#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P55317 uniprotkb:Q9Y261 intact:EBI-3918034|uniprotkb:Q9H2A0|uniprotkb:B2R9H6|ensembl:ENSP00000250448|uniprotkb:B7ZAP5 intact:EBI-7255248|ensembl:ENSP00000366319|uniprotkb:Q8WUW4|uniprotkb:Q96DF7|intact:MINT-6610868 psi-mi:foxa1_human(display_long)|uniprotkb:FOXA1(gene name)|psi-mi:FOXA1(display_short)|uniprotkb:HNF3A(gene name synonym)|uniprotkb:TCF3A(gene name synonym)|uniprotkb:Forkhead box protein A1(gene name synonym)|uniprotkb:Transcription factor 3A(gene name synonym) psi-mi:foxa2_human(display_long)|uniprotkb:FOXA2(gene name)|psi-mi:FOXA2(display_short)|uniprotkb:HNF3B(gene name synonym)|uniprotkb:TCF3B(gene name synonym)|uniprotkb:Forkhead box protein A2(gene name synonym)|uniprotkb:Transcription factor 3B(gene name synonym) psi-mi:"MI:0027"(cosedimentation) Pandey et al. (2009) pubmed:19769745|mint:MINT-7040428|mint:fj-09-0308 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7255241|mint:MINT-7040448 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004487.2|ensembl:ENSG00000129514(gene)|ensembl:ENST00000250448(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030154"(cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:1902691"(respiratory basal cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR018122|interpro:IPR018533|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:P55317|reactome:R-HSA-9018519|refseq:XP_016876735.1|dip:DIP-57138N|mint:MINT-7040450(identity) ensembl:ENSG00000125798(gene)|ensembl:ENST00000377115(transcript)|go:"GO:0000432"(positive regulation of transcription from RNA polymerase II promoter by glucose)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061987"(negative regulation of transcription from RNA polymerase II promoter by glucose)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2000971"(negative regulation of detection of glucose)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR018122|interpro:IPR018533|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:Q9Y261|rcsb pdb:5X07|reactome:R-HSA-210745|refseq:NP_710141.1|refseq:NP_068556.2|mint:MINT-7040451(identity) go:"GO:0005634"(nucleus) - comment:mint|function:Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes figure legend:F2A|comment:homomint|comment:mint taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2009/05/11 2014/10/16 rogid:RX9LFKwRrO2a2X9hXpHbZdcMpZE9606 rogid:4vF1YSzaAH8U/smjaLjSC3MS2sQ9606 intact-crc:77C51E3AC72973F4|rigid:YJyL9YkcngyDL0NK5lMJOo4npiU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P55317 uniprotkb:P20226 intact:EBI-3918034|uniprotkb:Q9H2A0|uniprotkb:B2R9H6|ensembl:ENSP00000250448|uniprotkb:B7ZAP5 intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869 psi-mi:foxa1_human(display_long)|uniprotkb:FOXA1(gene name)|psi-mi:FOXA1(display_short)|uniprotkb:HNF3A(gene name synonym)|uniprotkb:TCF3A(gene name synonym)|uniprotkb:Forkhead box protein A1(gene name synonym)|uniprotkb:Transcription factor 3A(gene name synonym) psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym) psi-mi:"MI:0027"(cosedimentation) Pandey et al. (2009) pubmed:19769745|mint:MINT-7040428|mint:fj-09-0308 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7255241|mint:MINT-7040448 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004487.2|ensembl:ENSG00000129514(gene)|ensembl:ENST00000250448(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030154"(cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:1902691"(respiratory basal cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR018122|interpro:IPR018533|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:P55317|reactome:R-HSA-9018519|refseq:XP_016876735.1|dip:DIP-57138N|mint:MINT-7040450(identity) refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N|mint:MINT-7040452(identity) go:"GO:0005634"(nucleus) - - figure legend:F2A|comment:homomint|comment:mint taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2009/05/11 2014/10/16 rogid:RX9LFKwRrO2a2X9hXpHbZdcMpZE9606 rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606 intact-crc:77C51E3AC72973F4|rigid:YJyL9YkcngyDL0NK5lMJOo4npiU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)