#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q00604	uniprotkb:O95859	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466403|ensembl:ENSP00000222747|ensembl:ENSP00000397699|uniprotkb:A4D0V8|uniprotkb:B4DRG6|uniprotkb:Q8N5Y0|intact:EBI-2809454|uniprotkb:Q549U9	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:tsn12_human(display_long)|uniprotkb:TSPAN12(gene name)|psi-mi:TSPAN12(display_short)|uniprotkb:NET2(gene name synonym)|uniprotkb:TM4SF12(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 12(gene name synonym)|uniprotkb:Tetraspan NET-2(gene name synonym)|uniprotkb:UNQ774/PRO1568(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466376|imex:IM-12098-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	ensembl:ENSG00000106025(gene)|ensembl:ENST00000222747(transcript)|ensembl:ENST00000415871(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010842"(retina layer formation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_036470.1|refseq:XP_011514295.1|refseq:XP_011514296.1|refseq:XP_005250296.1|refseq:XP_016867401.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5E, Supp. Fig. 10C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:KXDxb7yBerfJQsOM7ATOdI0EpFU9606	intact-crc:1A2D4B9578C6895E|rigid:KYb7JfipnalWAj4mKBY1eWfggJA	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00604	uniprotkb:Q9ULV1	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466376|imex:IM-12098-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5E, Supp. Fig. 10C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	intact-crc:1A2D4B9578C6895E|rigid:KYb7JfipnalWAj4mKBY1eWfggJA	false	flag tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00604	uniprotkb:O75197	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466421|ensembl:ENSP00000294304|uniprotkb:Q96TD6|uniprotkb:Q9UP66|uniprotkb:Q9UES7	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:lrp5_human(display_long)|uniprotkb:LRP5(gene name)|psi-mi:LRP5(display_short)|uniprotkb:LRP7(gene name synonym)|uniprotkb:LR3(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466376|imex:IM-12098-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	ensembl:ENSG00000162337(gene)|ensembl:ENST00000294304(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048539"(bone marrow development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75197|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5339717|reactome:R-HSA-5340588|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|refseq:NP_002326.2|refseq:NP_001278831.1|dip:DIP-47265N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5E, Supp. Fig. 10C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:5Or5NJwtSvZrk2kM2bBAQQOCW749606	intact-crc:1A2D4B9578C6895E|rigid:KYb7JfipnalWAj4mKBY1eWfggJA	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00604	uniprotkb:O75197	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466421|ensembl:ENSP00000294304|uniprotkb:Q96TD6|uniprotkb:Q9UP66|uniprotkb:Q9UES7	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:lrp5_human(display_long)|uniprotkb:LRP5(gene name)|psi-mi:LRP5(display_short)|uniprotkb:LRP7(gene name synonym)|uniprotkb:LR3(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466458|imex:IM-12098-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	ensembl:ENSG00000162337(gene)|ensembl:ENST00000294304(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048539"(bone marrow development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75197|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5339717|reactome:R-HSA-5340588|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|refseq:NP_002326.2|refseq:NP_001278831.1|dip:DIP-47265N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:5Or5NJwtSvZrk2kM2bBAQQOCW749606	intact-crc:7356C1376826E297|rigid:9yrk75XMIkx6W61oKhWdz0EwGUI	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00604	uniprotkb:Q9ULV1	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466458|imex:IM-12098-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	intact-crc:7356C1376826E297|rigid:9yrk75XMIkx6W61oKhWdz0EwGUI	false	flag tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00604	uniprotkb:O95859	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466403|ensembl:ENSP00000222747|ensembl:ENSP00000397699|uniprotkb:A4D0V8|uniprotkb:B4DRG6|uniprotkb:Q8N5Y0|intact:EBI-2809454|uniprotkb:Q549U9	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:tsn12_human(display_long)|uniprotkb:TSPAN12(gene name)|psi-mi:TSPAN12(display_short)|uniprotkb:NET2(gene name synonym)|uniprotkb:TM4SF12(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 12(gene name synonym)|uniprotkb:Tetraspan NET-2(gene name synonym)|uniprotkb:UNQ774/PRO1568(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466470|imex:IM-12098-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	ensembl:ENSG00000106025(gene)|ensembl:ENST00000222747(transcript)|ensembl:ENST00000415871(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010842"(retina layer formation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_036470.1|refseq:XP_011514295.1|refseq:XP_011514296.1|refseq:XP_005250296.1|refseq:XP_016867401.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5e, Supp. Fig. 510A, Supp. Fig. 10C|comment:Interaction shown not to occur in the absence of FZD4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:KXDxb7yBerfJQsOM7ATOdI0EpFU9606	intact-crc:7875176BE6CDA27A|rigid:eYJ4yU6w1RSKcPp4CPntqSKejy8	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00604	uniprotkb:Q9ULV1	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466470|imex:IM-12098-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5e, Supp. Fig. 510A, Supp. Fig. 10C|comment:Interaction shown not to occur in the absence of FZD4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	intact-crc:7875176BE6CDA27A|rigid:eYJ4yU6w1RSKcPp4CPntqSKejy8	false	flag tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULV1	uniprotkb:O95859	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	intact:EBI-2466403|ensembl:ENSP00000222747|ensembl:ENSP00000397699|uniprotkb:A4D0V8|uniprotkb:B4DRG6|uniprotkb:Q8N5Y0|intact:EBI-2809454|uniprotkb:Q549U9	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:tsn12_human(display_long)|uniprotkb:TSPAN12(gene name)|psi-mi:TSPAN12(display_short)|uniprotkb:NET2(gene name synonym)|uniprotkb:TM4SF12(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 12(gene name synonym)|uniprotkb:Tetraspan NET-2(gene name synonym)|uniprotkb:UNQ774/PRO1568(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466498|imex:IM-12098-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	ensembl:ENSG00000106025(gene)|ensembl:ENST00000222747(transcript)|ensembl:ENST00000415871(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010842"(retina layer formation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_036470.1|refseq:XP_011514295.1|refseq:XP_011514296.1|refseq:XP_005250296.1|refseq:XP_016867401.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 5A, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/26	2014/10/16	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	rogid:KXDxb7yBerfJQsOM7ATOdI0EpFU9606	intact-crc:4C134364ADCE85C4|rigid:Hk7XpouNTMv4ePZ85Rw93YvCggw	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q00604	uniprotkb:Q00604	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Junge et al. (2009)	imex:IM-12098|pubmed:19837033	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466508|imex:IM-12098-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/26	2014/10/16	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	intact-crc:D1B10C5DC9FB35B8|rigid:FVd9U/L66iM67BZ3Wo7XnN/FRv8	false	mutation decreasing interaction:95-95	mutation decreasing interaction:95-95	2	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)