#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q865S3	uniprotkb:Q9N1Q2	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	intact:EBI-7207962|intact:UNK-5992671	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:q9n1q2_canlf(display_long)|uniprotkb:ZONAB(gene name)|psi-mi:ZONAB(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7207984|mint:MINT-7292176|imex:IM-13817-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292179(identity)	mint:Q9N1Q2|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR019844|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|mint:MINT-7292178(identity)	-	comment:mint	comment:mint	figure legend:f2a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2009/10/15	2014/10/16	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	rogid:hDxWKVtZS2Xgvtsy9BrKaVPZp7k9615	intact-crc:17362B51188502A5|rigid:TAeCfrpeEFtd4E+0p7nrje5APoc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q865S3	uniprotkb:Q9N1Q2	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	intact:EBI-7207962|intact:UNK-5992671	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:q9n1q2_canlf(display_long)|uniprotkb:ZONAB(gene name)|psi-mi:ZONAB(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208033|mint:MINT-7292185|imex:IM-13817-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292187(identity)	mint:Q9N1Q2|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR019844|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|mint:MINT-7292189(identity)	-	comment:mint	comment:mint	figure legend:f2a f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2009/10/15	2014/10/16	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	rogid:hDxWKVtZS2Xgvtsy9BrKaVPZp7k9615	intact-crc:829AA9FD0B4D4A32|rigid:TAeCfrpeEFtd4E+0p7nrje5APoc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9N1Q2	uniprotkb:Q865S3	intact:EBI-7207962|intact:UNK-5992671	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	psi-mi:q9n1q2_canlf(display_long)|uniprotkb:ZONAB(gene name)|psi-mi:ZONAB(display_short)	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208053|mint:MINT-7292195|imex:IM-13817-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9N1Q2|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR019844|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|mint:MINT-7292197(identity)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292199(identity)	-	comment:mint	comment:mint	figure legend:f2d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:hDxWKVtZS2Xgvtsy9BrKaVPZp7k9615	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	intact-crc:5607E61D4643E26C|rigid:TAeCfrpeEFtd4E+0p7nrje5APoc	false	-	glutathione s tranferase tag:?-?(MINT-7292205)|binding-associated region:1-96(MINT-7292207)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q865S3	uniprotkb:Q9N1Q2	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	intact:EBI-7207962|intact:UNK-5992671	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:q9n1q2_canlf(display_long)|uniprotkb:ZONAB(gene name)|psi-mi:ZONAB(display_short)	psi-mi:"MI:0096"(pull down)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208071|mint:MINT-7292211|imex:IM-13817-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292213(identity)	mint:Q9N1Q2|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR019844|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|mint:MINT-7292220(identity)	-	comment:mint	comment:mint	figure legend:f2e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	rogid:hDxWKVtZS2Xgvtsy9BrKaVPZp7k9615	intact-crc:B604A54BE0E74F34|rigid:TAeCfrpeEFtd4E+0p7nrje5APoc	false	binding-associated region:1-96(MINT-7292214)|glutathione s tranferase tag:?-?(MINT-7292217)	tag:?-?(MINT-7292225)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9N1Q3	uniprotkb:Q865S3	intact:EBI-7208151|intact:MINT-7292242	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	psi-mi:q9n1q3_canlf(display_long)|uniprotkb:ZONAB(gene name)|psi-mi:ZONAB(display_short)	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208146|mint:MINT-7292228|imex:IM-13817-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9N1Q3|interpro:IPR011129(Cold shock protein)|refseq:NP_001003127.1|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR019844|go:"GO:0003676"(nucleic acid binding)|mint:MINT-7292230(identity)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292234(identity)	-	comment:mint	comment:mint	figure legend:f2e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:K4DrXIsapBgad5FOkGhzYbPqpjg9615	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	intact-crc:030461DFA1C3F20C|rigid:yg3JEvvFWBh4PxsDvtowVNztOWY	false	tag:?-?(MINT-7292231)	binding-associated region:1-96(MINT-7292235)|glutathione s tranferase tag:?-?(MINT-7292238)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q865S3	uniprotkb:Q9N1Q2	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	intact:EBI-7207962|intact:UNK-5992671	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:q9n1q2_canlf(display_long)|uniprotkb:ZONAB(gene name)|psi-mi:ZONAB(display_short)	psi-mi:"MI:0096"(pull down)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208180|mint:MINT-7292256|imex:IM-13817-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292262(identity)	mint:Q9N1Q2|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR019844|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|mint:MINT-7292258(identity)	-	comment:mint	comment:mint	figure legend:f2f|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	rogid:hDxWKVtZS2Xgvtsy9BrKaVPZp7k9615	intact-crc:1B3C844647BB8BE3|rigid:TAeCfrpeEFtd4E+0p7nrje5APoc	false	binding-associated region:1-96(MINT-7292263)|glutathione s tranferase tag:?-?(MINT-7292266)	his tag:?-?(MINT-7292259)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q865S3	intact:EBI-7208201	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	genbank_protein_gi:73983768|intact:MINT-7292351	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:mark/par1(display_short)|psi-mi:EBI-7208201(display_long)	psi-mi:"MI:0096"(pull down)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208225|mint:MINT-7292291|imex:IM-13817-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292295(identity)	mint:MINT-7292293(identity)	-	comment:mint	comment:mint|no-uniprot-update:	comment:mint|figure legend:sf4d sf4e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	-	intact-crc:44333B739686681A	false	binding-associated region:1-600(MINT-7292298)|glutathione s tranferase tag:?-?(MINT-7292296)	ha tag:?-?(MINT-7292303)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-7208201	uniprotkb:Q865S3	genbank_protein_gi:73983768|intact:MINT-7292351	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	psi-mi:mark/par1(display_short)|psi-mi:EBI-7208201(display_long)	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208206|mint:MINT-7292272|imex:IM-13817-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:MINT-7292281(identity)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292274(identity)	-	comment:mint|no-uniprot-update:	comment:mint	comment:mint|figure legend:sf4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/15	2014/10/16	-	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	intact-crc:4CAD7B343D996906	false	-	glutathione s tranferase tag:?-?(MINT-7292278)|binding-associated region:1-231(MINT-7292275)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q865S3	intact:EBI-7208201	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	genbank_protein_gi:73983768|intact:MINT-7292351	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:mark/par1(display_short)|psi-mi:EBI-7208201(display_long)	psi-mi:"MI:0416"(fluorescence microscopy)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208254|mint:MINT-7292311|imex:IM-13817-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292313(identity)	mint:MINT-7292322(identity)	go:"GO:0005737"(cytoplasm)	comment:mint	comment:mint|no-uniprot-update:	figure legend:f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2009/10/15	2014/10/16	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	-	intact-crc:A22C32170E325CD5	false	tag:?-?(MINT-7292319)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0708"(monoclonal antibody immunostaining)
uniprotkb:O97758	uniprotkb:Q865S3	intact:EBI-6988333|intact:MINT-1778189	intact:EBI-7207989|uniprotkb:Q865S2|intact:UNK-5968119	psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:arhg2_canlf(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Tight junction-associated guanine nucleotide exchange factor isoform A(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Nie et al. (2009)	pubmed:19730435|imex:IM-13817|mint:MINT-7292160|doi:10.1038/embor.2009.182	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7208269|mint:MINT-7292332|imex:IM-13817-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-7292347(identity)	interpro:IPR037806|mint:Q865S3|refseq:NP_001006123.1|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|refseq:NP_001002995.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR035899|interpro:IPR041020|mint:MINT-7292337(identity)	go:"GO:0005911"(cell-cell junction)	comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions	comment:mint	comment:mint|figure legend:sf2 sf3 sf8b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2009/10/15	2014/10/16	rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615	rogid:JgLJKXF0ARKi9mgxhePyEC15wsA9615	intact-crc:09E170C487A72AA5|rigid:Xm8IQmqTfELI2VZg+OU0mhy14dM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)