#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P15304 uniprotkb:P05132 intact:EBI-7154132|uniprotkb:Q6LCQ2|intact:MINT-4783535 intact:EBI-400564|uniprotkb:Q9JID0|ensembl:ENSMUSP00000005606 psi-mi:lips_rat(display_long)|uniprotkb:Lipe(gene name)|psi-mi:Lipe(display_short)|uniprotkb:Monoacylglycerol lipase LIPE(gene name synonym)|uniprotkb:Retinyl ester hydrolase(gene name synonym) psi-mi:kapca_mouse(display_long)|uniprotkb:Prkaca(gene name)|psi-mi:Prkaca(display_short)|uniprotkb:Pkaca(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Krintel et al. (2009) pubmed:19664063|mint:MINT-7211784|mint:fj-09-0269|doi:10.1111/j.1742-4658.2009.07172 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7154127|mint:MINT-7211789 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P15304|interpro:IPR033140|refseq:XP_006228456.1|go:"GO:0004771"(sterol esterase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0007565"(female pregnancy)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0017171"(serine hydrolase activity)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033878"(hormone-sensitive lipase activity)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042493"|go:"GO:0042758"(long-chain fatty acid catabolic process)|go:"GO:0046340"(diacylglycerol catabolic process)|go:"GO:0046485"(ether lipid metabolic process)|go:"GO:0047372"(acylglycerol lipase activity)|go:"GO:0047376"(all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity)|go:"GO:0050253"(retinyl-palmitate esterase activity)|go:"GO:0102258"(1,3-diacylglycerol acylhydrolase activity)|go:"GO:0102259"(1,2-diacylglycerol acylhydrolase activity)|rgd:3010|refseq:NP_036991.1|interpro:IPR029058|interpro:IPR002168(Lipase, GDXG, active site)|interpro:IPR010468(Hormone-sensitive lipase, N-terminal)|interpro:IPR013094(Alpha/beta hydrolase fold-3)|mint:MINT-7211791(identity) refseq:NP_001264827.1|refseq:NP_032880.1|reactome:R-MMU-8963896|reactome:R-MMU-983231|ensembl:ENSMUSG00000005469(gene)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P05132|ensembl:ENSMUST00000005606(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048792"(spontaneous exocytosis of neurotransmitter)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0097225"(sperm midpiece)|rcsb pdb:1APM|rcsb pdb:1ATP|rcsb pdb:1BKX|rcsb pdb:1BX6|rcsb pdb:1FMO|rcsb pdb:1J3H|rcsb pdb:1JBP|rcsb pdb:1JLU|rcsb pdb:1L3R|rcsb pdb:1PVK|rcsb pdb:1RDQ|rcsb pdb:1RE8|rcsb pdb:1REJ|rcsb pdb:1REK|rcsb pdb:1SYK|rcsb pdb:2CPK|rcsb pdb:2ERZ|rcsb pdb:2QCS|rcsb pdb:2QUR|rcsb pdb:2QVS|rcsb pdb:3FHI|rcsb pdb:3FJQ|rcsb pdb:3IDB|rcsb pdb:3IDC|rcsb pdb:3J4Q|rcsb pdb:3J4R|rcsb pdb:3O7L|rcsb pdb:3OW3|rcsb pdb:3PVB|rcsb pdb:3QAL|rcsb pdb:3QAM|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:3X2U|rcsb pdb:3X2V|rcsb pdb:3X2W|rcsb pdb:4DFX|rcsb pdb:4DFY|rcsb pdb:4DFZ|rcsb pdb:4DG0|rcsb pdb:4DG2|rcsb pdb:4DG3|rcsb pdb:4DH1|rcsb pdb:4DH3|rcsb pdb:4DH5|rcsb pdb:4DH7|rcsb pdb:4DH8|rcsb pdb:4DIN|rcsb pdb:4HPT|rcsb pdb:4HPU|rcsb pdb:4IAC|rcsb pdb:4IAD|rcsb pdb:4IAF|rcsb pdb:4IAI|rcsb pdb:4IAK|rcsb pdb:4IAY|rcsb pdb:4IAZ|rcsb pdb:4IB0|rcsb pdb:4IB1|rcsb pdb:4IB3|rcsb pdb:4NTS|rcsb pdb:4NTT|rcsb pdb:4O21|rcsb pdb:4O22|rcsb pdb:4WBB|rcsb pdb:4X6Q|rcsb pdb:4X6R|rcsb pdb:4XW4|rcsb pdb:4XW5|rcsb pdb:4XW6|rcsb pdb:5JR7|rcsb pdb:5X3F|rcsb pdb:6E21|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|rcsb pdb:6MM8|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-512988|reactome:R-MMU-5578775|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8854518|dip:DIP-6086N|mint:MINT-7211792(identity) - comment:mint|function:In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production - figure legend:F4A|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/22 2014/10/16 rogid:trp7LBbf5DJg9whCB/i2N3EU9bA10116 rogid:HdW51RuiujpUxo0Fu8TbWz3Yk8c10090 intact-crc:45D99642E1DD1430|rigid:EFh6NeboPATQ9jrFw7p7AZKxavI false his tag:?-?(MINT-7211796) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)