#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8CFG6	uniprotkb:Q71SA3	intact:EBI-2465752	intact:EBI-2465723	psi-mi:ca2d2_rat(display_long)|uniprotkb:Cacna2d2(gene name)|psi-mi:Cacna2d2(display_short)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-2(gene name synonym)	psi-mi:q71sa3_rat(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eroglu et al. (2009)	imex:IM-12097|pubmed:19818485	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2465771|imex:IM-12097-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0005245"(voltage-gated calcium channel activity)|rgd:631360|refseq:NP_783182.1|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR013608(VWA N-terminal)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR036465|reactome:R-RNO-112308|reactome:R-RNO-422356|reactome:R-RNO-5576892|reactome:R-RNO-5576893	rgd:1588455|refseq:NP_001013080.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-cortex)|taxid:10116(Rattus norvegicus brain cortex)	-	2009/10/22	2014/10/16	rogid:37EmdoLuaFeBIPfqqxHbUh6HjV010116	rogid:dNQya6QHTyXBcMb7aBwQmhRFJoI10116	intact-crc:3518673D135FE3FA|rigid:2uRJ5AJg5Cj3miQFbwo0aID7un4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFG6	intact:EBI-2465775	intact:EBI-2465752	-	psi-mi:ca2d2_rat(display_long)|uniprotkb:Cacna2d2(gene name)|psi-mi:Cacna2d2(display_short)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-2(gene name synonym)	psi-mi:d3z8h1_rat(display_short)|psi-mi:EBI-2465775(display_long)|uniprotkb:Thbs3(gene name)|psi-mi:Thbs3(display_short)|uniprotkb:LOC681309(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eroglu et al. (2009)	imex:IM-12097|pubmed:19818485	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2465778|imex:IM-12097-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0005245"(voltage-gated calcium channel activity)|rgd:631360|refseq:NP_783182.1|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR013608(VWA N-terminal)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR036465|reactome:R-RNO-112308|reactome:R-RNO-422356|reactome:R-RNO-5576892|reactome:R-RNO-5576893	uniprotkb:D3Z8H1(uniprot-removed-ac)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Fig. 3B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-cortex)|taxid:10116(Rattus norvegicus brain cortex)	-	2009/10/22	2014/10/16	rogid:37EmdoLuaFeBIPfqqxHbUh6HjV010116	rogid:hcEMdAKwtCA6xFdGlbFJ8MCmuF010116	intact-crc:D61679C1B7E8DEDA|rigid:lfsP9+Y0btMzWIUkWqEv6mtXcVI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49744	uniprotkb:Q8CFG6	intact:EBI-2465782	intact:EBI-2465752	psi-mi:tsp4_rat(display_long)|uniprotkb:Thbs4(gene name)|psi-mi:Thbs4(display_short)|uniprotkb:Tsp-4(gene name synonym)|uniprotkb:Tsp4(gene name synonym)	psi-mi:ca2d2_rat(display_long)|uniprotkb:Cacna2d2(gene name)|psi-mi:Cacna2d2(display_short)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eroglu et al. (2009)	imex:IM-12097|pubmed:19818485	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2465812|imex:IM-12097-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0008201"(heparin binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051451"(myoblast migration)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007399"(nervous system development)|go:"GO:0008083"(growth factor activity)|interpro:IPR001881(EGF-like calcium-binding)|rgd:62046|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024665|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR028974|reactome:R-RNO-186797	go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0005245"(voltage-gated calcium channel activity)|rgd:631360|refseq:NP_783182.1|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR013608(VWA N-terminal)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR036465|reactome:R-RNO-112308|reactome:R-RNO-422356|reactome:R-RNO-5576892|reactome:R-RNO-5576893	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-cortex)|taxid:10116(Rattus norvegicus brain cortex)	-	2009/10/22	2014/10/16	rogid:u/MmoxAO3/sQZ43IKHoa2z8FcXA10116	rogid:37EmdoLuaFeBIPfqqxHbUh6HjV010116	intact-crc:991C21EC62EEB27D|rigid:D1i+6oHmFcy0BgLXpmTAJHrQ4is	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22002	uniprotkb:Q8CFG6	intact:EBI-1185084|uniprotkb:P27733|uniprotkb:P27734|uniprotkb:Q62816|uniprotkb:Q63271|uniprotkb:Q64178	intact:EBI-2465752	psi-mi:cac1c_rat(display_long)|uniprotkb:Cacna1c(gene name)|psi-mi:Cacna1c(display_short)|uniprotkb:Cach2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)|uniprotkb:Rat brain class C(gene name synonym)|uniprotkb:Cacn2(gene name synonym)|uniprotkb:Cacnl1a1(gene name synonym)|uniprotkb:Cchl1a1(gene name synonym)	psi-mi:ca2d2_rat(display_long)|uniprotkb:Cacna2d2(gene name)|psi-mi:Cacna2d2(display_short)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eroglu et al. (2009)	imex:IM-12097|pubmed:19818485	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2465818|imex:IM-12097-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2245|refseq:NP_036649.2|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007507"(heart development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086065"(cell communication involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1905030"(voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|rcsb pdb:1VYT|reactome:R-RNO-422356|reactome:R-RNO-5576892|reactome:R-RNO-5576893|go:"GO:0070509"(calcium ion import)|interpro:IPR031649|interpro:IPR031688|interpro:IPR027359|mint:P22002	go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0005245"(voltage-gated calcium channel activity)|rgd:631360|refseq:NP_783182.1|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR013608(VWA N-terminal)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR036465|reactome:R-RNO-112308|reactome:R-RNO-422356|reactome:R-RNO-5576892|reactome:R-RNO-5576893	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-cortex)|taxid:10116(Rattus norvegicus brain cortex)	-	2009/10/22	2014/10/16	rogid:ZhDnBaC62g3sLHge7tQfis0iO9Q10116	rogid:37EmdoLuaFeBIPfqqxHbUh6HjV010116	intact-crc:8781AAA8F4FA90C3|rigid:K7HyLTwtV1AdLV7hu2/kyX/ulP0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54290	uniprotkb:P35442	intact:EBI-2466294	intact:EBI-2466249|ensembl:ENSP00000355751|ensembl:ENSP00000482784|ensembl:ENSP00000503020|ensembl:ENSP00000504820|uniprotkb:A6H8N1|uniprotkb:A7E232|uniprotkb:Q5RI52	psi-mi:ca2d1_rat(display_long)|uniprotkb:Cacna2d1(gene name)|psi-mi:Cacna2d1(display_short)|uniprotkb:Cacnl2a(gene name synonym)|uniprotkb:Cchl2a(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym)	psi-mi:tsp2_human(display_long)|uniprotkb:THBS2(gene name)|psi-mi:THBS2(display_short)|uniprotkb:TSP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Eroglu et al. (2009)	imex:IM-12097|pubmed:19818485	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466286|imex:IM-12097-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030315"(T-tubule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086048"(membrane depolarization during bundle of His cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR013608(VWA N-terminal)|interpro:IPR002035(von Willebrand factor, type A)|rgd:2247|interpro:IPR036465|mint:P54290	ensembl:ENSG00000186340(gene)|ensembl:ENST00000366787(transcript)|ensembl:ENST00000617924(transcript)|ensembl:ENST00000676498(transcript)|ensembl:ENST00000676760(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015455(Thrombospondin II)|interpro:IPR017897|interpro:IPR024731|interpro:IPR028974|interpro:IPR036383|rcsb pdb:1YO8|rcsb pdb:2RHP|reactome:R-HSA-186797|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005604"(basement membrane)|refseq:NP_003238.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 3C, 6D|caution:Exact coordinates of synaptogenic domain of THBS2 not given in paper so inferred from UniProtKB entry.|comment:Non-tagged endogenous human THBS2 protein also potentially identified as pulled down by the rat Cacna2d1 bait.|antagonist:Gabapentin|comment:Identity of THBS2 confirmed using anti-His Abs, although this appeared to cross-react with multiple proteins.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/22	2014/10/16	rogid:S7R5HLesr6V4Ugx1jVxYk2tE/8M10116	rogid:nTxYZvGrARj4JwHQxmzSi4sgdew9606	intact-crc:8DB05B96F5C7B2D4|rigid:Og+X+IPE/Xen1w2G9Qi1oo2TqrU	false	flag tag:?-?	sufficient binding region:1..1-692..692|myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35442	uniprotkb:P54290	intact:EBI-2466249|ensembl:ENSP00000355751|ensembl:ENSP00000482784|ensembl:ENSP00000503020|ensembl:ENSP00000504820|uniprotkb:A6H8N1|uniprotkb:A7E232|uniprotkb:Q5RI52	intact:EBI-2466294	psi-mi:tsp2_human(display_long)|uniprotkb:THBS2(gene name)|psi-mi:THBS2(display_short)|uniprotkb:TSP2(gene name synonym)	psi-mi:ca2d1_rat(display_long)|uniprotkb:Cacna2d1(gene name)|psi-mi:Cacna2d1(display_short)|uniprotkb:Cacnl2a(gene name synonym)|uniprotkb:Cchl2a(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Eroglu et al. (2009)	imex:IM-12097|pubmed:19818485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2466325|imex:IM-12097-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000186340(gene)|ensembl:ENST00000366787(transcript)|ensembl:ENST00000617924(transcript)|ensembl:ENST00000676498(transcript)|ensembl:ENST00000676760(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015455(Thrombospondin II)|interpro:IPR017897|interpro:IPR024731|interpro:IPR028974|interpro:IPR036383|rcsb pdb:1YO8|rcsb pdb:2RHP|reactome:R-HSA-186797|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005604"(basement membrane)|refseq:NP_003238.2	go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030315"(T-tubule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086048"(membrane depolarization during bundle of His cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR013608(VWA N-terminal)|interpro:IPR002035(von Willebrand factor, type A)|rgd:2247|interpro:IPR036465|mint:P54290	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3E|caution:Exact coordinates of synaptogenic domain of THBS2 not given in paper so inferred from UniProtKB entry.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/22	2014/10/16	rogid:nTxYZvGrARj4JwHQxmzSi4sgdew9606	rogid:S7R5HLesr6V4Ugx1jVxYk2tE/8M10116	intact-crc:6CE456FC3FEA1BA0|rigid:Og+X+IPE/Xen1w2G9Qi1oo2TqrU	false	sufficient binding region:1..1-692..692|myc tag:c-c|his tag:c-c	tag:c-c|sufficient binding region:248-432(IPR002035)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)