#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15514	uniprotkb:P26447	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211480|mint:MINT-7256485|imex:IM-13825-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N|mint:MINT-7256487(identity)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256488(identity)	-	-	-	figure legend:F3B F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rogid:58+txYVmiPdBmohFbqquykr9fT49606	intact-crc:848E99F08E431C5F|rigid:p8SNt7r/aNaCRJ+M2Q4TKNo8yT8	false	mutation decreasing interaction:170-170(MINT-7256549)|mutation decreasing interaction:172-172(MINT-7256615)|mutation decreasing interaction:171-171(MINT-7256552)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99075	uniprotkb:P26447	intact:EBI-7211558|ensembl:ENSP00000230990|intact:MINT-1511911|uniprotkb:B2R821	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	psi-mi:hbegf_human(display_long)|uniprotkb:HBEGF(gene name)|psi-mi:HBEGF(display_short)|uniprotkb:DTR(gene name synonym)|uniprotkb:HEGFL(gene name synonym)|uniprotkb:DTS(gene name synonym)	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211599|mint:MINT-7256494|imex:IM-13825-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113070(gene)|ensembl:ENST00000230990(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051545"(negative regulation of elastin biosynthetic process)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:Q99075|rcsb pdb:1XDT|rcsb pdb:2M8S|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-5336415|reactome:R-HSA-5638303|reactome:R-HSA-5673001|refseq:NP_001936.1|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665686|dip:DIP-114N|mint:MINT-7256498(identity)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256496(identity)	-	comment:mint|function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor	-	figure legend:f3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:k6FlgjTcQJaPiAUWEpUlbnyWrkU9606	rogid:58+txYVmiPdBmohFbqquykr9fT49606	intact-crc:0F6DE33F6D3C26BE|rigid:LGLxS8MXXIDIB3GoQtODLmedfp4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26447	uniprotkb:P04637	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211626|mint:MINT-7256502|imex:IM-13825-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256506(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-7256504(identity)	-	-	-	figure legend:f3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:58+txYVmiPdBmohFbqquykr9fT49606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:2F3771830C8B223D|rigid:v904nMT9uyfU9LI7C9R2A9vNC6k	false	-	binding-associated region:294-393(MINT-7256509)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15514	uniprotkb:P26447	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211665|mint:MINT-7256618|imex:IM-13825-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N|mint:MINT-7256622(identity)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256620(identity)	-	-	-	figure legend:F3B F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rogid:58+txYVmiPdBmohFbqquykr9fT49606	intact-crc:CCE71D36986B33B8|rigid:p8SNt7r/aNaCRJ+M2Q4TKNo8yT8	false	mutation decreasing interaction:154-154(MINT-7256633)|mutation decreasing interaction:153-153(MINT-7256631)|mutation decreasing interaction:171-171(MINT-7256627)|mutation decreasing interaction:172-172(MINT-7256623)|mutation decreasing interaction:170-170(MINT-7256625)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26447	uniprotkb:P01133	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	intact:EBI-640857|uniprotkb:B4DRK7|uniprotkb:E9PBF0|uniprotkb:Q52LZ6|uniprotkb:E7EVD2|ensembl:ENSP00000265171	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:egf_human(display_long)|uniprotkb:EGF(gene name)|psi-mi:EGF(display_short)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211653|mint:MINT-7256556|imex:IM-13825-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256560(identity)	refseq:NP_001171602.1|refseq:NP_001954.2|refseq:NP_001171601.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01133|rcsb pdb:1IVO|rcsb pdb:1JL9|rcsb pdb:1NQL|rcsb pdb:1P9J|rcsb pdb:2KV4|rcsb pdb:3NJP|reactome:R-HSA-114608|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|ensembl:ENSG00000138798(gene)|ensembl:ENST00000265171(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|dip:DIP-5767N|mint:MINT-7256558(identity)	-	-	-	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:58+txYVmiPdBmohFbqquykr9fT49606	rogid:H2Ewl436sfCPTMfgz7YGsLKq4Nk9606	intact-crc:7D201F1A7A78F2BE|rigid:vhZWCu6D8yXPf1KuwORWcHSmhsU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26447	uniprotkb:P35070	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	intact:EBI-6590057|ensembl:ENSP00000379092|uniprotkb:Q96F48	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:btc_human(display_long)|uniprotkb:BTC(gene name)|psi-mi:BTC(display_short)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211641|mint:MINT-7256512|imex:IM-13825-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256518(identity)	ensembl:ENSG00000174808(gene)|ensembl:ENST00000395743(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051781"(positive regulation of cell division)|interpro:IPR000742(EGF-like, type 3)|rcsb pdb:1IOX|rcsb pdb:1IP0|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665686|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P35070|refseq:NP_001303892.1|refseq:XP_011530513.1|refseq:NP_001720.1|dip:DIP-5768N|mint:MINT-7256514(identity)	-	-	-	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:58+txYVmiPdBmohFbqquykr9fT49606	rogid:Q9Dnm3pw9iZWp5STItQ/WCW/ppE9606	intact-crc:B2E7FE5453D16806|rigid:jpEx+7xk7vbvVcXA6AI7r9EEc98	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15514	uniprotkb:P29034	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	intact:EBI-752230|uniprotkb:O00266|uniprotkb:Q3KRB9|uniprotkb:Q5RHS8|uniprotkb:Q9BU83|ensembl:ENSP00000357697|ensembl:ENSP00000357698|ensembl:ENSP00000357699|ensembl:ENSP00000473260	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:s10a2_human(display_long)|uniprotkb:S100 calcium-binding protein A2(gene name synonym)|uniprotkb:CAN19(gene name synonym)|uniprotkb:S100A2(gene name)|psi-mi:S100A2(display_short)|uniprotkb:S100L(gene name synonym)|uniprotkb:Protein S-100L(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211717|mint:MINT-7256654|imex:IM-13825-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N|mint:MINT-7256658(identity)	refseq:NP_005969.1|ensembl:ENSG00000196754(gene)|ensembl:ENST00000368708(transcript)|ensembl:ENST00000368709(transcript)|ensembl:ENST00000368710(transcript)|ensembl:ENST00000487430(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034325|mint:P29034|rcsb pdb:2RGI|rcsb pdb:4DUQ|mint:MINT-7256656(identity)	-	-	-	figure legend:F4D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rogid:QcJWxtqLrbXj++33nNw9nHxj5oE9606	intact-crc:C1D9CE79C849EA54|rigid:dXX2BIWLLygv34BTUPWm6+12T40	false	v5 tag:?-?(MINT-7256666)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33763	uniprotkb:P15514	intact:EBI-7211732|uniprotkb:Q5RHS3|intact:MINT-7256702|ensembl:ENSP00000357706|ensembl:ENSP00000357707|uniprotkb:Q52LE7	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	psi-mi:s10a5_human(display_long)|uniprotkb:Protein S-100D(gene name synonym)|uniprotkb:S100A5(gene name)|psi-mi:S100A5(display_short)|uniprotkb:S100D(gene name synonym)|uniprotkb:S100 calcium-binding protein A5(gene name synonym)	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211757|mint:MINT-7256693|imex:IM-13825-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002953.2|ensembl:ENSG00000196420(gene)|ensembl:ENST00000368717(transcript)|ensembl:ENST00000368718(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028497|interpro:IPR034325|mint:P33763|rcsb pdb:2KAX|rcsb pdb:2KAY|rcsb pdb:4DIR|rcsb pdb:6WN7|go:"GO:0048306"(calcium-dependent protein binding)|refseq:XP_016857519.1|refseq:XP_016857520.1|refseq:XP_016857521.1|mint:MINT-7256695(identity)	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N|mint:MINT-7256697(identity)	-	comment:mint	-	figure legend:F4D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:n0b1mvv8PzOIecL8yINiaXnjM2w9606	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	intact-crc:061156A66BA08528|rigid:06xlGt2D7lyP4fV3bVD9TX7SGZI	false	-	v5 tag:?-?(MINT-7256698)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15514	uniprotkb:P26447	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211697|mint:MINT-7256636|imex:IM-13825-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N|mint:MINT-7256638(identity)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256650(identity)	-	-	-	figure legend:F3B F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rogid:58+txYVmiPdBmohFbqquykr9fT49606	intact-crc:B28AB65A3D876A68|rigid:p8SNt7r/aNaCRJ+M2Q4TKNo8yT8	false	mutation decreasing interaction:154-154(MINT-7256639)|mutation decreasing interaction:153-153(MINT-7256641)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15514	uniprotkb:P26447	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211802|mint:MINT-7256567|imex:IM-13825-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N|mint:MINT-7256571(identity)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256569(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rogid:58+txYVmiPdBmohFbqquykr9fT49606	intact-crc:84549F734535F881|rigid:p8SNt7r/aNaCRJ+M2Q4TKNo8yT8	false	v5 tag:?-?(MINT-7256580)|mutation decreasing interaction:153-153(MINT-7256572)|mutation decreasing interaction:172-172(MINT-7256589)|mutation decreasing interaction:171-171(MINT-7256586)|mutation decreasing interaction:170-170(MINT-7256584)|mutation decreasing interaction:154-154(MINT-7256574)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26447	uniprotkb:P35070	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	intact:EBI-6590057|ensembl:ENSP00000379092|uniprotkb:Q96F48	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:btc_human(display_long)|uniprotkb:BTC(gene name)|psi-mi:BTC(display_short)	psi-mi:"MI:0096"(pull down)	Klingelhöfer et al. (2009)	pubmed:19740107|imex:IM-13825|mint:MINT-7256480|mint:fj-09-0551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7211837|mint:MINT-7256593|imex:IM-13825-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N|mint:MINT-7256609(identity)	ensembl:ENSG00000174808(gene)|ensembl:ENST00000395743(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051781"(positive regulation of cell division)|interpro:IPR000742(EGF-like, type 3)|rcsb pdb:1IOX|rcsb pdb:1IP0|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665686|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P35070|refseq:NP_001303892.1|refseq:XP_011530513.1|refseq:NP_001720.1|dip:DIP-5768N|mint:MINT-7256595(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/11	2014/10/16	rogid:58+txYVmiPdBmohFbqquykr9fT49606	rogid:Q9Dnm3pw9iZWp5STItQ/WCW/ppE9606	intact-crc:4C51881C4604A76B|rigid:jpEx+7xk7vbvVcXA6AI7r9EEc98	false	-	v5 tag:?-?(MINT-7256606)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)