#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q2HR75 uniprotkb:P19338 intact:EBI-6884751|uniprotkb:O40938 intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195 psi-mi:icp27_hhv8p(display_long)|uniprotkb:EB2 protein homolog(gene name synonym)|uniprotkb:ORF57(orf name) psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Boyne et al. (2009) pubmed:19850040|imex:IM-15520|mint:MINT-7291307|doi:10.1016/j.febslet.2009.10.040|mint:d-09-01361 taxid:868565(hhv8p)|taxid:868565(Human herpesvirus 8) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7533131|mint:MINT-7291320|imex:IM-15520-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5ZB1|rcsb pdb:5ZB3|interpro:IPR008648(Herpesvirus transcriptional regulator)|refseq:YP_001129410.1|mint:Q2HR75|mint:MINT-7291323(identity) refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226|mint:MINT-7291322(identity) go:"GO:0005730"(nucleolus) - - figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bcbl_1)|taxid:9606(Homo sapiens lymphoma cell line) - 2009/10/13 2014/10/16 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ8868565 rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606 intact-crc:AD16268FAC7A83E8|rigid:qt/eDnIZMebKSbJefVEKhnhmW+c false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0708"(monoclonal antibody immunostaining) uniprotkb:P19338 uniprotkb:Q2HR75 intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195 intact:EBI-6884751|uniprotkb:O40938 psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym) psi-mi:icp27_hhv8p(display_long)|uniprotkb:EB2 protein homolog(gene name synonym)|uniprotkb:ORF57(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Boyne et al. (2009) pubmed:19850040|imex:IM-15520|mint:MINT-7291307|doi:10.1016/j.febslet.2009.10.040|mint:d-09-01361 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:868565(hhv8p)|taxid:868565(Human herpesvirus 8) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7533160|mint:MINT-7291330|imex:IM-15520-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226|mint:MINT-7291335(identity) go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5ZB1|rcsb pdb:5ZB3|interpro:IPR008648(Herpesvirus transcriptional regulator)|refseq:YP_001129410.1|mint:Q2HR75|mint:MINT-7291333(identity) go:"GO:0005730"(nucleolus) - - figure legend:f1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bcbl_1)|taxid:9606(Homo sapiens lymphoma cell line) - 2009/10/13 2014/10/16 rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ8868565 intact-crc:88636D049E6FA338|rigid:qt/eDnIZMebKSbJefVEKhnhmW+c false - - - - psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q2HR75 uniprotkb:Q86V81 intact:EBI-6884751|uniprotkb:O40938 intact:EBI-347640|uniprotkb:O43672 psi-mi:icp27_hhv8p(display_long)|uniprotkb:EB2 protein homolog(gene name synonym)|uniprotkb:ORF57(orf name) psi-mi:thoc4_human(display_long)|uniprotkb:ALYREF(gene name)|psi-mi:ALYREF(display_short)|uniprotkb:ALY(gene name synonym)|uniprotkb:Ally of AML-1 and LEF-1(gene name synonym)|uniprotkb:Aly/REF export factor(gene name synonym)|uniprotkb:BEF(gene name synonym)|uniprotkb:THOC4(gene name synonym)|uniprotkb:Transcriptional coactivator Aly/REF(gene name synonym)|uniprotkb:bZIP-enhancing factor BEF(gene name synonym) psi-mi:"MI:0096"(pull down) Boyne et al. (2009) pubmed:19850040|imex:IM-15520|mint:MINT-7291307|doi:10.1016/j.febslet.2009.10.040|mint:d-09-01361 taxid:868565(hhv8p)|taxid:868565(Human herpesvirus 8) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7533301|mint:MINT-7291377|imex:IM-15520-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5ZB1|rcsb pdb:5ZB3|interpro:IPR008648(Herpesvirus transcriptional regulator)|refseq:YP_001129410.1|mint:Q2HR75|mint:MINT-7291379(identity) refseq:NP_005773.3|mint:Q86V81|dip:DIP-32711N|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000346"(transcription export complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0031297"(replication fork processing)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|rcsb pdb:3ULH|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|interpro:IPR025715|mint:MINT-7291380(identity) - - - figure legend:f2d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/10/13 2014/10/16 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ8868565 rogid:beNqQmz9NZk8EdpXoQs0lIxOvTk9606 intact-crc:90944D7A9C29E6CF|rigid:vrqmvlhaHWxZlXQwwJn+NCl4woI false mutation disrupting interaction:148-148(MINT-7291705)|mutation disrupting interaction:126-126(MINT-7291690)|mutation disrupting interaction:124-124(MINT-7291684)|mutation disrupting interaction:147-147(MINT-7291702)|mutation disrupting interaction:143-143(MINT-7291699)|mutation disrupting interaction:122-122(MINT-7291681)|green fluorescent protein tag:?-?(MINT-7291390)|mutation disrupting interaction:128-128(MINT-7291693)|mutation disrupting interaction:151-151(MINT-7291708)|mutation disrupting interaction:152-152(MINT-7291711)|binding-associated region:121-130(MINT-7291387)|mutation disrupting interaction:121-121(MINT-7291678)|mutation disrupting interaction:125-125(MINT-7291687)|mutation disrupting interaction:130-130(MINT-7291696) glutathione s tranferase tag:?-?(MINT-7291382) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86V81 uniprotkb:Q2HR75 intact:EBI-347640|uniprotkb:O43672 intact:EBI-6884751|uniprotkb:O40938 psi-mi:thoc4_human(display_long)|uniprotkb:ALYREF(gene name)|psi-mi:ALYREF(display_short)|uniprotkb:ALY(gene name synonym)|uniprotkb:Ally of AML-1 and LEF-1(gene name synonym)|uniprotkb:Aly/REF export factor(gene name synonym)|uniprotkb:BEF(gene name synonym)|uniprotkb:THOC4(gene name synonym)|uniprotkb:Transcriptional coactivator Aly/REF(gene name synonym)|uniprotkb:bZIP-enhancing factor BEF(gene name synonym) psi-mi:icp27_hhv8p(display_long)|uniprotkb:EB2 protein homolog(gene name synonym)|uniprotkb:ORF57(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Boyne et al. (2009) pubmed:19850040|imex:IM-15520|mint:MINT-7291307|doi:10.1016/j.febslet.2009.10.040|mint:d-09-01361 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:868565(hhv8p)|taxid:868565(Human herpesvirus 8) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7533565|mint:MINT-7291715|imex:IM-15520-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005773.3|mint:Q86V81|dip:DIP-32711N|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000346"(transcription export complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0031297"(replication fork processing)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|rcsb pdb:3ULH|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|interpro:IPR025715|mint:MINT-7291717(identity) go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5ZB1|rcsb pdb:5ZB3|interpro:IPR008648(Herpesvirus transcriptional regulator)|refseq:YP_001129410.1|mint:Q2HR75|mint:MINT-7291721(identity) go:"GO:0005730"(nucleolus) - - figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2009/10/13 2014/10/16 rogid:beNqQmz9NZk8EdpXoQs0lIxOvTk9606 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ8868565 intact-crc:B379F09B4FECED67|rigid:vrqmvlhaHWxZlXQwwJn+NCl4woI false - mutation disrupting interaction:148-148(MINT-7291726)|mutation disrupting interaction:143-143(MINT-7291730)|mutation disrupting interaction:121-121(MINT-7291744)|mutation disrupting interaction:128-128(MINT-7291734)|mutation disrupting interaction:151-151(MINT-7291724)|green fluorescent protein tag:?-?(MINT-7291748)|binding-associated region:143-152(MINT-7291746)|mutation disrupting interaction:126-126(MINT-7291736)|mutation disrupting interaction:107-107(MINT-7292081)|mutation disrupting interaction:101-101(MINT-7292072)|mutation disrupting interaction:104-104(MINT-7292075)|mutation disrupting interaction:122-122(MINT-7291742)|mutation disrupting interaction:147-147(MINT-7291728)|mutation disrupting interaction:105-105(MINT-7292078)|mutation disrupting interaction:152-152(MINT-7291722)|mutation disrupting interaction:124-124(MINT-7291740)|mutation disrupting interaction:130-130(MINT-7291732)|mutation disrupting interaction:125-125(MINT-7291738) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0396"(predetermined participant)