#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9S814	uniprotkb:P49333	intact:EBI-2437287|ensemblplants:AT5G03280.1	intact:EBI-1606682|ensemblplants:AT1G66340.1	psi-mi:ein2_arath(display_long)|uniprotkb:EIN2(gene name)|psi-mi:EIN2(display_short)|uniprotkb:CKR1(gene name synonym)|uniprotkb:Cytokinin-resistant protein AtCKR1(gene name synonym)|uniprotkb:ORE3(gene name synonym)|uniprotkb:Protein ORESARA 3(gene name synonym)|uniprotkb:F12E4.10(orf name)|uniprotkb:MOK16.19(orf name)|uniprotkb:At5g03280(locus name)	psi-mi:etr1_arath(display_long)|uniprotkb:ETR1(gene name)|psi-mi:ETR1(display_short)|uniprotkb:T27F4.9(orf name)|uniprotkb:At1g66340(locus name)|uniprotkb:Protein ETHYLENE RESPONSE 1(gene name synonym)|uniprotkb:Protein ETR1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Bisson et al. (2009)	pubmed:19769567|imex:IM-19110	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2437283|imex:IM-19110-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195948.1|interpro:IPR017187(Ethylene-insensitive 2)|interpro:IPR001046(Natural resistance-associated macrophage protein)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0009408"(response to heat)|go:"GO:0009651"(response to salt stress)|go:"GO:0009734"(auxin-activated signaling pathway)|go:"GO:0009736"(cytokinin-activated signaling pathway)|go:"GO:0009789"(positive regulation of abscisic acid-activated signaling pathway)|go:"GO:0009871"(jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway)|go:"GO:0009873"(ethylene-activated signaling pathway)|go:"GO:0009926"(auxin polar transport)|go:"GO:0010087"(phloem or xylem histogenesis)|go:"GO:0010119"(regulation of stomatal movement)|go:"GO:0010150"(leaf senescence)|go:"GO:0010182"(sugar mediated signaling pathway)|go:"GO:0015086"(cadmium ion transmembrane transporter activity)|ensemblplants:AT5G03280(gene)|ensemblplants:AT5G03280.1(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0003729"(mRNA binding)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0048765"(root hair cell differentiation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051301"(cell division)|go:"GO:0052544"(defense response by callose deposition in cell wall)|go:"GO:0106167"(extracellular ATP signaling)|go:"GO:0031348"(negative regulation of defense response)	rcsb pdb:4PL9|refseq:NP_176808.3|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011006(CheY-like)|interpro:IPR003018(GAF)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR014525(Signal transduction histidine kinase, hybrid-type, ethylene sensor)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR001789(Signal transduction response regulator, receiver region)|rcsb pdb:1DCF|go:"GO:0009737"(response to abscisic acid)|go:"GO:0009739"(response to gibberellin)|go:"GO:0010087"(phloem or xylem histogenesis)|go:"GO:0010105"(negative regulation of ethylene-activated signaling pathway)|go:"GO:0010119"(regulation of stomatal movement)|go:"GO:0010162"(seed dormancy process)|go:"GO:0010182"(sugar mediated signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038199"(ethylene receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051301"(cell division)|go:"GO:0051740"(ethylene binding)|go:"GO:0052544"(defense response by callose deposition in cell wall)|go:"GO:1900140"(regulation of seedling development)|interpro:IPR029016|ensemblplants:AT1G66340(gene)|ensemblplants:AT1G66340.1(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006952"(defense response)|go:"GO:0009408"(response to heat)|go:"GO:0009625"(response to insect)|go:"GO:0009651"(response to salt stress)|go:"GO:0009690"(cytokinin metabolic process)|go:"GO:0009723"(response to ethylene)|go:"GO:0009727"(detection of ethylene stimulus)|go:"GO:0009733"(response to auxin)|interpro:IPR036097|interpro:IPR036890	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2009/09/25	2014/10/16	rogid:gNiiGxTFrMUeqEvVrvwcsz8h7cY3702	rogid:HU7HG7EHvZR/6trEt2M2wmFdHRY3702	intact-crc:2D2E0AFB003F5C3B|rigid:L1YTfxmZorIO16IAnETdg6ai6ww	false	red fluorescent protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9S814	uniprotkb:P49333	intact:EBI-2437287|ensemblplants:AT5G03280.1	intact:EBI-1606682|ensemblplants:AT1G66340.1	psi-mi:ein2_arath(display_long)|uniprotkb:EIN2(gene name)|psi-mi:EIN2(display_short)|uniprotkb:CKR1(gene name synonym)|uniprotkb:Cytokinin-resistant protein AtCKR1(gene name synonym)|uniprotkb:ORE3(gene name synonym)|uniprotkb:Protein ORESARA 3(gene name synonym)|uniprotkb:F12E4.10(orf name)|uniprotkb:MOK16.19(orf name)|uniprotkb:At5g03280(locus name)	psi-mi:etr1_arath(display_long)|uniprotkb:ETR1(gene name)|psi-mi:ETR1(display_short)|uniprotkb:T27F4.9(orf name)|uniprotkb:At1g66340(locus name)|uniprotkb:Protein ETHYLENE RESPONSE 1(gene name synonym)|uniprotkb:Protein ETR1(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Bisson et al. (2009)	pubmed:19769567|imex:IM-19110	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2437332|imex:IM-19110-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195948.1|interpro:IPR017187(Ethylene-insensitive 2)|interpro:IPR001046(Natural resistance-associated macrophage protein)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0009408"(response to heat)|go:"GO:0009651"(response to salt stress)|go:"GO:0009734"(auxin-activated signaling pathway)|go:"GO:0009736"(cytokinin-activated signaling pathway)|go:"GO:0009789"(positive regulation of abscisic acid-activated signaling pathway)|go:"GO:0009871"(jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway)|go:"GO:0009873"(ethylene-activated signaling pathway)|go:"GO:0009926"(auxin polar transport)|go:"GO:0010087"(phloem or xylem histogenesis)|go:"GO:0010119"(regulation of stomatal movement)|go:"GO:0010150"(leaf senescence)|go:"GO:0010182"(sugar mediated signaling pathway)|go:"GO:0015086"(cadmium ion transmembrane transporter activity)|ensemblplants:AT5G03280(gene)|ensemblplants:AT5G03280.1(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0003729"(mRNA binding)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0048765"(root hair cell differentiation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051301"(cell division)|go:"GO:0052544"(defense response by callose deposition in cell wall)|go:"GO:0106167"(extracellular ATP signaling)|go:"GO:0031348"(negative regulation of defense response)	rcsb pdb:4PL9|refseq:NP_176808.3|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011006(CheY-like)|interpro:IPR003018(GAF)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR014525(Signal transduction histidine kinase, hybrid-type, ethylene sensor)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR001789(Signal transduction response regulator, receiver region)|rcsb pdb:1DCF|go:"GO:0009737"(response to abscisic acid)|go:"GO:0009739"(response to gibberellin)|go:"GO:0010087"(phloem or xylem histogenesis)|go:"GO:0010105"(negative regulation of ethylene-activated signaling pathway)|go:"GO:0010119"(regulation of stomatal movement)|go:"GO:0010162"(seed dormancy process)|go:"GO:0010182"(sugar mediated signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038199"(ethylene receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051301"(cell division)|go:"GO:0051740"(ethylene binding)|go:"GO:0052544"(defense response by callose deposition in cell wall)|go:"GO:1900140"(regulation of seedling development)|interpro:IPR029016|ensemblplants:AT1G66340(gene)|ensemblplants:AT1G66340.1(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006952"(defense response)|go:"GO:0009408"(response to heat)|go:"GO:0009625"(response to insect)|go:"GO:0009651"(response to salt stress)|go:"GO:0009690"(cytokinin metabolic process)|go:"GO:0009723"(response to ethylene)|go:"GO:0009727"(detection of ethylene stimulus)|go:"GO:0009733"(response to auxin)|interpro:IPR036097|interpro:IPR036890	-	-	-	figure legend:Figure 4|caution:"The authors do not provide details of the substitution of endogenous tryptophan residues in both proteins. For information the authors state \"endogenous tryptophan residues at positions 11, 53, 74, 182, 265, 288 and 563 in ETR1 and at positions 622, 682, 812, 948, 1012, 1075, 1129, 1140 and 1158 in EIN2 were substituted either by phenylalanine or leucine by site-directed mutagenesis using sequential PCR steps\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/25	2014/10/16	rogid:gNiiGxTFrMUeqEvVrvwcsz8h7cY3702	rogid:HU7HG7EHvZR/6trEt2M2wmFdHRY3702	intact-crc:1980CD3121B42238|rigid:L1YTfxmZorIO16IAnETdg6ai6ww	false	sufficient binding region:479-1294	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)