#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-7163285 uniprotkb:P29320 intact:MINT-7145069 intact:EBI-1641575|uniprotkb:Q9H2V3|uniprotkb:Q9H2V4|ensembl:ENSP00000337451 psi-mi:ephopt(display_short)|psi-mi:EBI-7163285(display_long) psi-mi:epha3_human(display_long)|uniprotkb:EPHA3(gene name)|psi-mi:EPHA3(display_short)|uniprotkb:ETK(gene name synonym)|uniprotkb:ETK1(gene name synonym)|uniprotkb:TYRO4(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor ETK1(gene name synonym)|uniprotkb:HEK(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO4(gene name synonym)|uniprotkb:EPH-like kinase 4(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163281|mint:MINT-7145066 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145071(identity) refseq:NP_005224.2|refseq:NP_872585.1|dip:DIP-40307N|ensembl:ENSG00000044524(gene)|ensembl:ENST00000336596(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034266|interpro:IPR036116|mint:P29320|rcsb pdb:2GSF|rcsb pdb:2QO7|rcsb pdb:2QO9|rcsb pdb:2QOB|rcsb pdb:2QOC|rcsb pdb:2QOD|rcsb pdb:2QOF|rcsb pdb:2QOI|rcsb pdb:2QOK|rcsb pdb:2QOL|rcsb pdb:2QON|rcsb pdb:2QOO|rcsb pdb:2QOQ|rcsb pdb:3DZQ|rcsb pdb:3FXX|rcsb pdb:3FY2|rcsb pdb:4G2F|rcsb pdb:4GK2|rcsb pdb:4GK3|rcsb pdb:4GK4|rcsb pdb:4L0P|rcsb pdb:4P4C|rcsb pdb:4P5Q|rcsb pdb:4P5Z|rcsb pdb:4TWN|rcsb pdb:4TWO|rcsb pdb:6IN0|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:2QO2|mint:MINT-7145068(identity) - comment:mint|no-uniprot-update: - comment:mint|figure legend:T1 F2 F3 taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:uoSHY7LRqY5V/Wp58sXdMum8Sf0-2 rogid:YtQaP5rZsiJHmhpkXDelGBeL8e49606 intact-crc:67BCBEDD37EF6A04|rigid:4Gpcc3mYZCcUgc9NImSmPExi7BY false - binding-associated region:577-947(MINT-7145089) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163299 uniprotkb:P29320 intact:MINT-7145102 intact:EBI-1641575|uniprotkb:Q9H2V3|uniprotkb:Q9H2V4|ensembl:ENSP00000337451 psi-mi:optyf(display_short)|psi-mi:EBI-7163299(display_long) psi-mi:epha3_human(display_long)|uniprotkb:EPHA3(gene name)|psi-mi:EPHA3(display_short)|uniprotkb:ETK(gene name synonym)|uniprotkb:ETK1(gene name synonym)|uniprotkb:TYRO4(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor ETK1(gene name synonym)|uniprotkb:HEK(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO4(gene name synonym)|uniprotkb:EPH-like kinase 4(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163304|mint:MINT-7145092 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145104(identity) refseq:NP_005224.2|refseq:NP_872585.1|dip:DIP-40307N|ensembl:ENSG00000044524(gene)|ensembl:ENST00000336596(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034266|interpro:IPR036116|mint:P29320|rcsb pdb:2GSF|rcsb pdb:2QO7|rcsb pdb:2QO9|rcsb pdb:2QOB|rcsb pdb:2QOC|rcsb pdb:2QOD|rcsb pdb:2QOF|rcsb pdb:2QOI|rcsb pdb:2QOK|rcsb pdb:2QOL|rcsb pdb:2QON|rcsb pdb:2QOO|rcsb pdb:2QOQ|rcsb pdb:3DZQ|rcsb pdb:3FXX|rcsb pdb:3FY2|rcsb pdb:4G2F|rcsb pdb:4GK2|rcsb pdb:4GK3|rcsb pdb:4GK4|rcsb pdb:4L0P|rcsb pdb:4P4C|rcsb pdb:4P5Q|rcsb pdb:4P5Z|rcsb pdb:4TWN|rcsb pdb:4TWO|rcsb pdb:6IN0|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:2QO2|mint:MINT-7145094(identity) - comment:mint|no-uniprot-update: - figure legend:F3|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:AVgvN6bQLTlWYVXTrPqY+WBsb0s-2 rogid:YtQaP5rZsiJHmhpkXDelGBeL8e49606 intact-crc:B1F2F3473821E5AF|rigid:CA0E7N8vAIsqSk5fFlWBYvOvbfM false - binding-associated region:577-947(MINT-7145095) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163299 uniprotkb:P29320 intact:MINT-7145102 intact:EBI-1641575|uniprotkb:Q9H2V3|uniprotkb:Q9H2V4|ensembl:ENSP00000337451 psi-mi:optyf(display_short)|psi-mi:EBI-7163299(display_long) psi-mi:epha3_human(display_long)|uniprotkb:EPHA3(gene name)|psi-mi:EPHA3(display_short)|uniprotkb:ETK(gene name synonym)|uniprotkb:ETK1(gene name synonym)|uniprotkb:TYRO4(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor ETK1(gene name synonym)|uniprotkb:HEK(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO4(gene name synonym)|uniprotkb:EPH-like kinase 4(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163339|mint:MINT-7145127 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145133(identity) refseq:NP_005224.2|refseq:NP_872585.1|dip:DIP-40307N|ensembl:ENSG00000044524(gene)|ensembl:ENST00000336596(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034266|interpro:IPR036116|mint:P29320|rcsb pdb:2GSF|rcsb pdb:2QO7|rcsb pdb:2QO9|rcsb pdb:2QOB|rcsb pdb:2QOC|rcsb pdb:2QOD|rcsb pdb:2QOF|rcsb pdb:2QOI|rcsb pdb:2QOK|rcsb pdb:2QOL|rcsb pdb:2QON|rcsb pdb:2QOO|rcsb pdb:2QOQ|rcsb pdb:3DZQ|rcsb pdb:3FXX|rcsb pdb:3FY2|rcsb pdb:4G2F|rcsb pdb:4GK2|rcsb pdb:4GK3|rcsb pdb:4GK4|rcsb pdb:4L0P|rcsb pdb:4P4C|rcsb pdb:4P5Q|rcsb pdb:4P5Z|rcsb pdb:4TWN|rcsb pdb:4TWO|rcsb pdb:6IN0|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:2QO2|mint:MINT-7145129(identity) - comment:mint|no-uniprot-update: - comment:mint|figure legend:T2 T1 F1 ST1 ST2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:AVgvN6bQLTlWYVXTrPqY+WBsb0s-2 rogid:YtQaP5rZsiJHmhpkXDelGBeL8e49606 intact-crc:39322E287DC386D5|rigid:CA0E7N8vAIsqSk5fFlWBYvOvbfM false - mutation disrupting interaction:785-785(MINT-7145130) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163299 uniprotkb:P29320 intact:MINT-7145102 intact:EBI-1641575|uniprotkb:Q9H2V3|uniprotkb:Q9H2V4|ensembl:ENSP00000337451 psi-mi:optyf(display_short)|psi-mi:EBI-7163299(display_long) psi-mi:epha3_human(display_long)|uniprotkb:EPHA3(gene name)|psi-mi:EPHA3(display_short)|uniprotkb:ETK(gene name synonym)|uniprotkb:ETK1(gene name synonym)|uniprotkb:TYRO4(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor ETK1(gene name synonym)|uniprotkb:HEK(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO4(gene name synonym)|uniprotkb:EPH-like kinase 4(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163325|mint:MINT-7145108 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145114(identity) refseq:NP_005224.2|refseq:NP_872585.1|dip:DIP-40307N|ensembl:ENSG00000044524(gene)|ensembl:ENST00000336596(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034266|interpro:IPR036116|mint:P29320|rcsb pdb:2GSF|rcsb pdb:2QO7|rcsb pdb:2QO9|rcsb pdb:2QOB|rcsb pdb:2QOC|rcsb pdb:2QOD|rcsb pdb:2QOF|rcsb pdb:2QOI|rcsb pdb:2QOK|rcsb pdb:2QOL|rcsb pdb:2QON|rcsb pdb:2QOO|rcsb pdb:2QOQ|rcsb pdb:3DZQ|rcsb pdb:3FXX|rcsb pdb:3FY2|rcsb pdb:4G2F|rcsb pdb:4GK2|rcsb pdb:4GK3|rcsb pdb:4GK4|rcsb pdb:4L0P|rcsb pdb:4P4C|rcsb pdb:4P5Q|rcsb pdb:4P5Z|rcsb pdb:4TWN|rcsb pdb:4TWO|rcsb pdb:6IN0|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:2QO2|mint:MINT-7145110(identity) - comment:mint|no-uniprot-update: - comment:mint|figure legend:T2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:AVgvN6bQLTlWYVXTrPqY+WBsb0s-2 rogid:YtQaP5rZsiJHmhpkXDelGBeL8e49606 intact-crc:78842D8AD77A860A|rigid:CA0E7N8vAIsqSk5fFlWBYvOvbfM false - mutation decreasing interaction:830-830(MINT-7145123) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163285 uniprotkb:P29320 intact:MINT-7145069 intact:EBI-1641575|uniprotkb:Q9H2V3|uniprotkb:Q9H2V4|ensembl:ENSP00000337451 psi-mi:ephopt(display_short)|psi-mi:EBI-7163285(display_long) psi-mi:epha3_human(display_long)|uniprotkb:EPHA3(gene name)|psi-mi:EPHA3(display_short)|uniprotkb:ETK(gene name synonym)|uniprotkb:ETK1(gene name synonym)|uniprotkb:TYRO4(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor ETK1(gene name synonym)|uniprotkb:HEK(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO4(gene name synonym)|uniprotkb:EPH-like kinase 4(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163353|mint:MINT-7145145 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145149(identity) refseq:NP_005224.2|refseq:NP_872585.1|dip:DIP-40307N|ensembl:ENSG00000044524(gene)|ensembl:ENST00000336596(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034266|interpro:IPR036116|mint:P29320|rcsb pdb:2GSF|rcsb pdb:2QO7|rcsb pdb:2QO9|rcsb pdb:2QOB|rcsb pdb:2QOC|rcsb pdb:2QOD|rcsb pdb:2QOF|rcsb pdb:2QOI|rcsb pdb:2QOK|rcsb pdb:2QOL|rcsb pdb:2QON|rcsb pdb:2QOO|rcsb pdb:2QOQ|rcsb pdb:3DZQ|rcsb pdb:3FXX|rcsb pdb:3FY2|rcsb pdb:4G2F|rcsb pdb:4GK2|rcsb pdb:4GK3|rcsb pdb:4GK4|rcsb pdb:4L0P|rcsb pdb:4P4C|rcsb pdb:4P5Q|rcsb pdb:4P5Z|rcsb pdb:4TWN|rcsb pdb:4TWO|rcsb pdb:6IN0|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:2QO2|mint:MINT-7145147(identity) - comment:mint|no-uniprot-update: - comment:mint|figure legend:T2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:uoSHY7LRqY5V/Wp58sXdMum8Sf0-2 rogid:YtQaP5rZsiJHmhpkXDelGBeL8e49606 intact-crc:6CF589905C7C57B8|rigid:4Gpcc3mYZCcUgc9NImSmPExi7BY false - mutation disrupting interaction:785-785(MINT-7145154) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163285 uniprotkb:P29320 intact:MINT-7145069 intact:EBI-1641575|uniprotkb:Q9H2V3|uniprotkb:Q9H2V4|ensembl:ENSP00000337451 psi-mi:ephopt(display_short)|psi-mi:EBI-7163285(display_long) psi-mi:epha3_human(display_long)|uniprotkb:EPHA3(gene name)|psi-mi:EPHA3(display_short)|uniprotkb:ETK(gene name synonym)|uniprotkb:ETK1(gene name synonym)|uniprotkb:TYRO4(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor ETK1(gene name synonym)|uniprotkb:HEK(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO4(gene name synonym)|uniprotkb:EPH-like kinase 4(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163367|mint:MINT-7145158 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145164(identity) refseq:NP_005224.2|refseq:NP_872585.1|dip:DIP-40307N|ensembl:ENSG00000044524(gene)|ensembl:ENST00000336596(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034266|interpro:IPR036116|mint:P29320|rcsb pdb:2GSF|rcsb pdb:2QO7|rcsb pdb:2QO9|rcsb pdb:2QOB|rcsb pdb:2QOC|rcsb pdb:2QOD|rcsb pdb:2QOF|rcsb pdb:2QOI|rcsb pdb:2QOK|rcsb pdb:2QOL|rcsb pdb:2QON|rcsb pdb:2QOO|rcsb pdb:2QOQ|rcsb pdb:3DZQ|rcsb pdb:3FXX|rcsb pdb:3FY2|rcsb pdb:4G2F|rcsb pdb:4GK2|rcsb pdb:4GK3|rcsb pdb:4GK4|rcsb pdb:4L0P|rcsb pdb:4P4C|rcsb pdb:4P5Q|rcsb pdb:4P5Z|rcsb pdb:4TWN|rcsb pdb:4TWO|rcsb pdb:6IN0|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|rcsb pdb:2QO2|mint:MINT-7145160(identity) - comment:mint|no-uniprot-update: - comment:mint|figure legend:T2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:uoSHY7LRqY5V/Wp58sXdMum8Sf0-2 rogid:YtQaP5rZsiJHmhpkXDelGBeL8e49606 intact-crc:29263DDC2B14855A|rigid:4Gpcc3mYZCcUgc9NImSmPExi7BY false - mutation decreasing interaction:830-830(MINT-7145161) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163285 uniprotkb:P29323 intact:MINT-7145069 intact:EBI-1059294|uniprotkb:O43477|uniprotkb:Q5T0U6|uniprotkb:Q5T0U7|uniprotkb:Q5T0U8|intact:EBI-1383621|ensembl:ENSP00000383053 psi-mi:ephopt(display_short)|psi-mi:EBI-7163285(display_long) psi-mi:ephb2_human(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:DRT(gene name synonym)|uniprotkb:EPHT3(gene name synonym)|uniprotkb:EPTH3(gene name synonym)|uniprotkb:ERK(gene name synonym)|uniprotkb:HEK5(gene name synonym)|uniprotkb:TYRO5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-47(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO5(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Developmentally-regulated Eph-related tyrosine kinase(gene name synonym)|uniprotkb:ELK-related tyrosine kinase(gene name synonym)|uniprotkb:EPH tyrosine kinase 3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163407|mint:MINT-7145180 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145182(identity) refseq:NP_004433.2|refseq:NP_059145.2|refseq:NP_001296122.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|mint:P29323|rcsb pdb:1B4F|rcsb pdb:1F0M|rcsb pdb:3ZFM|reactome:R-HSA-2682334|reactome:R-HSA-373760|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|rcsb pdb:2QBX|ensembl:ENSG00000133216(gene)|ensembl:ENST00000400191(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001655"(urogenital system development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|go:"GO:0106028"(neuron projection retraction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|dip:DIP-1162N|mint:MINT-7145184(identity) - comment:mint|no-uniprot-update: - figure legend:ST2|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:uoSHY7LRqY5V/Wp58sXdMum8Sf0-2 rogid:be++0VNRygM3NsDcVt/OQ6fHpr09606 intact-crc:E3225DC71E29EAB3|rigid:JK6uHSNGwkIIJCZHGBLfExUlBBw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163285 uniprotkb:Q15375 intact:MINT-7145069 intact:EBI-1383428|uniprotkb:B7ZLK0|uniprotkb:A0AUX7|uniprotkb:Q59G40|uniprotkb:Q5VTU0|uniprotkb:Q8N368|uniprotkb:Q9H124|uniprotkb:B2R8W1|uniprotkb:B7ZLJ9|ensembl:ENSP00000358309 psi-mi:ephopt(display_short)|psi-mi:EBI-7163285(display_long) psi-mi:epha7_human(display_long)|uniprotkb:EPHA7(gene name)|psi-mi:EPHA7(display_short)|uniprotkb:EHK3(gene name synonym)|uniprotkb:HEK11(gene name synonym)|uniprotkb:EPH-like kinase 11(gene name synonym)|uniprotkb:EPH homology kinase 3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163417|mint:MINT-7145188 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145190(identity) refseq:NP_004431.1|refseq:XP_005248726.1|refseq:NP_001275558.1|refseq:NP_001275559.1|reactome:R-HSA-3928665|ensembl:ENSG00000135333(gene)|ensembl:ENST00000369303(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030425"(dendrite)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099175"(regulation of postsynapse organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034283|interpro:IPR036116|mint:Q15375|rcsb pdb:2REI|rcsb pdb:3DKO|rcsb pdb:3H8M|rcsb pdb:3NRU|reactome:R-HSA-2682334|reactome:R-HSA-3928663|mint:MINT-7145192(identity) - comment:mint|no-uniprot-update: - figure legend:ST2|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:uoSHY7LRqY5V/Wp58sXdMum8Sf0-2 rogid:hciF0ZNLEIZkcQUIiISZI02p26I9606 intact-crc:1E7B7726913F308D|rigid:JukRGze7Cj69M6cs2Q9n3ecskQM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163285 uniprotkb:P54756 intact:MINT-7145069 intact:EBI-1383718|uniprotkb:Q7Z3F2|ensembl:ENSP00000273854 psi-mi:ephopt(display_short)|psi-mi:EBI-7163285(display_long) psi-mi:epha5_human(display_long)|uniprotkb:EHK1(gene name synonym)|uniprotkb:HEK7(gene name synonym)|uniprotkb:EPH-like kinase 7(gene name synonym)|uniprotkb:EPH homology kinase 1(gene name synonym)|uniprotkb:EPHA5(gene name)|psi-mi:EPHA5(display_short)|uniprotkb:BSK(gene name synonym)|uniprotkb:TYRO4(gene name synonym)|uniprotkb:Brain-specific kinase(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163381|mint:MINT-7145168 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145174(identity) refseq:NP_004430.4|refseq:NP_872272.2|refseq:NP_001268694.1|refseq:NP_001268695.1|refseq:NP_001305690.1|ensembl:ENSG00000145242(gene)|ensembl:ENST00000273854(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0048666"(neuron development)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034277|interpro:IPR036116|mint:P54756|rcsb pdb:2R2P|rcsb pdb:4ET7|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|mint:MINT-7145170(identity) - comment:mint|no-uniprot-update: - figure legend:ST2|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:uoSHY7LRqY5V/Wp58sXdMum8Sf0-2 rogid:iUivhBiv5KFgvAnNmgQLNAYE/CU9606 intact-crc:E781CF7A4704932A|rigid:MsDq578FbhafcWeATr1vuS38U4o false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-7163285 uniprotkb:P54760 intact:MINT-7145069 intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896 psi-mi:ephopt(display_short)|psi-mi:EBI-7163285(display_long) psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Davis et al. (2009) pubmed:19678838|mint:MINT-7144997|doi:10.1111/j.1742-4658.2009.07147|mint:fj-09-0528 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7163427|mint:MINT-7145197 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) mint:MINT-7145199(identity) refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV|mint:MINT-7145201(identity) - comment:mint|no-uniprot-update: - figure legend:ST2|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/04 2014/10/16 rogid:uoSHY7LRqY5V/Wp58sXdMum8Sf0-2 rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606 intact-crc:3DB3AD883D7C79EB|rigid:8HTezDbiCWdW7eH9Dehyt0oC3h8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)