#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P01042 uniprotkb:Q61001 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-7176527|ensembl:ENSMUSP00000015791|uniprotkb:A2ABW7|uniprotkb:Q9JHQ6|intact:MINT-4100102 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lama5_mouse(display_long)|uniprotkb:Lama5(gene name)|psi-mi:Lama5(display_short)|uniprotkb:Laminin-10 subunit alpha(gene name synonym)|uniprotkb:Laminin-11 subunit alpha(gene name synonym)|uniprotkb:Laminin-15 subunit alpha(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176577|mint:MINT-7218019 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7218021(identity) ensembl:ENSMUSG00000015647(gene)|ensembl:ENSMUST00000015791(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005610"(laminin-5 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007517"(muscle organ development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0060271"(cilium assembly)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|go:"GO:0016477"(cell migration)|interpro:IPR009254(Laminin I)|go:"GO:0030155"(regulation of cell adhesion)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q61001|go:"GO:0030324"(lung development)|rcsb pdb:2Y38|reactome:R-MMU-3000157|reactome:R-MMU-8874081|go:"GO:0030334"(regulation of cell migration)|refseq:NP_001074640.1|mint:MINT-7218022(identity) - - comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae figure legend:T1|comment:homomint|comment:mint|comment:"The same interaction occurs between LM10/LM11(laminin a5, b1 and g1/laminin a5, b2 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2014/10/16 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:46eKm5qp2WYbLniz3O2Nfrc1GoE10090 intact-crc:8B9F0175100C833E|rigid:bTBShKeF8mQtJIa55eMJTfo3Th0 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:Q61001 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-7176527|ensembl:ENSMUSP00000015791|uniprotkb:A2ABW7|uniprotkb:Q9JHQ6|intact:MINT-4100102 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lama5_mouse(display_long)|uniprotkb:Lama5(gene name)|psi-mi:Lama5(display_short)|uniprotkb:Laminin-10 subunit alpha(gene name synonym)|uniprotkb:Laminin-11 subunit alpha(gene name synonym)|uniprotkb:Laminin-15 subunit alpha(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176577|mint:MINT-7218019 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7218021(identity) ensembl:ENSMUSG00000015647(gene)|ensembl:ENSMUST00000015791(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005610"(laminin-5 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007517"(muscle organ development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0060271"(cilium assembly)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|go:"GO:0016477"(cell migration)|interpro:IPR009254(Laminin I)|go:"GO:0030155"(regulation of cell adhesion)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q61001|go:"GO:0030324"(lung development)|rcsb pdb:2Y38|reactome:R-MMU-3000157|reactome:R-MMU-8874081|go:"GO:0030334"(regulation of cell migration)|refseq:NP_001074640.1|mint:MINT-7219339(identity) - - comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae figure legend:T1|comment:homomint|comment:mint|comment:"The same interaction occurs between LM10/LM11(laminin a5, b1 and g1/laminin a5, b2 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2014/10/16 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:46eKm5qp2WYbLniz3O2Nfrc1GoE10090 intact-crc:8B9F0175100C833E|rigid:bTBShKeF8mQtJIa55eMJTfo3Th0 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:P02469 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-6662997|ensembl:ENSMUSP00000002979|ensembl:ENSMUSP00000132778|uniprotkb:E9PXZ9 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lamb1_mouse(display_long)|uniprotkb:Lamb1(gene name)|psi-mi:Lamb1(display_short)|uniprotkb:Lamb-1(gene name synonym)|uniprotkb:Lamb1-1(gene name synonym)|uniprotkb:Laminin B1 chain(gene name synonym)|uniprotkb:Laminin-1 subunit beta(gene name synonym)|uniprotkb:Laminin-10 subunit beta(gene name synonym)|uniprotkb:Laminin-12 subunit beta(gene name synonym)|uniprotkb:Laminin-2 subunit beta(gene name synonym)|uniprotkb:Laminin-6 subunit beta(gene name synonym)|uniprotkb:Laminin-8 subunit beta(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176577|mint:MINT-7218019 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7218021(identity) refseq:XP_006515055.2|ensembl:ENSMUSG00000002900(gene)|ensembl:ENSMUST00000002979(transcript)|ensembl:ENSMUST00000169088(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005607"(laminin-2 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0007611"(learning or memory)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0021812"(neuronal-glial interaction involved in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042476"(odontogenesis)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043256"(laminin complex)|go:"GO:0043257"(laminin-8 complex)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8874081|go:"GO:0070831"(basement membrane assembly)|reactome:R-MMU-8957275|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR013015(Laminin IV)|mint:P02469|rcsb pdb:4AQS|rcsb pdb:5MC9|refseq:XP_006515056.1|mint:MINT-7218023(identity) - - - figure legend:T1|comment:homomint|comment:mint|comment:"The same interaction occurs between LM10/LM11(laminin a5, b1 and g1/laminin a5, b2 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2014/10/16 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:cUuVqY2JMeRrS9sDYudPy7hSIL010090 intact-crc:8B9F0175100C833E|rigid:bTBShKeF8mQtJIa55eMJTfo3Th0 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:Q61292 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-7176465|ensembl:ENSMUSP00000069087|uniprotkb:Q62182|uniprotkb:Q8R0Y0|intact:MINT-4100139 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lamb2_mouse(display_long)|uniprotkb:Lamb2(gene name)|psi-mi:Lamb2(display_short)|uniprotkb:Lams(gene name synonym)|uniprotkb:Laminin-11 subunit beta(gene name synonym)|uniprotkb:Laminin-14 subunit beta(gene name synonym)|uniprotkb:Laminin-15 subunit beta(gene name synonym)|uniprotkb:Laminin-3 subunit beta(gene name synonym)|uniprotkb:Laminin-4 subunit beta(gene name synonym)|uniprotkb:Laminin-7 subunit beta(gene name synonym)|uniprotkb:Laminin-9 subunit beta(gene name synonym)|uniprotkb:S-laminin subunit beta(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176577|mint:MINT-7218019 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7218021(identity) refseq:XP_006511711.1|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005608"(laminin-3 complex)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007601"(visual perception)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016477"(cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043256"(laminin complex)|go:"GO:0045202"(synapse)|go:"GO:0048677"(axon extension involved in regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072249"(metanephric glomerular visceral epithelial cell development)|go:"GO:0072274"(metanephric glomerular basement membrane development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR013015(Laminin IV)|mint:Q61292|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000052911(gene)|ensembl:ENSMUST00000065014(transcript)|refseq:NP_032509.2|mint:MINT-7219338(identity) - - function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components|comment:mint|function:"Laminin-3 (S-laminin) regulates the formation of motor nerve terminals" figure legend:T1|comment:homomint|comment:mint|comment:"The same interaction occurs between LM10/LM11(laminin a5, b1 and g1/laminin a5, b2 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2014/10/16 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:jiVR9bAgoadH77D+jloa9onHH8Q10090 intact-crc:8B9F0175100C833E|rigid:bTBShKeF8mQtJIa55eMJTfo3Th0 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:P02468 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-7059830|intact:MINT-1031545 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lamc1_mouse(display_long)|uniprotkb:Lamc1(gene name)|psi-mi:Lamc1(display_short)|uniprotkb:Lamb-2(gene name synonym)|uniprotkb:Lamc-1(gene name synonym)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176577|mint:MINT-7218019 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7218021(identity) mint:P02468|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|rcsb pdb:1KLO|rcsb pdb:1NPE|rcsb pdb:1TLE|rcsb pdb:4AQT|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8874081|dip:DIP-41793N|mint:MINT-7219359(identity) - - comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components figure legend:T1|comment:homomint|comment:mint|comment:"The same interaction occurs between LM10/LM11(laminin a5, b1 and g1/laminin a5, b2 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2014/10/16 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:LTc4oIJUjQ8INjkodiPpXvL/rx010090 intact-crc:8B9F0175100C833E|rigid:bTBShKeF8mQtJIa55eMJTfo3Th0 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:P02468 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-7059830|intact:MINT-1031545 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lamc1_mouse(display_long)|uniprotkb:Lamc1(gene name)|psi-mi:Lamc1(display_short)|uniprotkb:Lamb-2(gene name synonym)|uniprotkb:Lamc-1(gene name synonym)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176577|mint:MINT-7218019 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7218021(identity) mint:P02468|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|rcsb pdb:1KLO|rcsb pdb:1NPE|rcsb pdb:1TLE|rcsb pdb:4AQT|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8874081|dip:DIP-41793N|mint:MINT-7218024(identity) - - comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components figure legend:T1|comment:homomint|comment:mint|comment:"The same interaction occurs between LM10/LM11(laminin a5, b1 and g1/laminin a5, b2 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2014/10/16 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:LTc4oIJUjQ8INjkodiPpXvL/rx010090 intact-crc:8B9F0175100C833E|rigid:bTBShKeF8mQtJIa55eMJTfo3Th0 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:P19137 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-7176628|ensembl:ENSMUSP00000043957|intact:MINT-2635122|uniprotkb:F8VQ40 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lama1_mouse(display_long)|uniprotkb:Lama1(gene name)|psi-mi:Lama1(display_short)|uniprotkb:Lama(gene name synonym)|uniprotkb:Lama-1(gene name synonym)|uniprotkb:Laminin A chain(gene name synonym)|uniprotkb:Laminin-1 subunit alpha(gene name synonym)|uniprotkb:Laminin-3 subunit alpha(gene name synonym)|uniprotkb:S-laminin subunit alpha(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176673|mint:MINT-7219326 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7219334(identity) ensembl:ENSMUSG00000032796(gene)|ensembl:ENSMUST00000035471(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005608"(laminin-3 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043256"(laminin complex)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR009254(Laminin I)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:P19137|rcsb pdb:2JD4|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-8874081|go:"GO:0045995"(regulation of embryonic development)|refseq:NP_032506.2|mint:MINT-7219332(identity) - - function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components|comment:mint figure legend:F2A|comment:homomint|comment:mint|comment:"The same interaction occurs between LM1(laminin a1, b1 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2018/07/23 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:5L6nnYFEE3kmWteC4VtG4c87LHs10090 intact-crc:1F052EE024999C82|rigid:UtH9eJIlMFh/6tlpFQ77RwLL8hU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:P02469 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-6662997|ensembl:ENSMUSP00000002979|ensembl:ENSMUSP00000132778|uniprotkb:E9PXZ9 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lamb1_mouse(display_long)|uniprotkb:Lamb1(gene name)|psi-mi:Lamb1(display_short)|uniprotkb:Lamb-1(gene name synonym)|uniprotkb:Lamb1-1(gene name synonym)|uniprotkb:Laminin B1 chain(gene name synonym)|uniprotkb:Laminin-1 subunit beta(gene name synonym)|uniprotkb:Laminin-10 subunit beta(gene name synonym)|uniprotkb:Laminin-12 subunit beta(gene name synonym)|uniprotkb:Laminin-2 subunit beta(gene name synonym)|uniprotkb:Laminin-6 subunit beta(gene name synonym)|uniprotkb:Laminin-8 subunit beta(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176673|mint:MINT-7219326 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7219334(identity) refseq:XP_006515055.2|ensembl:ENSMUSG00000002900(gene)|ensembl:ENSMUST00000002979(transcript)|ensembl:ENSMUST00000169088(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005607"(laminin-2 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0007611"(learning or memory)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0021812"(neuronal-glial interaction involved in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042476"(odontogenesis)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043256"(laminin complex)|go:"GO:0043257"(laminin-8 complex)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8874081|go:"GO:0070831"(basement membrane assembly)|reactome:R-MMU-8957275|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR013015(Laminin IV)|mint:P02469|rcsb pdb:4AQS|rcsb pdb:5MC9|refseq:XP_006515056.1|mint:MINT-7219330(identity) - - - figure legend:F2A|comment:homomint|comment:mint|comment:"The same interaction occurs between LM1(laminin a1, b1 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2018/07/23 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:cUuVqY2JMeRrS9sDYudPy7hSIL010090 intact-crc:1F052EE024999C82|rigid:UtH9eJIlMFh/6tlpFQ77RwLL8hU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01042 uniprotkb:P02468 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-7059830|intact:MINT-1031545 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:lamc1_mouse(display_long)|uniprotkb:Lamc1(gene name)|psi-mi:Lamc1(display_short)|uniprotkb:Lamb-2(gene name synonym)|uniprotkb:Lamc-1(gene name synonym)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Schousboe et al. (2009) pubmed:19691495|mint:MINT-7217880|mint:fj-09-0273|doi:10.1111/j.1742-4658.2009.07218 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7176673|mint:MINT-7219326 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1|mint:MINT-7219334(identity) mint:P02468|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|rcsb pdb:1KLO|rcsb pdb:1NPE|rcsb pdb:1TLE|rcsb pdb:4AQT|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8874081|dip:DIP-41793N|mint:MINT-7219328(identity) - - comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components figure legend:F2A|comment:homomint|comment:mint|comment:"The same interaction occurs between LM1(laminin a1, b1 and g1) and the two-chain protein, HKa." taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/07/10 2018/07/23 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:LTc4oIJUjQ8INjkodiPpXvL/rx010090 intact-crc:1F052EE024999C82|rigid:UtH9eJIlMFh/6tlpFQ77RwLL8hU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0396"(predetermined participant)