#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48023	uniprotkb:P07948	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481502|imex:IM-20398-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	intact-crc:B920D2B17B310129|rigid:qzF4a7S/Vor2WUyzlKCm6dbQec0	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:63..63-123..123(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:O43586	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481513|imex:IM-20398-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606	intact-crc:7DB6DF13684E3C8E|rigid:eemmOc8heLzl9Bcyvg51wP1LTeA	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:359..359-416..416(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q92882	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-1051152|uniprotkb:Q5W126|uniprotkb:Q96IJ4|ensembl:ENSP00000340836	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:ostf1_human(display_long)|uniprotkb:OSTF1(gene name)|psi-mi:OSTF1(display_short)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481524|imex:IM-20398-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_036515.4|ensembl:ENSG00000134996(gene)|ensembl:ENST00000346234(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036770|mint:Q92882|rcsb pdb:1X2K|rcsb pdb:1ZLM|rcsb pdb:3EHQ|rcsb pdb:3EHR|reactome:R-HSA-6798695	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:0nz6SBCE9meig3C9vDuhLZTIq2s9606	intact-crc:3B82F1E97941AC0B|rigid:0ysho124oWf1/zUS4VaUW2usQbc	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:12..12-71..71	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WV41	uniprotkb:P48023	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481553|imex:IM-20398-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:FC237F0799681719|rigid:7kxcdg3pJi4+YUrJQEljhrP6Sno	false	sufficient binding region:1..1-61..61(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:P08631	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481564|imex:IM-20398-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	intact-crc:960855E1030723C8|rigid:8zf9MZdIbCzbxIHAbhULp5190ak	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:78..78-138..138(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P16333	uniprotkb:P48023	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481576|imex:IM-20398-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:2A4542B252F5AFD6|rigid:4wlsxTeTgH4bxnTfUv4IhlAUSdU	false	sufficient binding region:190..190-252..252(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:P07947	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481608|imex:IM-20398-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:8EDC7D37FD3F811D|rigid:FvmrWF/q1rBUtcs0FN9Yzb0rvR4	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:91..91-152..152(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:P12931	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481635|imex:IM-20398-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:6738559505AB7E93|rigid:Wa445TZy3Mfa26qtYCoYlbd+cZ0	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:84..84-145..145(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5X1	uniprotkb:P48023	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481694|imex:IM-20398-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:BCEF1C9BAB0FEE9E|rigid:iDiqzWwjXiW5isuWb74GMmihR4A	false	sufficient binding region:1..1-62..62(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z6B7	uniprotkb:P48023	intact:EBI-2481729|uniprotkb:Q9H8A3|uniprotkb:Q9P2P2|ensembl:ENSP00000347198	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:srgp1_human(display_long)|uniprotkb:SRGAP1(gene name)|psi-mi:SRGAP1(display_short)|uniprotkb:ARHGAP13(gene name synonym)|uniprotkb:KIAA1304(gene name synonym)|uniprotkb:Rho GTPase-activating protein 13(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481761|imex:IM-20398-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196935(gene)|ensembl:ENST00000355086(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030336"(negative regulation of cell migration)|interpro:IPR000198(RhoGAP)|interpro:IPR001060(Cdc15/Fes/CIP4)|go:"GO:0005737"(cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|interpro:IPR031160|interpro:IPR035648|interpro:IPR036028|interpro:IPR037451|mint:Q7Z6B7|reactome:R-HSA-428543|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:NP_065813.1|refseq:NP_001333130.1|dip:DIP-53826N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:90QBhF8JA+PU6aRd6e4WwQ/FSvg9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:3791527308AE8276|rigid:QA+a9nRHfdIxKYRNLgx+ynMnM2E	false	sufficient binding region:743..743-802..802(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A1X283	uniprotkb:P48023	intact:EBI-2481776|uniprotkb:B6F0V2|uniprotkb:Q9P2Q1|ensembl:ENSP00000309714	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:spd2b_human(display_long)|uniprotkb:Tyrosine kinase substrate with four SH3 domains(gene name synonym)|uniprotkb:SH3PXD2B(gene name)|psi-mi:SH3PXD2B(display_short)|uniprotkb:FAD49(gene name synonym)|uniprotkb:KIAA1295(gene name synonym)|uniprotkb:Adapter protein HOFI(gene name synonym)|uniprotkb:Factor for adipocyte differentiation 49(gene name synonym)|uniprotkb:TKS4(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481800|imex:IM-20398-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042995"(cell projection)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060348"(bone development)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071800"(podosome assembly)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030512|interpro:IPR035477|interpro:IPR035478|interpro:IPR035479|go:"GO:0042169"(SH2 domain binding)|interpro:IPR035480|interpro:IPR036028|interpro:IPR036871|ensembl:ENSG00000174705(gene)|ensembl:ENST00000311601(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001654"(eye development)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|mint:A1X283|interpro:IPR037961|refseq:NP_001017995.1	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:GOhZr1suKq2v9mpmOmA774KvEBg9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:38C9F613F3791A2E|rigid:HU8Pn+5YojJFTjkMY98yFbigotc	false	sufficient binding region:368..368-427..427,849..849-911..911(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06187	uniprotkb:P48023	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481814|imex:IM-20398-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:9D55028207A8CFF5|rigid:0PIbfJ921J7AJ9sq/5Sbm7aTYYE	false	sufficient binding region:214..214-274..274(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q8TE67	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2481829|uniprotkb:A8K833|uniprotkb:Q5T8Q6|uniprotkb:Q5T8Q7|uniprotkb:Q5T8Q8|uniprotkb:Q96E47|uniprotkb:Q9H719|ensembl:ENSP00000355255	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:es8l3_human(display_long)|uniprotkb:EPS8L3(gene name)|psi-mi:EPS8L3(display_short)|uniprotkb:EPS8R3(gene name synonym)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 3(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481869|imex:IM-20398-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	rcsb pdb:1WXT|mint:Q8TE67|ensembl:ENSG00000198758(gene)|ensembl:ENST00000361965(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|refseq:NP_001306881.1|refseq:NP_078802.2|refseq:NP_573444.2|refseq:NP_620641.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:BQlq+GTodb3HDcU4k11+SyW/Fh49606	intact-crc:F4DB1A92CCEA3500|rigid:vTENF4+GbIodUtUeNgvqtsXrMWI	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:450..450-509..509	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q9BRR9	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-750254|uniprotkb:E9PDX9|uniprotkb:Q8NAF3|uniprotkb:Q8TCJ3|uniprotkb:Q8WYR0|uniprotkb:Q96EZ2|uniprotkb:Q96S74|uniprotkb:B4DVI3|intact:EBI-28982582|ensembl:ENSP00000377386	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:rhg09_human(display_long)|uniprotkb:Rho-type GTPase-activating protein 9(gene name synonym)|uniprotkb:ARHGAP9(gene name)|psi-mi:ARHGAP9(display_short)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481882|imex:IM-20398-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001073625.1|refseq:NP_001073626.1|refseq:NP_115885.2|refseq:XP_011536958.1|refseq:XP_011536961.1|ensembl:ENST00000393791|ensembl:ENSP00000377380|ensembl:ENSP00000377386|ensembl:ENST00000424809|ensembl:ENSP00000394307|ensembl:ENST00000430041|ensembl:ENSP00000397950|refseq:NP_001306779.1|refseq:NP_001306780.1|refseq:NP_001306781.1|refseq:XP_005269140.1|refseq:XP_016875289.1|refseq:XP_016875290.1|ensembl:ENSG00000123329(gene)|ensembl:ENST00000393797(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035465|interpro:IPR036020|interpro:IPR036028|rcsb pdb:2P0D|rcsb pdb:2P0F|rcsb pdb:2P0H|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR001452(Src homology-3)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:xMZoj/BPtfx1PnMPt4XsjXbGv1k9606	intact-crc:BF476F70AE30E4CA|rigid:vPe3AZID89cwx9DJt+dC2wbakBE	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:22..22-88..88(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q9UKN7	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-715302|uniprotkb:B4DFC7|intact:EBI-28973079|ensembl:ENSP00000495481	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:myo15_human(display_long)|uniprotkb:Unconventional myosin-15(gene name synonym)|uniprotkb:MYO15A(gene name)|psi-mi:MYO15A(display_short)|uniprotkb:MYO15(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481899|imex:IM-20398-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_057323.3|ensembl:ENST00000418233|ensembl:ENSP00000408800|ensembl:ENSP00000495481|ensembl:ENSG00000091536(gene)|ensembl:ENST00000647165(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|rcsb pdb:6KZ1|reactome:R-HSA-9662360|reactome:R-HSA-9662361	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:MWwfRkw2a7EVQGyy1+0qEzTVdEA9606	intact-crc:3B39271B1F70AB75|rigid:rKHXVCWeWzSUd+OVtBKlscEjKyc	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:2867..2867-2953..2953(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43639	uniprotkb:P48023	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481916|imex:IM-20398-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:FA4FC665D74BAD9E|rigid:j9frzXPId6CNAi2mggNZg9+J9D4	false	sufficient binding region:111..111-170..170(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:O15117	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-1753267|uniprotkb:O00359|ensembl:ENSP00000316460|ensembl:ENSP00000426346|uniprotkb:A8K2Y8|uniprotkb:E9PBV9|uniprotkb:Q9NZI9|uniprotkb:B4DLN2	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:fyb1_human(display_long)|uniprotkb:FYB1(gene name)|psi-mi:FYB1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLAP130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481992|imex:IM-20398-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:XP_011512310.1|refseq:XP_011512311.1|refseq:XP_011512312.1|refseq:NP_955367.1|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|mint:O15117|rcsb pdb:1RI9|rcsb pdb:2GTJ|rcsb pdb:2GTO|reactome:R-HSA-202433|reactome:R-HSA-391160|ensembl:ENSG00000082074(gene)|ensembl:ENST00000351578(transcript)|ensembl:ENST00000515010(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|refseq:NP_001230022.1|refseq:NP_001456.3|refseq:XP_006714527.1|refseq:XP_006714528.1|refseq:XP_006714529.1|dip:DIP-42204N	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:ObeGCVefTolMBQGVT/WhglH5F009606	intact-crc:A7E596630DC8A287|rigid:Nsnll6SL/K0xwHpGPsCzu//vfDA	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:514..514-570..570(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42680	uniprotkb:P48023	intact:EBI-1383480|uniprotkb:Q3MIS5|uniprotkb:B7ZKZ6|ensembl:ENSP00000370912	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:tec_human(display_long)|uniprotkb:PSCTK4(gene name synonym)|uniprotkb:TEC(gene name)|psi-mi:TEC(display_short)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2482131|imex:IM-20398-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003206.2|ensembl:ENSG00000135605(gene)|ensembl:ENST00000381501(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860|mint:P42680|rcsb pdb:2LUL|reactome:R-HSA-1433557|reactome:R-HSA-2871809|reactome:R-HSA-512988	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:eZR8Xggl8x1HB+0gUnzBPpbcK3Y9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:501EFB9249F7A46D|rigid:MnZ64aV9hxEHLhsmaQkQOfgSwG8	false	sufficient binding region:179..179-239..239(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02549	uniprotkb:P48023	intact:EBI-375617|uniprotkb:Q15514|uniprotkb:Q6LDY5|ensembl:ENSP00000495214|uniprotkb:Q5VYL1|uniprotkb:Q5VYL2	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:spta1_human(display_long)|uniprotkb:SPTA1(gene name)|psi-mi:SPTA1(display_short)|uniprotkb:Erythroid alpha-spectrin(gene name synonym)|uniprotkb:SPTA(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2482190|imex:IM-20398-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|ensembl:ENSG00000163554(gene)|ensembl:ENST00000643759(transcript)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008091"(spectrin)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030424"(axon)|interpro:IPR018159|interpro:IPR036028|mint:P02549|rcsb pdb:1OWA|rcsb pdb:3LBX|rcsb pdb:5J4O|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|interpro:IPR014837(EF-hand, Ca insensitive)|refseq:NP_003117.2|refseq:XP_011508218.1|dip:DIP-17031N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:ypX1j52WRHo4kBjtDJWfSAF99949606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:0639BAE270C8DBFF|rigid:7OKMWRSOxEPsctiaAY9oUVfraAo	false	sufficient binding region:977..977-1036..1036	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q9NSI8	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2482265|ensembl:ENSP00000383411|uniprotkb:Q8NFF7|uniprotkb:Q9C041|uniprotkb:B3KWJ3|uniprotkb:F8WAA1	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:samn1_human(display_long)|uniprotkb:SAMSN1(gene name)|psi-mi:SAMSN1(display_short)|uniprotkb:HACS1(gene name synonym)|uniprotkb:SAM domain, SH3 domain and nuclear localization signals protein 1(gene name synonym)|uniprotkb:SH3-SAM adaptor protein(gene name synonym)|uniprotkb:Hematopoietic adaptor containing SH3 and SAM domains 1(gene name synonym)|uniprotkb:Nash1(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2482305|imex:IM-20398-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001273452.1|ensembl:ENSG00000155307(gene)|ensembl:ENST00000400566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002820"(negative regulation of adaptive immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021090|interpro:IPR036028|interpro:IPR037623|rcsb pdb:6UZJ|refseq:NP_071419.3|refseq:NP_001243299.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:wLYLZiF5sNlxk+OVcBhPQ06ol0g9606	intact-crc:22587E9823ED4B85|rigid:x3T2e39ApZlH07NgGqBm5CMQ3Yw	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:166..166-222..222(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q8TEC5	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2130111|uniprotkb:A8K961|uniprotkb:Q08AM9|uniprotkb:Q6GMR9|uniprotkb:Q8N5S8|uniprotkb:Q96LP8|ensembl:ENSP00000352028|ensembl:ENSP00000424497	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:sh3r2_human(display_long)|uniprotkb:POSH-eliminating RING protein(gene name synonym)|uniprotkb:POSH3(gene name synonym)|uniprotkb:POSHER(gene name synonym)|uniprotkb:SH3RF2(gene name)|psi-mi:SH3RF2(display_short)|uniprotkb:Heart protein phosphatase 1-binding protein(gene name synonym)|uniprotkb:PPP1R39(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 39(gene name synonym)|uniprotkb:RING finger protein 158(gene name synonym)|uniprotkb:RNF158(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2482390|imex:IM-20398-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:XP_011535871.1|refseq:NP_689763.3|refseq:XP_016864625.1|refseq:XP_006714820.1|ensembl:ENSG00000156463(gene)|ensembl:ENST00000359120(transcript)|ensembl:ENST00000511217(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR028511|interpro:IPR035792|interpro:IPR035794|interpro:IPR035822|interpro:IPR036028	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:ipP8ZHmrTHHf+77eHJSoHFA45449606	intact-crc:A54AA9166CEABD22|rigid:3iNmcC/h2Trq8Egz1298QNOZSmg	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:380..380-441..441	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15700	uniprotkb:P48023	intact:EBI-80426|ensembl:ENSP00000381355|uniprotkb:Q59G57|uniprotkb:Q68CQ8|uniprotkb:Q6ZTA8|uniprotkb:B7WNY8|uniprotkb:F8W9V6|uniprotkb:Q5H9Q4	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:dlg2_human(display_long)|uniprotkb:DLG2(gene name)|psi-mi:DLG2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483139|imex:IM-20398-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150672(gene)|ensembl:ENST00000398309(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR008144(Guanylate kinase)|rcsb pdb:2BYG|rcsb pdb:2HE2|reactome:R-HSA-438066|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|reactome:R-HSA-442982|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|reactome:R-HSA-5673001|reactome:R-HSA-6794361|interpro:IPR035759|reactome:R-HSA-9609736|reactome:R-HSA-9617324|interpro:IPR036028|reactome:R-HSA-9620244|refseq:NP_001355.2|refseq:NP_001136171.1|refseq:NP_001136172.1|refseq:NP_001136174.1|refseq:NP_001193698.1	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:hBuRCYIzH2etGCJINoeHIYFGTrc9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:DF079899EA002938|rigid:ndhhYm7we/SgSxS2xKHrSY82WHI	false	sufficient binding region:536..536-606..606(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O60504	uniprotkb:P48023	intact:EBI-741237|ensembl:ENSP00000240123|uniprotkb:Q5BJE4|uniprotkb:Q6NX54|uniprotkb:Q9UQE4|intact:EBI-1222937|uniprotkb:Q96FY4	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:vinex_human(display_long)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483150|imex:IM-20398-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120896(gene)|ensembl:ENST00000240123(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0017166"(vinculin binding)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR028510|interpro:IPR035607|interpro:IPR035608|interpro:IPR035609|interpro:IPR036028|mint:O60504|rcsb pdb:2CT3|rcsb pdb:2DLM|rcsb pdb:2NWM|rcsb pdb:2YUP|reactome:R-HSA-445355|refseq:NP_001018003.1|refseq:NP_005766.3|refseq:XP_005273428.1|refseq:XP_016868433.1|refseq:XP_016868434.1|refseq:XP_016868435.1	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:Mq3VXduU/1gqfUwliO9sBBOb/Vc9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:9D5D943EDA747454|rigid:X9cz1kpHKm/IoNyclfGs1uk9VRM	false	sufficient binding region:454..454-515..515(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:O75563	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2483161|ensembl:ENSP00000005587|uniprotkb:Q53GP6|uniprotkb:Q75MK6|uniprotkb:Q75MZ4|uniprotkb:Q9UBZ3|uniprotkb:Q9UED8|uniprotkb:A4D173	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:skap2_human(display_long)|uniprotkb:SKAP2(gene name)|psi-mi:SKAP2(display_short)|uniprotkb:PRAP(gene name synonym)|uniprotkb:RA70(gene name synonym)|uniprotkb:SAPS(gene name synonym)|uniprotkb:SCAP2(gene name synonym)|uniprotkb:SKAP55R(gene name synonym)|uniprotkb:Src family-associated phosphoprotein 2(gene name synonym)|uniprotkb:Src kinase-associated phosphoprotein 55-related protein(gene name synonym)|uniprotkb:SKAP55 homolog(gene name synonym)|uniprotkb:Src-associated adapter protein with PH and SH3 domains(gene name synonym)|uniprotkb:Pyk2/RAFTK-associated protein(gene name synonym)|uniprotkb:Retinoic acid-induced protein 70(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483194|imex:IM-20398-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSG00000005020(gene)|ensembl:ENST00000345317(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|interpro:IPR037781|rcsb pdb:3OMH|reactome:R-HSA-391160|refseq:NP_001290397.1|refseq:NP_003921.2|refseq:XP_016868260.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:/DicuSIa8/M32bXSYfuzrx8gHK89606	intact-crc:B4A6019677E6E6B8|rigid:ZvjmapYsk0cVYcS30TddHJZZGTk	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:297..297-358..358(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46108	uniprotkb:P48023	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483205|imex:IM-20398-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:B3122CAFEA435508|rigid:0zU7qa1vG799nfbh+B81O5AHnh0	false	sufficient binding region:256..256-296..296	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q9NZQ3	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-745080|ensembl:ENSP00000294129|uniprotkb:B4DFL5|uniprotkb:Q6SPF3|uniprotkb:Q8TC10|uniprotkb:Q9UGM8|intact:EBI-957585|uniprotkb:Q6GU34	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:spn90_human(display_long)|uniprotkb:NCKIPSD(gene name)|psi-mi:NCKIPSD(display_short)|uniprotkb:AF3P21(gene name synonym)|uniprotkb:SPIN90(gene name synonym)|uniprotkb:54 kDa VacA-interacting protein(gene name synonym)|uniprotkb:54 kDa vimentin-interacting protein(gene name synonym)|uniprotkb:90 kDa SH3 protein interacting with Nck(gene name synonym)|uniprotkb:AF3p21(gene name synonym)|uniprotkb:Dia-interacting protein 1(gene name synonym)|uniprotkb:Diaphanous protein-interacting protein(gene name synonym)|uniprotkb:SH3 adapter protein SPIN90(gene name synonym)|uniprotkb:WASP-interacting SH3-domain protein(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483216|imex:IM-20398-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	go:"GO:0007010"(cytoskeleton organization)|ensembl:ENSG00000213672(gene)|ensembl:ENST00000294129(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006897"(endocytosis)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017022"(myosin binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0071933"(Arp2/3 complex binding)|interpro:IPR001452(Src homology-3)|interpro:IPR018556|interpro:IPR030125|interpro:IPR035514|interpro:IPR036028|mint:Q9NZQ3|refseq:NP_057537.1|refseq:NP_909119.1|rcsb pdb:6DEC|rcsb pdb:6DED|rcsb pdb:6DEE|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9664422	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:GPUSFE2sszpigAuSg81Cmk7HJCM9606	intact-crc:C80D53211E6E733C|rigid:/OgxYRhBsp9EfBVi8uHvUVmF+UI	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:1..1-58..58(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5TCZ1	uniprotkb:P48023	intact:EBI-2483234|uniprotkb:O43302|uniprotkb:Q5TCZ2|uniprotkb:Q5TDQ8|uniprotkb:D3DR98|ensembl:ENSP00000358789	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:spd2a_human(display_long)|uniprotkb:Tyrosine kinase substrate with five SH3 domains(gene name synonym)|uniprotkb:SH3PXD2A(gene name)|psi-mi:SH3PXD2A(display_short)|uniprotkb:FISH(gene name synonym)|uniprotkb:KIAA0418(gene name synonym)|uniprotkb:SH3MD1(gene name synonym)|uniprotkb:SH3 multiple domains protein 1(gene name synonym)|uniprotkb:Five SH3 domain-containing protein(gene name synonym)|uniprotkb:Adapter protein TKS5(gene name synonym)|uniprotkb:TKS5(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483227|imex:IM-20398-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055446.2|refseq:XP_005270351.1|ensembl:ENSG00000107957(gene)|ensembl:ENST00000369774(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030054"(cell junction)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042995"(cell projection)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072675"(osteoclast fusion)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034917|interpro:IPR035449|interpro:IPR035450|interpro:IPR035452|interpro:IPR035453|interpro:IPR035454|interpro:IPR036028|interpro:IPR036871|interpro:IPR037961|rcsb pdb:2DNU|rcsb pdb:2EGA|rcsb pdb:2EGC|rcsb pdb:2EKH|mint:Q5TCZ1|reactome:R-HSA-8941237|reactome:R-HSA-9013148	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:XnTFFWWCeseePTNypWPnbkI+Y6I9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:267B3183C438AA3E|rigid:/+URFXxQ24zQi+e72tH4i1J7JXE	false	sufficient binding region:1071..1071-1133..1133(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UHR4	uniprotkb:P48023	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483301|imex:IM-20398-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:D2786ECCC8B66FCC|rigid:EfWVb90O/5FQPeEwXUazi6ixxjM	false	sufficient binding region:339..339-402..402(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q99963	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483312|imex:IM-20398-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	intact-crc:0CF3A461B43ACD63|rigid:bBAlts642FaCCajcyGNetVKnNvo	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:285..285-344..344(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O95049	uniprotkb:P48023	intact:EBI-1171427|uniprotkb:A6NFP3|uniprotkb:Q32N01|uniprotkb:B3KR73|uniprotkb:B4E2W6|uniprotkb:F5H2X0|uniprotkb:F5H4S9|uniprotkb:B3KXZ0|uniprotkb:K7EK22|intact:EBI-10970160|ensembl:ENSP00000439278	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:zo3_human(display_long)|uniprotkb:Zonula occludens protein 3(gene name synonym)|uniprotkb:Zona occludens protein 3(gene name synonym)|uniprotkb:Tight junction protein 3(gene name synonym)|uniprotkb:TJP3(gene name)|psi-mi:TJP3(display_short)|uniprotkb:ZO3(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483324|imex:IM-20398-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001254489.1|refseq:NP_001254490.1|ensembl:ENSG00000105289(gene)|ensembl:ENST00000541714(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005420(Zona occludens protein ZO-3)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|rcsb pdb:3KFV|go:"GO:0005923"(bicellular tight junction)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:bJciuPizUo/lOq89solMYusjm009606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:B4947D703F3895FB|rigid:7Qx3sxnB5IoZfnpTv3Sh3clfQ2E	false	sufficient binding region:475..475-549..549(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P54284	uniprotkb:P48023	intact:EBI-1184651|uniprotkb:Q13913|uniprotkb:A8K0Z4|ensembl:ENSP00000301050|uniprotkb:B7Z4Q1|uniprotkb:B7Z973|uniprotkb:B7ZAK8|uniprotkb:F5GZW7|uniprotkb:F5H2P6|uniprotkb:F8VSG3	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:cacb3_human(display_long)|uniprotkb:CACNB3(gene name)|psi-mi:CACNB3(display_short)|uniprotkb:CACNLB3(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 3(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483335|imex:IM-20398-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000716.2|ensembl:ENSG00000167535(gene)|ensembl:ENST00000301050(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR008079(Voltage-dependent calcium channel, L-type, beta-3 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035760|interpro:IPR036028|reactome:R-HSA-112308|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:1905788"(negative regulation of detection of mechanical stimulus involved in sensory perception of touch)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|refseq:NP_001193844.1|refseq:NP_001193845.1|refseq:NP_001193846.1|dip:DIP-39138N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:UTOg/TyylvvNXDm9Yt7LvIx47049606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:BFEDD932CACC7631|rigid:N8evrOwDdkW5pF82NAhHLuAMHvM	false	sufficient binding region:59..59-160..160(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q96JB8	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483396|imex:IM-20398-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606	intact-crc:34AD72345212F48A|rigid:toYW4vrByuXktPK74qUzIc6DRoc	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:242..242-312..312(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P27986	uniprotkb:P48023	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483408|imex:IM-20398-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:EE427B56FA6E5899|rigid:+ekCBvAOtc5eO2SQvdqhY21pxac	false	sufficient binding region:3..3-79..79(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q6XZF7	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2483419|ensembl:ENSP00000315659|uniprotkb:Q8IVY3|uniprotkb:Q9Y2L3	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:dnmbp_human(display_long)|uniprotkb:DNMBP(gene name)|psi-mi:DNMBP(display_short)|uniprotkb:KIAA1010(gene name synonym)|uniprotkb:Scaffold protein Tuba(gene name synonym)|uniprotkb:ARHGEF36(gene name synonym)|uniprotkb:TUBA(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483457|imex:IM-20398-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSG00000107554(gene)|ensembl:ENST00000324109(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007568"(aging)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0098793"(presynapse)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035469|interpro:IPR035817|interpro:IPR035818|interpro:IPR035819|interpro:IPR035820|interpro:IPR035899|interpro:IPR036028|mint:Q6XZF7|rcsb pdb:1UG1|rcsb pdb:1UHC|rcsb pdb:4CC2|rcsb pdb:4CC3|rcsb pdb:4CC4|rcsb pdb:4CC7|rcsb pdb:4GLM|reactome:R-HSA-9013148|refseq:XP_011537861.1|refseq:NP_056036.1|refseq:NP_001305255.1|refseq:NP_001305256.1|dip:DIP-53822N	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:Pnps+8tUGF35nxMUaPgDr5hzRzc9606	intact-crc:6F6A367413407410|rigid:G8sUC7xkna2gEgLsA5MG/Kquo7g	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:243..243-302..302(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q8N1I0	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-1059186|uniprotkb:O14584|uniprotkb:O94824|uniprotkb:Q8NB45|ensembl:ENSP00000404179	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:dock4_human(display_long)|uniprotkb:DOCK4(gene name)|psi-mi:DOCK4(display_short)|uniprotkb:KIAA0716(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483468|imex:IM-20398-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENST00000428084|ensembl:ENSP00000410746|ensembl:ENSP00000404179|refseq:NP_055520.3|refseq:XP_006716251.1|refseq:XP_006716252.1|ensembl:ENSG00000128512(gene)|ensembl:ENST00000437633(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0060326"(cell chemotaxis)|go:"GO:1904694"(negative regulation of vascular associated smooth muscle contraction)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|interpro:IPR032376|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-983231|interpro:IPR035769|interpro:IPR035892|interpro:IPR036028|interpro:IPR037014|interpro:IPR037811	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:gfkRZEKBQCgsZ/zjJ8NWqL3uJZk9606	intact-crc:A75FD23594A11ACF|rigid:dhzpwSYDrOHLgeDcbEsz4gewSag	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:6..6-67..67(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:O60229	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-949233|ensembl:ENSP00000353109|intact:EBI-1104807|uniprotkb:Q8TBQ5|uniprotkb:Q9NSZ4|uniprotkb:Q9Y2A5|uniprotkb:Q6ZN45|uniprotkb:A8MSI4|uniprotkb:J3QSW6|intact:EBI-3866438|uniprotkb:C9JQ37	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:kalrn_human(display_long)|uniprotkb:KALRN(gene name)|psi-mi:KALRN(display_short)|uniprotkb:DUET(gene name synonym)|uniprotkb:DUO(gene name synonym)|uniprotkb:HAPIP(gene name synonym)|uniprotkb:TRAD(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483487|imex:IM-20398-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036865|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5687128|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|ensembl:ENSG00000160145(gene)|ensembl:ENST00000360013(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|refseq:NP_001309929.1|refseq:NP_001019831.2|refseq:NP_003938.1|refseq:NP_008995.2|refseq:NP_001309930.1|refseq:NP_001309917.1|refseq:NP_001309918.1|refseq:NP_001309923.1|refseq:NP_001309924.1|refseq:NP_001309925.1|refseq:NP_001309926.1|refseq:NP_001309927.1|refseq:NP_001309928.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2019/08/05	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:E7oPA6ps2iq0KD8jlTCm/mNQj949606	intact-crc:A21F20A81F876F1A|rigid:kSf9cA1q9/6F0O5WVvJZSJtpLMI	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:1646..1646-1711..1711(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q6ZN28	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2483498|ensembl:ENSP00000328410|ensembl:ENSP00000383185|ensembl:ENSP00000466864|uniprotkb:A8MUS5|uniprotkb:B2RNR9|uniprotkb:Q6ZQN8|uniprotkb:Q7Z5A5	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:macc1_human(display_long)|uniprotkb:MACC1(gene name)|psi-mi:MACC1(display_short)|uniprotkb:SH3 domain-containing protein 7a5(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483518|imex:IM-20398-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSG00000183742(gene)|ensembl:ENST00000332878(transcript)|ensembl:ENST00000400331(transcript)|ensembl:ENST00000589011(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0008083"(growth factor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051781"(positive regulation of cell division)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|refseq:NP_877439.3	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:oxGaJSY19Sf/hU0oQbtMH3sIyLc9606	intact-crc:CDF07427F1E44DDD|rigid:4VSkPuWe6o2wu5qYVV2vNt6jV+o	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:552..552-618..618(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:O43295	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-368166|uniprotkb:Q8IX13|uniprotkb:Q8IZV8|ensembl:ENSP00000373347	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:srgp3_human(display_long)|uniprotkb:SRGAP2(gene name synonym)|uniprotkb:SRGAP3(gene name)|psi-mi:SRGAP3(display_short)|uniprotkb:ARHGAP14(gene name synonym)|uniprotkb:KIAA0411(gene name synonym)|uniprotkb:MEGAP(gene name synonym)|uniprotkb:KIAA1156(gene name synonym)|uniprotkb:WAVE-associated Rac GTPase-activating protein(gene name synonym)|uniprotkb:Mental disorder-associated GAP(gene name synonym)|uniprotkb:Rho GTPase-activating protein 14(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483531|imex:IM-20398-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001028289.1|refseq:NP_055665.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|interpro:IPR031160|interpro:IPR035648|interpro:IPR036028|mint:O43295|reactome:R-HSA-428543|reactome:R-HSA-9013148|reactome:R-HSA-9013149|ensembl:ENSG00000196220(gene)|ensembl:ENST00000383836(transcript)|go:"GO:0005096"(GTPase activator activity)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:HLVloXKWOPDKajmruSjcnkctxBs9606	intact-crc:E9EF8921081DF08C|rigid:iVFB1tiA8ZO1x4M9JLVxGgt0ev8	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:720..720-779..779(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06241	uniprotkb:P48023	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483546|imex:IM-20398-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:C0A61A924253FB66|rigid:/mgvD64TRMB2zfImhq7o3JikrV8	false	sufficient binding region:82..82-143..143(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q16674	uniprotkb:P48023	intact:EBI-2483557|ensembl:ENSP00000263369|ensembl:ENSP00000469499|ensembl:ENSP00000470129|uniprotkb:Q6FHV3	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:mia_human(display_long)|uniprotkb:MIA(gene name)|psi-mi:MIA(display_short)|uniprotkb:Melanoma inhibitory activity protein(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483574|imex:IM-20398-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000261857(gene)|ensembl:ENST00000263369(transcript)|ensembl:ENST00000594436(transcript)|ensembl:ENST00000597784(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008083"(growth factor activity)|go:"GO:0030198"(extracellular matrix organization)|interpro:IPR001452(Src homology-3)|interpro:IPR036028|interpro:IPR043369|rcsb pdb:1HJD|rcsb pdb:1I1J|rcsb pdb:1K0X|rcsb pdb:5IXB|refseq:NP_001189482.1|refseq:NP_006524.1	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:rtmlPZLmLwiahvRcur/zEA6af2o9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:8A9B4A4282D1A28D|rigid:ljdH4zeb9II90zqOoHPQDW100H4	false	sufficient binding region:43..43-113..113(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:O75044	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-1051034|ensembl:ENSP00000459615|uniprotkb:A2RUF3	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:srgp2_human(display_long)|uniprotkb:Formin-binding protein 2(gene name synonym)|uniprotkb:SRGAP2(gene name)|psi-mi:SRGAP2(display_short)|uniprotkb:FNBP2(gene name synonym)|uniprotkb:KIAA0456(gene name synonym)|uniprotkb:ARHGAP34(gene name synonym)|uniprotkb:Rho GTPase-activating protein 34(gene name synonym)|uniprotkb:SRGAP2A(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483668|imex:IM-20398-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001164108.1|refseq:NP_056141.2|ensembl:ENSG00000266028(gene)|ensembl:ENST00000573034(transcript)|go:"GO:0003363"(lamellipodium assembly involved in ameboidal cell migration)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021816"(extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051014"(actin filament severing)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060996"(dendritic spine development)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000198(RhoGAP)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|interpro:IPR030252|interpro:IPR031160|interpro:IPR035648|interpro:IPR036028|mint:O75044|rcsb pdb:2DL8|rcsb pdb:4RTT|rcsb pdb:4RUG|rcsb pdb:5I6J|rcsb pdb:5I6R|rcsb pdb:5I7D|reactome:R-HSA-428543|reactome:R-HSA-5663220|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|dip:DIP-37618N|refseq:XP_005277567.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2018/01/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:/0NBTrPy/51L4LGytNP/80OifEE9606	intact-crc:0F08A931B1EDD348|rigid:X4yQS3MB0uJZHnBxX7M0wwsbbTI	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:728..728-787..787(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZM3	uniprotkb:P48023	intact:EBI-308689|uniprotkb:O95062|uniprotkb:Q15812|uniprotkb:Q9HAK4|uniprotkb:Q9NXE6|uniprotkb:Q9NYG0|uniprotkb:Q9NZM2|uniprotkb:Q9ULG4|ensembl:ENSP00000347244	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:itsn2_human(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483819|imex:IM-20398-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000347244|ensembl:ENST00000361999|ensembl:ENSP00000354561|ensembl:ENST00000406921|ensembl:ENSP00000384499|ensembl:ENSG00000198399(gene)|ensembl:ENST00000355123(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR027029|interpro:IPR035737|interpro:IPR035738|interpro:IPR035739|interpro:IPR035740|interpro:IPR035741|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|rcsb pdb:1J3T|rcsb pdb:1UDL|rcsb pdb:1UE9|rcsb pdb:1UFF|rcsb pdb:1UHF|rcsb pdb:3GF9|rcsb pdb:3JZY|rcsb pdb:4IIO|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_006268.2|refseq:NP_062541.3|refseq:NP_671494.2	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:dxUqeWmW1uwOqgZ89UhT98/pt809606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:B10700C996596210|rigid:VVxVnu8Qr8R2ExOF2RH1GhXH+Ls	false	sufficient binding region:898..898-956..956(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14598	uniprotkb:P48023	intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2483950|imex:IM-20398-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2018/04/30	rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:C1343422F1AE8BEE|rigid:U/VRqD+xi8ggFv7v0cZcD7ReOrE	false	sufficient binding region:156..156-215..215(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q08881	uniprotkb:P48023	intact:EBI-968552|intact:EBI-5773727|intact:EBI-28978067|ensembl:ENSP00000398655|uniprotkb:Q32ML7|uniprotkb:B2R752	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:itk_human(display_long)|uniprotkb:ITK(gene name)|psi-mi:ITK(display_short)|uniprotkb:EMT(gene name synonym)|uniprotkb:LYK(gene name synonym)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase Lyk(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Interleukin-2-inducible T-cell kinase(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2484147|imex:IM-20398-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113263(gene)|ensembl:ENST00000422843(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042110"(T cell activation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q08881|rcsb pdb:1SM2|rcsb pdb:1SNU|rcsb pdb:1SNX|rcsb pdb:2E6I|rcsb pdb:2LMJ|rcsb pdb:2YUQ|rcsb pdb:3MIY|rcsb pdb:3MJ1|rcsb pdb:3MJ2|rcsb pdb:3QGW|rcsb pdb:3QGY|rcsb pdb:3T9T|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:3V5J|rcsb pdb:3V5L|rcsb pdb:3V8T|rcsb pdb:3V8W|rcsb pdb:4HCT|rcsb pdb:4HCU|rcsb pdb:4HCV|rcsb pdb:4KIO|rcsb pdb:4L7S|rcsb pdb:4M0Y|rcsb pdb:4M0Z|rcsb pdb:4M12|rcsb pdb:4M13|rcsb pdb:4M14|rcsb pdb:4M15|rcsb pdb:4MF0|rcsb pdb:4MF1|rcsb pdb:4PP9|rcsb pdb:4PPA|rcsb pdb:4PPB|rcsb pdb:4PPC|rcsb pdb:4PQN|rcsb pdb:4QD6|rcsb pdb:4RFM|reactome:R-HSA-202433|reactome:R-HSA-2871809|refseq:NP_005537.3|ensembl:ENSP00000398655|dip:DIP-29974N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:DbmEoJ3gxf6xJrG1Qn4mAXASfw89606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:D0DC0DE9043C295D|rigid:LWt5wMnsMyTXBMYOlvRhrsII/cQ	false	sufficient binding region:171..171-231..231(IPR001452)	glutathione s tranferase tag:?-?|sufficient binding region:1-80	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:O00305	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-714838|uniprotkb:O60515|uniprotkb:Q6B000|uniprotkb:Q96L40|uniprotkb:A8K1Y4|ensembl:ENSP00000438949|uniprotkb:A7BJ74|uniprotkb:B4DG40	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:cacb4_human(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 4(gene name synonym)|uniprotkb:CACNB4(gene name)|psi-mi:CACNB4(display_short)|uniprotkb:CACNLB4(gene name synonym)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2484330|imex:IM-20398-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_000717.2|refseq:NP_001005747.1|refseq:NP_001139270.1|ensembl:ENSG00000182389(gene)|ensembl:ENST00000539935(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0045202"(synapse)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|rcsb pdb:2D46|reactome:R-HSA-112308|reactome:R-HSA-419037|refseq:NP_001005746.1|refseq:NP_001307651.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:lZH10l3OCtB22f3xtOthoeGdXcU9606	intact-crc:126EB10ACD111221|rigid:R9W4oQ1ndGyubViy0erui/9rokw	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:118..118-153..153(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:A6NJZ7	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-2484467|intact:EBI-28983531|ensembl:ENSP00000390630	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:rim3c_human(display_long)|uniprotkb:RIMS-binding protein 3.3(gene name synonym)|uniprotkb:RIMBP3C(gene name)|psi-mi:RIMBP3C(display_short)	psi-mi:"MI:0084"(phage display)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2484490|imex:IM-20398-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSG00000183246(gene)|ensembl:ENST00000433039(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030156"(benzodiazepine receptor binding)|go:"GO:0045202"(synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR035515|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325|ensembl:ENSP00000390630|refseq:NP_001122105.1	-	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:tA3+zG0u73zN+3SSlT3vElPIIGI9606	intact-crc:AA792A801193F0B4|rigid:KvIz4mDeeQvYXrpagqm0qAfsStI	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	sufficient binding region:1452..1452-1520..1520(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48023	uniprotkb:Q08881	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-968552|intact:EBI-5773727|intact:EBI-28978067|ensembl:ENSP00000398655|uniprotkb:Q32ML7|uniprotkb:B2R752	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:itk_human(display_long)|uniprotkb:ITK(gene name)|psi-mi:ITK(display_short)|uniprotkb:EMT(gene name synonym)|uniprotkb:LYK(gene name synonym)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase Lyk(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Interleukin-2-inducible T-cell kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2485980|imex:IM-20398-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSG00000113263(gene)|ensembl:ENST00000422843(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042110"(T cell activation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q08881|rcsb pdb:1SM2|rcsb pdb:1SNU|rcsb pdb:1SNX|rcsb pdb:2E6I|rcsb pdb:2LMJ|rcsb pdb:2YUQ|rcsb pdb:3MIY|rcsb pdb:3MJ1|rcsb pdb:3MJ2|rcsb pdb:3QGW|rcsb pdb:3QGY|rcsb pdb:3T9T|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:3V5J|rcsb pdb:3V5L|rcsb pdb:3V8T|rcsb pdb:3V8W|rcsb pdb:4HCT|rcsb pdb:4HCU|rcsb pdb:4HCV|rcsb pdb:4KIO|rcsb pdb:4L7S|rcsb pdb:4M0Y|rcsb pdb:4M0Z|rcsb pdb:4M12|rcsb pdb:4M13|rcsb pdb:4M14|rcsb pdb:4M15|rcsb pdb:4MF0|rcsb pdb:4MF1|rcsb pdb:4PP9|rcsb pdb:4PPA|rcsb pdb:4PPB|rcsb pdb:4PPC|rcsb pdb:4PQN|rcsb pdb:4QD6|rcsb pdb:4RFM|reactome:R-HSA-202433|reactome:R-HSA-2871809|refseq:NP_005537.3|ensembl:ENSP00000398655|dip:DIP-29974N	-	-	-	figure legend:Fig. 3|comment:SH3 region of ITK inferred from the uniProtKB entry. Expression details of ITK construct not given in the paper.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:DbmEoJ3gxf6xJrG1Qn4mAXASfw89606	intact-crc:FA18BC5308F966BF|rigid:LWt5wMnsMyTXBMYOlvRhrsII/cQ	false	-	sufficient binding region:171..171-231..231(IPR001452)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08881	uniprotkb:P48023	intact:EBI-968552|intact:EBI-5773727|intact:EBI-28978067|ensembl:ENSP00000398655|uniprotkb:Q32ML7|uniprotkb:B2R752	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:itk_human(display_long)|uniprotkb:ITK(gene name)|psi-mi:ITK(display_short)|uniprotkb:EMT(gene name synonym)|uniprotkb:LYK(gene name synonym)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase Lyk(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Interleukin-2-inducible T-cell kinase(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0096"(pull down)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2486135|imex:IM-20398-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113263(gene)|ensembl:ENST00000422843(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042110"(T cell activation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q08881|rcsb pdb:1SM2|rcsb pdb:1SNU|rcsb pdb:1SNX|rcsb pdb:2E6I|rcsb pdb:2LMJ|rcsb pdb:2YUQ|rcsb pdb:3MIY|rcsb pdb:3MJ1|rcsb pdb:3MJ2|rcsb pdb:3QGW|rcsb pdb:3QGY|rcsb pdb:3T9T|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:3V5J|rcsb pdb:3V5L|rcsb pdb:3V8T|rcsb pdb:3V8W|rcsb pdb:4HCT|rcsb pdb:4HCU|rcsb pdb:4HCV|rcsb pdb:4KIO|rcsb pdb:4L7S|rcsb pdb:4M0Y|rcsb pdb:4M0Z|rcsb pdb:4M12|rcsb pdb:4M13|rcsb pdb:4M14|rcsb pdb:4M15|rcsb pdb:4MF0|rcsb pdb:4MF1|rcsb pdb:4PP9|rcsb pdb:4PPA|rcsb pdb:4PPB|rcsb pdb:4PPC|rcsb pdb:4PQN|rcsb pdb:4QD6|rcsb pdb:4RFM|reactome:R-HSA-202433|reactome:R-HSA-2871809|refseq:NP_005537.3|ensembl:ENSP00000398655|dip:DIP-29974N	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Fig. 3|comment:SH3 region of ITK inferred from the uniProtKB entry. Expression details of ITK construct not given in the paper.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/25	2014/10/16	rogid:DbmEoJ3gxf6xJrG1Qn4mAXASfw89606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:55876E1025BDB1A7|rigid:LWt5wMnsMyTXBMYOlvRhrsII/cQ	false	sufficient binding region:171..171-231..231(IPR001452)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WV41	uniprotkb:P48023	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2486299|imex:IM-20398-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	-	-	-	figure legend:Fig. 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/25	2014/10/16	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	intact-crc:36E882FE0C4D8DF7|rigid:7kxcdg3pJi4+YUrJQEljhrP6Sno	false	ha tag:?-?	sufficient binding region:1-80|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P48023	uniprotkb:Q9Y5X1	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2486434|imex:IM-20398-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	-	-	-	figure legend:Fig. 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	intact-crc:D02B33440C43EE42|rigid:iDiqzWwjXiW5isuWb74GMmihR4A	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	ha tag:?-?(IPR001452)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P48023	uniprotkb:Q96RF0	intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694	intact:EBI-298169|uniprotkb:Q05BB3|uniprotkb:Q0VG02|ensembl:ENSP00000342276|uniprotkb:B4E2B3|uniprotkb:H7BXX3	psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym)	psi-mi:snx18_human(display_long)|uniprotkb:SNX18(gene name)|psi-mi:SNX18(display_short)|uniprotkb:SH3 and PX domain-containing protein 3B(gene name synonym)|uniprotkb:SH3PXD3B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Voss et al. (2009)	pubmed:19807924|imex:IM-20398	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2486516|imex:IM-20398-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor)	refseq:NP_001096045.1|refseq:NP_001138899.1|refseq:NP_443102.2|ensembl:ENSG00000178996(gene)|go:"GO:0006897"(endocytosis)|ensembl:ENST00000343017(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028646|interpro:IPR035557|interpro:IPR035703|interpro:IPR036028|interpro:IPR036871|mint:Q96RF0|reactome:R-HSA-8856828	-	-	-	figure legend:Fig. 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/25	2014/10/16	rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606	rogid:HpHLfTZ0EfhC6oMHeSr1GCgZaI49606	intact-crc:EF0342F71482C8F7|rigid:L8ZvOS2BBGfUakVR3w++gjR5gag	false	glutathione s tranferase tag:?-?|sufficient binding region:1-80	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)