#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26361	uniprotkb:P19120	intact:EBI-6115317|uniprotkb:Q63893|uniprotkb:Q63894|uniprotkb:Q9JKQ6|ensembl:ENSMUSP00000049228	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	psi-mi:cftr_mouse(display_long)|uniprotkb:Cftr(gene name)|psi-mi:Cftr(display_short)|uniprotkb:Abcc7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7555714|mint:MINT-7265886|imex:IM-15533-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066388.1|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904446"(positive regulation of establishment of Sertoli cell barrier)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|mint:P26361|rcsb pdb:1Q3H|rcsb pdb:1R0W|ensembl:ENSMUSG00000041301(gene)|ensembl:ENSMUST00000045706(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006821"(chloride transport)|go:"GO:0006833"(water transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042311"(vasodilation)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|refseq:XP_006505040.1|refseq:XP_006505041.1|dip:DIP-29618N|reactome:R-MMU-8856828|reactome:R-MMU-9013406|reactome:R-MMU-9646399|reactome:R-MMU-8856825|rcsb pdb:1R0X|rcsb pdb:1R0Y|rcsb pdb:1R0Z|rcsb pdb:1R10|rcsb pdb:1XF9|rcsb pdb:1XFA|rcsb pdb:3SI7|reactome:R-MMU-382556|reactome:R-MMU-5627083|reactome:R-MMU-5689880|mint:MINT-7265888(identity)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7265889(identity)	-	-	-	figure legend:F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/01	2014/10/16	rogid:DkfDbDUFD82LoluVzldqf0AJbhQ10090	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	intact-crc:A008757D95EE351E|rigid:7NOFF1Oev71RXu0wsGXlXlpzOwA	false	binding-associated region:389-673(MINT-7265894)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26361	uniprotkb:P19120	intact:EBI-6115317|uniprotkb:Q63893|uniprotkb:Q63894|uniprotkb:Q9JKQ6|ensembl:ENSMUSP00000049228	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	psi-mi:cftr_mouse(display_long)|uniprotkb:Cftr(gene name)|psi-mi:Cftr(display_short)|uniprotkb:Abcc7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7555818|mint:MINT-7265906|imex:IM-15533-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066388.1|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904446"(positive regulation of establishment of Sertoli cell barrier)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|mint:P26361|rcsb pdb:1Q3H|rcsb pdb:1R0W|ensembl:ENSMUSG00000041301(gene)|ensembl:ENSMUST00000045706(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006821"(chloride transport)|go:"GO:0006833"(water transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042311"(vasodilation)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|refseq:XP_006505040.1|refseq:XP_006505041.1|dip:DIP-29618N|reactome:R-MMU-8856828|reactome:R-MMU-9013406|reactome:R-MMU-9646399|reactome:R-MMU-8856825|rcsb pdb:1R0X|rcsb pdb:1R0Y|rcsb pdb:1R0Z|rcsb pdb:1R10|rcsb pdb:1XF9|rcsb pdb:1XFA|rcsb pdb:3SI7|reactome:R-MMU-382556|reactome:R-MMU-5627083|reactome:R-MMU-5689880|mint:MINT-7265908(identity)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7265912(identity)	-	-	-	figure legend:F3B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/01	2014/10/16	rogid:DkfDbDUFD82LoluVzldqf0AJbhQ10090	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	intact-crc:19269DA09D93CE47|rigid:7NOFF1Oev71RXu0wsGXlXlpzOwA	false	binding-associated region:389-673(MINT-7265909)|mutation decreasing interaction:508-508(MINT-7265919)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13569	uniprotkb:P19120	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7555880|mint:MINT-7265924|imex:IM-15533-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N|mint:MINT-7265928(identity)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7265926(identity)	-	-	-	figure legend:F3B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/01	2014/10/16	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	intact-crc:9E06B488265B12D5|rigid:Nj9zt8g8WYff2c+9IHhwMZ9kn+E	false	binding-associated region:389-673(MINT-7265931)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13569	uniprotkb:P19120	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7555938|mint:MINT-7265939|imex:IM-15533-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N|mint:MINT-7265941(identity)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7265945(identity)	-	-	-	figure legend:F3D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/01	2014/10/16	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	intact-crc:C5648AA9108B3A2B|rigid:Nj9zt8g8WYff2c+9IHhwMZ9kn+E	false	binding-associated region:389-673(MINT-7265942)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19120	uniprotkb:P26361	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	intact:EBI-6115317|uniprotkb:Q63893|uniprotkb:Q63894|uniprotkb:Q9JKQ6|ensembl:ENSMUSP00000049228	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:cftr_mouse(display_long)|uniprotkb:Cftr(gene name)|psi-mi:Cftr(display_short)|uniprotkb:Abcc7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7555978|mint:MINT-7265951|imex:IM-15533-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7265953(identity)	refseq:NP_066388.1|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904446"(positive regulation of establishment of Sertoli cell barrier)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|mint:P26361|rcsb pdb:1Q3H|rcsb pdb:1R0W|ensembl:ENSMUSG00000041301(gene)|ensembl:ENSMUST00000045706(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006821"(chloride transport)|go:"GO:0006833"(water transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042311"(vasodilation)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|refseq:XP_006505040.1|refseq:XP_006505041.1|dip:DIP-29618N|reactome:R-MMU-8856828|reactome:R-MMU-9013406|reactome:R-MMU-9646399|reactome:R-MMU-8856825|rcsb pdb:1R0X|rcsb pdb:1R0Y|rcsb pdb:1R0Z|rcsb pdb:1R10|rcsb pdb:1XF9|rcsb pdb:1XFA|rcsb pdb:3SI7|reactome:R-MMU-382556|reactome:R-MMU-5627083|reactome:R-MMU-5689880|mint:MINT-7265955(identity)	-	-	-	figure legend:F3D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/01	2014/10/16	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	rogid:DkfDbDUFD82LoluVzldqf0AJbhQ10090	intact-crc:9DF24772B99CB415|rigid:7NOFF1Oev71RXu0wsGXlXlpzOwA	false	-	mutation increasing interaction:508-508(MINT-7265956)|binding-associated region:389-673(MINT-7265958)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19120	uniprotkb:P26361	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	intact:EBI-6115317|uniprotkb:Q63893|uniprotkb:Q63894|uniprotkb:Q9JKQ6|ensembl:ENSMUSP00000049228	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:cftr_mouse(display_long)|uniprotkb:Cftr(gene name)|psi-mi:Cftr(display_short)|uniprotkb:Abcc7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7556102|mint:MINT-7265981|imex:IM-15533-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7265984(identity)	refseq:NP_066388.1|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904446"(positive regulation of establishment of Sertoli cell barrier)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|mint:P26361|rcsb pdb:1Q3H|rcsb pdb:1R0W|ensembl:ENSMUSG00000041301(gene)|ensembl:ENSMUST00000045706(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006821"(chloride transport)|go:"GO:0006833"(water transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042311"(vasodilation)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|refseq:XP_006505040.1|refseq:XP_006505041.1|dip:DIP-29618N|reactome:R-MMU-8856828|reactome:R-MMU-9013406|reactome:R-MMU-9646399|reactome:R-MMU-8856825|rcsb pdb:1R0X|rcsb pdb:1R0Y|rcsb pdb:1R0Z|rcsb pdb:1R10|rcsb pdb:1XF9|rcsb pdb:1XFA|rcsb pdb:3SI7|reactome:R-MMU-382556|reactome:R-MMU-5627083|reactome:R-MMU-5689880|mint:MINT-7265986(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.39x10^-8(molar)	2009/10/01	2014/10/16	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	rogid:DkfDbDUFD82LoluVzldqf0AJbhQ10090	intact-crc:3E3EB0A7F48483E3|rigid:7NOFF1Oev71RXu0wsGXlXlpzOwA	false	-	binding-associated region:389-673(MINT-7265987)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26361	uniprotkb:P19120	intact:EBI-6115317|uniprotkb:Q63893|uniprotkb:Q63894|uniprotkb:Q9JKQ6|ensembl:ENSMUSP00000049228	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	psi-mi:cftr_mouse(display_long)|uniprotkb:Cftr(gene name)|psi-mi:Cftr(display_short)|uniprotkb:Abcc7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7556039|mint:MINT-7265964|imex:IM-15533-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066388.1|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904446"(positive regulation of establishment of Sertoli cell barrier)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|mint:P26361|rcsb pdb:1Q3H|rcsb pdb:1R0W|ensembl:ENSMUSG00000041301(gene)|ensembl:ENSMUST00000045706(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006821"(chloride transport)|go:"GO:0006833"(water transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042311"(vasodilation)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|refseq:XP_006505040.1|refseq:XP_006505041.1|dip:DIP-29618N|reactome:R-MMU-8856828|reactome:R-MMU-9013406|reactome:R-MMU-9646399|reactome:R-MMU-8856825|rcsb pdb:1R0X|rcsb pdb:1R0Y|rcsb pdb:1R0Z|rcsb pdb:1R10|rcsb pdb:1XF9|rcsb pdb:1XFA|rcsb pdb:3SI7|reactome:R-MMU-382556|reactome:R-MMU-5627083|reactome:R-MMU-5689880|mint:MINT-7265966(identity)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7265972(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.6x10^-9(molar)	2009/10/01	2014/10/16	rogid:DkfDbDUFD82LoluVzldqf0AJbhQ10090	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	intact-crc:4A3CC0D60A9BC819|rigid:7NOFF1Oev71RXu0wsGXlXlpzOwA	false	mutation increasing interaction:508-508(MINT-7265967)|binding-associated region:389-673(MINT-7265969)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00711	uniprotkb:P19120	intact:EBI-7080486|intact:MINT-1487560|uniprotkb:Q95NE4|uniprotkb:Q3T111	intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4	psi-mi:lalba_bovin(display_long)|uniprotkb:LALBA(gene name)|psi-mi:LALBA(display_short)|uniprotkb:ALACTA(gene name synonym)|uniprotkb:Lactose synthase B protein(gene name synonym)	psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Scott-Ward et al. (2009)	pubmed:19878303|imex:IM-15533|mint:MINT-7265878|doi:10.1111/j.1742-4658.2009.07421	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7556119|mint:MINT-7265996|imex:IM-15533-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P00711|go:"GO:0004461"(lactose synthase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005989"(lactose biosynthetic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042802"(identical protein binding)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|rcsb pdb:1F6R|rcsb pdb:1F6S|rcsb pdb:1HFZ|rcsb pdb:2G4N|rcsb pdb:6IP9|interpro:IPR019799|interpro:IPR023346|refseq:NP_776803.1|interpro:IPR000545(Lactalbumin)|interpro:IPR001916(Glycoside hydrolase, family 22)|mint:MINT-7265998(identity)	ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD|mint:MINT-7266004(identity)	-	comment:mint|comment:homomint|function:Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins	-	figure legend:F3C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/01	2014/10/16	rogid:jEnBQQgOzSEaNmxGJLAV+KkbnGs9913	rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913	intact-crc:E2D5A08AEE474055|rigid:C4m6NarIDWCoHmwAgs5JeZerNrY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)