#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0A988 uniprotkb:P05845 intact:EBI-542385|uniprotkb:P00583|uniprotkb:Q2M813|ensemblbacteria:AAC76724|ensemblbacteria:BAE77593 intact:EBI-2434514|uniprotkb:Q7AJH8 psi-mi:dpo3b_ecoli(display_long)|uniprotkb:dnaN(gene name)|psi-mi:dnaN(display_short)|uniprotkb:Beta-clamp processivity factor(gene name synonym)|uniprotkb:DNA polymerase III beta sliding clamp subunit(gene name synonym)|uniprotkb:JW3678(locus name)|uniprotkb:b3701(locus name) psi-mi:tnse_ecolx(display_long)|uniprotkb:tnsE(gene name)|psi-mi:tnsE(display_short)|uniprotkb:Protein D(gene name synonym) psi-mi:"MI:0018"(two hybrid) Parks et al. (2009) imex:IM-12082|pubmed:19703395 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:562(ecolx)|taxid:562(Escherichia coli) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2434537|imex:IM-12082-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC76724(transcript)|ensemblbacteria:b3701(gene)|ensemblbacteria:BAE77593(gene)|ensemblbacteria:BAE77593(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044787"(bacterial-type DNA replication)|interpro:IPR001001(DNA polymerase III, beta chain)|interpro:IPR022634|interpro:IPR022635|interpro:IPR022637|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1MMI|rcsb pdb:1OK7|rcsb pdb:1UNN|rcsb pdb:1WAI|rcsb pdb:2POL|rcsb pdb:2XUR|rcsb pdb:3BEP|rcsb pdb:3D1E|rcsb pdb:3D1F|rcsb pdb:3D1G|rcsb pdb:3F1V|rcsb pdb:3PWE|rcsb pdb:3Q4J|rcsb pdb:3Q4K|rcsb pdb:3Q4L|rcsb pdb:3QSB|rcsb pdb:4K3K|rcsb pdb:4K3L|rcsb pdb:4K3M|rcsb pdb:4K3O|rcsb pdb:4K3P|rcsb pdb:4K3Q|rcsb pdb:4K3R|rcsb pdb:4K3S|rcsb pdb:4MJP|rcsb pdb:4MJQ|rcsb pdb:4MJR|rcsb pdb:4N94|rcsb pdb:4N95|rcsb pdb:4N96|rcsb pdb:4N97|rcsb pdb:4N98|rcsb pdb:4N99|rcsb pdb:4N9A|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:6E8E|rcsb pdb:6FVL|refseq:NP_418156.1|refseq:WP_000673464.1|dip:DIP-36038N refseq:NP_065316.1|interpro:IPR016421(Transposition, TnsE)|rcsb pdb:5D16|rcsb pdb:5D17|refseq:WP_000251879.1|interpro:IPR041419|go:"GO:0003677"(DNA binding)|go:"GO:0006310"(DNA recombination)|go:"GO:0032196"(transposition) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot. - figure legend:Figs. 2, 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2009/09/03 2014/10/16 rogid:9CWZmgLmO/kNXmVq75u0u04mX2g83333 rogid:Co73do/LBTYRXC/lyKrLoUoyK6E562 intact-crc:35C7B45FD5963E5B|rigid:YYHazeBViBYIYQU2QV/WOOPOUSQ false - mutation decreasing interaction:122-122|mutation decreasing interaction:123-123|mutation decreasing interaction:125-125|mutation decreasing interaction:129-129|mutation decreasing interaction:130-130|mutation decreasing interaction:131-131 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0A988 uniprotkb:P28630 intact:EBI-542385|uniprotkb:P00583|uniprotkb:Q2M813|ensemblbacteria:AAC76724|ensemblbacteria:BAE77593 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 psi-mi:dpo3b_ecoli(display_long)|uniprotkb:dnaN(gene name)|psi-mi:dnaN(display_short)|uniprotkb:Beta-clamp processivity factor(gene name synonym)|uniprotkb:DNA polymerase III beta sliding clamp subunit(gene name synonym)|uniprotkb:JW3678(locus name)|uniprotkb:b3701(locus name) psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:"MI:0018"(two hybrid) Parks et al. (2009) imex:IM-12082|pubmed:19703395 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2434543|imex:IM-12082-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC76724(transcript)|ensemblbacteria:b3701(gene)|ensemblbacteria:BAE77593(gene)|ensemblbacteria:BAE77593(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044787"(bacterial-type DNA replication)|interpro:IPR001001(DNA polymerase III, beta chain)|interpro:IPR022634|interpro:IPR022635|interpro:IPR022637|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1MMI|rcsb pdb:1OK7|rcsb pdb:1UNN|rcsb pdb:1WAI|rcsb pdb:2POL|rcsb pdb:2XUR|rcsb pdb:3BEP|rcsb pdb:3D1E|rcsb pdb:3D1F|rcsb pdb:3D1G|rcsb pdb:3F1V|rcsb pdb:3PWE|rcsb pdb:3Q4J|rcsb pdb:3Q4K|rcsb pdb:3Q4L|rcsb pdb:3QSB|rcsb pdb:4K3K|rcsb pdb:4K3L|rcsb pdb:4K3M|rcsb pdb:4K3O|rcsb pdb:4K3P|rcsb pdb:4K3Q|rcsb pdb:4K3R|rcsb pdb:4K3S|rcsb pdb:4MJP|rcsb pdb:4MJQ|rcsb pdb:4MJR|rcsb pdb:4N94|rcsb pdb:4N95|rcsb pdb:4N96|rcsb pdb:4N97|rcsb pdb:4N98|rcsb pdb:4N99|rcsb pdb:4N9A|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:6E8E|rcsb pdb:6FVL|refseq:NP_418156.1|refseq:WP_000673464.1|dip:DIP-36038N refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot. crc64:87239A678FE16BE2 figure legend:Fig. 2|comment:Positive control|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2009/09/03 2014/10/16 rogid:9CWZmgLmO/kNXmVq75u0u04mX2g83333 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 intact-crc:B62EA4B752B78FC7|rigid:5iKBR6VGt8HBCAdfCbUFVDvWkhs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P05845 uniprotkb:P0A988 intact:EBI-2434514|uniprotkb:Q7AJH8 intact:EBI-542385|uniprotkb:P00583|uniprotkb:Q2M813|ensemblbacteria:AAC76724|ensemblbacteria:BAE77593 psi-mi:tnse_ecolx(display_long)|uniprotkb:tnsE(gene name)|psi-mi:tnsE(display_short)|uniprotkb:Protein D(gene name synonym) psi-mi:dpo3b_ecoli(display_long)|uniprotkb:dnaN(gene name)|psi-mi:dnaN(display_short)|uniprotkb:Beta-clamp processivity factor(gene name synonym)|uniprotkb:DNA polymerase III beta sliding clamp subunit(gene name synonym)|uniprotkb:JW3678(locus name)|uniprotkb:b3701(locus name) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Parks et al. (2009) imex:IM-12082|pubmed:19703395 taxid:562(ecolx)|taxid:562(Escherichia coli) taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2434555|imex:IM-12082-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065316.1|interpro:IPR016421(Transposition, TnsE)|rcsb pdb:5D16|rcsb pdb:5D17|refseq:WP_000251879.1|interpro:IPR041419|go:"GO:0003677"(DNA binding)|go:"GO:0006310"(DNA recombination)|go:"GO:0032196"(transposition) ensemblbacteria:AAC76724(transcript)|ensemblbacteria:b3701(gene)|ensemblbacteria:BAE77593(gene)|ensemblbacteria:BAE77593(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044787"(bacterial-type DNA replication)|interpro:IPR001001(DNA polymerase III, beta chain)|interpro:IPR022634|interpro:IPR022635|interpro:IPR022637|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1MMI|rcsb pdb:1OK7|rcsb pdb:1UNN|rcsb pdb:1WAI|rcsb pdb:2POL|rcsb pdb:2XUR|rcsb pdb:3BEP|rcsb pdb:3D1E|rcsb pdb:3D1F|rcsb pdb:3D1G|rcsb pdb:3F1V|rcsb pdb:3PWE|rcsb pdb:3Q4J|rcsb pdb:3Q4K|rcsb pdb:3Q4L|rcsb pdb:3QSB|rcsb pdb:4K3K|rcsb pdb:4K3L|rcsb pdb:4K3M|rcsb pdb:4K3O|rcsb pdb:4K3P|rcsb pdb:4K3Q|rcsb pdb:4K3R|rcsb pdb:4K3S|rcsb pdb:4MJP|rcsb pdb:4MJQ|rcsb pdb:4MJR|rcsb pdb:4N94|rcsb pdb:4N95|rcsb pdb:4N96|rcsb pdb:4N97|rcsb pdb:4N98|rcsb pdb:4N99|rcsb pdb:4N9A|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:6E8E|rcsb pdb:6FVL|refseq:NP_418156.1|refseq:WP_000673464.1|dip:DIP-36038N psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot. figure legend:Fig. 3A|comment:dnaN is radio-labelled enzymatically using PKA.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/09/03 2014/10/16 rogid:Co73do/LBTYRXC/lyKrLoUoyK6E562 rogid:9CWZmgLmO/kNXmVq75u0u04mX2g83333 intact-crc:AC46C779AC56F22E|rigid:YYHazeBViBYIYQU2QV/WOOPOUSQ false - 32p radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P0A988 uniprotkb:P05845 intact:EBI-542385|uniprotkb:P00583|uniprotkb:Q2M813|ensemblbacteria:AAC76724|ensemblbacteria:BAE77593 intact:EBI-2434514|uniprotkb:Q7AJH8 psi-mi:dpo3b_ecoli(display_long)|uniprotkb:dnaN(gene name)|psi-mi:dnaN(display_short)|uniprotkb:Beta-clamp processivity factor(gene name synonym)|uniprotkb:DNA polymerase III beta sliding clamp subunit(gene name synonym)|uniprotkb:JW3678(locus name)|uniprotkb:b3701(locus name) psi-mi:tnse_ecolx(display_long)|uniprotkb:tnsE(gene name)|psi-mi:tnsE(display_short)|uniprotkb:Protein D(gene name synonym) psi-mi:"MI:0047"(far western blotting) Parks et al. (2009) imex:IM-12082|pubmed:19703395 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:562(ecolx)|taxid:562(Escherichia coli) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2434569|imex:IM-12082-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC76724(transcript)|ensemblbacteria:b3701(gene)|ensemblbacteria:BAE77593(gene)|ensemblbacteria:BAE77593(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044787"(bacterial-type DNA replication)|interpro:IPR001001(DNA polymerase III, beta chain)|interpro:IPR022634|interpro:IPR022635|interpro:IPR022637|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1MMI|rcsb pdb:1OK7|rcsb pdb:1UNN|rcsb pdb:1WAI|rcsb pdb:2POL|rcsb pdb:2XUR|rcsb pdb:3BEP|rcsb pdb:3D1E|rcsb pdb:3D1F|rcsb pdb:3D1G|rcsb pdb:3F1V|rcsb pdb:3PWE|rcsb pdb:3Q4J|rcsb pdb:3Q4K|rcsb pdb:3Q4L|rcsb pdb:3QSB|rcsb pdb:4K3K|rcsb pdb:4K3L|rcsb pdb:4K3M|rcsb pdb:4K3O|rcsb pdb:4K3P|rcsb pdb:4K3Q|rcsb pdb:4K3R|rcsb pdb:4K3S|rcsb pdb:4MJP|rcsb pdb:4MJQ|rcsb pdb:4MJR|rcsb pdb:4N94|rcsb pdb:4N95|rcsb pdb:4N96|rcsb pdb:4N97|rcsb pdb:4N98|rcsb pdb:4N99|rcsb pdb:4N9A|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:6E8E|rcsb pdb:6FVL|refseq:NP_418156.1|refseq:WP_000673464.1|dip:DIP-36038N refseq:NP_065316.1|interpro:IPR016421(Transposition, TnsE)|rcsb pdb:5D16|rcsb pdb:5D17|refseq:WP_000251879.1|interpro:IPR041419|go:"GO:0003677"(DNA binding)|go:"GO:0006310"(DNA recombination)|go:"GO:0032196"(transposition) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot. - figure legend:Fig. 3B|comment:dnaN is radio-labelled enzymatically using PKA.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/09/03 2014/10/16 rogid:9CWZmgLmO/kNXmVq75u0u04mX2g83333 rogid:Co73do/LBTYRXC/lyKrLoUoyK6E562 intact-crc:E7FE9EA0D7EF36CE|rigid:YYHazeBViBYIYQU2QV/WOOPOUSQ false 32p radiolabel:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P05845 uniprotkb:P0A988 intact:EBI-2434514|uniprotkb:Q7AJH8 intact:EBI-542385|uniprotkb:P00583|uniprotkb:Q2M813|ensemblbacteria:AAC76724|ensemblbacteria:BAE77593 psi-mi:tnse_ecolx(display_long)|uniprotkb:tnsE(gene name)|psi-mi:tnsE(display_short)|uniprotkb:Protein D(gene name synonym) psi-mi:dpo3b_ecoli(display_long)|uniprotkb:dnaN(gene name)|psi-mi:dnaN(display_short)|uniprotkb:Beta-clamp processivity factor(gene name synonym)|uniprotkb:DNA polymerase III beta sliding clamp subunit(gene name synonym)|uniprotkb:JW3678(locus name)|uniprotkb:b3701(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Parks et al. (2009) imex:IM-12082|pubmed:19703395 taxid:562(ecolx)|taxid:562(Escherichia coli) taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2434595|imex:IM-12082-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065316.1|interpro:IPR016421(Transposition, TnsE)|rcsb pdb:5D16|rcsb pdb:5D17|refseq:WP_000251879.1|interpro:IPR041419|go:"GO:0003677"(DNA binding)|go:"GO:0006310"(DNA recombination)|go:"GO:0032196"(transposition) ensemblbacteria:AAC76724(transcript)|ensemblbacteria:b3701(gene)|ensemblbacteria:BAE77593(gene)|ensemblbacteria:BAE77593(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044787"(bacterial-type DNA replication)|interpro:IPR001001(DNA polymerase III, beta chain)|interpro:IPR022634|interpro:IPR022635|interpro:IPR022637|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1MMI|rcsb pdb:1OK7|rcsb pdb:1UNN|rcsb pdb:1WAI|rcsb pdb:2POL|rcsb pdb:2XUR|rcsb pdb:3BEP|rcsb pdb:3D1E|rcsb pdb:3D1F|rcsb pdb:3D1G|rcsb pdb:3F1V|rcsb pdb:3PWE|rcsb pdb:3Q4J|rcsb pdb:3Q4K|rcsb pdb:3Q4L|rcsb pdb:3QSB|rcsb pdb:4K3K|rcsb pdb:4K3L|rcsb pdb:4K3M|rcsb pdb:4K3O|rcsb pdb:4K3P|rcsb pdb:4K3Q|rcsb pdb:4K3R|rcsb pdb:4K3S|rcsb pdb:4MJP|rcsb pdb:4MJQ|rcsb pdb:4MJR|rcsb pdb:4N94|rcsb pdb:4N95|rcsb pdb:4N96|rcsb pdb:4N97|rcsb pdb:4N98|rcsb pdb:4N99|rcsb pdb:4N9A|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:6E8E|rcsb pdb:6FVL|refseq:NP_418156.1|refseq:WP_000673464.1|dip:DIP-36038N psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot. figure legend:Figs. 3C, 4B|kinetics:Wild type tnsE KD=2.4E-6M. gln122ala KD=1E-5M. leu123ala KD=7E-6M, leu129ala KD=1E-5M. leu131ala KD=6E-6M.|kinetic_conditions:pH 7.4, Flow rate = 5 μl/min on a CM-5 chip|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/09/03 2014/10/16 rogid:Co73do/LBTYRXC/lyKrLoUoyK6E562 rogid:9CWZmgLmO/kNXmVq75u0u04mX2g83333 intact-crc:A8BCD0109794DE72|rigid:YYHazeBViBYIYQU2QV/WOOPOUSQ false mutation decreasing interaction:122-122|mutation decreasing interaction:123-123|mutation decreasing interaction:125-125|mutation decreasing interaction:129-129|mutation decreasing interaction:130-130|mutation decreasing interaction:131-131 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0A988 uniprotkb:P28630 intact:EBI-542385|uniprotkb:P00583|uniprotkb:Q2M813|ensemblbacteria:AAC76724|ensemblbacteria:BAE77593 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 psi-mi:dpo3b_ecoli(display_long)|uniprotkb:dnaN(gene name)|psi-mi:dnaN(display_short)|uniprotkb:Beta-clamp processivity factor(gene name synonym)|uniprotkb:DNA polymerase III beta sliding clamp subunit(gene name synonym)|uniprotkb:JW3678(locus name)|uniprotkb:b3701(locus name) psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Parks et al. (2009) imex:IM-12082|pubmed:19703395 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2434614|imex:IM-12082-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC76724(transcript)|ensemblbacteria:b3701(gene)|ensemblbacteria:BAE77593(gene)|ensemblbacteria:BAE77593(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044787"(bacterial-type DNA replication)|interpro:IPR001001(DNA polymerase III, beta chain)|interpro:IPR022634|interpro:IPR022635|interpro:IPR022637|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1MMI|rcsb pdb:1OK7|rcsb pdb:1UNN|rcsb pdb:1WAI|rcsb pdb:2POL|rcsb pdb:2XUR|rcsb pdb:3BEP|rcsb pdb:3D1E|rcsb pdb:3D1F|rcsb pdb:3D1G|rcsb pdb:3F1V|rcsb pdb:3PWE|rcsb pdb:3Q4J|rcsb pdb:3Q4K|rcsb pdb:3Q4L|rcsb pdb:3QSB|rcsb pdb:4K3K|rcsb pdb:4K3L|rcsb pdb:4K3M|rcsb pdb:4K3O|rcsb pdb:4K3P|rcsb pdb:4K3Q|rcsb pdb:4K3R|rcsb pdb:4K3S|rcsb pdb:4MJP|rcsb pdb:4MJQ|rcsb pdb:4MJR|rcsb pdb:4N94|rcsb pdb:4N95|rcsb pdb:4N96|rcsb pdb:4N97|rcsb pdb:4N98|rcsb pdb:4N99|rcsb pdb:4N9A|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:6E8E|rcsb pdb:6FVL|refseq:NP_418156.1|refseq:WP_000673464.1|dip:DIP-36038N refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot. crc64:87239A678FE16BE2 figure legend:Fig. 3C|comment:Positive control|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/09/03 2014/10/16 rogid:9CWZmgLmO/kNXmVq75u0u04mX2g83333 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 intact-crc:51C60C7C77A74443|rigid:5iKBR6VGt8HBCAdfCbUFVDvWkhs false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0A988 uniprotkb:P06710 intact:EBI-542385|uniprotkb:P00583|uniprotkb:Q2M813|ensemblbacteria:AAC76724|ensemblbacteria:BAE77593 intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249 psi-mi:dpo3b_ecoli(display_long)|uniprotkb:dnaN(gene name)|psi-mi:dnaN(display_short)|uniprotkb:Beta-clamp processivity factor(gene name synonym)|uniprotkb:DNA polymerase III beta sliding clamp subunit(gene name synonym)|uniprotkb:JW3678(locus name)|uniprotkb:b3701(locus name) psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Parks et al. (2009) imex:IM-12082|pubmed:19703395 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2434619|imex:IM-12082-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC76724(transcript)|ensemblbacteria:b3701(gene)|ensemblbacteria:BAE77593(gene)|ensemblbacteria:BAE77593(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044787"(bacterial-type DNA replication)|interpro:IPR001001(DNA polymerase III, beta chain)|interpro:IPR022634|interpro:IPR022635|interpro:IPR022637|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1MMI|rcsb pdb:1OK7|rcsb pdb:1UNN|rcsb pdb:1WAI|rcsb pdb:2POL|rcsb pdb:2XUR|rcsb pdb:3BEP|rcsb pdb:3D1E|rcsb pdb:3D1F|rcsb pdb:3D1G|rcsb pdb:3F1V|rcsb pdb:3PWE|rcsb pdb:3Q4J|rcsb pdb:3Q4K|rcsb pdb:3Q4L|rcsb pdb:3QSB|rcsb pdb:4K3K|rcsb pdb:4K3L|rcsb pdb:4K3M|rcsb pdb:4K3O|rcsb pdb:4K3P|rcsb pdb:4K3Q|rcsb pdb:4K3R|rcsb pdb:4K3S|rcsb pdb:4MJP|rcsb pdb:4MJQ|rcsb pdb:4MJR|rcsb pdb:4N94|rcsb pdb:4N95|rcsb pdb:4N96|rcsb pdb:4N97|rcsb pdb:4N98|rcsb pdb:4N99|rcsb pdb:4N9A|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:6E8E|rcsb pdb:6FVL|refseq:NP_418156.1|refseq:WP_000673464.1|dip:DIP-36038N refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot. - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/09/03 2014/10/16 rogid:9CWZmgLmO/kNXmVq75u0u04mX2g83333 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 intact-crc:6552069D83955FA5|rigid:2CrZtRyJvLtBOyVAXVaNWMWPIzI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)