#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A1ZAW0 uniprotkb:Q9V9K7 intact:EBI-84244|ensemblmetazoa:FBpp0086061|intact:EBI-2409754 intact:EBI-283668|uniprotkb:A4UZ50|uniprotkb:Q53XG1|uniprotkb:Q95TJ0|uniprotkb:Q8SWW6|intact:EBI-283674|ensemblmetazoa:FBpp0085354|ensemblmetazoa:FBpp0085356|ensemblmetazoa:FBpp0085357 psi-mi:a1zaw0_drome(display_long)|uniprotkb:Dcr-2(gene name)|psi-mi:Dcr-2(display_short)|uniprotkb:Dcr-2-RA(gene name synonym)|uniprotkb:DCR-2(gene name synonym)|uniprotkb:DCR2(gene name synonym)|uniprotkb:DICER(gene name synonym)|uniprotkb:Dcr(gene name synonym)|uniprotkb:Dcr2(gene name synonym)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Dicer2(gene name synonym)|uniprotkb:Dmel\CG6493(gene name synonym)|uniprotkb:cg6493(gene name synonym)|uniprotkb:dDcr2(gene name synonym)|uniprotkb:dcr(gene name synonym)|uniprotkb:dcr-2(gene name synonym)|uniprotkb:dcr2(gene name synonym)|uniprotkb:dic2(gene name synonym)|uniprotkb:dicer(gene name synonym)|uniprotkb:dicer-2(gene name synonym)|uniprotkb:dicer2(gene name synonym)|uniprotkb:dmDcr-2(gene name synonym)|uniprotkb:CG6493(orf name)|uniprotkb:Dmel_CG6493(orf name)|uniprotkb:DICER-2(gene name synonym) psi-mi:srrt_drome(display_long)|uniprotkb:Ars2(gene name)|psi-mi:Ars2(display_short)|uniprotkb:CG7843(orf name)|uniprotkb:Arsenite-resistance protein 2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sabin et al. (2009) imex:IM-12204|pubmed:19632183 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2409750|imex:IM-12204-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_523778.2|flybase:FBgn0034246|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006342"|go:"GO:0007626"(locomotory behavior)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0009047"(dosage compensation by hyperactivation of X chromosome)|go:"GO:0009597"(detection of virus)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016443"(bidentate ribonuclease III activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0033227"(dsRNA transport)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035197"(siRNA binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|ensemblmetazoa:FBgn0034246(gene)|ensemblmetazoa:FBtr0086904(transcript)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036389|interpro:IPR038248|rcsb pdb:6BU9|rcsb pdb:6BUA|dip:DIP-54444N refseq:NP_610203.2|refseq:NP_724453.1|refseq:NP_724454.1|flybase:FBgn0033062|dip:DIP-24057N|ensemblmetazoa:FBgn0033062(gene)|ensemblmetazoa:FBtr0086018(transcript)|ensemblmetazoa:FBtr0086020(transcript)|ensemblmetazoa:FBtr0086021(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0016246"(RNA interference)|go:"GO:0016604"(nuclear body)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR007042(Arsenite-resistance protein 2)|interpro:IPR021933|interpro:IPR039727|reactome:R-DME-6807505|reactome:R-DME-72163 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 5E|comment:The interaction is RNA independent.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2009/08/10 2014/10/16 rogid:Ti1bBqs1sFBecB2FZwqHM2VcSRY7227 rogid:fJWmZJWKDchr5vF4Wqv5TyWqLNc7227 intact-crc:235849C4B5622100|rigid:b3Ix3lot/puOf+08LS5mpDi8fVA false flag tag:?-? calmodulin binding peptide plus protein a tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V9K7 uniprotkb:Q9V9V7 intact:EBI-283668|uniprotkb:A4UZ50|uniprotkb:Q53XG1|uniprotkb:Q95TJ0|uniprotkb:Q8SWW6|intact:EBI-283674|ensemblmetazoa:FBpp0085354|ensemblmetazoa:FBpp0085356|ensemblmetazoa:FBpp0085357 intact:EBI-168994|ensemblmetazoa:FBpp0085181|ensemblmetazoa:FBpp0307961 psi-mi:srrt_drome(display_long)|uniprotkb:Ars2(gene name)|psi-mi:Ars2(display_short)|uniprotkb:CG7843(orf name)|uniprotkb:Arsenite-resistance protein 2 homolog(gene name synonym) psi-mi:q9v9v7_drome(display_long)|uniprotkb:pasha(gene name)|psi-mi:pasha(display_short)|uniprotkb:DGCR8(gene name synonym)|uniprotkb:Dmel\CG1800(gene name synonym)|uniprotkb:PASHA(gene name synonym)|uniprotkb:Pasha(gene name synonym)|uniprotkb:dmDGCR8(gene name synonym)|uniprotkb:Dmel_CG1800(orf name)|uniprotkb:CG1800(orf name)|uniprotkb:cg1800(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sabin et al. (2009) imex:IM-12204|pubmed:19632183 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2409789|imex:IM-12204-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_610203.2|refseq:NP_724453.1|refseq:NP_724454.1|flybase:FBgn0033062|dip:DIP-24057N|ensemblmetazoa:FBgn0033062(gene)|ensemblmetazoa:FBtr0086018(transcript)|ensemblmetazoa:FBtr0086020(transcript)|ensemblmetazoa:FBtr0086021(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0016246"(RNA interference)|go:"GO:0016604"(nuclear body)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR007042(Arsenite-resistance protein 2)|interpro:IPR021933|interpro:IPR039727|reactome:R-DME-6807505|reactome:R-DME-72163 refseq:NP_651879.1|flybase:FBgn0039861|refseq:NP_001263150.1|ensemblmetazoa:FBtr0337032(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0016319"(mushroom body development)|go:"GO:0020037"(heme binding)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042802"(identical protein binding)|ensemblmetazoa:FBgn0039861(gene)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR040375|ensemblmetazoa:FBtr0085820(transcript) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 6D|comment:The interaction is RNA independent.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2009/08/10 2014/10/16 rogid:fJWmZJWKDchr5vF4Wqv5TyWqLNc7227 rogid:IBoarTXL0lrqJcYhWuF0lLStS1Q7227 intact-crc:2E50AB75F4CB4BAB|rigid:E+Ypm8hcTAHfPBOsX3jiqH6Aldc false calmodulin binding peptide plus protein a tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)