#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q05787	uniprotkb:P00729	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181763|mint:MINT-7302247|imex:IM-13940-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346|mint:MINT-7302257(identity)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7302249(identity)	-	-	crc64:7227F3489CBDD952	figure legend:f1a|comment:homomint|comment:mint|comment:cpy* refers to misfolded ERAD-L substrate CPY|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	intact-crc:0037F31E57821314|rigid:YoZDllebxZGoiQU5ikOQOpFAq1k	false	ha tag:n-n(MINT-7302258)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q05787	uniprotkb:P25694	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181763|mint:MINT-7302247|imex:IM-13940-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346|mint:MINT-7302257(identity)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-7302255(identity)	-	-	crc64:02ADDB9A227614D8	figure legend:f1a|comment:homomint|comment:mint|comment:cpy* refers to misfolded ERAD-L substrate CPY|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:0037F31E57821314|rigid:YoZDllebxZGoiQU5ikOQOpFAq1k	false	ha tag:n-n(MINT-7302258)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q05787	uniprotkb:P32915	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181763|mint:MINT-7302247|imex:IM-13940-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346|mint:MINT-7302257(identity)	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915|mint:MINT-7302267(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint|comment:cpy* refers to misfolded ERAD-L substrate CPY|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	intact-crc:0037F31E57821314|rigid:YoZDllebxZGoiQU5ikOQOpFAq1k	false	ha tag:n-n(MINT-7302258)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q05787	uniprotkb:Q08109	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181763|mint:MINT-7302247|imex:IM-13940-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346|mint:MINT-7302257(identity)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346|mint:MINT-7302253(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint|comment:cpy* refers to misfolded ERAD-L substrate CPY|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:0037F31E57821314|rigid:YoZDllebxZGoiQU5ikOQOpFAq1k	false	ha tag:n-n(MINT-7302258)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P32915	uniprotkb:P00729	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181818|mint:MINT-7303687|imex:IM-13940-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915|mint:MINT-7303690(identity)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7303689(identity)	-	-	crc64:7227F3489CBDD952	figure legend:f2a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	intact-crc:560E45B684E5FF12|rigid:DpzQFz+wmn6P2W9C+zxt1EhunQI	false	-	ha tag:?-?(MINT-7303693)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P32915	uniprotkb:Q05787	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181803|mint:MINT-7302619|imex:IM-13940-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915|mint:MINT-7302622(identity)	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346|mint:MINT-7302621(identity)	-	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	intact-crc:4BD5E3F8875A95C3|rigid:oKwfas1KVHbwR1emxONXffZag7w	false	-	ha tag:?-?(MINT-7302624)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00729	uniprotkb:P32915	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181872|mint:MINT-7303719|imex:IM-13940-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7303721(identity)	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915|mint:MINT-7303725(identity)	-	crc64:7227F3489CBDD952	-	figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	intact-crc:AD1F7248AE346DED|rigid:DpzQFz+wmn6P2W9C+zxt1EhunQI	false	mutation increasing interaction:255-255(MINT-7303722)	ha tag:?-?(MINT-7303726)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00729	uniprotkb:P32915	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181853|mint:MINT-7303699|imex:IM-13940-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7303703(identity)	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915|mint:MINT-7303701(identity)	-	crc64:7227F3489CBDD952	-	figure legend:f5c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	intact-crc:EC3E364055A54380|rigid:DpzQFz+wmn6P2W9C+zxt1EhunQI	false	mutation increasing interaction:255-255(MINT-7303713)	ha tag:?-?(MINT-7303708)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00729	uniprotkb:P0CG63	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-7000452|ensemblfungi:YLL039C|intact:MINT-545233|uniprotkb:D6VXW7|uniprotkb:P61864|uniprotkb:Q6LA96|uniprotkb:P04838	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:ubi4p_yeast(display_long)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181891|mint:MINT-7303734|imex:IM-13940-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7303746(identity)	ensemblfungi:YLL039C(gene)|ensemblfungi:YLL039C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:2KDI|rcsb pdb:2L00|rcsb pdb:3CMM|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3OLM|rcsb pdb:4HCN|rcsb pdb:4NNJ|rcsb pdb:4Q5E|rcsb pdb:4Q5H|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-156827|reactome:R-SCE-174113|reactome:R-SCE-1799339|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5687128|reactome:R-SCE-5689603|reactome:R-SCE-5689877|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-5696395|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6791226|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-72649|reactome:R-SCE-72689|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72706|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-8948747|reactome:R-SCE-8948751|reactome:R-SCE-901032|reactome:R-SCE-9020702|reactome:R-SCE-9033241|reactome:R-SCE-917729|reactome:R-SCE-9646399|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-983168|interpro:IPR000626(Ubiquitin)|sgd:S000003962|interpro:IPR019956|interpro:IPR019954|refseq:NP_013061.1|interpro:IPR029071|mint:P0CG63|mint:MINT-7306084(identity)	-	crc64:7227F3489CBDD952	function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:+GNv/Jc7C11q8cgu2qZ6YkcsIeI559292	intact-crc:CEB2E192945DB03A|rigid:m2ApUgBPn/lTFxo+dsdZlBqITUU	false	ha tag:?-?(MINT-7303749)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00729	uniprotkb:P32915	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181891|mint:MINT-7303734|imex:IM-13940-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7303746(identity)	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915|mint:MINT-7303736(identity)	-	crc64:7227F3489CBDD952	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	intact-crc:CEB2E192945DB03A|rigid:m2ApUgBPn/lTFxo+dsdZlBqITUU	false	ha tag:?-?(MINT-7303749)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P00729	uniprotkb:P25694	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181891|mint:MINT-7303734|imex:IM-13940-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7303746(identity)	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725|mint:MINT-7303742(identity)	-	crc64:7227F3489CBDD952	crc64:02ADDB9A227614D8	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:CEB2E192945DB03A|rigid:m2ApUgBPn/lTFxo+dsdZlBqITUU	false	ha tag:?-?(MINT-7303749)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P00729	uniprotkb:Q08109	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schäfer et al. (2009)	pubmed:19696741|imex:IM-13940|mint:MINT-7295833|doi:10.1038/emboj.2009.231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7181891|mint:MINT-7303734|imex:IM-13940-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC|mint:MINT-7303746(identity)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346|mint:MINT-7303744(identity)	-	crc64:7227F3489CBDD952	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/11/19	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:CEB2E192945DB03A|rigid:m2ApUgBPn/lTFxo+dsdZlBqITUU	false	ha tag:?-?(MINT-7303749)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)