|rcsb pdb:6HIK|rcsb pdb:6HIL|rcsb pdb:6Q2X|reactome:R-HSA-1251985|reactome:R-HSA-2028269|reactome:R-HSA-2032785|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-8951671|reactome:R-HSA-9619665|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060242"(contact inhibition)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0065003"(protein-containing complex assembly)|ensembl:ENSP00000282441|ensembl:ENST00000345877|ensembl:ENSP00000331023|ensembl:ENST00000524575|ensembl:ENSP00000435602|ensembl:ENST00000526343|refseq:NP_001269027.1|refseq:NP_001269028.1|refseq:NP_001269029.1|refseq:NP_001269030.1|ensembl:ENSP00000434134|ensembl:ENST00000531439|ensembl:ENSP00000431574|ensembl:ENSP00000487519|ensembl:ENST00000537274|ensembl:ENSP00000445635|ensembl:ENST00000615667|ensembl:ENSP00000478927|ensembl:ENST00000629586|dip:DIP-40839N	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6C, Supp. Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/18	2014/10/16	rogid:bDNDhtCh5Qjdk1+PNM8Qb/340A09606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:B3696611D387227E|rigid:AJdBbDSAlUzDMb2ax/g2/4ZqUWY	false	-	flag tag:?-?|mutation decreasing interaction:187-187,214-214,195-195,206-206	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15797	uniprotkb:P46937	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-1044059|uniprotkb:Q7Z574|uniprotkb:Q8IUY9|ensembl:ENSP00000282441|intact:EBI-28992622|uniprotkb:B7ZA01|uniprotkb:E3WEB5|uniprotkb:E3WEB6|uniprotkb:E9PRV2|uniprotkb:F5H202|uniprotkb:K0KQ18|uniprotkb:K0KYZ8|uniprotkb:K0L195|uniprotkb:K0L1G3|uniprotkb:B4DTY1	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:yap1_human(display_long)|uniprotkb:YAP1(gene name)|psi-mi:YAP1(display_short)|uniprotkb:YAP65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479775|imex:IM-12107-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_001269026.1|ensembl:ENST00000282441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003015"(heart process)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|ensembl:ENSG00000137693(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035329"(hippo signaling)|go:"GO:0042060"(wound healing)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050847"(progesterone receptor signaling pathway)|refseq:NP_001123617.1|refseq:NP_001181973.1|refseq:NP_001181974.1|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140552"(TEAD-YAP complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|mint:P46937|rcsb pdb:1JMQ|rcsb pdb:1K5R|rcsb pdb:1K9Q|rcsb pdb:1K9R|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LTV|rcsb pdb:2LTW|rcsb pdb:3KYS|rcsb pdb:3MHR|rcsb pdb:4RE1|rcsb pdb:4REX|rcsb pdb:5OAQ|rcsb pdb:5YDX|rcsb pdb:5YDY|rcsb pdb:6G6X|rcsb pdb:6G8I|rcsb pdb:6G8J|rcsb pdb:6G8K|rcsb pdb:6G8L|rcsb pdb:6G8P|rcsb pdb:6G8Q|rcsb pdb:6GE3|rcsb pdb:6GE4|rcsb pdb:6GE5|rcsb pdb:6GE6|rcsb pdb:6GEC|rcsb pdb:6GEE|rcsb pdb:6GEG|go:"GO:0070064"(proline-rich region binding)|rcsb pdb:6GEI|rcsb pdb:6GEK|rcsb pdb:6HIK|rcsb pdb:6HIL|rcsb pdb:6Q2X|reactome:R-HSA-1251985|reactome:R-HSA-2028269|reactome:R-HSA-2032785|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-8951671|reactome:R-HSA-9619665|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060242"(contact inhibition)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0065003"(protein-containing complex assembly)|ensembl:ENSP00000282441|ensembl:ENST00000345877|ensembl:ENSP00000331023|ensembl:ENST00000524575|ensembl:ENSP00000435602|ensembl:ENST00000526343|refseq:NP_001269027.1|refseq:NP_001269028.1|refseq:NP_001269029.1|refseq:NP_001269030.1|ensembl:ENSP00000434134|ensembl:ENST00000531439|ensembl:ENSP00000431574|ensembl:ENSP00000487519|ensembl:ENST00000537274|ensembl:ENSP00000445635|ensembl:ENST00000615667|ensembl:ENSP00000478927|ensembl:ENST00000629586|dip:DIP-40839N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6D|antagonist:Flavopiridol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/18	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:bDNDhtCh5Qjdk1+PNM8Qb/340A09606	intact-crc:63BD3C282741AF56|rigid:AJdBbDSAlUzDMb2ax/g2/4ZqUWY	false	flag tag:?-?|O-phospho-L-serine:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15797	uniprotkb:Q9HCE7	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2479787|imex:IM-12107-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6D|antagonist:Flavopiridol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/18	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:F392640DE74291BB|rigid:cVmnwLy7i7DlWLgwOGYxIE7Ye1Q	false	flag tag:?-?|O-phospho-L-serine:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q45VV3	uniprotkb:P42003	intact:EBI-141254|uniprotkb:Q9W1B6|uniprotkb:A2RVH0|uniprotkb:A2RVH4|uniprotkb:Q0E8X1|uniprotkb:Q7KVG6|ensemblmetazoa:FBpp0288697|ensemblmetazoa:FBpp0301274|intact:EBI-2480586|uniprotkb:Q95TU5	intact:EBI-162238|uniprotkb:Q9VQM3|ensemblmetazoa:FBpp0077302	psi-mi:yap1_drome(display_long)|uniprotkb:yki(gene name)|psi-mi:yki(display_short)|uniprotkb:Protein yorkie(gene name synonym)|uniprotkb:Transcriptional coactivator YAP1 homolog(gene name synonym)|uniprotkb:CG4005(orf name)	psi-mi:mad_drome(display_long)|uniprotkb:Mad(gene name)|psi-mi:Mad(display_short)|uniprotkb:CG12399(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2480582|imex:IM-12107-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036568.2|refseq:NP_611879.4|flybase:FBgn0034970|ensemblmetazoa:FBgn0034970(gene)|ensemblmetazoa:FBtr0290258(transcript)|ensemblmetazoa:FBtr0309372(transcript)|go:"GO:0001708"(cell fate specification)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035329"(hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0120081"(obsolete positive regulation of microfilament motor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1905437"(positive regulation of histone H3-K4 trimethylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|reactome:R-DME-1251985|reactome:R-DME-2028269|reactome:R-DME-2032785|reactome:R-DME-2173796|reactome:R-DME-390098|reactome:R-DME-390193|reactome:R-DME-451806|reactome:R-DME-8939236|reactome:R-DME-8951671|refseq:NP_726414.3	refseq:NP_477017.1|flybase:FBgn0011648|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007419"(ventral cord development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007560"(imaginal disc morphogenesis)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009653"(anatomical structure morphogenesis)|ensemblmetazoa:FBgn0011648(gene)|ensemblmetazoa:FBtr0077616(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035290"(trunk segmentation)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:3DIT|reactome:R-DME-201451|reactome:R-DME-8941326|rcsb pdb:3GMJ|dip:DIP-18256N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2009/11/18	2014/10/16	rogid:XRXB3wMsUcluStu33RaFw7JVf1k7227	rogid:WIV5vzeVJTr8sKiZNxHA9qmPahE7227	intact-crc:5FA44B06C5616C14|rigid:dK08h/ZZtdFplkDFOT7kz68Vf+s	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42003	uniprotkb:Q45VV3	intact:EBI-162238|uniprotkb:Q9VQM3|ensemblmetazoa:FBpp0077302	intact:EBI-141254|uniprotkb:Q9W1B6|uniprotkb:A2RVH0|uniprotkb:A2RVH4|uniprotkb:Q0E8X1|uniprotkb:Q7KVG6|ensemblmetazoa:FBpp0288697|ensemblmetazoa:FBpp0301274|intact:EBI-2480586|uniprotkb:Q95TU5	psi-mi:mad_drome(display_long)|uniprotkb:Mad(gene name)|psi-mi:Mad(display_short)|uniprotkb:CG12399(orf name)	psi-mi:yap1_drome(display_long)|uniprotkb:yki(gene name)|psi-mi:yki(display_short)|uniprotkb:Protein yorkie(gene name synonym)|uniprotkb:Transcriptional coactivator YAP1 homolog(gene name synonym)|uniprotkb:CG4005(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2480601|imex:IM-12107-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477017.1|flybase:FBgn0011648|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007419"(ventral cord development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007560"(imaginal disc morphogenesis)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009653"(anatomical structure morphogenesis)|ensemblmetazoa:FBgn0011648(gene)|ensemblmetazoa:FBtr0077616(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035290"(trunk segmentation)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:3DIT|reactome:R-DME-201451|reactome:R-DME-8941326|rcsb pdb:3GMJ|dip:DIP-18256N	refseq:NP_001036568.2|refseq:NP_611879.4|flybase:FBgn0034970|ensemblmetazoa:FBgn0034970(gene)|ensemblmetazoa:FBtr0290258(transcript)|ensemblmetazoa:FBtr0309372(transcript)|go:"GO:0001708"(cell fate specification)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035329"(hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0120081"(obsolete positive regulation of microfilament motor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1905437"(positive regulation of histone H3-K4 trimethylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|reactome:R-DME-1251985|reactome:R-DME-2028269|reactome:R-DME-2032785|reactome:R-DME-2173796|reactome:R-DME-390098|reactome:R-DME-390193|reactome:R-DME-451806|reactome:R-DME-8939236|reactome:R-DME-8951671|refseq:NP_726414.3	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6G, 6H|comment:Interaction not observed with a MAD linker mutant or with a Yorkie WW domain mutant - details of the mutants not given.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2009/11/18	2014/10/16	rogid:WIV5vzeVJTr8sKiZNxHA9qmPahE7227	rogid:XRXB3wMsUcluStu33RaFw7JVf1k7227	intact-crc:B80FA6E2F4BC5813|rigid:dK08h/ZZtdFplkDFOT7kz68Vf+s	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
ensembl:ENSMUSG00000042745	uniprotkb:P46938	intact:EBI-2479621	intact:EBI-1211949|uniprotkb:Q91WL1|uniprotkb:Q52KJ5|ensembl:ENSMUSP00000069554	psi-mi:id1_mouse_gene(display_short)|psi-mi:ENSMUSG00000042745(display_long)	psi-mi:yap1_mouse(display_long)|uniprotkb:Yap1(gene name)|psi-mi:Yap1(display_short)|uniprotkb:Yap(gene name synonym)|uniprotkb:Yap65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2480617|imex:IM-12107-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001164618.1|refseq:NP_033560.1|dip:DIP-40015N|ensembl:ENSMUSG00000053110(gene)|ensembl:ENSMUST00000065353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003015"(heart process)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060242"(contact inhibition)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140552"(TEAD-YAP complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|mint:P46938|rcsb pdb:3JUA|rcsb pdb:6JK0|rcsb pdb:6JK1|reactome:R-MMU-1251985|reactome:R-MMU-2028269|reactome:R-MMU-2032785|reactome:R-MMU-8939236|reactome:R-MMU-8951671|go:"GO:0035329"(hippo signaling)	go:"GO:0043565"(sequence-specific DNA binding)	-	-	figure legend:Fig. 7A|comment:The BMP-responsive regions of the Id1 gene were sufficient to bind in this interaction.|agonist:"Bone morphogenetic protein (BMP)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/11/18	2014/10/16	-	rogid:3HcM3+sEb7cqRcBxi3jCxXRjT1810090	intact-crc:12E16F9A0FEB1B7B	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P46938	ensembl:ENSMUSG00000020644	intact:EBI-1211949|uniprotkb:Q91WL1|uniprotkb:Q52KJ5|ensembl:ENSMUSP00000069554	intact:EBI-2480625	psi-mi:yap1_mouse(display_long)|uniprotkb:Yap1(gene name)|psi-mi:Yap1(display_short)|uniprotkb:Yap(gene name synonym)|uniprotkb:Yap65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym)	psi-mi:id2_mouse_gene(display_short)|psi-mi:ENSMUSG00000020644(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Alarcon et al. (2009)	imex:IM-12107|pubmed:19914168	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2480627|imex:IM-12107-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001164618.1|refseq:NP_033560.1|dip:DIP-40015N|ensembl:ENSMUSG00000053110(gene)|ensembl:ENSMUST00000065353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003015"(heart process)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060242"(contact inhibition)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140552"(TEAD-YAP complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|mint:P46938|rcsb pdb:3JUA|rcsb pdb:6JK0|rcsb pdb:6JK1|reactome:R-MMU-1251985|reactome:R-MMU-2028269|reactome:R-MMU-2032785|reactome:R-MMU-8939236|reactome:R-MMU-8951671|go:"GO:0035329"(hippo signaling)	-	go:"GO:0043565"(sequence-specific DNA binding)	-	-	figure legend:Fig. 7A|comment:The BMP-responsive regions of the Id1 gene were sufficient to bind in this interaction.|agonist:"Bone morphogenetic protein (BMP)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/11/18	2014/10/16	rogid:3HcM3+sEb7cqRcBxi3jCxXRjT1810090	-	intact-crc:7C66349AC2936DF5	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)