#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0CB50	uniprotkb:Q3KTM2	intact:EBI-2464239|ensembl:ENSGALP00000016629|ensembl:ENSGALP00000048502|ensembl:ENSGALP00000060290	intact:EBI-2464223	psi-mi:prdx1_chick(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:gdpd5_chick(display_long)|uniprotkb:GDPD5(gene name)|psi-mi:GDPD5(display_short)|uniprotkb:GDE2(gene name synonym)|uniprotkb:Glycerophosphodiester phosphodiesterase 2(gene name synonym)|uniprotkb:Glycerophosphocholine phosphodiesterase GDPD5(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C GDPD5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yan et al. (2009)	imex:IM-12091|pubmed:19766572	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464235|imex:IM-12091-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258861.1|ensembl:ENSGALG00000010243(gene)|ensembl:ENSGALT00000016648(transcript)|ensembl:ENSGALT00000062686(transcript)|ensembl:ENSGALT00000086986(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-GGA-3299685|reactome:R-GGA-5628897	interpro:IPR017946|interpro:IPR030395|go:"GO:0047389"(glycerophosphocholine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008889"(glycerophosphodiester phosphodiesterase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9031(chick-embryonic_spine)|taxid:9031(Chick embryonic spinal chord)	-	2009/10/16	2014/10/16	rogid:8hV40EY6JzKKBNPy1yW3RLgN6+E9031	rogid:RioQ9Vo3v5Y05PaMZO4NDEph+vk9031	intact-crc:C46CB0AC8749EF4F|rigid:I8OfFFt2IRcEcoxZ5AeQM2NWGqA	false	-	flag tag:n-n	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q3KTM2	uniprotkb:Q06830	intact:EBI-2464223	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:gdpd5_chick(display_long)|uniprotkb:GDPD5(gene name)|psi-mi:GDPD5(display_short)|uniprotkb:GDE2(gene name synonym)|uniprotkb:Glycerophosphodiester phosphodiesterase 2(gene name synonym)|uniprotkb:Glycerophosphocholine phosphodiesterase GDPD5(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C GDPD5(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yan et al. (2009)	imex:IM-12091|pubmed:19766572	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464259|imex:IM-12091-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017946|interpro:IPR030395|go:"GO:0047389"(glycerophosphocholine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008889"(glycerophosphodiester phosphodiesterase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/16	2014/10/16	rogid:RioQ9Vo3v5Y05PaMZO4NDEph+vk9031	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:91F69D39014DB4CB|rigid:BtbZiOKMcU9vnuFvpVUSRk5cW1g	false	flag tag:n-n	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q3KTM2	uniprotkb:P0CB50	intact:EBI-2464223	intact:EBI-2464239|ensembl:ENSGALP00000016629|ensembl:ENSGALP00000048502|ensembl:ENSGALP00000060290	psi-mi:gdpd5_chick(display_long)|uniprotkb:GDPD5(gene name)|psi-mi:GDPD5(display_short)|uniprotkb:GDE2(gene name synonym)|uniprotkb:Glycerophosphodiester phosphodiesterase 2(gene name synonym)|uniprotkb:Glycerophosphocholine phosphodiesterase GDPD5(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C GDPD5(gene name synonym)	psi-mi:prdx1_chick(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yan et al. (2009)	imex:IM-12091|pubmed:19766572	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464284|imex:IM-12091-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017946|interpro:IPR030395|go:"GO:0047389"(glycerophosphocholine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008889"(glycerophosphodiester phosphodiesterase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)	refseq:NP_001258861.1|ensembl:ENSGALG00000010243(gene)|ensembl:ENSGALT00000016648(transcript)|ensembl:ENSGALT00000062686(transcript)|ensembl:ENSGALT00000086986(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-GGA-3299685|reactome:R-GGA-5628897	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G, Supp. Fig. 8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/16	2014/10/16	rogid:RioQ9Vo3v5Y05PaMZO4NDEph+vk9031	rogid:8hV40EY6JzKKBNPy1yW3RLgN6+E9031	intact-crc:BA07F3EF64B84B00|rigid:I8OfFFt2IRcEcoxZ5AeQM2NWGqA	false	necessary binding region:1-38|flag tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0CB50	uniprotkb:Q3KTM2	intact:EBI-2464239|ensembl:ENSGALP00000016629|ensembl:ENSGALP00000048502|ensembl:ENSGALP00000060290	intact:EBI-2464223	psi-mi:prdx1_chick(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:gdpd5_chick(display_long)|uniprotkb:GDPD5(gene name)|psi-mi:GDPD5(display_short)|uniprotkb:GDE2(gene name synonym)|uniprotkb:Glycerophosphodiester phosphodiesterase 2(gene name synonym)|uniprotkb:Glycerophosphocholine phosphodiesterase GDPD5(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C GDPD5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yan et al. (2009)	imex:IM-12091|pubmed:19766572	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464350|imex:IM-12091-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258861.1|ensembl:ENSGALG00000010243(gene)|ensembl:ENSGALT00000016648(transcript)|ensembl:ENSGALT00000062686(transcript)|ensembl:ENSGALT00000086986(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-GGA-3299685|reactome:R-GGA-5628897	interpro:IPR017946|interpro:IPR030395|go:"GO:0047389"(glycerophosphocholine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008889"(glycerophosphodiester phosphodiesterase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 2|delivery method:Q3KTM2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/16	2014/10/16	rogid:8hV40EY6JzKKBNPy1yW3RLgN6+E9031	rogid:RioQ9Vo3v5Y05PaMZO4NDEph+vk9031	intact-crc:A0DE03FB6250A7A4|rigid:I8OfFFt2IRcEcoxZ5AeQM2NWGqA	false	myc tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3KTM2	uniprotkb:P0CB50	intact:EBI-2464223	intact:EBI-2464239|ensembl:ENSGALP00000016629|ensembl:ENSGALP00000048502|ensembl:ENSGALP00000060290	psi-mi:gdpd5_chick(display_long)|uniprotkb:GDPD5(gene name)|psi-mi:GDPD5(display_short)|uniprotkb:GDE2(gene name synonym)|uniprotkb:Glycerophosphodiester phosphodiesterase 2(gene name synonym)|uniprotkb:Glycerophosphocholine phosphodiesterase GDPD5(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C GDPD5(gene name synonym)	psi-mi:prdx1_chick(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yan et al. (2009)	imex:IM-12091|pubmed:19766572	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464716|imex:IM-12091-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017946|interpro:IPR030395|go:"GO:0047389"(glycerophosphocholine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008889"(glycerophosphodiester phosphodiesterase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)	refseq:NP_001258861.1|ensembl:ENSGALG00000010243(gene)|ensembl:ENSGALT00000016648(transcript)|ensembl:ENSGALT00000062686(transcript)|ensembl:ENSGALT00000086986(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-GGA-3299685|reactome:R-GGA-5628897	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6D, Supp. Fig. 8, Supp. Fig. 9|delivery method:Q3KTM2 transfection|comment:Addition of beta-mercaptoethanol abolished formation of the 120-130 kDa complex. Mutations disrupting GDE2 and Prdx1 catalytic activity or of the GDE2 intracellular Cysteines do not  compromise formation of GDE2/Prdx1 complexes.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/16	2014/10/16	rogid:RioQ9Vo3v5Y05PaMZO4NDEph+vk9031	rogid:8hV40EY6JzKKBNPy1yW3RLgN6+E9031	intact-crc:30F03AD76091683B|rigid:I8OfFFt2IRcEcoxZ5AeQM2NWGqA	false	-	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35700	uniprotkb:Q3KTM2	intact:EBI-444948|uniprotkb:Q3UBV4|uniprotkb:Q9CWI2|ensembl:ENSMUSP00000102078|ensembl:ENSMUSP00000114159	intact:EBI-2464223	psi-mi:prdx1_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Osteoblast-specific factor 3(gene name synonym)|uniprotkb:Macrophage 23 kDa stress protein(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Msp23(gene name synonym)|uniprotkb:Paga(gene name synonym)|uniprotkb:Tdpx2(gene name synonym)	psi-mi:gdpd5_chick(display_long)|uniprotkb:GDPD5(gene name)|psi-mi:GDPD5(display_short)|uniprotkb:GDE2(gene name synonym)|uniprotkb:Glycerophosphodiester phosphodiesterase 2(gene name synonym)|uniprotkb:Glycerophosphocholine phosphodiesterase GDPD5(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C GDPD5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yan et al. (2009)	imex:IM-12091|pubmed:19766572	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464725|imex:IM-12091-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035164.1|ensembl:ENSMUST00000135573(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P35700|reactome:R-MMU-3299685|reactome:R-MMU-5628897|ensembl:ENSMUST00000106470(transcript)|ensembl:ENSMUSG00000028691(gene)	interpro:IPR017946|interpro:IPR030395|go:"GO:0047389"(glycerophosphocholine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008889"(glycerophosphodiester phosphodiesterase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 6|delivery method:Q3KTM2 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/16	2014/10/16	rogid:xOppWev1GtpILoJ1rY+tSPoymVU10090	rogid:RioQ9Vo3v5Y05PaMZO4NDEph+vk9031	intact-crc:D60AFE16DF243DAA|rigid:Ar0UyqfrH/EIh6WWivyRTuMIwxo	false	ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3KTM2	uniprotkb:P0CB50	intact:EBI-2464223	intact:EBI-2464239|ensembl:ENSGALP00000016629|ensembl:ENSGALP00000048502|ensembl:ENSGALP00000060290	psi-mi:gdpd5_chick(display_long)|uniprotkb:GDPD5(gene name)|psi-mi:GDPD5(display_short)|uniprotkb:GDE2(gene name synonym)|uniprotkb:Glycerophosphodiester phosphodiesterase 2(gene name synonym)|uniprotkb:Glycerophosphocholine phosphodiesterase GDPD5(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C GDPD5(gene name synonym)	psi-mi:prdx1_chick(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0401"(biochemical)	Yan et al. (2009)	imex:IM-12091|pubmed:19766572	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2464477|imex:IM-12091-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017946|interpro:IPR030395|go:"GO:0047389"(glycerophosphocholine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008889"(glycerophosphodiester phosphodiesterase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)	refseq:NP_001258861.1|ensembl:ENSGALG00000010243(gene)|ensembl:ENSGALT00000016648(transcript)|ensembl:ENSGALT00000062686(transcript)|ensembl:ENSGALT00000086986(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-GGA-3299685|reactome:R-GGA-5628897	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|comment:Cys25_576ser mutation can still bind PRDX1|comment:Addition of DTT caused further shifts in GDE2 mobility consistent with the presence of additional disulfide bonds in GDE2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/16	2014/10/16	rogid:RioQ9Vo3v5Y05PaMZO4NDEph+vk9031	rogid:8hV40EY6JzKKBNPy1yW3RLgN6+E9031	intact-crc:A81799B4E537F171|rigid:I8OfFFt2IRcEcoxZ5AeQM2NWGqA	false	biotin tag:?-?|flag tag:n-n|mutation:576-576,25-25	mutation disrupting interaction:173-173,52-52	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)