#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14635	uniprotkb:O95067	intact:EBI-495332|uniprotkb:A8K066|uniprotkb:Q5TZP9|ensembl:ENSP00000256442	intact:EBI-375024|uniprotkb:Q6FI99|uniprotkb:B3KM93|ensembl:ENSP00000288207	psi-mi:ccnb1_human(display_long)|uniprotkb:CCNB1(gene name)|psi-mi:CCNB1(display_short)|uniprotkb:CCNB(gene name synonym)	psi-mi:ccnb2_human(display_long)|uniprotkb:CCNB2(gene name)|psi-mi:CCNB2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476819|imex:IM-12101-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114172.1|dip:DIP-59N|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046680"(response to DDT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048565"(digestive tract development)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060623"(regulation of chromosome condensation)|ensembl:ENSG00000134057(gene)|ensembl:ENST00000256442(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|go:"GO:2000775"(obsolete histone H3-S10 phosphorylation involved in chromosome condensation)|interpro:IPR004367(Cyclin, C-terminal)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071283"("cellular response to iron(III) ion")|interpro:IPR039361|mint:P14635|rcsb pdb:2B9R|rcsb pdb:2JGZ|rcsb pdb:4Y72|rcsb pdb:4YC3|go:"GO:0071398"(cellular response to fatty acid)|rcsb pdb:5HQ0|go:"GO:0071407"(cellular response to organic cyclic compound)|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|reactome:R-HSA-113507|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174048|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|go:"GO:0071456"(cellular response to hypoxia)|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-4419969|reactome:R-HSA-6804114|reactome:R-HSA-68875|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8878166|reactome:R-HSA-8852276	refseq:NP_004692.1|ensembl:ENSG00000157456(gene)|ensembl:ENST00000288207(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040008"(regulation of growth)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045296"(cadherin binding)|go:"GO:0048538"(thymus development)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|mint:O95067|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-8852276|dip:DIP-31730N	go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:WCQWqI2kWZfatq4L2DC0hm26Ix09606	rogid:7ztz22HOOgNq/6KO1iXhGT3tb+A9606	intact-crc:F6B12A5FFB900CF8|rigid:M99ipe+O4yxB5v8WOICj9f8xe1c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14635	uniprotkb:P06493	intact:EBI-495332|uniprotkb:A8K066|uniprotkb:Q5TZP9|ensembl:ENSP00000256442	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:ccnb1_human(display_long)|uniprotkb:CCNB1(gene name)|psi-mi:CCNB1(display_short)|uniprotkb:CCNB(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476819|imex:IM-12101-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114172.1|dip:DIP-59N|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046680"(response to DDT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048565"(digestive tract development)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060623"(regulation of chromosome condensation)|ensembl:ENSG00000134057(gene)|ensembl:ENST00000256442(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|go:"GO:2000775"(obsolete histone H3-S10 phosphorylation involved in chromosome condensation)|interpro:IPR004367(Cyclin, C-terminal)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071283"("cellular response to iron(III) ion")|interpro:IPR039361|mint:P14635|rcsb pdb:2B9R|rcsb pdb:2JGZ|rcsb pdb:4Y72|rcsb pdb:4YC3|go:"GO:0071398"(cellular response to fatty acid)|rcsb pdb:5HQ0|go:"GO:0071407"(cellular response to organic cyclic compound)|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|reactome:R-HSA-113507|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174048|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|go:"GO:0071456"(cellular response to hypoxia)|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-4419969|reactome:R-HSA-6804114|reactome:R-HSA-68875|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8878166|reactome:R-HSA-8852276	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:WCQWqI2kWZfatq4L2DC0hm26Ix09606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:F6B12A5FFB900CF8|rigid:M99ipe+O4yxB5v8WOICj9f8xe1c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14635	uniprotkb:Q9XTF3-2	intact:EBI-495332|uniprotkb:A8K066|uniprotkb:Q5TZP9|ensembl:ENSP00000256442	intact:EBI-2565597|ensemblmetazoa:F49E11.1a.1	psi-mi:ccnb1_human(display_long)|uniprotkb:CCNB1(gene name)|psi-mi:CCNB1(display_short)|uniprotkb:CCNB(gene name synonym)	psi-mi:q9xtf3-2(display_long)|uniprotkb:mbk-2(gene name)|psi-mi:mbk-2(display_short)|uniprotkb:Dual specificity Yak1-related kinase mbk-2(gene name synonym)|uniprotkb:Minibrain Kinase 2(gene name synonym)|uniprotkb:F49E11.1(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476819|imex:IM-12101-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114172.1|dip:DIP-59N|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046680"(response to DDT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048565"(digestive tract development)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060623"(regulation of chromosome condensation)|ensembl:ENSG00000134057(gene)|ensembl:ENST00000256442(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|go:"GO:2000775"(obsolete histone H3-S10 phosphorylation involved in chromosome condensation)|interpro:IPR004367(Cyclin, C-terminal)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071283"("cellular response to iron(III) ion")|interpro:IPR039361|mint:P14635|rcsb pdb:2B9R|rcsb pdb:2JGZ|rcsb pdb:4Y72|rcsb pdb:4YC3|go:"GO:0071398"(cellular response to fatty acid)|rcsb pdb:5HQ0|go:"GO:0071407"(cellular response to organic cyclic compound)|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|reactome:R-HSA-113507|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174048|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|go:"GO:0071456"(cellular response to hypoxia)|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-4419969|reactome:R-HSA-6804114|reactome:R-HSA-68875|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8878166|reactome:R-HSA-8852276	intact:EBI-2005616(isoform-parent)|ensemblmetazoa:F49E11.1a.1(transcript)|ensemblmetazoa:WBGene00003150(gene)	go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:WCQWqI2kWZfatq4L2DC0hm26Ix09606	rogid:xcoYiiIBLgNVj1TBjkcDayzPG+M6239	intact-crc:F6B12A5FFB900CF8|rigid:M99ipe+O4yxB5v8WOICj9f8xe1c	false	-	maltose binding protein tag:?-?|mutation:196-196	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XTF3-2	uniprotkb:P34808	intact:EBI-2565597|ensemblmetazoa:F49E11.1a.1	intact:EBI-323248|intact:EBI-521368|uniprotkb:Q8I4G6|ensemblmetazoa:T01G9.5a.1	psi-mi:q9xtf3-2(display_long)|uniprotkb:mbk-2(gene name)|psi-mi:mbk-2(display_short)|uniprotkb:Dual specificity Yak1-related kinase mbk-2(gene name synonym)|uniprotkb:Minibrain Kinase 2(gene name synonym)|uniprotkb:F49E11.1(orf name)	psi-mi:ktna1_caeel(display_long)|uniprotkb:mei-1(gene name)|psi-mi:mei-1(display_short)|uniprotkb:Katanin p60 ATPase-containing subunit A1(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)|uniprotkb:T01G9.5(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476831|imex:IM-12101-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2005616(isoform-parent)|ensemblmetazoa:F49E11.1a.1(transcript)|ensemblmetazoa:WBGene00003150(gene)	refseq:NP_492257.1|refseq:NP_871793.1|wormbase:T01G9.5a|wormbase:T01G9.5b|ensemblmetazoa:T01G9.5a.1(transcript)|ensemblmetazoa:WBGene00003183(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000785"(chromatin)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0051013"(microtubule severing)|go:"GO:0051229"(meiotic spindle disassembly)|go:"GO:0051301"(cell division)|go:"GO:0005813"(centrosome)|go:"GO:0071688"(striated muscle myosin thick filament assembly)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090619"(meiotic spindle pole)|go:"GO:0090736"(MATH domain binding)|go:"GO:1902120"(negative regulation of meiotic spindle elongation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR028596|interpro:IPR041569|rcsb pdb:5WC0|rcsb pdb:5WC1|rcsb pdb:5WCB|rcsb pdb:6B5D|go:"GO:0005819"(spindle)|rcsb pdb:6UGD|rcsb pdb:6UGE|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|rcsb pdb:6UGF|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016853"(isomerase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|dip:DIP-25343N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 3A|resulting-ptm:Phosphorylation of mei-1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:xcoYiiIBLgNVj1TBjkcDayzPG+M6239	rogid:W8dzUByepgfcMfSsWiLQdK+/pus6239	intact-crc:38456229D8DB5FBE|rigid:OzaTwR42gorpZrx3ynTkT02AwK8	false	glutathione s tranferase tag:?-?|mutation:68-68|mutation:68-68	sufficient binding region:51-150|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XTF3-2	uniprotkb:P34808	intact:EBI-2565597|ensemblmetazoa:F49E11.1a.1	intact:EBI-323248|intact:EBI-521368|uniprotkb:Q8I4G6|ensemblmetazoa:T01G9.5a.1	psi-mi:q9xtf3-2(display_long)|uniprotkb:mbk-2(gene name)|psi-mi:mbk-2(display_short)|uniprotkb:Dual specificity Yak1-related kinase mbk-2(gene name synonym)|uniprotkb:Minibrain Kinase 2(gene name synonym)|uniprotkb:F49E11.1(orf name)	psi-mi:ktna1_caeel(display_long)|uniprotkb:mei-1(gene name)|psi-mi:mei-1(display_short)|uniprotkb:Katanin p60 ATPase-containing subunit A1(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)|uniprotkb:T01G9.5(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476852|imex:IM-12101-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2005616(isoform-parent)|ensemblmetazoa:F49E11.1a.1(transcript)|ensemblmetazoa:WBGene00003150(gene)	refseq:NP_492257.1|refseq:NP_871793.1|wormbase:T01G9.5a|wormbase:T01G9.5b|ensemblmetazoa:T01G9.5a.1(transcript)|ensemblmetazoa:WBGene00003183(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000785"(chromatin)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0051013"(microtubule severing)|go:"GO:0051229"(meiotic spindle disassembly)|go:"GO:0051301"(cell division)|go:"GO:0005813"(centrosome)|go:"GO:0071688"(striated muscle myosin thick filament assembly)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090619"(meiotic spindle pole)|go:"GO:0090736"(MATH domain binding)|go:"GO:1902120"(negative regulation of meiotic spindle elongation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR028596|interpro:IPR041569|rcsb pdb:5WC0|rcsb pdb:5WC1|rcsb pdb:5WCB|rcsb pdb:6B5D|go:"GO:0005819"(spindle)|rcsb pdb:6UGD|rcsb pdb:6UGE|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|rcsb pdb:6UGF|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016853"(isomerase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|dip:DIP-25343N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:xcoYiiIBLgNVj1TBjkcDayzPG+M6239	rogid:W8dzUByepgfcMfSsWiLQdK+/pus6239	intact-crc:C9665FF87370B0D8|rigid:OzaTwR42gorpZrx3ynTkT02AwK8	false	mutation:196-196|flag tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:51-150	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XTF3-2	uniprotkb:Q20402	intact:EBI-2565597|ensemblmetazoa:F49E11.1a.1	intact:EBI-2476895|ensemblmetazoa:F44F4.2.1|ensemblmetazoa:F44F4.2.2	psi-mi:q9xtf3-2(display_long)|uniprotkb:mbk-2(gene name)|psi-mi:mbk-2(display_short)|uniprotkb:Dual specificity Yak1-related kinase mbk-2(gene name synonym)|uniprotkb:Minibrain Kinase 2(gene name synonym)|uniprotkb:F49E11.1(orf name)	psi-mi:egg3_caeel(display_long)|uniprotkb:egg-3(gene name)|psi-mi:egg-3(display_short)|uniprotkb:Egg sterile protein 3(gene name synonym)|uniprotkb:F44F4.2(orf name)	psi-mi:"MI:0096"(pull down)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476880|imex:IM-12101-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2005616(isoform-parent)|ensemblmetazoa:F49E11.1a.1(transcript)|ensemblmetazoa:WBGene00003150(gene)	go:"GO:0030703"(eggshell formation)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|ensemblmetazoa:F44F4.2.1(transcript)|ensemblmetazoa:F44F4.2.2(transcript)|ensemblmetazoa:WBGene00009701(gene)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005938"(cell cortex)|go:"GO:0019901"(protein kinase binding)|interpro:IPR029021|refseq:NP_496341.1|wormbase:F44F4.2|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:xcoYiiIBLgNVj1TBjkcDayzPG+M6239	rogid:LZSWtgn56eXltr+itq6Y8ABnCgU6239	intact-crc:CF2F50B3349249B7|rigid:NJYB0JwuYX3hrJicQKxPKGwnhjg	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9XTF3-2	uniprotkb:O01767	intact:EBI-2565597|ensemblmetazoa:F49E11.1a.1	intact:EBI-2476926|ensemblmetazoa:T21E3.1.1	psi-mi:q9xtf3-2(display_long)|uniprotkb:mbk-2(gene name)|psi-mi:mbk-2(display_short)|uniprotkb:Dual specificity Yak1-related kinase mbk-2(gene name synonym)|uniprotkb:Minibrain Kinase 2(gene name synonym)|uniprotkb:F49E11.1(orf name)	psi-mi:egg4_caeel(display_long)|uniprotkb:egg-4(gene name)|psi-mi:egg-4(display_short)|uniprotkb:Egg sterile protein 4(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like protein egg-4(gene name synonym)|uniprotkb:T21E3.1(orf name)	psi-mi:"MI:0096"(pull down)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476911|imex:IM-12101-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2005616(isoform-parent)|ensemblmetazoa:F49E11.1a.1(transcript)|ensemblmetazoa:WBGene00003150(gene)	ensemblmetazoa:T21E3.1.1(transcript)|ensemblmetazoa:WBGene00020652(gene)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030703"(eggshell formation)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|refseq:NP_491269.1|wormbase:T21E3.1|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:xcoYiiIBLgNVj1TBjkcDayzPG+M6239	rogid:Zpy5XrJwZG0rJEAvwRq0EDJZha06239	intact-crc:83461D25B825D87A|rigid:UkLKBtPBYSnSQVSKV3+5eQQ2+7c	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:196-196|mutation decreasing interaction:325-325,327-327	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9XTF3-2	uniprotkb:O61789	intact:EBI-2565597|ensemblmetazoa:F49E11.1a.1	intact:EBI-2476960|ensemblmetazoa:R12E2.10.1	psi-mi:q9xtf3-2(display_long)|uniprotkb:mbk-2(gene name)|psi-mi:mbk-2(display_short)|uniprotkb:Dual specificity Yak1-related kinase mbk-2(gene name synonym)|uniprotkb:Minibrain Kinase 2(gene name synonym)|uniprotkb:F49E11.1(orf name)	psi-mi:egg5_caeel(display_long)|uniprotkb:egg-5(gene name)|psi-mi:egg-5(display_short)|uniprotkb:Egg sterile protein 5(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like protein egg-5(gene name synonym)|uniprotkb:R12E2.10(orf name)	psi-mi:"MI:0096"(pull down)	Cheng et al. (2009)	imex:IM-12101|pubmed:19879842	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2476945|imex:IM-12101-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2005616(isoform-parent)|ensemblmetazoa:F49E11.1a.1(transcript)|ensemblmetazoa:WBGene00003150(gene)	ensemblmetazoa:R12E2.10.1(transcript)|ensemblmetazoa:WBGene00020035(gene)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005938"(cell cortex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030703"(eggshell formation)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|refseq:NP_491316.1|wormbase:R12E2.10|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:xcoYiiIBLgNVj1TBjkcDayzPG+M6239	rogid:2XUiJDht8s7kyoLBpHv4IcmDb4A6239	intact-crc:01AC14EB61362834|rigid:0La8CplCU74WYPEJfpzUklHELZc	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:196-196|mutation decreasing interaction:327-327,325-325	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)