#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14676	uniprotkb:O60934	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-494844|uniprotkb:O60672|uniprotkb:Q32NF7|uniprotkb:Q53FM6|uniprotkb:Q63HR6|uniprotkb:Q7LDM2|uniprotkb:B2R626|uniprotkb:B2RNC5|ensembl:ENSP00000265433	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:nbn_human(display_long)|uniprotkb:Nijmegen breakage syndrome protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein p95(gene name synonym)|uniprotkb:NBN(gene name)|psi-mi:NBN(display_short)|uniprotkb:NBS1(gene name synonym)|uniprotkb:NBS(gene name synonym)|uniprotkb:P95(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lloyd et al. (2009)	imex:IM-12090|pubmed:19804756	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2463948|imex:IM-12090-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_002476.2|refseq:NP_001019859.1|refseq:XP_011515347.1|dip:DIP-33605N|ensembl:ENSG00000104320(gene)|ensembl:ENST00000265433(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045190"(isotype switching)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090656"(t-circle formation)|go:"GO:0090737"(telomere maintenance via telomere trimming)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013908(DNA  repair Nbs1, C-terminal)|interpro:IPR016592(Nibrin)|interpro:IPR032429|interpro:IPR036420|interpro:IPR040227|interpro:IPR043014|mint:O60934|rcsb pdb:5WQD|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, 5B, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:CTx61/3iHRb2kWfb5u/CSye5A2k9606	intact-crc:B56C85932EAC0191|rigid:RwLO3lNM/8WLXLjcr98Q6UTJvdc	false	sufficient binding region:325-336|O-phospho-L-serine:329-329|O-phospho-L-threonine:331-331	sufficient binding region:1-382|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60934	uniprotkb:Q14676	intact:EBI-494844|uniprotkb:O60672|uniprotkb:Q32NF7|uniprotkb:Q53FM6|uniprotkb:Q63HR6|uniprotkb:Q7LDM2|uniprotkb:B2R626|uniprotkb:B2RNC5|ensembl:ENSP00000265433	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	psi-mi:nbn_human(display_long)|uniprotkb:Nijmegen breakage syndrome protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein p95(gene name synonym)|uniprotkb:NBN(gene name)|psi-mi:NBN(display_short)|uniprotkb:NBS1(gene name synonym)|uniprotkb:NBS(gene name synonym)|uniprotkb:P95(gene name synonym)	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lloyd et al. (2009)	imex:IM-12090|pubmed:19804756	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2463967|imex:IM-12090-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002476.2|refseq:NP_001019859.1|refseq:XP_011515347.1|dip:DIP-33605N|ensembl:ENSG00000104320(gene)|ensembl:ENST00000265433(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045190"(isotype switching)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090656"(t-circle formation)|go:"GO:0090737"(telomere maintenance via telomere trimming)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013908(DNA  repair Nbs1, C-terminal)|interpro:IPR016592(Nibrin)|interpro:IPR032429|interpro:IPR036420|interpro:IPR040227|interpro:IPR043014|mint:O60934|rcsb pdb:5WQD|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, 5B, 6C, Supp. Table 1|comment:The combination of the Thr331Ser  MDC1 mutation and Lys160Met NBN mutation disrupted binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:CTx61/3iHRb2kWfb5u/CSye5A2k9606	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	intact-crc:D1C3D80AD12A6FDD|rigid:RwLO3lNM/8WLXLjcr98Q6UTJvdc	false	mutation decreasing interaction:28-28|mutation disrupting interaction:160-160,42-42|sufficient binding region:1-382|his tag:c-c|mutation decreasing interaction:42-42|mutation decreasing interaction:160-160	mutation decreasing interaction:331-331|sufficient binding region:325-336	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14676	uniprotkb:O43070	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-2125045|uniprotkb:Q86ZQ0|ensemblfungi:"SPBC6B1.09c.1:pep"	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:nbs1_schpo(display_long)|uniprotkb:nbs1(gene name)|psi-mi:nbs1(display_short)|uniprotkb:SPBC6B1.09c(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lloyd et al. (2009)	imex:IM-12090|pubmed:19804756	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464097|imex:IM-12090-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_001018823.1|dip:DIP-52387N|reactome:R-SPO-2559586|reactome:R-SPO-5685939|reactome:R-SPO-5693548|reactome:R-SPO-5693565|ensemblfungi:SPBC6B1.09c(gene)|ensemblfungi:SPBC6B1.09c.1(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1990166"(protein localization to site of double-strand break)|go:"GO:1990898"(meiotic DNA double-strand break clipping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|interpro:IPR040227|rcsb pdb:3HUE|rcsb pdb:3HUF|rcsb pdb:3I0M|rcsb pdb:3I0N|rcsb pdb:4FBK|rcsb pdb:4FBQ|rcsb pdb:4FBW	psi-mi:"MI:0469"(intact)	-	crc64:B3384CCC85F96DD1	figure legend:Fig. 3A, 3C, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:5h/qx0stPyVRQ9vtqO50Ftq0mvM284812	intact-crc:36985C10A1B901DC|rigid:SvbKZ5PBgl5+u3+fHQs10tKI+GQ	false	mutation decreasing interaction:334-334|sufficient binding region:325-334|O-phospho-L-threonine:331-331	his tag:c-c|sufficient binding region:1-324	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14676	uniprotkb:O43070	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-2125045|uniprotkb:Q86ZQ0|ensemblfungi:"SPBC6B1.09c.1:pep"	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:nbs1_schpo(display_long)|uniprotkb:nbs1(gene name)|psi-mi:nbs1(display_short)|uniprotkb:SPBC6B1.09c(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lloyd et al. (2009)	imex:IM-12090|pubmed:19804756	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464114|imex:IM-12090-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_001018823.1|dip:DIP-52387N|reactome:R-SPO-2559586|reactome:R-SPO-5685939|reactome:R-SPO-5693548|reactome:R-SPO-5693565|ensemblfungi:SPBC6B1.09c(gene)|ensemblfungi:SPBC6B1.09c.1(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1990166"(protein localization to site of double-strand break)|go:"GO:1990898"(meiotic DNA double-strand break clipping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|interpro:IPR040227|rcsb pdb:3HUE|rcsb pdb:3HUF|rcsb pdb:3I0M|rcsb pdb:3I0N|rcsb pdb:4FBK|rcsb pdb:4FBQ|rcsb pdb:4FBW	psi-mi:"MI:0469"(intact)	-	crc64:B3384CCC85F96DD1	figure legend:Fig. 3A, 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:5h/qx0stPyVRQ9vtqO50Ftq0mvM284812	intact-crc:D757DE2CA452EBD6|rigid:SvbKZ5PBgl5+u3+fHQs10tKI+GQ	false	-	his tag:c-c|sufficient binding region:1-324|mutation decreasing interaction:45-45|mutation decreasing interaction:76-76|mutation decreasing interaction:103-103	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43070	uniprotkb:O74986	intact:EBI-2125045|uniprotkb:Q86ZQ0|ensemblfungi:"SPBC6B1.09c.1:pep"	intact:EBI-2463766|uniprotkb:A9LJ21|ensemblfungi:"SPCC338.08.1:pep"	psi-mi:nbs1_schpo(display_long)|uniprotkb:nbs1(gene name)|psi-mi:nbs1(display_short)|uniprotkb:SPBC6B1.09c(orf name)	psi-mi:com1_schpo(display_long)|uniprotkb:Double-strand break repair protein ctp1(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2 homolog(gene name synonym)|uniprotkb:ctp1(gene name)|psi-mi:ctp1(display_short)|uniprotkb:mug38(gene name synonym)|uniprotkb:nip1(gene name synonym)|uniprotkb:slr9(gene name synonym)|uniprotkb:Nbs1-interacting protein 1(gene name synonym)|uniprotkb:Meiotically up-regulated gene 38 protein(gene name synonym)|uniprotkb:SPCC338.08(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lloyd et al. (2009)	imex:IM-12090|pubmed:19804756	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464148|imex:IM-12090-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018823.1|dip:DIP-52387N|reactome:R-SPO-2559586|reactome:R-SPO-5685939|reactome:R-SPO-5693548|reactome:R-SPO-5693565|ensemblfungi:SPBC6B1.09c(gene)|ensemblfungi:SPBC6B1.09c.1(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1990166"(protein localization to site of double-strand break)|go:"GO:1990898"(meiotic DNA double-strand break clipping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|interpro:IPR040227|rcsb pdb:3HUE|rcsb pdb:3HUF|rcsb pdb:3I0M|rcsb pdb:3I0N|rcsb pdb:4FBK|rcsb pdb:4FBQ|rcsb pdb:4FBW	refseq:NP_588159.2|dip:DIP-54853N|ensemblfungi:SPCC338.08(gene)|ensemblfungi:SPCC338.08.1(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0070336"(flap-structured DNA binding)|go:"GO:0106260"(DNA-DNA tethering activity)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|go:"GO:0120290"(stalled replication fork localization to nuclear periphery)|go:"GO:1903211"(mitotic recombination involved in replication fork processing)|go:"GO:1990898"(meiotic DNA double-strand break clipping)|go:"GO:1990899"(meiotic DNA double-strand break resectioning)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR033316|rcsb pdb:3HUF|rcsb pdb:4X01	psi-mi:"MI:0469"(intact)	crc64:B3384CCC85F96DD1	crc64:857AD70D23B88D68	figure legend:Fig. 5A, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:5h/qx0stPyVRQ9vtqO50Ftq0mvM284812	rogid:fr8PErR9V8pkC9g84uSjFyW5BDg284812	intact-crc:10801EE85A62A99B|rigid:VMF/FEVrRdvT4lNbmzvl8XYZOQU	false	his tag:c-c|sufficient binding region:1-324	sufficient binding region:73-84|mutation increasing interaction:76-76|O-phospho-L-serine:77-77	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43070	uniprotkb:O74986	intact:EBI-2125045|uniprotkb:Q86ZQ0|ensemblfungi:"SPBC6B1.09c.1:pep"	intact:EBI-2463766|uniprotkb:A9LJ21|ensemblfungi:"SPCC338.08.1:pep"	psi-mi:nbs1_schpo(display_long)|uniprotkb:nbs1(gene name)|psi-mi:nbs1(display_short)|uniprotkb:SPBC6B1.09c(orf name)	psi-mi:com1_schpo(display_long)|uniprotkb:Double-strand break repair protein ctp1(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2 homolog(gene name synonym)|uniprotkb:ctp1(gene name)|psi-mi:ctp1(display_short)|uniprotkb:mug38(gene name synonym)|uniprotkb:nip1(gene name synonym)|uniprotkb:slr9(gene name synonym)|uniprotkb:Nbs1-interacting protein 1(gene name synonym)|uniprotkb:Meiotically up-regulated gene 38 protein(gene name synonym)|uniprotkb:SPCC338.08(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lloyd et al. (2009)	imex:IM-12090|pubmed:19804756	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464163|imex:IM-12090-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018823.1|dip:DIP-52387N|reactome:R-SPO-2559586|reactome:R-SPO-5685939|reactome:R-SPO-5693548|reactome:R-SPO-5693565|ensemblfungi:SPBC6B1.09c(gene)|ensemblfungi:SPBC6B1.09c.1(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1990166"(protein localization to site of double-strand break)|go:"GO:1990898"(meiotic DNA double-strand break clipping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|interpro:IPR040227|rcsb pdb:3HUE|rcsb pdb:3HUF|rcsb pdb:3I0M|rcsb pdb:3I0N|rcsb pdb:4FBK|rcsb pdb:4FBQ|rcsb pdb:4FBW	refseq:NP_588159.2|dip:DIP-54853N|ensemblfungi:SPCC338.08(gene)|ensemblfungi:SPCC338.08.1(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0070336"(flap-structured DNA binding)|go:"GO:0106260"(DNA-DNA tethering activity)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|go:"GO:0120290"(stalled replication fork localization to nuclear periphery)|go:"GO:1903211"(mitotic recombination involved in replication fork processing)|go:"GO:1990898"(meiotic DNA double-strand break clipping)|go:"GO:1990899"(meiotic DNA double-strand break resectioning)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR033316|rcsb pdb:3HUF|rcsb pdb:4X01	psi-mi:"MI:0469"(intact)	crc64:B3384CCC85F96DD1	crc64:857AD70D23B88D68	figure legend:Fig. 5A Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:5h/qx0stPyVRQ9vtqO50Ftq0mvM284812	rogid:fr8PErR9V8pkC9g84uSjFyW5BDg284812	intact-crc:C888F4FCB72916AD|rigid:VMF/FEVrRdvT4lNbmzvl8XYZOQU	false	sufficient binding region:1-324|his tag:c-c	O-phospho-L-serine:87-87|sufficient binding region:85-94	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60934	uniprotkb:Q14676	intact:EBI-494844|uniprotkb:O60672|uniprotkb:Q32NF7|uniprotkb:Q53FM6|uniprotkb:Q63HR6|uniprotkb:Q7LDM2|uniprotkb:B2R626|uniprotkb:B2RNC5|ensembl:ENSP00000265433	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	psi-mi:nbn_human(display_long)|uniprotkb:Nijmegen breakage syndrome protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein p95(gene name synonym)|uniprotkb:NBN(gene name)|psi-mi:NBN(display_short)|uniprotkb:NBS1(gene name synonym)|uniprotkb:NBS(gene name synonym)|uniprotkb:P95(gene name synonym)	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lloyd et al. (2009)	imex:IM-12090|pubmed:19804756	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464186|imex:IM-12090-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002476.2|refseq:NP_001019859.1|refseq:XP_011515347.1|dip:DIP-33605N|ensembl:ENSG00000104320(gene)|ensembl:ENST00000265433(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045190"(isotype switching)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090656"(t-circle formation)|go:"GO:0090737"(telomere maintenance via telomere trimming)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013908(DNA  repair Nbs1, C-terminal)|interpro:IPR016592(Nibrin)|interpro:IPR032429|interpro:IPR036420|interpro:IPR040227|interpro:IPR043014|mint:O60934|rcsb pdb:5WQD|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/15	2014/10/16	rogid:CTx61/3iHRb2kWfb5u/CSye5A2k9606	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	intact-crc:3E2DB573C4FC297E|rigid:RwLO3lNM/8WLXLjcr98Q6UTJvdc	false	yellow fluorescent protein tag:?-?|mutation decreasing interaction:28-28|mutation decreasing interaction:160-160	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)