#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q02539	uniprotkb:Q57V41	intact:EBI-932603|uniprotkb:Q3MJ34|ensembl:ENSP00000244573	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	psi-mi:h11_human(display_long)|uniprotkb:H1-1(gene name)|psi-mi:H1-1(display_short)|uniprotkb:H1F1(gene name synonym)|uniprotkb:HIST1H1A(gene name synonym)|uniprotkb:Histone H1a(gene name synonym)	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7579992|mint:MINT-7288298	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005316.1|ensembl:ENSG00000124610(gene)|ensembl:ENST00000244573(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q02539|reactome:R-HSA-140342|reactome:R-HSA-2559584|mint:MINT-7288301(identity)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288300(identity)	-	-	comment:mint	figure legend:F1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:4u8P8jFM3onWx43+SxL320urjhk9606	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	intact-crc:35DC965EA572D20C|rigid:pJCxJnCFV0NIX6shdZXNmonjvaA	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02253	uniprotkb:Q57V41	intact:EBI-7580031|intact:MINT-1519695|uniprotkb:A3KN02	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	psi-mi:h12_bovin(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:CTL-1(gene name synonym)	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580027|mint:MINT-7288305	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P02253|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|refseq:NP_001076894.1|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR036390|mint:MINT-7288307(identity)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288308(identity)	-	comment:"fragmentation type: fragment"|function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures|comment:mint	comment:mint	figure legend:F2B F2C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:tdmuvsh52s5dv/Cf7gxN1QVoS5A9913	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	intact-crc:A76F5F1590328B8C|rigid:1BYPJ/8ge1WJBZLJtuPQPTjYz98	false	mutation decreasing interaction:32-32(MINT-7288315)|binding-associated region:24-36(MINT-7288313)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q57V41	uniprotkb:P02253	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	intact:EBI-7580031|intact:MINT-1519695|uniprotkb:A3KN02	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:h12_bovin(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:CTL-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580082|mint:MINT-7288325	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288327(identity)	mint:P02253|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|refseq:NP_001076894.1|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR036390|mint:MINT-7288329(identity)	-	comment:mint	comment:"fragmentation type: fragment"|function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures|comment:mint	figure legend:F2B F2C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	rogid:tdmuvsh52s5dv/Cf7gxN1QVoS5A9913	intact-crc:D7CEE5905B066FC9|rigid:1BYPJ/8ge1WJBZLJtuPQPTjYz98	false	-	binding-associated region:24-36(MINT-7288332)|mutation decreasing interaction:33-33(MINT-7288330)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P02253	uniprotkb:Q57V41	intact:EBI-7580031|intact:MINT-1519695|uniprotkb:A3KN02	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	psi-mi:h12_bovin(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:CTL-1(gene name synonym)	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580120|mint:MINT-7288352	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P02253|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|refseq:NP_001076894.1|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR036390|mint:MINT-7288356(identity)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288354(identity)	-	comment:"fragmentation type: fragment"|function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures|comment:mint	comment:mint	figure legend:F2B|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:tdmuvsh52s5dv/Cf7gxN1QVoS5A9913	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	intact-crc:4549A15D61BCB350|rigid:1BYPJ/8ge1WJBZLJtuPQPTjYz98	false	binding-associated region:78-90(MINT-7288361)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q57V41	uniprotkb:P02253	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	intact:EBI-7580031|intact:MINT-1519695|uniprotkb:A3KN02	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:h12_bovin(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:CTL-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580099|mint:MINT-7288338	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288346(identity)	mint:P02253|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|refseq:NP_001076894.1|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR036390|mint:MINT-7288340(identity)	-	comment:mint	comment:"fragmentation type: fragment"|function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures|comment:mint	figure legend:F2B F2C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	rogid:tdmuvsh52s5dv/Cf7gxN1QVoS5A9913	intact-crc:97F768642C28B949|rigid:1BYPJ/8ge1WJBZLJtuPQPTjYz98	false	-	mutation disrupting interaction:32-32(MINT-7288349)|binding-associated region:24-36(MINT-7288341)|mutation disrupting interaction:33-33(MINT-7288343)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q57V41	uniprotkb:P02253	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	intact:EBI-7580031|intact:MINT-1519695|uniprotkb:A3KN02	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:h12_bovin(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:CTL-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580176|mint:MINT-7288412	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288418(identity)	mint:P02253|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|refseq:NP_001076894.1|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR036390|mint:MINT-7288414(identity)	-	comment:mint	comment:"fragmentation type: fragment"|function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures|comment:mint	figure legend:F3|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	rogid:tdmuvsh52s5dv/Cf7gxN1QVoS5A9913	intact-crc:48A36FE6276907D6|rigid:1BYPJ/8ge1WJBZLJtuPQPTjYz98	false	-	binding-associated region:78-90(MINT-7288415)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P02253	uniprotkb:Q57V41	intact:EBI-7580031|intact:MINT-1519695|uniprotkb:A3KN02	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	psi-mi:h12_bovin(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:CTL-1(gene name synonym)	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580163|mint:MINT-7288395	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P02253|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|refseq:NP_001076894.1|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR036390|mint:MINT-7288399(identity)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288397(identity)	-	comment:"fragmentation type: fragment"|function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures|comment:mint	comment:mint	figure legend:F3|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:tdmuvsh52s5dv/Cf7gxN1QVoS5A9913	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	intact-crc:3DB2E7BF6304B7BC|rigid:1BYPJ/8ge1WJBZLJtuPQPTjYz98	false	binding-associated region:24-36(MINT-7288402)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q57V41	uniprotkb:P02253	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	intact:EBI-7580031|intact:MINT-1519695|uniprotkb:A3KN02	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:h12_bovin(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:CTL-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580150|mint:MINT-7288370	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288376(identity)	mint:P02253|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|refseq:NP_001076894.1|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR036390|mint:MINT-7288372(identity)	-	comment:mint	comment:"fragmentation type: fragment"|function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures|comment:mint	figure legend:F2B|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	rogid:tdmuvsh52s5dv/Cf7gxN1QVoS5A9913	intact-crc:D8C0EF2ACEC36FE4|rigid:1BYPJ/8ge1WJBZLJtuPQPTjYz98	false	-	binding-associated region:80-92(MINT-7288373)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q02539	uniprotkb:P54922	intact:EBI-932603|uniprotkb:Q3MJ34|ensembl:ENSP00000244573	intact:EBI-6657604|ensembl:ENSP00000349496|ensembl:ENSP00000417430|ensembl:ENSP00000417528|ensembl:ENSP00000420200|uniprotkb:D3DN83|uniprotkb:B2R8H1	psi-mi:h11_human(display_long)|uniprotkb:H1-1(gene name)|psi-mi:H1-1(display_short)|uniprotkb:H1F1(gene name synonym)|uniprotkb:HIST1H1A(gene name synonym)|uniprotkb:Histone H1a(gene name synonym)	psi-mi:adprh_human(display_long)|uniprotkb:ADPRH(gene name)|psi-mi:ADPRH(display_short)|uniprotkb:ADP-ribose-L-arginine cleaving enzyme(gene name synonym)|uniprotkb:ARH1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580189|mint:MINT-7288424	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005316.1|ensembl:ENSG00000124610(gene)|ensembl:ENST00000244573(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q02539|reactome:R-HSA-140342|reactome:R-HSA-2559584|mint:MINT-7288428(identity)	ensembl:ENSG00000144843(gene)|ensembl:ENST00000357003(transcript)|ensembl:ENST00000465513(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|ensembl:ENST00000478399(transcript)|ensembl:ENST00000478927(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030955"(potassium ion binding)|go:"GO:0051725"(protein de-ADP-ribosylation)|go:"GO:0055037"(recycling endosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000785"(regulation of autophagosome assembly)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR005502(ADP-ribosylation/Crystallin J1)|interpro:IPR012108(ADP-ribosylarginine hydrolase)|interpro:IPR036705|mint:P54922|rcsb pdb:3HFW|rcsb pdb:6G28|rcsb pdb:6G2A|rcsb pdb:6IUX|go:"GO:0003875"(ADP-ribosylarginine hydrolase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005776"(autophagosome)|refseq:XP_011510740.1|refseq:NP_001116.1|refseq:NP_001278878.1|refseq:NP_001278879.1|mint:MINT-7288426(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:4u8P8jFM3onWx43+SxL320urjhk9606	rogid:PvSVGCVKSKQgGeX9uynsWqZI7xc9606	intact-crc:7FA54AFD804978D0|rigid:PSdMGBd99+EAyC0P2fkw7eT29tk	false	-	glutathione s tranferase tag:?-?(MINT-7288447)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02539	uniprotkb:Q57V41	intact:EBI-932603|uniprotkb:Q3MJ34|ensembl:ENSP00000244573	intact:EBI-7579996|intact:MINT-7288287|uniprotkb:D6XK87|uniprotkb:O96670	psi-mi:h11_human(display_long)|uniprotkb:H1-1(gene name)|psi-mi:H1-1(display_short)|uniprotkb:H1F1(gene name synonym)|uniprotkb:HIST1H1A(gene name synonym)|uniprotkb:Histone H1a(gene name synonym)	psi-mi:sir2_tryb2(display_long)|uniprotkb:SIR2rp1(gene name)|psi-mi:SIR2rp1(display_short)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)|uniprotkb:SIR2(gene name synonym)|uniprotkb:SIR2-related protein 1(gene name synonym)|uniprotkb:Tb927.7.1690(orf name)	psi-mi:"MI:0406"(deacetylase assay)	Fahie et al. (2009)	pubmed:19895577|mint:MINT-7288282|doi:10.1111/j.1742-4658.2009.07427	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)")	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7580240|mint:MINT-7288385	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005316.1|ensembl:ENSG00000124610(gene)|ensembl:ENST00000244573(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q02539|reactome:R-HSA-140342|reactome:R-HSA-2559584|mint:MINT-7288389(identity)	mint:Q57V41|interpro:IPR026591|interpro:IPR026590|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|refseq:XP_845793.1|interpro:IPR029035|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0070403"(NAD+ binding)|mint:MINT-7288387(identity)	-	-	comment:mint	figure legend:SF2C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/06	2014/10/16	rogid:4u8P8jFM3onWx43+SxL320urjhk9606	rogid:6l3JiymkkqyTrkgmhk47yuZFexY185431	intact-crc:34638CDA8DAD4966|rigid:pJCxJnCFV0NIX6shdZXNmonjvaA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)